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Publications:  Prof David van Heel

Cuvertino S, Hartill V, Colyer A, Garner T, Nair N, Al-Gazali L, Canham N, Faundes V et al.(2020). A restricted spectrum of missense KMT2D variants cause a multiple malformations disorder distinct from Kabuki syndrome. Genetics in Medicine
10.1038/s41436-019-0743-3
Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK et al.(2019). Associations of autozygosity with a broad range of human phenotypes. Nature Communications vol. 10, (1) 4957-4957.
10.1038/s41467-019-12283-6
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61102
Finer S, Martin HC, Khan A, Hunt KA, MacLaughlin B, Ahmed Z, Ashcroft R, Durham C et al.(2019). Cohort profile: East London genes & health (ELGH), a community-based population genomics and health study of British Bangladeshi and British Pakistani people. Int J Epidemiol
10.1093/ije/dyz174
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62209
Gräf S, Haimel M, Bleda M, Hadinnapola C, Southgate L, Li W, Hodgson J, Liu B et al.(2018). Identification of rare sequence variation underlying heritable pulmonary arterial hypertension. Nature Communications vol. 9, (1)
10.1038/s41467-018-03672-4
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36610
KELSELL DP, O'TOOLE E, PIGORS M, SCOTT CA, Tabarra N, VAN HEEL DA(2018). Exome sequencing and rare variant analysis reveals multiple filaggrin mutations in Bangladeshi atopic eczema families and novel risk genes. Journal of Investigative Dermatology
10.1016/j.jid.2018.05.013
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39403
VAN HEEL DA(2018). Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference. Nature Communications
10.1038/s41467-018-03109-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/33623
Narasimhan VM, Rahbari R, Scally A, Wuster A, Mason D, Xue Y, Wright J, Trembath RC et al.(2017). Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes. Nature Communications vol. 8, (1)
10.1038/s41467-017-00323-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/28691
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH et al.(2017). Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol vol. 3, (5) 636-651.
10.1001/jamaoncol.2016.5945
https://qmro.qmul.ac.uk/xmlui/handle/123456789/28275
Tummala H, Walne AJ, Williams M, Bockett N, Collopy L, Cardoso S, Ellison A, Wynn R et al.(2016). DNAJC21 Mutations Link a Cancer-Prone Bone Marrow Failure Syndrome to Corruption in 60S Ribosome Subunit Maturation. American Journal of Human Genetics vol. 99, (1) 115-124.
10.1016/j.ajhg.2016.05.002
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15700
Prins BP, Abbasi A, Wong A, Vaez A, Nolte I, Franceschini N, Stuart PE, Guterriez Achury J et al.(2016). Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. PLOS Medicine vol. 13, (6) e1001976-e1001976.
10.1371/journal.pmed.1001976
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13382
Narasimhan VM, Hunt KA, Mason D, Baker CL, Karczewski KJ, Barnes MR, Barnett AH, Bates C et al.(2016). Health and population effects of rare gene knockouts in adult humans with related parents. Science vol. 352, (6284) 474-477.
10.1126/science.aac8624
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11646
Lenz TL, Deutsch AJ, Han B, Hu X, Okada Y, Eyre S, Knapp M, Zhernakova A et al.(2015). Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. Nature Genetics vol. 47, (9) 1085-1090.
10.1038/ng.3379
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11945
Lenz TL, Deutsch AJ, Han B, Hu X, Okada Y, Eyre S, Knapp M, Zhernakova A et al.(2015). Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. Nature Genetics
10.1038/ng.3379
Gutierrez-Achury J, Zhernakova A, Pulit SL, Trynka G, Hunt KA, Romanos J, Raychaudhuri S, Van Heel DA et al.(2015). Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease. Nature Genetics vol. 47, (6) 577-578.
10.1038/ng.3268
https://qmro.qmul.ac.uk/xmlui/handle/123456789/8667
Mistry V, Bockett NA, Levine AP, Mirza MM, Hunt KA, Ciclitira PJ, Hummerich H, Neuhausen SL et al.(2015). Exome sequencing of 75 individuals from multiply affected coeliac families and large scale resequencing follow up. PLoS ONE vol. 10, (1)
10.1371/journal.pone.0116845
Heap GA, Weedon MN, Bewshea CM, Singh A, Chen M, Satchwell JB, Vivian JP, So K et al.(2014). HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. Nat Genet vol. 46, (10) 1131-1134.
