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Publications:  Andrew Stagg

Vossenkämper A, Hundsrucker C, Page K et al. (2014) . A CD3-Specific Antibody Reduces Cytokine Production and Alters Phosphoprotein Profiles in Intestinal Tissues From Patients With Inflammatory Bowel Disease.Gastroenterology vol. 147, (1) 172-183.
10.1053/j.gastro.2014.03.049
http://qmro.qmul.ac.uk/jspui/handle/123456789/5879
Hedin C, van der Gast C, Rogers G et al. (2014) . OC-051 Siblings Of Crohn's Disease Patients Exhibit A Biologically Relevant Dysbiosis In The Mucosal Microbial Community: A 16s Rrna Gene Pyrosequencing Study.Gut vol. 63 Suppl 1,
10.1136/gutjnl-2014-307263.51
Al-Hassi HO, Mann ER, Sanchez B et al. (2014) . Altered human gut dendritic cell properties in ulcerative colitis are reversed by Lactobacillus plantarum extracellular encrypted peptide STp.Mol Nutr Food Res vol. 58, (5) 1132-1143.
10.1002/mnfr.201300596
Sanders TJ, McCarthy NE, Giles EM et al. (2014) . Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease.Gastroenterology vol. 146, (5)
10.1053/j.gastro.2014.01.057
Vossenkamper A, Blair P, Safinia N et al. (2013) . A role for gut-associated lymphoid tissue in shaping the human B cell repertoire. IMMUNOLOGY. vol. 140, 27-27.
Giles E, Pathak M, Sanders TJ et al. (2013) . Constitutive Type I Interferon, via STAT1 activation, promotes regulatory T cell function in the healthy human intestine, but not in inflammatory bowel disease. IMMUNOLOGY. vol. 140, 168-168.
Wildemann M, Mushtaq N, Sanders TJ et al. (2013) . Fossil fuel derived particulate matter (PM10) induces maturation and aryl hydrocarbon receptor (AhR) signalling in human dendritic cells. IMMUNOLOGY. vol. 140, 33-33.
Sanders TJ, McCarthy NE, Giles EM et al. (2013) . Retinoic acid generation by human intestinal CD14(+) macrophages is enhanced in Crohn's disease and maintains an inflammatory phenotype. IMMUNOLOGY. vol. 140, 32-32.
McCarthy NE, Bashir Z, Vossenkämper A et al. (2013) . Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells.J Immunol vol. 191, (5) 2752-2763.
10.4049/jimmunol.1202959
http://qmro.qmul.ac.uk/jspui/handle/123456789/5470
Vossenkämper A, Blair PA, Safinia N et al. (2013) . A role for gut-associated lymphoid tissue in shaping the human B cell repertoire.J Exp Med vol. 210, (9) 1665-1674.
10.1084/jem.20122465
http://qmro.qmul.ac.uk/jspui/handle/123456789/5436
Al-Hassi HO, Bernardo D, Murugananthan AU et al. (2013) . A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease.Mucosal Immunol vol. 6, (4) 751-761.
10.1038/mi.2012.113
Groves KC, Bibby DF, Clark DA et al. (2012) . Disease Progression in HIV-1-Infected Viremic Controllers.J Acquir Immune Defic Syndr vol. 61, (4) 407-416.
10.1097/QAI.0b013e318269c414
Mann ER, McCarthy NE, Peake ST et al. (2012) . Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease.Clin Exp Immunol vol. 170, (2) 122-130.
10.1111/j.1365-2249.2012.04649.x
Sanders TJ, McCarthy NE, Giles EM et al. (2012) . Retinoic acid production in the human intestine: antigen presenting cell retinaldehyde dehydrogenase activity is enhanced in inflammatory bowel disease. IMMUNOLOGY. vol. 137, 78-78.
McCarthy NE, Hedin CR, Vossenkaemper A et al. (2012) . HUMAN ANTI-MICROBIAL V delta 2+T-CELLS ARE NOVEL INTESTINAL LYMPHOCYTES WITH FUNCTIONAL RELEVANCE IN CROHN'S DISEASE.GUT vol. 61, A4-A4.
10.1136/gutjnl-2012-302514a.9
Mann ER, Bernardo D, Al-Hassi HO et al. (2012) . Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironment.Inflamm Bowel Dis vol. 18, (7) 1275-1286.
10.1002/ibd.21893
Sanders TJ, McCarthy NE, Giles E et al. (2012) . INTESTINAL INFLAMMATION REGULATES RETINOIC ACID DEPENDENT IMPRINTING OF GUT TROPISM BY DENDRITIC CELLS INDEPENDENTLY OF RALDH EXPRESSION.GUT vol. 61, A402-A402.
10.1136/gutjnl-2012-302514d.256
Hedin CR, Taylor K, Louis P et al. (2012) . MICROBIAL, PHENOTYPIC AND GENETIC MARKERS OF RISK: ASPECTS OF CROHN'S DISEASE THAT ARE SHARED BY UNAFFECTED SIBLINGS.GUT vol. 61, A22-A23.
10.1136/gutjnl-2012-302514a.51
Hedin CR, Louis P, Farquharson F et al. (2012) . PREBOTICS AS PRIMARY PREVENTION OF CROHN'S DISEASE: IMPACT ON LUMINAL MICROBIOLOGY AND ELEVATED FAECAL CALPROTECTIN IS GREATER IN HEALTHY SIBLINGS THAN IN PATIENTS.GUT vol. 61, A171-A171.
10.1136/gutjnl-2012-302514b.237
Sanders TJ, McCarthy NE, Giles EM et al. (2012) . THE ROLE OF RDH10 AND RALDH ENZYMES IN RETINOIC ACID-MEDIATED IMMUNE REGULATION BY ANTIGEN PRESENTING CELLS IN THE HUMAN INTESTINE.GUT vol. 61, A402-A403.
10.1136/gutjnl-2012-302514d.257
Benjamin JL, Hedin CRH, Koutsoumpas A et al. (2012) . Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota.INFLAMMATORY BOWEL DISEASES vol. 18, (6) 1092-1100.
10.1002/ibd.21864
Hedin CR, Stagg AJ, Whelan K et al. (2012) . Family studies in Crohn's disease: new horizons in understanding disease pathogenesis, risk and prevention.Gut vol. 61, (2) 311-318.
10.1136/gut.2011.238568
Ng SC, Benjamin JL, McCarthy NE et al. (2011) . Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease.Inflamm Bowel Dis vol. 17, (10) 2027-2037.
10.1002/ibd.21590
Benjamin JL, Hedin CR, Koutsoumpas A et al. (2011) . Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease.Gut vol. 60, (7) 923-929.
10.1136/gut.2010.232025
Hedin CR, McCarthy NE, Bhattacharjee S et al. (2011) . V Delta 2+T CELL EXPANSION IN CROHN'S DISEASE: IMPACT OF INFLAMMATION, DISEASE ACTIVITY AND TREATMENT. GUT. vol. 60,
10.1136/gut.2011.239301.314
Ng SC, Benjamin JL, McCarthy NE et al. (2010) . Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease.Inflamm Bowel Dis
10.1002/ibd.21590
Al-Hassi HO, Murugananthan A, Bernardo DO et al. (2010) . CCR7-induced homing of human gut dendritic cells mediated by LepRb; differences between ileum and colon and in Crohn's disease. IMMUNOLOGY. vol. 131, 161-162.
McCarthy NE, Hedin CRH, Bhattacharjee S et al. (2010) . Circulating 'gut-tropic' V delta 2 T-cells are expanded in some Crohn's disease patients and their siblings but are ablated by azathioprine therapy. IMMUNOLOGY. vol. 131, 107-107.
Sanders T, McCarthy N, Gellatly N et al. (2010) . Factors from inflamed human intestinal mucosa act on dendritic cells to uncouple the imprinting of gut tropism from FoxP(3)(+) T cell generation. IMMUNOLOGY. vol. 131, 30-31.
Sanders T, McCarthy N, Gellatly N et al. (2010) . Factors from inflamed human intestinal mucosa act on dendritic cells to uncouple the imprinting of gut tropism from FoxP3(+) T cell generation. IMMUNOLOGY. vol. 131, 134-135.
Mann ER, Bernardo D, Al-Hassi HO et al. (2010) . Human dendritic cell function is dependent on tissue of residence. IMMUNOLOGY. vol. 131, 40-40.
Hedin CR, Mullard M, Sharratt E et al. (2010) . Probiotic and prebiotic use in patients with inflammatory bowel disease: a case-control study.Inflamm Bowel Dis vol. 16, (12) 2099-2108.
10.1002/ibd.21286
Gellatly NL, Sanders TJ, Ahmed M et al. (2010) . Retinoic acid and aryl hydrocarbon receptor signalling: opposing effects on human dendritic cell differentiation and ability to imprint gut homing. IMMUNOLOGY. vol. 131, 155-155.
Groves K, Bibby D, Clark D et al. (2010) . Disease Progression Despite Suppressed Plasma Viral Load in Human Immunodeficiency Infected Viremic Controllers. AIDS RESEARCH AND HUMAN RETROVIRUSES. vol. 26, A163-A163.
Vossenkämper A, Marchès O, Fairclough PD et al. (2010) . Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE.J Immunol vol. 185, (7) 4118-4127.
10.4049/jimmunol.1000500
Ng SC, Kamm MA, Stagg AJ et al. (2010) . Intestinal dendritic cells: their role in bacterial recognition, lymphocyte homing, and intestinal inflammation.Inflamm Bowel Dis vol. 16, (10) 1787-1807.
10.1002/ibd.21247
Ng SC, Plamondon S, Kamm MA et al. (2010) . Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis.Inflamm Bowel Dis vol. 16, (8) 1286-1298.
10.1002/ibd.21222
Price CL, Hassi HO, English NR et al. (2010) . Methylglyoxal modulates immune responses: relevance to diabetes.J Cell Mol Med vol. 14, (6B) 1806-1815.
10.1111/j.1582-4934.2009.00803.x
Benjamin JL, Koutsoumpas A, Hedin CRH et al. (2010) . DEMOGRAPHIC, CLINICAL AND GENETIC FACTORS ASSOCIATED WITH DYSBIOSIS IN PATIENTS WITH ACTIVE CROHN'S DISEASE. GUT. vol. 59, A5-A5.
10.1136/gut.2009.208934k
Benjamin JL, Hedin CRH, Koutsoumpas A et al. (2010) . NO CLINICAL BENEFIT OF PREBIOTICS IN THE TREATMENT OF ACTIVE CROHN'S DISEASE: A DOUBLE-BLIND, RANDOMISED, PLACEBO-CONTROLLED TRIAL. GUT. vol. 59, A1-A2.
10.1136/gut.2009.208934c
Ng SC, Plamondon S, Al-Hassi HO et al. (2009) . A novel population of human CD56+ human leucocyte antigen D-related (HLA-DR+) colonic lamina propria cells is associated with inflammation in ulcerative colitis.Clin Exp Immunol vol. 158, (2) 205-218.
10.1111/j.1365-2249.2009.04012.x
Mann ER, McCarthy NE, Milestone AN et al. (2009) . LOSS OF HUMAN GAMMA DELTA T-CELLS IN CROHN'S DISEASE AND ULCERATIVE COLITIS. GUT. vol. 58, A61-A61.
Ng SC, Hart AL, Kamm MA et al. (2009) . Mechanisms of action of probiotics: recent advances.Inflamm Bowel Dis vol. 15, (2) 300-310.
10.1002/ibd.20602
Groves KC, Bibby D, Isaksen A et al. (2009) . Altered T cell homeostasis and activation in HIV-1 elite suppressors with low CD4+T-cell counts.RETROVIROLOGY vol. 6, Article P250,
Gellatly NL, Knight SC, Stagg AJ (2008) . Dendritic cell (DC) imprinting of homing markers on human T-cells is modulated by bacteria. IMMUNOLOGY. vol. 125, 23-23.
Mann ER, McCarthy NE, Hart AL et al. (2008) . Distinct gut and skin homing phenotypes of human dendritic cells and T-cells. IMMUNOLOGY. vol. 125, 22-23.
Ng SC, Plamondon S, Kamm MA et al. (2008) . Dysregulated gut homing in patients with ulcerative colitis is associated with altered CD103 (alpha-E) expression by human colonic dendritic cells. IMMUNOLOGY. vol. 125, 23-23.
Mann ER, McCarthy NE, Hart AL et al. (2008) . Loss of human gamma delta T-cells in Crohn's disease and ulcerative colitis. IMMUNOLOGY. vol. 125, 104-104.
Ng SC, Plamondon S, Hart AL et al. (2008) . Oral probiotic bacteria, VSL#3, is associated with the down-regulation of pro-inflammatory cytokine production by gut dendritic cells in patients with ulcerative colitis. IMMUNOLOGY. vol. 125, 129-129.
Ng SC, McCarthy NE, Plamondon S et al. (2008) . TNF-alpha production and differential release of Th1/Th2 cytokines from gut biopsies is associated with 'trauma responses' in inflammatory bowel disease but not in controls. IMMUNOLOGY. vol. 125, 96-96.
Al-Hassi HO, Price CL, Hart AL et al. (2008) . The expression of ILT3 upregulated on DC from inflamed mucosa: role for probiotic bacteria. IMMUNOLOGY. vol. 125, 110-110.
Arebi N, Gurmany S, Bullas D et al. (2008) . Review article: the psychoneuroimmunology of irritable bowel syndrome--an exploration of interactions between psychological, neurological and immunological observations.Aliment Pharmacol Ther vol. 28, (7) 830-840.
10.1111/j.1365-2036.2008.03801.x
Bedford PA, Burke F, Stagg AJ et al. (2008) . Dendritic cells derived from bone marrow cells fail to acquire and present major histocompatibility complex antigens from other dendritic cells.Immunology vol. 124, (4) 542-552.
10.1111/j.1365-2567.2008.02808.x
Hedin CRH, Koutsoumpas A, Forbes A et al. (2008) . Factors that limit recruitment to clinical trials in crohn's disease. GUT. vol. 57, A118-A118.
Ng SC, Koutsoumpas A, Hedin CR et al. (2008) . Production of il-10 by colonic dendritic cells is associated with higher concentrations of faecal microbiota in patients with active crohn's disease. GUT. vol. 57, A144-A144.
Koutsoumpas A, Hedin CRH, Ng SC et al. (2008) . Smokers with active crohn's disease have differences in the concentration and proportion of key bacterial groups of the faecal microbiota. GUT. vol. 57, A152-A153.
Di Sabatino A, Pickard KM, Gordon JN et al. (2007) . Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease.Gastroenterology vol. 133, (4) 1175-1187.
10.1053/j.gastro.2007.08.018
http://qmro.qmul.ac.uk/jspui/handle/123456789/2040
Ng SC, Plamondon S, Knight SC et al. (2007) . Accumulation of plasmacytoid dendritic cells in the intestine of acute ulcerative colitis. GUT. vol. 56, A116-A116.
McCarthy NE, Jones HA, Marks NA et al. (2007) . Inhaled allergen-driven CD1c up-regulation and enhanced antigen uptake by activated human respiratory-tract dendritic cells in atopic asthma.Clin Exp Allergy vol. 37, (1) 72-82.
10.1111/j.1365-2222.2006.02631.x
Critchley-Thorne RJ, Stagg AJ, Vassaux G (2006) . Recombinant Escherichia coli expressing invasin targets the Peyer's patches: the basis for a bacterial formulation for oral vaccination.Mol Ther vol. 14, (2) 183-191.
10.1016/j.ymthe.2006.01.011
Lindsay JO, Whelan K, Stagg AJ et al. (2006) . Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease.Gut vol. 55, (3) 348-355.
10.1136/gut.2005.074971
McCarthy NE, Jones HA, Marks NA et al. (2005) . Enhanced CD1 expression by activated human respiratory tract dendritic cells in atopic asthma: a role for lipid antigen in allergen tolerance?.IMMUNOLOGY vol. 116, 22-22.
Al-Hassi HO, Lindsay JO, Whelan K et al. (2005) . Modulation of intestinal dendritic cells (DC) in Crohn's disease patients taking a fructo-oligosaccharide prebiotic.IMMUNOLOGY vol. 116, 4-4.
Stagg AJ, Rigby R, Al-Hassi HO et al. (2005) . Polarisation of T lymphocyte homing by dendritic cells in health and intestinal disease.IMMUNOLOGY vol. 116, 27-28.
Hart AL, Al-Hassi HO, Rigby RJ et al. (2005) . Characteristics of intestinal dendritic cells in inflammatory bowel diseases.Gastroenterology vol. 129, (1) 50-65.
10.1053/j.gastro.2005.05.013
Mason MR, Stagg AJ, Knight SC et al. (2005) . The measurement of dendritic cells in umbilical cord blood: a novel technique using small volumes of whole blood.J Soc Gynecol Investig vol. 12, (4) 246-252.
10.1016/j.jsgi.2004.12.003
Lindsay JO, Whelan K, Stagg A et al. (2005) . Prebiotic fructo-oligosaccharide as a therapy for Crohn's disease: An open label trial. GUT. vol. 54, A23-A24.
Rigby RJ, Knight SC, Kamm MA et al. (2005) . Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli.Clin Exp Immunol vol. 139, (2) 245-256.
10.1111/j.1365-2249.2004.02674.x
Hart AL, Lammers K, Brigidi P et al. (2004) . Modulation of human dendritic cell phenotype and function by probiotic bacteria.Gut vol. 53, (11) 1602-1609.
10.1136/gut.2003.037325
Hart AL, Kamm MA, Knight SC et al. (2004) . Prospective evaluation of intestinal homing memory T cells in ulcerative colitis.INFLAMM BOWEL DIS vol. 10, (5) 496-503.
10.1097/00054725-200409000-00002
Burke F, Stagg AJ, Bedford PA et al. (2004) . IL-10-producing B220+CD11c- APC in mouse spleen.J Immunol vol. 173, (4) 2362-2372.
Lammers KM, Hart AL, Brigidi P et al. (2004) . DNA derived from probiotic bacteria modulates human dendritic cell phenotype and function. GUT. vol. 53, A65-A65.
Hart AL, Al-Hassi HO, Kamm MA et al. (2004) . Dendritic cells may drive proinflammatory T cell immune responses in Crohn's disease by production of IL-12 and IL-6. GUT. vol. 53, A97-A98.
Stagg AJ, Hart AL, Knight SC et al. (2004) . Interactions between dendritic cells and bacteria in the regulation of intestinal immunity.BEST PRACT RES CL GA vol. 18, (2) 255-270.
10.1053/ybega.2004.441
Stagg AJ, Hart AL, Knight SC et al. (2004) . Microbial-gut interactions in health and disease. Interactions between dendritic cells and bacteria in the regulation of intestinal immunity.Best Pract Res Clin Gastroenterol vol. 18, (2) 255-270.
10.1016/j.bpg.2003.10.004
Hart AL, Al-Hassi HO, Kamm MA et al. (2004) . Toll like receptors 2 and 4 are upregulated on human lamina propria dendritic cells in intestinal inflammation. GUT. vol. 53, A3-A3.
Hart AL, Kamm MA, Knight SC et al. (2004) . Quantitative and functional characteristics of intestinal-homing memory T cells: analysis of Crohn's disease patients and healthy controls.CLIN EXP IMMUNOL vol. 135, (1) 137-145.
10.1046/j.1365-2249.2004.02347.x
Stagg AJ, Hart AL, Knight SC et al. (2003) . The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria.Gut vol. 52, (10) 1522-1529.
10.1136/gut.52.10.1522
Hart AL, Kamm MA, Knight SC et al. (2003) . The maturation and cytokine expression of human dendritic cells are differentially modulated by probiotic bacteria. GUT. vol. 52, A56-A57.
Hart AL, Stagg AJ, Kamm MA (2003) . Use of probiotics in the treatment of inflammatory bowel disease.J Clin Gastroenterol vol. 36, (2) 111-119.
10.1097/00004836-200302000-00005
Hart AL, Stagg AJ, Frame M et al. (2002) . Review article: the role of the gut flora in health and disease, and its modification as therapy.ALIMENT PHARM THERAP vol. 16, (8) 1383-1393.
10.1046/j.1365-2036.2002.01310.x
Stagg AJ, Kamm MA, Knight SC (2002) . Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin.Eur J Immunol vol. 32, (5) 1445-1454.
10.1002/1521-4141(200205)32:5<1445::AID-IMMU1445>3.0.CO;2-E
Hart AL, Rigby R, Jones A et al. (2002) . Circulating mucosal homing (beta 7+) memory T cells are decreased in number and display altered cytokine production in Crohn's disease.GUT vol. 50, A74-A74.
Rigby RJ, Hart AL, Westcott EDA et al. (2002) . Identification of possible gut homing dendritic cells in peripheral blood by expression of B7 integrin.GUT vol. 50, A67-A67.
Stagg AJ, Kamm MA, Knight SC (2002) . Intestinal dendritic cells increase T cell expression of alpha 4 beta 7 integrin.GUT vol. 50, A26-A27.
Rigby R, Kamm MA, Knight SC et al. (2002) . Pathogenic bacteria stimulate colonic dendritic cells to produce pro-inflammatory IL-12 while the response to probiotic bacteria is to produce anti-inflammatory IL-10.GUT vol. 50, A70-A70.
Hart AL, Rigby R, Stagg AJ et al. (2002) . Probiotic bacteria stimulate natural killer (NK) cell activation and cytokine production, an early step in innate immunity.GUT vol. 50, A69-A69.
Hart AL, Stagg AJ, Rigby R et al. (2002) . Streptococcus faecium, a possible probiotic bacterium, but not Lactobacillus acidophilus or Escherichia coli (Nissle), decreases proinflammatory cytokine production (IFN-Gamma) by an IL-10 dependent mechanism.GUT vol. 50, A67-A67.
Jebbari H, Stagg AJ, Davidson RN et al. (2002) . Leishmania major promastigotes inhibit dendritic cell motility in vitro.Infect Immun vol. 70, (2) 1023-1026.
10.1128/IAI.70.2.1023-1026.2002
Bell SJ, Rigby R, English N et al. (2001) . Migration and maturation of human colonic dendritic cells.J Immunol vol. 166, (8) 4958-4967.
Stagg AJ, Burke F, Hill S et al. (2001) . Isolation of mouse spleen dendritic cells.Methods Mol Med vol. 64, 9-22.
10.1385/1-59259-150-7:9
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