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Publications:  Prof Daniel Pennington

Sumaria N, Martin S, Pennington DJ(2019). Developmental origins of murine γδ T-cell subsets. Immunology vol. 156, (4) 299-304.
10.1111/imm.13032
Grandjean CL, Sumaria N, Martin S, Pennington DJ(2017). Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ(+)CD8αα(+) intraepithelial lymphocytes. Sci Rep vol. 7, (1)
10.1038/s41598-017-09368-x
CABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB et al.(2017). Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma. PLoS Medicine
10.1371/journal.pmed.1002352
https://qmro.qmul.ac.uk/xmlui/handle/123456789/26246
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al.(2017). Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. PLoS Med vol. 14, (7)
10.1371/journal.pmed.1002352
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25043
Sumaria N, Grandjean CL, Silva-Santos B, Pennington DJ(2017). Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells. Cell Rep vol. 19, (12) 2469-2476.
10.1016/j.celrep.2017.05.071
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34315
Muñoz-Ruiz M, Sumaria N, Pennington DJ, Silva-Santos B(2017). Thymic Determinants of γδ T Cell Differentiation. Trends Immunol vol. 38, (5) 336-344.
10.1016/j.it.2017.01.007
Fechter K, Dorronsoro A, Jakobsson E, Ferrin I, Lang V, Sepulveda P, Pennington DJ, Trigueros C(2017). IFNγ Regulates Activated Vδ2+ T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells. PLoS One vol. 12, (1) e0169362-e0169362.
10.1371/journal.pone.0169362
https://qmro.qmul.ac.uk/xmlui/handle/123456789/33646
Ryan PL, Sumaria N, Holland CJ, Bradford CM, Izotova N, Grandjean CL, Jawad AS, Bergmeier LA et al.(2016). Heterogeneous yet stable Vδ2(+) T cell profiles define distinct cytotoxic effector potentials in healthy human individuals. Proceedings of the National Academy of Sciences vol. 113, (50) 14378-14383.
10.1073/pnas.1611098113
https://qmro.qmul.ac.uk/xmlui/handle/123456789/17882
Manson J, Cole E, De¿Ath HD, Vulliamy P, Meier U, Pennington D, Brohi K(2016). Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients. Critical Care vol. 20, (1)
10.1186/s13054-016-1341-2
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13173
Muñoz-Ruiz M, Ribot JC, Grosso AR, Gonçalves-Sousa N, Pamplona A, Pennington DJ, Regueiro JR, Fernández-Malavé E et al.(2016). TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets. Nature immunology
10.1038/ni.3424
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18858
Escorcio-Correia M, Provan A, Pennington DJ (2015). Immune Profiling of Immune Thrombocytopenia (ITP) Patients: Evidence for CD8 T Cell Involvement in the Disease. BLOOD. vol. 126,
Torrance H, Brohi K, Warnes G, Owen HC, Hinds CJ, Pennington DJ, O'Dwyer MJ(2015). T-helper cell polarisation following severe polytrauma. Intensive Care Med Exp vol. 3, (Suppl 1)
10.1186/2197-425X-3-S1-A848
Leslie RD, Dang MA, Hawa MI, Cunningham S, Bradford CM, Lowe R, Paul DM, Libertini E et al. (2015). DNA Methylation Variation in Type 1 Diabetes Mellitus. DIABETES. vol. 64, A81-A81.
Rei M, Pennington DJ, Silva-Santos B(2015). The emerging Protumor role of γδ T lymphocytes: implications for cancer immunotherapy. Cancer Res vol. 75, (5) 798-802.
10.1158/0008-5472.CAN-14-3228
Sumaria N, Grandjean CLA, Pang DJ, Neves JF, Stoenchev KV, Silva-Santos B, Pennington DJ (2014). A requirement for PI3K in gamma delta T-cell development. IMMUNOLOGY. vol. 143, 53-53.