10.1038/ng.3093
Heap GA, Weedon MN, Bewshea CM, Singh A, Chen M, Satchwell JB, Vivian JP, So K et al.(2014). HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. Nature Genetics vol. 46, (10) 1131-1134.
10.1038/ng.3093
Conte I, Merella S, Garcia-Manteiga JM, Migliore C, Lazarevic D, Carrella S, Marco-Ferreres R, Avellino R et al.(2014). The combination of transcriptomics and informatics identifies pathways targeted by miR-204 during neurogenesis and axon guidance. Nucleic Acids Res vol. 42, (12) 7793-7806.
10.1093/nar/gku498
Romanos J, Rosén A, Kumar V, Trynka G, Franke L, Szperl A, Gutierrez-Achury J, van Diemen CC et al.(2014). Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants. Gut vol. 63, (3) 415-422.
10.1136/gutjnl-2012-304110
Ludvigsson JF, Bai JC, Biagi F, Card TR, Ciacci C, Ciclitira PJ, Green PHR, Hadjivassiliou M et al.(2014). Diagnosis and management of adult coeliac disease: Guidelines from the British society of gastroenterology. Gut vol. 63, (8) 1210-1228.
10.1136/gutjnl-2013-306578
Parkes M, Cortes A, Van Heel DA, Brown MA(2013). Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nature Reviews Genetics vol. 14, (9) 661-673.
10.1038/nrg3502
Parkes M, Cortes A, van Heel DA, Brown MA(2013). Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat Rev Genet vol. 14, (9) 661-673.
10.1038/nrg3502
Hunt KA, Mistry V, Bockett NA, Ahmad T, Ban M, Barker JN, Barrett JC, Blackburn H et al.(2013). Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature vol. 498, (7453) 232-235.
10.1038/nature12170
Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK et al.(2013). Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. Nat Genet vol. 45, (6) 670-675.
10.1038/ng.2616
Hunt KA, Mistry V, Bockett NA, Ahmad T, Ban M, Barker JN, Barrett JC, Blackburn H et al.(2013). Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature vol. 498, (7453) 232-235.
10.1038/nature12170
Fu J, Wolfs MGM, Deelen P, Westra H-J, Fehrmann RSN, Te Meerman GJ, Buurman WA, Rensen SSM et al.(2012). Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression. PLoS Genet vol. 8, (1)
10.1371/journal.pgen.1002431
https://qmro.qmul.ac.uk/xmlui/handle/123456789/4921
Hunt KA, Smyth DJ, Balschun T, Ban M, Mistry V, Ahmad T, Anand V, Barrett JC et al.(2011). Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet vol. 44, (1) 3-5.
10.1038/ng.1037
Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A, Bakker SF, Bardella MT et al.(2011). Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet vol. 43, (12) 1193-1201.
10.1038/ng.998
Nanty L, Carbajosa G, Heap GA, Ratnieks F, van Heel DA, Down TA, Rakyan VK(2011). Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates. Genome Res vol. 21, (11) 1841-1850.
10.1101/gr.121640.111
Blaydon DC, Biancheri P, Di W-L, Plagnol V, Cabral RM, Brooke MA, van Heel DA, Ruschendorf F et al.(2011). Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med vol. 365, (16) 1502-1508.
10.1056/NEJMoa1100721
Blaydon DC, Nitoiu D, Eckl K-M, Cabral RM, Bland P, Hausser I, van Heel DA, Rajpopat S et al.(2011). Mutations in CSTA, encoding Cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion. Am J Hum Genet vol. 89, (4) 564-571.
10.1016/j.ajhg.2011.09.001
Westra H-J, Jansen RC, Fehrmann RSN, te Meerman GJ, van Heel D, Wijmenga C, Franke L(2011). MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects. Bioinformatics vol. 27, (15) 2104-2111.
