Menu
 
Research menu
Jump to menu

Publications:  Dr Andrew Stagg

Hedin CRH, Vavricka SR, Stagg AJ, Schoepfer A, Raine T, Puig L, Pleyer U, Navarini A et al.(2019). The Pathogenesis of Extraintestinal Manifestations: Implications for IBD Research, Diagnosis, and Therapy. J Crohns Colitis vol. 13, (5) 541-554.
10.1093/ecco-jcc/jjy191
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54511
Mwanza-Lisulo M, Chomba MS, Chama M, Besa EC, Funjika E, Zyambo K, Banda R, Imikendu M et al.(2018). Retinoic acid elicits a coordinated expression of gut homing markers on T lymphocytes of Zambian men receiving oral Vivotif, but not Rotarix, Dukoral or OPVERO vaccines. Vaccine vol. 36, (28) 4134-4141.
10.1016/j.vaccine.2018.04.083
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55922
Stagg AJ(2018). Intestinal Dendritic Cells in Health and Gut Inflammation. Front Immunol vol. 9,
10.3389/fimmu.2018.02883
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54510
Hedin CR, van der Gast CJ, Stagg AJ, Lindsay JO, Whelan K(2017). The gut microbiota of siblings offers insights into microbial pathogenesis of inflammatory bowel disease. Gut Microbes vol. 8, (4) 359-365.
10.1080/19490976.2017.1284733
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19559
Gordon H, Hoti I, Lindsay JO, Stagg AJ (2017). CIRCULATING NON-CLASSICAL MONOCYTES ARE REDUCED IN PATIENTS WITH ACTIVE IBD BUT INCREASE AFTER VEDOLIZUMAB: A ROLE FOR alpha 4 beta 7 IN MYELOID CELL RECRUITMENT TO THE INFLAMED INTESTINE. GASTROENTEROLOGY. vol. 152, S1003-S1004.
10.1016/S0016-5085(17)33405-4
Giles EM, Stagg AJ(2017). Type 1 Interferon in the Human Intestine-A Co-ordinator of the Immune Response to the Microbiota. Inflamm Bowel Dis vol. 23, (4) 524-533.
10.1097/MIB.0000000000001078
MCCARTHY NE, Tyler CJ, Lindsay JO, Stagg AJ, Moser B, Eberl M(2017). Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectin. Journal of Immunology
10.4049/jimmunol.1700003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19499
Gordon H, Hoti I, Lindsay JO, Stagg A (2017). Circulating non-classical monocytes are reduced in patients with active IBD but increase after vedolizumab: a role for alpha 4 beta 7 in myeloid cell recruitment to the inflamed intestine. JOURNAL OF CROHNS & COLITIS. vol. 11, S104-S105.
McCarthy N, Gordon H, Rahman S, Harrow P, Stagg A, Lindsay J (2017). Mucosal inflammation promotes activation of circulating Vd2+T-cells in Crohn's disease. JOURNAL OF CROHNS & COLITIS. vol. 11, S107-S107.
McCarthy N, Gordon H, Rahman S, Harrow P, Stagg A, Lindsay J(2017). P059 Mucosal inflammation promotes activation of circulating Vδ2+ T-cells in Crohn's disease. J Crohns Colitis vol. 11, (suppl_1)
10.1093/ecco-jcc/jjx002.185
Hoti I, McCarthy NE, Giles EM, Ayada I, Gordon H, Stagg AJ, Lindsay JO (2017). TNF alpha production by classical monocytes is poorly controlled by IL-10 in patients with IBD. JOURNAL OF CROHNS & COLITIS. Conference: 12th Congress of ECCO - European Crohn's and Colitis Organisation (Barcelona, Spain) from: 18/02/2017 to: 15/02/2017, vol. 11, S112-S112.
10.1093/ecco-jcc/jjx002.196
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55126
Giles EM, Sanders TJ, McCarthy NE, Lung J, Pathak M, MacDonald TT, Lindsay JO, Stagg AJ(2017). Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease. Mucosal Immunol vol. 10, (1) 184-193.
10.1038/mi.2016.44
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12894
Hedin C, van der Gast CJ, Rogers GB, Cuthbertson L, McCartney S, Stagg AJ, Lindsay JO, Whelan K(2016). Siblings of patients with Crohn's disease exhibit a biologically relevant dysbiosis in mucosal microbial metacommunities. Gut vol. 65, (6) 944-953.
10.1136/gutjnl-2014-308896
Tyler C, McCarthy N, Moser B, Stagg A, Eberl M, Lindsay J(2016). Human intestinal V delta 2+T-cells acquire antigen-presenting potency upon exposure to microbial phosphoantigen: modulation by mucosal inflammation and vedolizumab therapy. JOURNAL OF CROHNS & COLITIS vol. 10, S29-S29.
Whitehouse A, Mushtaq N, McCarthy N, Stagg A, Grigg J (2016). Increased Airway Dendritic Cell Activation And Altered Subset Distribution In London Children Exposed To Higher Levels Of Pollution. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 193,
Anderson JL, Hedin CR, Benjamin JL, Koutsoumpas A, Ng SC, Hart AL, Forbes A, Stagg AJ et al.(2015). Dietary intake of inulin-type fructans in active and inactive Crohn's disease and healthy controls: a case-control study. J Crohns Colitis vol. 9, (11) 1024-1031.
10.1093/ecco-jcc/jjv136
McCarthy NE, Hedin CR, Sanders TJ, Amon P, Hoti I, Ayada I, Baji V, Giles EM et al.(2015). Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn’s disease. Journal of Clinical Investigation vol. 125, (8) 3215-3225.
10.1172/JCI80840
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14670
Peiris M, Dogra H, Araujo EJDA, Stagg AJ, Blackshaw A (2015). CD11c Positive Dendritic Cells Express the Ion Channel TRPM8 in Human Colon, Which Regulates Immune Responses. GASTROENTEROLOGY. vol. 148, S693-S694.
Lahiri R, Derwa Y, Bashir Z, Giles E, Torrance H, O'Dwyer M, Owen H, O'Brien A et al. (2015). EARLY MONOCYTE DYSFUNCTION IN PATIENTS WHO DEVELOP SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS) AND SEPSIS AFTER HEPATOPANCREATICOBILIARY SURGERY. JOURNAL OF HEPATOLOGY. vol. 62, S290-S291.
10.1016/S0168-8278(15)30209-9
Beamish E, Pattisson C, Johnson J, Scott N, Bhowmick A, Stagg A, Rigby R (2015). Improving the Outcome of Stoma Reversal Surgery: Impact of Microflora. FASEB JOURNAL. vol. 29,
Brugha R, Mushtaq N, McCarthy NE, Stagg AJ, Grigg J(2015). Respiratory tract dendritic cells in paediatric asthma. Clin Exp Allergy vol. 45, (3) 624-631.
10.1111/cea.12457
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6638
Lahiri R, Derwa Y, Bashir Z, Giles E, Torrance HD, Owen HC, O'Dwyer MJ, O'Brien A et al.(2015). Systemic Inflammatory Response Syndrome After Major Abdominal Surgery Predicted by Early Upregulation of TLR4 and TLR5. Ann Surg vol. 2015, (3)
10.5966/sctm.2012-0137
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9508
McCarthy NE, Hedin CR, Sanders TJ, Amon P, Baji V, Giles EM, Wildemann M, Bashir Z et al. (2014). Colonic V delta 2+T-cells display elevated TNF production and reversible ablation by azathioprine therapy in Crohn's disease. IMMUNOLOGY. vol. 143, 165-165.
Wildemann M, Mushtaq N, McCarthy N, Whitehouse A, Brugha R, Sanders T, Grigg J, Stagg A(2014). Fossil fuel derived ambient particulate matter (PM10) induces multiple pathways of activation in human dendritic cells. IMMUNOLOGY vol. 143, 99-99.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6739
Mann ER, Bernardo D, Ng SC, Rigby RJ, Al-Hassi HO, Landy J, Peake STC, Spranger H et al.(2014). Human gut dendritic cells drive aberrant gut-specific t-cell responses in ulcerative colitis, characterized by increased IL-4 production and loss of IL-22 and IFNγ. Inflamm Bowel Dis vol. 20, (12) 2299-2307.
10.1097/MIB.0000000000000223
Giles E, Sanders TJ, McCarthy NE, Sanderson I, Lindsay J, MacDonald TT, Stagg AJ (2014). Constitutive Type I Interferon, via STAT1 activation, selectively promotes regulatory T cell function in the healthy human intestine, but not in IBD. IMMUNOLOGY. vol. 143, 17-17.
Vossenkämper A, Hundsrucker C, Page K, van Maurik A, Sanders TJ, Stagg AJ, Das L, MacDonald TT(2014). A CD3-specific antibody reduces cytokine production and alters phosphoprotein profiles in intestinal tissues from patients with inflammatory bowel disease. Gastroenterology vol. 147, (1) 172-183.
10.1053/j.gastro.2014.03.049
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5879
Hedin C, van der Gast C, Rogers G, McCartney S, Stagg A, Lindsay J, Whelan K(2014). OC-051 Siblings Of Crohn's Disease Patients Exhibit A Biologically Relevant Dysbiosis In The Mucosal Microbial Community: A 16s Rrna Gene Pyrosequencing Study. Gut vol. 63 Suppl 1,
10.1136/gutjnl-2014-307263.51
Al-Hassi HO, Mann ER, Sanchez B, English NR, Peake STC, Landy J, Man R, Urdaci M et al.(2014). Altered human gut dendritic cell properties in ulcerative colitis are reversed by Lactobacillus plantarum extracellular encrypted peptide STp. Mol Nutr Food Res vol. 58, (5) 1132-1143.
10.1002/mnfr.201300596
Giles E, Pathak M, Sanders TJ, McCarthy NE, Sanderson IR, Thomas M, Lindsay JO, Stagg AJ (2014). Constitutive Type I Interferon, via STAT1 Activation, Selectively Promotes Regulatory T Cell Function in the Healthy Human Intestine, but Not in Inflammatory Bowel Disease. GASTROENTEROLOGY. vol. 146, S293-S294.
Sanders TJ, McCarthy NE, Giles EM, Davidson KLM, Haltalli MLR, Hazell S, Lindsay JO, Stagg AJ(2014). Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease. Gastroenterology vol. 146, (5)
10.1053/j.gastro.2014.01.057
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15329
Hedin C, van der Gast C, Rogers G, McCartney S, Stagg AJ, Lindsay JO, Whelan K(2014). 16S rRNA gene pyrosequencing indicate that siblings of Crohn's disease patients exhibit a biologically relevant dysbiosis in the mucosal microbiota communities. JOURNAL OF CROHNS & COLITIS vol. 8, S11-S12.
10.1016/S1873-9946(14)60021-0
Hedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Taylor K, Prescott NJ, Murrells T et al.(2014). Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings. Gut
10.1136/gutjnl-2013-306226
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15330
Hedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Taylor K, Prescott NJ, Murrells T et al.(2014). Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings. Gut vol. 63, (10) 1578-1586.
10.1136/gutjnl-2013-306226
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15330
Brugha RE, Mushtaq N, Stagg A, Grigg J (2014). First Description Of Dendritic Cell Subsets In Induced Sputum From Children With Asthma. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 189,
Wildemann M, Mushtaq N, Sanders TJ, Zhou Z, Ezzati M, Grigg J, Stagg AJ (2014). Fossil Fuel And Biomass Derived Particulate Matter (pm) Induce Distinct Profiles Of Activation And Aryl Hydrocarbon Receptor (ahr) Signalling In Human Dendritic Cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 189,
Vossenkamper A, Blair P, Safinia N, Fraser L, Das L, Sanders T, Stagg A, Sanderson J et al. (2013). A role for gut-associated lymphoid tissue in shaping the human B cell repertoire. IMMUNOLOGY. vol. 140, 27-27.
Giles E, Pathak M, Sanders TJ, McCarthy NE, Sanderson IR, MacDonald TT, Lindsay JO, Stagg AJ (2013). Constitutive Type I Interferon, via STAT1 activation, promotes regulatory T cell function in the healthy human intestine, but not in inflammatory bowel disease. IMMUNOLOGY. vol. 140, 168-168.
Wildemann M, Mushtaq N, Sanders TJ, Grigg J, Stagg AJ (2013). Fossil fuel derived particulate matter (PM10) induces maturation and aryl hydrocarbon receptor (AhR) signalling in human dendritic cells. IMMUNOLOGY. vol. 140, 33-33.
Sanders TJ, McCarthy NE, Giles EM, Davidson KLM, Haltalli MLR, Hazell S, Lindsay JO, Stagg AJ (2013). Retinoic acid generation by human intestinal CD14(+) macrophages is enhanced in Crohn's disease and maintains an inflammatory phenotype. IMMUNOLOGY. vol. 140, 32-32.
McCarthy NE, Bashir Z, Vossenkämper A, Hedin CR, Giles EM, Bhattacharjee S, Brown SG, Sanders TJ et al.(2013). Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells. J Immunol vol. 191, (5) 2752-2763.
10.4049/jimmunol.1202959
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5470
Vossenkämper A, Blair PA, Safinia N, Fraser LD, Das L, Sanders TJ, Stagg AJ, Sanderson JD et al.(2013). A role for gut-associated lymphoid tissue in shaping the human B cell repertoire. J Exp Med vol. 210, (9) 1665-1674.
10.1084/jem.20122465
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5436
Al-Hassi HO, Bernardo D, Murugananthan AU, Mann ER, English NR, Jones A, Kamm MA, Arebi N et al.(2013). A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease. Mucosal Immunol vol. 6, (4) 751-761.
10.1038/mi.2012.113
Alazawi W, Lahiri R, Spyrou A, Giles E, Bashir Z, O'Brien A, Stagg A, Waters J et al. (2013). PATIENTS WITH COMPENSATED CIRRHOSIS HAVE SELECTIVE PARESIS OF FLAGELLIN-INDUCED INNATE IMMUNE RESPONSES DUE TO FAILURES IN ERK SIGNALLING. JOURNAL OF HEPATOLOGY. vol. 58, S133-S134.
10.1016/S0168-8278(13)60321-9
Groves KC, Bibby DF, Clark DA, Isaksen A, Deayton JR, Anderson J, Orkin C, Stagg AJ et al.(2012). Disease Progression in HIV-1-Infected Viremic Controllers. J Acquir Immune Defic Syndr vol. 61, (4) 407-416.
10.1097/QAI.0b013e318269c414
Mann ER, McCarthy NE, Peake STC, Milestone AN, Al-Hassi HO, Bernardo D, Tee CT, Landy J et al.(2012). Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease. Clin Exp Immunol vol. 170, (2) 122-130.
10.1111/j.1365-2249.2012.04649.x
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15333
Sanders TJ, McCarthy NE, Giles EM, Lindsay JO, Stagg AJ (2012). Retinoic acid production in the human intestine: antigen presenting cell retinaldehyde dehydrogenase activity is enhanced in inflammatory bowel disease. IMMUNOLOGY. vol. 137, 78-78.
McCarthy NE, Hedin CR, Vossenkaemper A, Bhattacharjee S, Brown SG, Sanders TJ, Giles EM, Whelan K et al. (2012). HUMAN ANTI-MICROBIAL V delta 2+T-CELLS ARE NOVEL INTESTINAL LYMPHOCYTES WITH FUNCTIONAL RELEVANCE IN CROHN'S DISEASE. GUT. vol. 61, A4-A4.
10.1136/gutjnl-2012-302514a.9
Mann ER, Bernardo D, Al-Hassi HO, English NR, Clark SK, McCarthy NE, Milestone AN, Cochrane SA et al.(2012). Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironment. Inflamm Bowel Dis vol. 18, (7) 1275-1286.
10.1002/ibd.21893
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15337
Sanders TJ, McCarthy NE, Giles E, Lindsay JO, Stagg AJ (2012). INTESTINAL INFLAMMATION REGULATES RETINOIC ACID DEPENDENT IMPRINTING OF GUT TROPISM BY DENDRITIC CELLS INDEPENDENTLY OF RALDH EXPRESSION. GUT. vol. 61, A402-A402.
10.1136/gutjnl-2012-302514d.256
Hedin CR, Taylor K, Louis P, Farquharson F, McCartney S, Prescott NJ, Stagg AJ, Lindsay JO et al.(2012). MICROBIAL, PHENOTYPIC AND GENETIC MARKERS OF RISK: ASPECTS OF CROHN'S DISEASE THAT ARE SHARED BY UNAFFECTED SIBLINGS. GUT vol. 61, A22-A23.
10.1136/gutjnl-2012-302514a.51
Hedin CR, Louis P, Farquharson F, McCartney S, Stagg AJ, Lindsay JO, Whelan K(2012). PREBOTICS AS PRIMARY PREVENTION OF CROHN'S DISEASE: IMPACT ON LUMINAL MICROBIOLOGY AND ELEVATED FAECAL CALPROTECTIN IS GREATER IN HEALTHY SIBLINGS THAN IN PATIENTS. GUT vol. 61, A171-A171.
10.1136/gutjnl-2012-302514b.237
Sanders TJ, McCarthy NE, Giles EM, Lindsay JO, Stagg AJ (2012). THE ROLE OF RDH10 AND RALDH ENZYMES IN RETINOIC ACID-MEDIATED IMMUNE REGULATION BY ANTIGEN PRESENTING CELLS IN THE HUMAN INTESTINE. GUT. vol. 61, A402-A403.
10.1136/gutjnl-2012-302514d.257
Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Prescott NJ, Pessoa-Lopes P, Mathew CG et al.(2012). Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota. INFLAMMATORY BOWEL DISEASES vol. 18, (6) 1092-1100.
10.1002/ibd.21864
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15332
Hedin CR, Stagg AJ, Whelan K, Lindsay JO(2012). Family studies in Crohn's disease: new horizons in understanding disease pathogenesis, risk and prevention. Gut vol. 61, (2) 311-318.
10.1136/gut.2011.238568
Ng SC, Benjamin JL, McCarthy NE, Hedin CRH, Koutsoumpas A, Plamondon S, Price CL, Hart AL et al.(2011). Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease. Inflamm Bowel Dis vol. 17, (10) 2027-2037.
10.1002/ibd.21590
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15335
Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Hart AL, Kamm MA, Sanderson JD et al.(2011). Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease. Gut vol. 60, (7) 923-929.
10.1136/gut.2010.232025
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15338
Hedin CR, McCarthy NE, Bhattacharjee S, James G, Whelan K, Lindsay JO, Stagg AJ (2011). V Delta 2+T CELL EXPANSION IN CROHN'S DISEASE: IMPACT OF INFLAMMATION, DISEASE ACTIVITY AND TREATMENT. GUT. vol. 60,
10.1136/gut.2011.239301.314
Ng SC, Benjamin JL, McCarthy NE, Hedin CR, Koutsoumpas A, Plamondon S, Price CL, Hart AL et al. (2010). Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease. Inflamm Bowel Dis.
10.1002/ibd.21590
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15336
Al-Hassi HO, Murugananthan A, Bernardo DO, Mann ER, English N, Milestone A, Hart AL, Blakemore AIF et al. (2010). CCR7-induced homing of human gut dendritic cells mediated by LepRb; differences between ileum and colon and in Crohn's disease. IMMUNOLOGY. vol. 131, 161-162.
McCarthy NE, Hedin CRH, Bhattacharjee S, James GS, Whelan K, Lindsay JO, Stagg AJ (2010). Circulating 'gut-tropic' V delta 2 T-cells are expanded in some Crohn's disease patients and their siblings but are ablated by azathioprine therapy. IMMUNOLOGY. vol. 131, 107-107.
Sanders T, McCarthy N, Gellatly N, Lindsay J, Stagg A (2010). Factors from inflamed human intestinal mucosa act on dendritic cells to uncouple the imprinting of gut tropism from FoxP(3)(+) T cell generation. IMMUNOLOGY. vol. 131, 30-31.
Sanders T, McCarthy N, Gellatly N, Lindsay J, Stagg A (2010). Factors from inflamed human intestinal mucosa act on dendritic cells to uncouple the imprinting of gut tropism from FoxP3(+) T cell generation. IMMUNOLOGY. vol. 131, 134-135.
Mann ER, Bernardo D, Al-Hassi HO, Clark SK, McCarthy NE, Milestone AN, Cochrane SA, Hart AL et al. (2010). Human dendritic cell function is dependent on tissue of residence. IMMUNOLOGY. vol. 131, 40-40.
Hedin CRH, Mullard M, Sharratt E, Jansen C, Sanderson JD, Shirlaw P, Howe LC, Djemal S et al.(2010). Probiotic and prebiotic use in patients with inflammatory bowel disease: a case-control study. Inflamm Bowel Dis vol. 16, (12) 2099-2108.
10.1002/ibd.21286
Gellatly NL, Sanders TJ, Ahmed M, Mughal S, McCarthy NE, Pattni G, Lindsay JO, Stagg AJ (2010). Retinoic acid and aryl hydrocarbon receptor signalling: opposing effects on human dendritic cell differentiation and ability to imprint gut homing. IMMUNOLOGY. vol. 131, 155-155.
Groves K, Bibby D, Clark D, Isaksen A, Deayton J, Anderson J, Orkin C, Stagg AJ et al. (2010). Disease Progression Despite Suppressed Plasma Viral Load in Human Immunodeficiency Infected Viremic Controllers. AIDS RESEARCH AND HUMAN RETROVIRUSES. vol. 26, A163-A163.
Vossenkämper A, Marchès O, Fairclough PD, Warnes G, Stagg AJ, Lindsay JO, Evans PC, Luong LA et al.(2010). Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE. J Immunol vol. 185, (7) 4118-4127.
10.4049/jimmunol.1000500
Ng SC, Kamm MA, Stagg AJ, Knight SC(2010). Intestinal dendritic cells: their role in bacterial recognition, lymphocyte homing, and intestinal inflammation. Inflamm Bowel Dis vol. 16, (10) 1787-1807.
10.1002/ibd.21247
Ng SC, Plamondon S, Kamm MA, Hart AL, Al-Hassi HO, Guenther T, Stagg AJ, Knight SC(2010). Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis. Inflamm Bowel Dis vol. 16, (8) 1286-1298.
10.1002/ibd.21222
Price CL, Hassi HOSA, English NR, Blakemore AIF, Stagg AJ, Knight SC(2010). Methylglyoxal modulates immune responses: relevance to diabetes. J Cell Mol Med vol. 14, (6B) 1806-1815.
10.1111/j.1582-4934.2009.00803.x
Benjamin JL, Koutsoumpas A, Hedin CRH, Ng SC, Prescott NJ, Pessoa-Lopes P, Mathew CG, Kamm MA et al. (2010). DEMOGRAPHIC, CLINICAL AND GENETIC FACTORS ASSOCIATED WITH DYSBIOSIS IN PATIENTS WITH ACTIVE CROHN'S DISEASE. GUT. vol. 59, A5-A5.
10.1136/gut.2009.208934k
Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, Hart AL, Kamm MA, Sanderson JD, Knight SC et al. (2010). NO CLINICAL BENEFIT OF PREBIOTICS IN THE TREATMENT OF ACTIVE CROHN'S DISEASE: A DOUBLE-BLIND, RANDOMISED, PLACEBO-CONTROLLED TRIAL. GUT. vol. 59, A1-A2.
10.1136/gut.2009.208934c
Ng SC, Plamondon S, Al-Hassi HO, English N, Gellatly N, Kamm MA, Knight SC, Stagg AJ(2009). A novel population of human CD56+ human leucocyte antigen D-related (HLA-DR+) colonic lamina propria cells is associated with inflammation in ulcerative colitis. Clin Exp Immunol vol. 158, (2) 205-218.
10.1111/j.1365-2249.2009.04012.x
Mann ER, McCarthy NE, Milestone AN, Cochrane SA, Stagg AJ, Hart AL, Knight SC (2009). LOSS OF HUMAN GAMMA DELTA T-CELLS IN CROHN'S DISEASE AND ULCERATIVE COLITIS. GUT. vol. 58, A61-A61.
Ng SC, Hart AL, Kamm MA, Stagg AJ, Knight SC(2009). Mechanisms of action of probiotics: recent advances. Inflamm Bowel Dis vol. 15, (2) 300-310.
10.1002/ibd.20602
Groves KC, Bibby D, Isaksen A, Deayton J, Anderson J, Orkin C, Stagg AJ, McKnight A(2009). Altered T cell homeostasis and activation in HIV-1 elite suppressors with low CD4+T-cell counts. RETROVIROLOGY vol. 6, Article P250,
10.1186/1742-4690-6-S3-P250
Gellatly NL, Knight SC, Stagg AJ (2008). Dendritic cell (DC) imprinting of homing markers on human T-cells is modulated by bacteria. IMMUNOLOGY. vol. 125, 23-23.
Mann ER, McCarthy NE, Hart AL, Al-Hassi HO, Clark SK, Cochrane SA, Stagg AJ, Knight SC (2008). Distinct gut and skin homing phenotypes of human dendritic cells and T-cells. IMMUNOLOGY. vol. 125, 22-23.
Ng SC, Plamondon S, Kamm MA, Knight SC, Stagg AJ (2008). Dysregulated gut homing in patients with ulcerative colitis is associated with altered CD103 (alpha-E) expression by human colonic dendritic cells. IMMUNOLOGY. vol. 125, 23-23.
Mann ER, McCarthy NE, Hart AL, Milestone AN, Cochrane SA, Stagg AJ, Knight SC (2008). Loss of human gamma delta T-cells in Crohn's disease and ulcerative colitis. IMMUNOLOGY. vol. 125, 104-104.
Ng SC, Plamondon S, Hart AL, Kamm MA, Stagg AJ, Knight SC (2008). Oral probiotic bacteria, VSL#3, is associated with the down-regulation of pro-inflammatory cytokine production by gut dendritic cells in patients with ulcerative colitis. IMMUNOLOGY. vol. 125, 129-129.
Ng SC, McCarthy NE, Plamondon S, Kamm MA, Stagg AJ, Knight SC (2008). TNF-alpha production and differential release of Th1/Th2 cytokines from gut biopsies is associated with 'trauma responses' in inflammatory bowel disease but not in controls. IMMUNOLOGY. vol. 125, 96-96.
Al-Hassi HO, Price CL, Hart AL, Stagg AJ, Knight SC (2008). The expression of ILT3 upregulated on DC from inflamed mucosa: role for probiotic bacteria. IMMUNOLOGY. vol. 125, 110-110.
Arebi N, Gurmany S, Bullas D, Hobson A, Stagg A, Kamm M(2008). Review article: the psychoneuroimmunology of irritable bowel syndrome--an exploration of interactions between psychological, neurological and immunological observations. Aliment Pharmacol Ther vol. 28, (7) 830-840.
10.1111/j.1365-2036.2008.03801.x
Bedford PA, Burke F, Stagg AJ, Knight SC(2008). Dendritic cells derived from bone marrow cells fail to acquire and present major histocompatibility complex antigens from other dendritic cells. Immunology vol. 124, (4) 542-552.
10.1111/j.1365-2567.2008.02808.x
Ng SC, Koutsoumpas A, Hedin CR, McCarthy NE, Plamondon S, Kamm MA, Knight SC, Forbes A et al. (2008). Production of IL-10 by colonic dendritic cells is associated with higher concentrations of faecal microbiota in patients with active Crohn's disease. GASTROENTEROLOGY. vol. 134, A653-A654.
Koutsoumpas A, Hedin CR, Ng SC, Kamm MA, Sanderson JD, Knight SC, Stagg AJ, Forbes A et al.(2008). The concentration and proportion of key bacterial groups of the faecal microbiota are different between smokers and non-smokers with active Crohn's disease. GASTROENTEROLOGY vol. 134, (4) A497-A497.
Hedin CRH, Koutsoumpas A, Forbes A, Sanderson J, Stagg AJ, Knight SC, Whelan K, Lindsay JO (2008). Factors that limit recruitment to clinical trials in crohn's disease. GUT. vol. 57, A118-A118.
Ng SC, Koutsoumpas A, Hedin CR, McCarthy NE, Plamondon S, Kamm MA, Knight SC, Forbes A et al. (2008). Production of il-10 by colonic dendritic cells is associated with higher concentrations of faecal microbiota in patients with active crohn's disease. GUT. vol. 57, A144-A144.
Koutsoumpas A, Hedin CRH, Ng SC, Kamm MA, Sanderson JD, Knight SC, Stagg AJ, Forbes A et al. (2008). Smokers with active crohn's disease have differences in the concentration and proportion of key bacterial groups of the faecal microbiota. GUT. vol. 57, A152-A153.
Di Sabatino A, Pickard KM, Gordon JN, Salvati V, Mazzarella G, Beattie RM, Vossenkaemper A, Rovedatti L et al.(2007). Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease. Gastroenterology vol. 133, (4) 1175-1187.
10.1053/j.gastro.2007.08.018
https://qmro.qmul.ac.uk/xmlui/handle/123456789/2040
Ng SC, Plamondon S, Knight SC, Kamm MA, Stagg AJ (2007). Accumulation of plasmacytoid dendritic cells in the intestine of acute ulcerative colitis. GUT. vol. 56, A116-A116.
McCarthy NE, Jones HA, Marks NA, Shiner RJ, Ind PW, Al-Hassi HO, English NR, Murray CM et al.(2007). Inhaled allergen-driven CD1c up-regulation and enhanced antigen uptake by activated human respiratory-tract dendritic cells in atopic asthma. Clin Exp Allergy vol. 37, (1) 72-82.
10.1111/j.1365-2222.2006.02631.x
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15347
Critchley-Thorne RJ, Stagg AJ, Vassaux G(2006). Recombinant Escherichia coli expressing invasin targets the Peyer's patches: the basis for a bacterial formulation for oral vaccination. Mol Ther vol. 14, (2) 183-191.
10.1016/j.ymthe.2006.01.011
Lindsay JO, Whelan K, Stagg AJ, Gobin P, Al-Hassi HO, Rayment N, Kamm MA, Knight SC et al.(2006). Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease. Gut vol. 55, (3) 348-355.
10.1136/gut.2005.074971
McCarthy NE, Jones HA, Marks NA, Shiner RJ, Ind PW, Al-Harrsi HO, English NR, Murray C et al. (2005). Enhanced CD1 expression by activated human respiratory tract dendritic cells in atopic asthma: a role for lipid antigen in allergen tolerance?. IMMUNOLOGY. vol. 116, 22-22.
Al-Hassi HO, Lindsay JO, Whelan K, Gobin P, Forbes A, Kamm MA, Knight SC, Stagg AJ(2005). Modulation of intestinal dendritic cells (DC) in Crohn's disease patients taking a fructo-oligosaccharide prebiotic. IMMUNOLOGY vol. 116, 4-4.
Stagg AJ, Rigby R, Al-Hassi HO, Hart AL, Kamm MA, Knight SC(2005). Polarisation of T lymphocyte homing by dendritic cells in health and intestinal disease. IMMUNOLOGY vol. 116, 27-28.
Hart AL, Al-Hassi HO, Rigby RJ, Bell SJ, Emmanuel AV, Knight SC, Kamm MA, Stagg AJ(2005). Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology vol. 129, (1) 50-65.
10.1053/j.gastro.2005.05.013
Mason MR, Stagg AJ, Knight SC, Lamont RF(2005). The measurement of dendritic cells in umbilical cord blood: a novel technique using small volumes of whole blood. J Soc Gynecol Investig vol. 12, (4) 246-252.
10.1016/j.jsgi.2004.12.003
Lindsay JO, Whelan K, Stagg A, Gobin P, Omar H, Kamm MA, Knight SC, Forbes A (2005). Prebiotic fructo-oligosaccharide as a therapy for Crohn's disease: An open label trial. GUT. vol. 54, A23-A24.
Rigby RJ, Knight SC, Kamm MA, Stagg AJ(2005). Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli. Clin Exp Immunol vol. 139, (2) 245-256.
10.1111/j.1365-2249.2004.02674.x
Hart AL, Lammers K, Brigidi P, Vitali B, Rizzello F, Gionchetti P, Campieri M, Kamm MA et al.(2004). Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut vol. 53, (11) 1602-1609.
10.1136/gut.2003.037325
Hart AL, Kamm MA, Knight SC, Stagg AJ(2004). Prospective evaluation of intestinal homing memory T cells in ulcerative colitis. INFLAMM BOWEL DIS vol. 10, (5) 496-503.
10.1097/00054725-200409000-00002
Burke F, Stagg AJ, Bedford PA, English N, Knight SC(2004). IL-10-producing B220+CD11c- APC in mouse spleen. J Immunol vol. 173, (4) 2362-2372.
10.4049/jimmunol.173.4.2362
Lammers KM, Hart AL, Brigidi P, Vitali B, Rizzello F, Gionchetti P, Campieri M, Kamm MA et al. (2004). DNA derived from probiotic bacteria modulates human dendritic cell phenotype and function. GUT. vol. 53, A65-A65.
Hart AL, Al-Hassi HO, Kamm MA, Knight SC, Stagg AJ (2004). Dendritic cells may drive proinflammatory T cell immune responses in Crohn's disease by production of IL-12 and IL-6. GUT. vol. 53, A97-A98.
Stagg AJ, Hart AL, Knight SC, Kamm MA(2004). Interactions between dendritic cells and bacteria in the regulation of intestinal immunity. BEST PRACT RES CL GA vol. 18, (2) 255-270.
10.1053/ybega.2004.441
Stagg AJ, Hart AL, Knight SC, Kamm MA(2004). Microbial-gut interactions in health and disease. Interactions between dendritic cells and bacteria in the regulation of intestinal immunity. Best Pract Res Clin Gastroenterol vol. 18, (2) 255-270.
10.1016/j.bpg.2003.10.004
Hart AL, Al-Hassi HO, Kamm MA, Knight SC, Stagg AJ (2004). Toll like receptors 2 and 4 are upregulated on human lamina propria dendritic cells in intestinal inflammation. GUT. vol. 53, A3-A3.
Hart AL, Kamm MA, Knight SC, Stagg AJ(2004). Quantitative and functional characteristics of intestinal-homing memory T cells: analysis of Crohn's disease patients and healthy controls. CLIN EXP IMMUNOL vol. 135, (1) 137-145.
10.1046/j.1365-2249.2004.02347.x
Stagg AJ, Hart AL, Knight SC, Kamm MA(2003). The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria. Gut vol. 52, (10) 1522-1529.
10.1136/gut.52.10.1522
Hart AL, Kamm MA, Knight SC, Stagg AJ (2003). The maturation and cytokine expression of human dendritic cells are differentially modulated by probiotic bacteria. GUT. vol. 52, A56-A57.
Hart AL, Stagg AJ, Kamm MA(2003). Use of probiotics in the treatment of inflammatory bowel disease. J Clin Gastroenterol vol. 36, (2) 111-119.
10.1097/00004836-200302000-00005
Hart AL, Stagg AJ, Frame M, Graffner H, Glise H, Falk P, Kamm MA(2002). Review article: the role of the gut flora in health and disease, and its modification as therapy. ALIMENT PHARM THERAP vol. 16, (8) 1383-1393.
10.1046/j.1365-2036.2002.01310.x
Stagg AJ, Kamm MA, Knight SC(2002). Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin. Eur J Immunol vol. 32, (5) 1445-1454.
10.1002/1521-4141(200205)32:5<1445::AID-IMMU1445>3.0.CO;2-E
Hart AL, Rigby R, Jones A, Kamm MA, Knight SC, Stagg AJ(2002). Circulating mucosal homing (beta 7+) memory T cells are decreased in number and display altered cytokine production in Crohn's disease. GUT vol. 50, A74-A74.
Rigby RJ, Hart AL, Westcott EDA, Kamm MA, Windsor A, Knight SC, Stagg AJ(2002). Identification of possible gut homing dendritic cells in peripheral blood by expression of B7 integrin. GUT vol. 50, A67-A67.
Stagg AJ, Kamm MA, Knight SC(2002). Intestinal dendritic cells increase T cell expression of alpha 4 beta 7 integrin. GUT vol. 50, A26-A27.
Rigby R, Kamm MA, Knight SC, Hart AL, Stagg AJ(2002). Pathogenic bacteria stimulate colonic dendritic cells to produce pro-inflammatory IL-12 while the response to probiotic bacteria is to produce anti-inflammatory IL-10. GUT vol. 50, A70-A70.
Hart AL, Rigby R, Stagg AJ, Lammers K, Rizzello F, Gionchetti P, Campieri M, Knight SC et al.(2002). Probiotic bacteria stimulate natural killer (NK) cell activation and cytokine production, an early step in innate immunity. GUT vol. 50, A69-A69.
Hart AL, Stagg AJ, Rigby R, Jones A, Lammers L, Rizzello F, Gionchetti P, Campieri M et al.(2002). Streptococcus faecium, a possible probiotic bacterium, but not Lactobacillus acidophilus or Escherichia coli (Nissle), decreases proinflammatory cytokine production (IFN-Gamma) by an IL-10 dependent mechanism. GUT vol. 50, A67-A67.
Jebbari H, Stagg AJ, Davidson RN, Knight SC(2002). Leishmania major promastigotes inhibit dendritic cell motility in vitro. Infect Immun vol. 70, (2) 1023-1026.
10.1128/iai.70.2.1023-1026.2002
Bell SJ, Rigby R, English N, Mann SD, Knight SC, Kamm MA, Stagg AJ(2001). Migration and maturation of human colonic dendritic cells. J Immunol vol. 166, (8) 4958-4967.
10.4049/jimmunol.166.8.4958
Stagg AJ, Burke F, Hill S, Knight SC(2001). Isolation of mouse spleen dendritic cells. Methods Mol Med vol. 64, 9-22.
10.1385/1-59259-150-7:9
Return to top