Turner MD, Nedjai B, Hurst T, Pennington DJ(2014). Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. Biochim Biophys Acta vol. 1843, (11) 2563-2582.
10.1016/j.bbamcr.2014.05.014
Rei M, Gonçalves-Sousa N, Lança T, Thompson RG, Mensurado S, Balkwill FR, Kulbe H, Pennington DJ et al.(2014). Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages. Proc Natl Acad Sci U S A vol. 111, (34) E3562-E3570.
10.1073/pnas.1403424111
Dorronsoro A, Ferrin I, Salcedo JM, Jakobsson E, Fernández-Rueda J, Lang V, Sepulveda P, Fechter K et al.(2014). Human mesenchymal stromal cells modulate T-cell responses through TNF-α-mediated activation of NF-κB. Eur J Immunol vol. 44, (2) 480-488.
10.1002/eji.201343668
Schmolka N, Serre K, Grosso AR, Rei M, Pennington DJ, Gomes AQ, Silva-Santos B(2013). Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets. Nat Immunol vol. 14, (10) 1093-1100.
10.1038/ni.2702
Prinz I, Silva-Santos B, Pennington DJ(2013). Functional development of γδ T cells. Eur J Immunol vol. 43, (8) 1988-1994.
10.1002/eji.201343759
Coquet JM, Ribot JC, B¿ba¿a N, Middendorp S, van der Horst G, Xiao Y, Neves JF, Fonseca-Pereira D et al.(2013). Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway. J Exp Med vol. 210, (4) 715-728.
10.1084/jem.20112061
https://qmro.qmul.ac.uk/xmlui/handle/123456789/17887
Michel M-L, Pang DJ, Haque SFY, Potocnik AJ, Pennington DJ, Hayday AC(2012). Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells. Proc Natl Acad Sci U S A vol. 109, (43) 17549-17554.
10.1073/pnas.1204327109
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3222
Ribot JC, Coquet JM, Middendorp S, van der Horst G, Babala N, Neves JF, Pennington DJ, Jacobs HB et al. (2012). CD70-CD27 interactions promote CD4(+)Foxp3(+) regulatory T cell development in the thymic medulla. IMMUNOLOGY. vol. 137, 37-37.
Sumaria N, Pang DJ, Neves JF, Stoenchev KV, Silva-Santos B, Pennington DJ (2012). TCR requirements for gamma delta T cell development. IMMUNOLOGY. vol. 137, 402-403.
Grandjean CLA, Mahtani-Patching J, Pang DJ, Pennington DJ (2012). The role of pTalpha isoforms in alpha beta T cell development. IMMUNOLOGY. vol. 137, 369-369.
Pang DJ, Neves JF, Sumaria N, Pennington DJ(2012). Understanding the complexity of γδ T-cell subsets in mouse and human. Immunology vol. 136, (3) 283-290.
10.1111/j.1365-2567.2012.03582.x
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3223
Turchinovich G, Pennington DJ(2011). T cell receptor signalling in γδ cell development: strength isn't everything. Trends Immunol vol. 32, (12) 567-573.
10.1016/j.it.2011.09.005
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3225
Mahtani-Patching J, Neves JF, Pang DJ, Stoenchev KV, Aguirre-Blanco AM, Silva-Santos B, Pennington DJ(2011). PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization. Sci Signal vol. 4, (182)
10.1126/scisignal.2001765
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3284
Cárcamo-Orive I, Gaztelumendi A, Delgado J, Tejados N, Dorronsoro A, Fernández-Rueda J, Pennington DJ, Trigueros C(2010). Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk. J Bone Miner Res vol. 25, (10) 2115-2125.
10.1002/jbmr.120
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3298
Afifi A, Raja SG, Pennington DJ, Tsang VT(2010). For neonates undergoing cardiac surgery does thymectomy as opposed to thymic preservation have any adverse immunological consequences?. Interact Cardiovasc Thorac Surg vol. 11, (3) 287-291.
10.1510/icvts.2010.237172
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3299
Sengupta N, MacFie TS, MacDonald TT, Pennington D, Silver AR(2010). Cancer immunoediting and "spontaneous" tumor regression. Pathol Res Pract vol. 206, (1) 1-8.
10.1016/j.prp.2009.10.001
Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J et al.(2009). CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets. Nat Immunol vol. 10, (4) 427-436.
10.1038/ni.1717
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3294
McKnight A, Pennington DJ(2009). HIV Vaccine Approaches. Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/329
Sancho D, Mourão-Sá D, Joffre OP, Schulz O, Rogers NC, Pennington DJ, Carlyle JR, Reis e Sousa C(2008). Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J Clin Invest vol. 118, (6) 2098-2110.
10.1172/JCI34584
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3162
Hunt KA, Zhernakova A, Turner G, Heap GAR, Franke L, Bruinenberg M, Romanos J, Dinesen LC et al.(2008). Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet vol. 40, (4) 395-402.
10.1038/ng.102
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3282
Hayday AC, Pennington DJ(2007). Key factors in the organized chaos of early T cell development. Nat Immunol vol. 8, (2) 137-144.
10.1038/ni1436
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3224
Pennington DJ, Silva-Santos B, Silberzahn T, Escorcio-Correia M, Woodward MJ, Roberts SJ, Smith AL, Dyson PJ et al.(2006). Early events in the thymus affect the balance of effector and regulatory T cells. NATURE vol. 444, (7122) 1073-1077.
10.1038/nature06051
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3295
Pennington DJ, Silva-Santos B, Correia M, Hayday AC(2005). The regulation of gamma delta cell functional potential by alpha alpha beta T cell progenitors in the thymus. IMMUNOLOGY vol. 116, 88-88.
Pennington DJ, Silva-Santos B, Hayday AC(2005). Gammadelta T cell development--having the strength to get there. Curr Opin Immunol vol. 17, (2) 108-115.
10.1016/j.coi.2005.01.009
Silva-Santos B, Pennington DJ, Hayday AC(2005). Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors. Science vol. 307, (5711) 925-928.
10.1126/science.1103978
Pennington DJ, Vermijlen D, Wise EL, Clarke SL, Tigelaar RE, Hayday AC(2005). The integration of conventional and unconventional T cells that characterizes cell-mediated responses. Adv Immunol vol. 87, 27-59.
10.1016/S0065-2776(05)87002-6
Comalada M, Xaus J, Valledor AF, López-López C, Pennington DJ, Celada A(2003). PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages. Am J Physiol Cell Physiol vol. 285, (5) C1235-C1245.
10.1152/ajpcell.00228.2003
Pennington DJ, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Wise EL, Tigelaar RE, Owen MJ et al.(2003). The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. Nat Immunol vol. 4, (10) 991-998.
10.1038/ni979
Hayday AC, Pennington DJ, Giuggio VM(2003). Genomics and immunology. Semin Immunol vol. 15, (4) 201-208.
10.1016/S1044-5323(03)00045-9
Trigueros C, Hozumi K, Silva-Santos B, Bruno L, Hayday AC, Owen MJ, Pennington DJ(2003). Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage. Eur J Immunol vol. 33, (7) 1968-1977.
10.1002/eji.200323831
Aliberti J, Schulz O, Pennington DJ, Tsujimura H, Reis e Sousa C, Ozato K, Sher A(2003). Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells. Blood vol. 101, (1) 305-310.
10.1182/blood-2002-04-1088
Saurin AT, Pennington DJ, Raat NJH, Latchman DS, Owen MJ, Marber MS(2002). Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts. Cardiovasc Res vol. 55, (3) 672-680.
10.1016/s0008-6363(02)00325-5
Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shi-Wen X, Chen Y, Venstrom K et al.(2002). Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts. Arthritis Rheum vol. 46, (7) 1857-1865.
10.1002/art.10333
Schulz O, Pennington DJ, Hodivala-Dilke K, Febbraio M, Reis e Sousa C(2002). CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ murine dendritic cells. J Immunol vol. 168, (12) 6057-6065.
10.4049/jimmunol.168.12.6057
Holmes A, Shi-Wen X, Ponticos M, Rajkumar V, Pennington D, Mukerjee D, Abraham DJ, Black CM(2002). CONNECTIVE TISSUE GROWTH FACTOR PRODUCED BY LUNG FIBROBLASTS IN RESPONSE TO INJURY MEDIATES EXTRACELLULAR MATRIX DEPOSITION IN BLEOMYCIN-INDUCED LUNG FIBROSIS. RHEUMATOLOGY vol. 41, 58-58.
Castrillo A, Pennington DJ, Otto F, Parker PJ, Owen MJ, Boscá L(2001). Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection. J Exp Med vol. 194, (9) 1231-1242.
10.1084/jem.194.9.1231
https://qmro.qmul.ac.uk/xmlui/handle/123456789/17892
Saurin AT, Pennington DJ, Raat H, Owen MJ, Marber MS(2000). Ischemic preconditioning in isolated mouse hearts - An essential role for PKC-epsilon. CIRCULATION vol. 102, (18) 155-155.
Shi-wen X, Pennington D, Holmes A, Leask A, Bradham D, Beauchamp JR, Fonseca C, du Bois RM et al.(2000). Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis. Exp Cell Res vol. 259, (1) 213-224.
10.1006/excr.2000.4972
Buckland J, Pennington DJ, Bruno L, Owen MJ(2000). Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development. Eur J Immunol vol. 30, (1) 8-18.
10.1002/1521-4141(200001)30:1<8::AID-IMMU8>3.0.CO;2-8
Holmes A, Fonseca C, Pennington D, Shiwen X, Rajkumar V, Black C, Abraham D(1999). Identification of over expressed genes involved in the maintance of fibrosis: representational difference analysis of scleroderma fibroblasts. ARTHRITIS RHEUM vol. 42, (9) S203-S203.
Pennington DJ, Jenkins SA, Brady HJ, Miles CG, Dzierzak EA, Abraham DJ(1997). HIV- I Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism. Genes Funct vol. 1, (5-6) 321-335.
Brady HJ, Abraham DJ, Pennington DJ, Miles CG, Jenkins S, Dzierzak EA(1995). Altered cytokine expression in T lymphocytes from human immunodeficiency virus Tat transgenic mice. J Virol vol. 69, (12) 7622-7629.
ABRAHAM D, PENNINGTON D, MILES C, JENKINS S, BRADY H, DZIERZAK E(1995). T-CELLS FROM HIV-1 TAT TRANSGENIC MICE SHOW ALTERED CYTOKINE EXPRESSION. J CELL BIOCHEM200-200.
Brady HJ, Pennington DJ, Dzierzak EA(1994). Transgenic mice as models of human immunodeficiency virus expression and related cellular effects. J Gen Virol vol. 75 ( Pt 10), 2549-2558.
10.1099/0022-1317-75-10-2549
Brady HJ, Miles CG, Pennington DJ, Dzierzak EA(1994). Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses. Proc Natl Acad Sci U S A vol. 91, (1) 365-369.
10.1073/pnas.91.1.365
Brady HJ, Pennington DJ, Miles CG, Dzierzak EA(1993). CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration. EMBO J vol. 12, (13) 4923-4932.
10.1002/j.1460-2075.1993.tb06186.x
Brady HJ, Miles CG, Pennington DJ, Dzierzak EA(1993). Studies of HIV-2 promoter activity and cell specific ablation. Leukemia vol. 7 Suppl 2, S61-S65.
DZIERZAK EA, MILES C, PENNINGTON D, BRADY HJM(1993). SPECIFIC ABLATION OF HIV-TAT EXPRESSING CELLS BY CONDITIONALLY TOXIC RETROVIRUSES. J CELL BIOCHEM249-249.
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