10.1093/bioinformatics/btr323
Cotsapas C, Voight BF, Rossin E, Lage K, Neale BM, Wallace C, Abecasis GR, Barrett JC et al.(2011). Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet vol. 7, (8)
10.1371/journal.pgen.1002254
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5403
Fehrmann RSN, Jansen RC, Veldink JH, Westra H-J, Arends D, Bonder MJ, Fu J, Deelen P et al.(2011). Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS Genet vol. 7, (8)
10.1371/journal.pgen.1002197
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5407
Billmann-Born S, Till A, Arlt A, Lipinski S, Sina C, Latiano A, Annese V, Häsler R et al.(2011). Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC. J Immunol vol. 186, (7) 4027-4038.
10.4049/jimmunol.1000085
Festen EAM, Goyette P, Green T, Boucher G, Beauchamp C, Trynka G, Dubois PC, Lagacé C et al.(2011). A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease. PLoS Genet vol. 7, (1)
10.1371/journal.pgen.1001283
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5464
Trynka G, Wijmenga C, van Heel DA(2010). A genetic perspective on coeliac disease. Trends Mol Med vol. 16, (11) 537-550.
10.1016/j.molmed.2010.09.003
Tye-Din JA, Stewart JA, Dromey JA, Beissbarth T, van Heel DA, Tatham A, Henderson K, Mannering SI et al.(2010). Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease. Sci Transl Med vol. 2, (41)
10.1126/scitranslmed.3001012
Zhernakova A, Elbers CC, Ferwerda B, Romanos J, Trynka G, Dubois PC, de Kovel CGF, Franke L et al.(2010). Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection. Am J Hum Genet vol. 86, (6) 970-977.
10.1016/j.ajhg.2010.05.004
Dubois PCA, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GAR et al.(2010). Multiple common variants for celiac disease influencing immune gene expression. Nat Genet vol. 42, (4) 295-302.
10.1038/ng.543
Heap GA, Yang JHM, Downes K, Healy BC, Hunt KA, Bockett N, Franke L, Dubois PC et al.(2010). Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing. Hum Mol Genet vol. 19, (1) 122-134.
10.1093/hmg/ddp473
Heap GA, van Heel DA(2009). Genetics and pathogenesis of coeliac disease. Semin Immunol vol. 21, (6) 346-354.
10.1016/j.smim.2009.04.001
Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B et al.(2009). A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet vol. 41, (11) 1182-1190.
10.1038/ng.467
Coenen MJH, Trynka G, Heskamp S, Franke B, van Diemen CC, Smolonska J, van Leeuwen M, Brouwer E et al.(2009). Common and different genetic background for rheumatoid arthritis and coeliac disease. Hum Mol Genet vol. 18, (21) 4195-4203.
10.1093/hmg/ddp365
Garner CP, Murray JA, Ding YC, Tien Z, van Heel DA, Neuhausen SL(2009). Replication of celiac disease UK genome-wide association study results in a US population. Hum Mol Genet vol. 18, (21) 4219-4225.
10.1093/hmg/ddp364
Romanos J, van Diemen CC, Nolte IM, Trynka G, Zhernakova A, Fu J, Bardella MT, Barisani D et al.(2009). Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease. Gastroenterology vol. 137, (3) 834-840.e3.
10.1053/j.gastro.2009.05.040
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA et al.(2009). Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Gut vol. 58, (8) 1078-1083.
10.1136/gut.2008.169052
Heap GA, van Heel DA(2009). The genetics of chronic inflammatory diseases. Hum Mol Genet vol. 18, (R1) R101-R106.
10.1093/hmg/ddp001
Hunt KA, van Heel DA(2009). Recent advances in coeliac disease genetics. Gut vol. 58, (4) 473-476.
10.1136/gut.2008.155879
Koskinen LLE, Einarsdottir E, Dukes E, Heap GAR, Dubois P, Korponay-Szabo IR, Kaukinen K, Kurppa K et al.(2009). Association study of the IL18RAP locus in three European populations with coeliac disease. Hum Mol Genet vol. 18, (6) 1148-1155.
10.1093/hmg/ddn438
Dubois P, Hunt K, van Heel D(2009). Sex differences in HLA DQ in celiac disease. Am J Gastroenterol vol. 104, (3)
10.1038/ajg.2009.16
Heap GA, Trynka G, Jansen RC, Bruinenberg M, Swertz MA, Dinesen LC, Hunt KA, Wijmenga C et al.(2009). Complex nature of SNP genotype effects on gene expression in primary human leucocytes. BMC Med Genomics vol. 2,
10.1186/1755-8794-2-1
Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JHM, Howson JMM, Stevens H et al.(2008). Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease. NEW ENGL J MED vol. 359, (26) 2767-2777.
10.1056/NEJMoa0807917
Dubois PC, van Heel DA(2008). Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease. Clin Exp Immunol vol. 153, (2) 162-173.
10.1111/j.1365-2249.2008.03704.x
Adamovic S, Amundsen SS, Lie BA, Gudjónsdóttir AH, Ascher H, Ek J, van Heel DA, Nilsson S et al.(2008). Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families. Genes Immun vol. 9, (4) 364-367.
10.1038/gene.2008.27
Franke L, de Kovel CGF, Aulchenko YS, Trynka G, Zhernakova A, Hunt KA, Blauw HM, van den Berg LH et al.(2008). Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays. Am J Hum Genet vol. 82, (6) 1316-1333.
10.1016/j.ajhg.2008.05.008
Dubois PC, van Heel DA(2008). New susceptibility genes for ulcerative colitis. NAT GENET vol. 40, (6) 686-688.
10.1038/ng0608-686
Monsuur AJ, de Bakker PIW, Zhernakova A, Pinto D, Verduijn W, Romanos J, Auricchio R, Lopez A et al.(2008). Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms. PLoS One vol. 3, (5)
10.1371/journal.pone.0002270
Zhernakova A, Festen EM, Franke L, Trynka G, van Diemen CC, Monsuur AJ, Bevova M, Nijmeijer RM et al.(2008). Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet vol. 82, (5) 1202-1210.
10.1016/j.ajhg.2008.03.016
Hunt KA, Franke L, Deloukas P, Wjmenga C, Van Heel DA(2008). No evidence in a large UK collection for celiac disease risk variants reported by a Spanish study. GASTROENTEROLOGY vol. 134, (5) 1629-1630.
10.1053/j.gastro.2008.03.068
Wapenaar MC, Monsuur AJ, van Bodegraven AA, Weersma RK, Bevova MR, Linskens RK, Howdle P, Holmes G et al.(2008). Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis. Gut vol. 57, (4) 463-467.
10.1136/gut.2007.133132
Hunt KA, Zhernakova A, Turner G, Heap GAR, Franke L, Bruinenberg M, Romanos J, Dinesen LC et al.(2008). Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet vol. 40, (4) 395-402.
10.1038/ng.102
https://qmro.qmul.ac.uk/xmlui/handle/123456789/3282
Butler M, Chaudhary R, van Heel DA, Playford RJ, Ghosh S(2007). NOD2 activity modulates the phenotype of LPS-stimulated dendritic cells to promote the development of T-helper type 2-like lymphocytes - Possible implications for NOD2-associated Crohn's disease. J CROHNS COLITIS vol. 1, (2) 106-115.
10.1016/j.crohns.2007.08.006
Zhernakova A, Alizadeh BZ, Bevova M, van Leeuwen MA, Coenen MJH, Franke B, Franke L, Posthumus MD et al.(2007). Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases. Am J Hum Genet vol. 81, (6) 1284-1288.
10.1086/522037
Marchbank T, Mahmood A, Fitzgerald AJ, Domin J, Butler M, Goodlad RA, Elia G, Cox HM et al.(2007). Human pancreatic secretory trypsin inhibitor stabilizes intestinal mucosa against noxious agents. Am J Pathol vol. 171, (5) 1462-1473.
10.2353/ajpath.2007.070192
van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MCNM et al.(2007). A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet vol. 39, (7) 827-829.
10.1038/ng2058
Henderson KN, Tye-Din JA, Reid HH, Chen Z, Borg NA, Beissbarth T, Tatham A, Mannering SI et al.(2007). A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease. Immunity vol. 27, (1) 23-34.
10.1016/j.immuni.2007.05.015
Cartwright N, Murch O, McMaster SK, Paul-Clark MJ, van Heel DA, Ryffel B, Quesniaux VFJ, Evans TW et al.(2007). Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo. AM J RESP CRIT CARE vol. 175, (6) 595-603.
10.1164/rccm.200608-1103OC
van Bodegraven AA, Curley CR, Hunt KA, Monsuur AJ, Linskens RK, Onnie CM, Crusius JBA, Annese V et al.(2006). Genetic variation in myosin IXB is associated with ulcerative colitis. Gastroenterology vol. 131, (6) 1768-1774.
10.1053/j.gastro.2006.09.011
Walters JRF, Balesaria S, Chavele K-M, Taylor V, Berry JL, Khair U, Barley NF, van Heel DA et al.(2006). Calcium channel TRPV6 expression in human duodenum: different relationships to the vitamin D system and aging in men and women. J Bone Miner Res vol. 21, (11) 1770-1777.
10.1359/jbmr.060721
McGovern DPB, Butler H, Ahmad T, Paolucci M, van Heel DA, Negoro K, Hysi P, Ragoussis J et al.(2006). TUCAN (CARD8) genetic variants and inflammatory bowel disease. Gastroenterology vol. 131, (4) 1190-1196.
10.1053/j.gastro.2006.08.008
van Heel DA, Playford RJ(2006). To the editor - Response. EUR J IMMUNOL vol. 36, (10) 2818-2819.
10.1002/eji.200636631
van Heel DA, Hunt KA, King K, Ghosh S, Gabe SM, Mathew CG, Forbes A, Playford RJ(2006). Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease. Inflamm Bowel Dis vol. 12, (7) 598-605.
10.1097/01.ibd.0000225344.21979.89
Hunt KA, Monsuur AJ, McArdle WL, Kumar PJ, Travis SPL, Walters JRF, Jewell DP, Strachan DP et al.(2006). Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. Gut vol. 55, (7) 969-972.
10.1136/gut.2005.086769
https://qmro.qmul.ac.uk/xmlui/handle/123456789/173
van Heel DA, West J(2006). Recent advances in coeliac disease. Gut vol. 55, (7) 1037-1046.
10.1136/gut.2005.075119
van Heel DA, Hunt KA, Ghosh S, Hervé M, Playford RJ(2006). Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's disease. Eur J Immunol vol. 36, (6) 1629-1635.
10.1002/eji.200535636
Anderson RP, van Heel DA, Tye-Din JA, Jewell DP, Hill AVS(2006). Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac disease. Gut vol. 55, (4) 485-491.
10.1136/gut.2005.064550
van Heel DA(2006). Interleukin 15: its role in intestinal inflammation. Gut vol. 55, (4) 444-445.
10.1136/gut.2005.079335
Butler M, Ng C-Y, van Heel DA, Lombardi G, Lechler R, Playford RJ, Ghosh S(2006). Modulation of dendritic cell phenotype and function in an in vitro model of the intestinal epithelium. Eur J Immunol vol. 36, (4) 864-874.
10.1002/eji.200535497
van Heel DA, Ghosh S, Hunt KA, Mathew CG, Forbes A, Jewell DP, Playford RJ(2005). Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease. Gut vol. 54, (11) 1553-1557.
10.1136/gut.2005.065888
https://qmro.qmul.ac.uk/xmlui/handle/123456789/1022
van Heel DA, Dart J, Nichols S, Jewell DP, Playford RJ(2005). Novel presentation of coeliac disease after following the Atkins' low carbohydrate diet. Gut vol. 54, (9)
10.1136/gut.2004.062588
Anderson RP, van Heel DA, Tye-Din JA, Barnardo M, Salio M, Jewell DP, Hill AVS(2005). T cells in peripheral blood after gluten challenge in coeliac disease. Gut vol. 54, (9) 1217-1223.
10.1136/gut.2004.059998
van Heel DA, Ghosh S, Butler M, Hunt K, Foxwell BMJ, Mengin-Lecreulx D, Playford RJ(2005). Synergistic enhancement of Toll-like receptor responses by NOD1 activation. