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Publications:  Dr Shane Wilkinson

Meredith EL, Kumar A, Konno A et al. (2017) . Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs.Molecular Microbiology vol. 106, (2) 207-222.
10.1111/mmi.13767
http://qmro.qmul.ac.uk/xmlui/handle/123456789/25315
Guerrero SA, Arias DG, Cabeza MS et al. (2017) . Functional characterization of the methionine sulfoxide reductase repertoire in Trypanosoma brucei.Free Radic Biol Med vol. 112, 524-533.
10.1016/j.freeradbiomed.2017.08.023
http://qmro.qmul.ac.uk/xmlui/handle/123456789/25888
Ranzani AT, Nowicki C, WILKINSON SR et al. (2017) . Identification of Specific Inhibitors of Trypanosoma cruzi Malic Enzyme Isoforms by Target-Based HTS.SLAS Discovery vol. 22, (9) 1150-1161.
10.1177/2472555217706649
http://qmro.qmul.ac.uk/xmlui/handle/123456789/22823
de Padua RAP, Kia AM, Filho AJC et al. (2017) . Characterisation of the fumarate hydratase repertoire in Trypanosoma cruzi.International Journal of Biological Macromolecules vol. 102, 42-51.
10.1016/j.ijbiomac.2017.03.099
http://qmro.qmul.ac.uk/xmlui/handle/123456789/22341
Papadopoulou MV, Bloomer WD, Rosenzweig HS et al. (2016) . Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity.European Journal of Medicinal Chemistry vol. 123, 895-904.
10.1016/j.ejmech.2016.08.002
http://qmro.qmul.ac.uk/xmlui/handle/123456789/15702
Papadopoulou MV, Bloomer WD, Rosenzweig HS et al. (2016) . Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds.European Journal of Medicinal Chemistry vol. 117, 179-186.
10.1016/j.ejmech.2016.04.010
http://qmro.qmul.ac.uk/xmlui/handle/123456789/11848
O'Shea IP, Shahed M, Aguilera-Venegas B et al. (2016) . Evaluating 5-nitrothiazoles as trypanocidal agents.Antimicrobial Agents and Chemotherapy vol. 60, (2) 1137-1140.
10.1128/AAC.02006-15
http://qmro.qmul.ac.uk/xmlui/handle/123456789/10016
Papadopoulou MV, Bloomer WD, Rosenzweig HS et al. (2015) . 3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.European Journal of Medicinal Chemistry vol. 103, Article C, 325-334.
10.1016/j.ejmech.2015.08.042
http://qmro.qmul.ac.uk/xmlui/handle/123456789/11658
Papadopoulou MV, Bloomer WD, Rosenzweig HS et al. (2015) . Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.Bioorganic & Medicinal Chemistry vol. 23, (19) 6467-6476.
10.1016/j.bmc.2015.08.014
http://qmro.qmul.ac.uk/xmlui/handle/123456789/11657
Taylor MC, Lewis MD, Fortes-Francisco A et al. (2015) . The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence.PLoS Neglected Tropical Diseases vol. 9, (4)
10.1371/journal.pntd.0003707
http://qmro.qmul.ac.uk/xmlui/handle/123456789/7339
Sullivan JA, Tong JL, Wong M et al. (2015) . Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.Molecular Microbiology vol. 96, (4) 827-838.
10.1111/mmi.12973
http://qmro.qmul.ac.uk/xmlui/handle/123456789/10015
Shameer S, Logan-Klumper F, Vinson F et al. (2015) . TrypanoCyc: A community led biochemical pathways database for Trypanosoma brucei.Nucleic Acids Research vol. 43, D637-D644.
10.1093/nar/gku944
http://qmro.qmul.ac.uk/xmlui/handle/123456789/11604
Papadopoulou MV, Bloomer WD, Lepesheva GI et al. (2015) . Novel 3-nitrotriazole-based amides and carbinols as bifunctional anti-Chagasic agents.Journal of Medicinal Chemistry vol. 58, (3) 1307-1319.
10.1021/jm5015742
http://qmro.qmul.ac.uk/xmlui/handle/123456789/11605
Papadopoulou MV, Bloomer WD, Rosenzweig HS et al. (2014) . Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents.European Journal of Medicinal Chemistry vol. 87, 79-88.
10.1016/j.ejmech.2014.09.045
http://qmro.qmul.ac.uk/xmlui/handle/123456789/10880
Carvalho AS, Salomão K, Castro SL et al. (2014) . Megazol and its bioisostere 4H-1,2,4-triazole: Comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the T. brucei nitroreductase enzyme (TbNTR).Memórias do Instituto Oswaldo Cruz vol. 109, (3) 315-323.
10.1590/0074-0276140497
Voak AA, Seifert K, Helsby NA et al. (2014) . Evaluating aziridinyl nitrobenzamide compounds as leishmanicidal prodrugs.Antimicrobial Agents and Chemotherapy vol. 58, (1) 370-377.
10.1128/AAC.01459-13
http://qmro.qmul.ac.uk/xmlui/handle/123456789/10013
Papadopoulou MV, Bloomer WD, Rosenzweig HS et al. (2013) . Novel 3-nitro-1H-1,2,4-triazole-based compounds as potential anti-Chagasic drugs: In vivo studies.Future Medicinal Chemistry vol. 5, (15) 1763-1776.
10.4155/fmc.13.108
Roussaki M, Hall B, Lima SC et al. (2013) . Synthesis and anti-parasitic activity of a novel quinolinylchalcones series.Bioorganic and Medicinal Chemistry Letters vol. 23, 6436-6441.
10.1016/j.bmcl.2013.09.047
Voak AA, Gobalakrishnapillai V, Seifert K et al. (2013) . An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs.Journal of Biological Chemistry vol. 288, (40) 28466-28476.
10.1074/jbc.M113.494781
http://qmro.qmul.ac.uk/xmlui/handle/123456789/12388
Buchanan-Kilbey G, Djumpah J, Papadopoulou MV et al. (2013) . Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish.Acta Tropica vol. 128, (3) 701-705.
10.1016/j.actatropica.2013.07.022
Bot C, Hall BS, Alvarez G et al. (2013) . Evaluating 5-nitrofurans as trypanocidal agents.Antimicrobial Agents and Chemotherapy vol. 57, 1638-1647.
10.1128/AAC.02046-12
http://qmro.qmul.ac.uk/xmlui/handle/123456789/12578
Kelly JM, WILKINSON SR (2013) . Mechanisms of resistance to antiparasitic drugs in Trypanosoma cruzi. Is there a correlation between genotype and resistance?.Revista. Espanola de Salud Publica. vol. 87, 17-23.
Hall BS, Meredith EL, WILKINSON SR (2012) . Targeting the substrate preference of a type I nitroreductase to develop anti-trypanosomal quinone-based prodrugs.Antimicrobial Agents and Chemotherapy vol. 56, (11) 5821-5830.
10.1128/AAC.01227-12
http://qmro.qmul.ac.uk/xmlui/handle/123456789/12577
Papadopoulou MV, Bloomer WD, Rosenzweig HS et al. (2012) . Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents.Journal of Medicinal Chemistry vol. 55, (11) 5554-5565.
10.1021/jm300508n
Caminos AP, Panozzo-Zenere EA, WILKINSON SR et al. (2012) . Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.Bioorganic and Medicinal Chemistry Letters vol. 22, (4) 1712-1715.
10.1016/j.bmcl.2011.12.101
Hall BS, Wilkinson SR (2012) . Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation.Antimicrobial Agents and Chemotherapy vol. 56, (1) 115-123.
10.1128/AAC.05135-11
Mejia AM, Hall BS, Taylor MC et al. (2012) . Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population.Journal of Infectious Diseases vol. 2, (206) 220-228.
10.1093/infdis/jis331
http://qmro.qmul.ac.uk/xmlui/handle/123456789/12389
Yang Y, Voak A, WILKINSON SR et al. (2012) . Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation.Bioorganic and Medicinal Chemistry Letters vol. 22, (21) 6583-6586.
10.1016/j.bmcl.2012.09.005
Papadopoulou MV, Trunz BB, Bloomer WD et al. (2011) . Novel 3-Nitro-1H-1,2,4-triazole-based Aliphatic and Aromatic Amines as anti-Chagasic Agents.Journal of Medicinal Chemistry vol. 54, (23) 8214-8223.
10.1021/jm201215n
Hu L, Wu X, Han J et al. (2011) . Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs.Bioorg. Med. Chem. Lett vol. 21, 3986-3991.
10.1016/j.bmcl.2011.05.009
http://qmro.qmul.ac.uk/xmlui/handle/123456789/1179
Hall BS, Bot C, Wilkinson SR (2011) . Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.Journal of Biological Chemistry vol. 286, (15) 13088-13095.
10.1074/jbc.M111.230847
http://qmro.qmul.ac.uk/xmlui/handle/123456789/982
Papadopoulou MV, Bloomer WD, Chatelain E et al. (2011) . Novel nitrotriazole/imidazole-based amides and sulfonamides as potential anti-trypanosomal drugs, III. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. vol. 241,
Wilkinson SR, Bot C, Kelly JM et al. (2011) . Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.Current Topics in Medicinal Chemistry vol. 11, (16) 2072-2084.
10.2174/156802611796575894
Sarell CJ, Wilkinson SR, Viles JH (2010) . Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease.Journal of Biological Chemistry vol. 285, (53) 41533-41540.
10.1074/jbc.M110.171355
Bot C, Hall BS, Bashir N et al. (2010) . Trypanocidal activity of aziridinyl nitrobenzamide prodrugs.Antimicrobial Agents and Chemotherapy vol. 54, (10) 4246-4252.
10.1128/AAC.00800-10
Hall BS, Wu X, Hu L et al. (2010) . Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.Antimicrobial Agents and Chemotherapy vol. 54, (3) 1193-1199.
10.1128/AAC.01213-09
http://qmro.qmul.ac.uk/xmlui/handle/123456789/896
Patel S, Hussain S, Harris R et al. (2010) . Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I).Biochemical Journal vol. 425, 513-522.
10.1042/BJ20091167
http://qmro.qmul.ac.uk/xmlui/handle/123456789/841
Schnick C, Polley SD, Fivelman QL et al. (2009) . Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages.Molecular Microbiology vol. 71, (2) 533-545.
10.1111/j.1365-2958.2008.06544.x
Wilkinson SR, Kelly JM (2009) . Trypanocidal drugs: mechanisms, resistance and new targets.Expert Reviews in Molecular Medicine vol. 11,
10.1017/S1462399409001252
http://qmro.qmul.ac.uk/xmlui/handle/123456789/290
Irigoin F, Cibils L, Comini MA et al. (2008) . Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification.Free Radical Biology and Medicine vol. 45, (6) 733-742.
10.1016/j.freeradbiomed.2008.05.028
http://qmro.qmul.ac.uk/xmlui/handle/123456789/633
Wilkinson SR, Taylor MC, Horn D et al. (2008) . A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.Proceedings of the National Academy of Sciences of USA vol. 105, (13) 5022-5027.
10.1073/pnas.0711014105
http://qmro.qmul.ac.uk/xmlui/handle/123456789/913
Piacenza L, Peluffo G, Alvarez MN et al. (2008) . Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite.Biochemical Journal vol. 410, 359-368.
10.1042/BJ20071138
Taylor MC, Kaur H, Blessington B et al. (2008) . Validation of spermidine synthase as a drug target in African trypanosomes.Biochemical Journal vol. 409, (2) 563-569.
10.1042/BJ20071185
Logan FJ, Taylor MC, Wilkinson SR et al. (2007) . The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase.Biochemical Journal vol. 407, (3) 419-426.
10.1042/BJ20070766
Piacenza L, Irigoin F, Alvarez MN et al. (2007) . Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression.Biochemical Journal vol. 403, 323-334.
10.1042/BJ20061281
Prathalingham SR, Wilkinson SR, Horn D et al. (2007) . Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.Antimicrobial Agents and Chemotherapy vol. 51, (2) 755-758.
10.1128/AAC.01360-06
http://qmro.qmul.ac.uk/xmlui/handle/123456789/299
Wilkinson SR, Prathalingam SR, Taylor MC et al. (2006) . Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.Free Radical Biology and Medicine vol. 40, (2) 198-209.
10.1016/j.freeradbiomed.2005.06.022
Wilkinson SR, Prathalingam SR, Taylor MC et al. (2005) . Vitamin C biosynthesis in trypanosomes: A role for the glycosome.P NATL ACAD SCI USA vol. 102, (33) 11645-11650.
10.1073/pnas.0504251102
Obado SO, Taylor MC, Wilkinson SR et al. (2005) . Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature.Genome Research vol. 15, (1) 36-43.
10.1101/gr.2895105
Bromley EV, Taylor MC, Wilkinson SR et al. (2004) . The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal (vol 34, pg 63, 2004).INT J PARASITOL vol. 34, (8) 989-989.
10.1016/j.ijpara.2003.09.013
Bromley EV, Taylor MC, Wilkinson SR et al. (2004) . The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal.International Journal of Parasitology vol. 34, (1) 63-71.
10.1016/j.ipara.2003.09.004
Wilkinson SR, Horn D, Prathalingam SR et al. (2003) . RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the African trypanosome.J BIOL CHEM vol. 278, (34) 31640-31646.
10.1074/jbc.M303035200
Wilkinson SR, Kelly JM (2003) . The role of glutathione peroxidases in trypanosomatids.Biol Chem vol. 384, (4) 517-525.
10.1515/BC.2003.060
Wilkinson SR, Obado SO, Mauricio IL et al. (2002) . Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum.Proc Natl Acad Sci U S A vol. 99, (21) 13453-13458.
10.1073/pnas.202422899
Wilkinson SR, Taylor MC, Touitha S et al. (2002) . TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum.BIOCHEM J vol. 364, 787-794.
10.1042/BJ20020038
Wilkinson SR, Meyer DJ, Taylor MC et al. (2002) . The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.J Biol Chem vol. 277, (19) 17062-17071.
10.1074/jbc.M111126200
Wilkinson SR, Meyer DJ, Kelly JM (2000) . Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activity.BIOCHEM J vol. 352, 755-761.
10.1042/0264-6021:3520755
http://qmro.qmul.ac.uk/xmlui/handle/123456789/12072
Mondragon A, Wilkinson SR, Taylor MC et al. (1999) . Optimization of conditions for growth of wild-type and genetically transformed Trypanosoma cruzi on agarose plates.PARASITOLOGY vol. 118, 461-467.
10.1017/S0031182099004230
Temperton NJ, Wilkinson SR, Meyer DJ et al. (1998) . Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole.MOLECULAR AND BIOCHEMICAL PARASITOLOGY vol. 96, (1-2) 167-176.
10.1016/S0166-6851(98)00127-3
Tovar J, Wilkinson S, Mottram JC et al. (1998) . Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus.MOLECULAR MICROBIOLOGY vol. 29, (2) 653-660.
10.1046/j.1365-2958.1998.00968.x
http://qmro.qmul.ac.uk/xmlui/handle/123456789/12071
Temperton NJ, Wilkinson SR, Kelly JM (1996) . Cloning of an Fe-superoxide dismutase gene homologue from Trypanosoma cruzi.MOLECULAR AND BIOCHEMICAL PARASITOLOGY vol. 76, (1-2) 339-343.
10.1016/0166-6851(95)02553-7
WILKINSON SR, Temperton NJ, Mondragon A et al.. Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.Journal of Biological Chemistry vol. 275, (11) 8220-8225.
10.1074/jbc.275.11.8220
SULLIVAN JA. Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.Molecular Microbiology
10.1111/mmi.12973
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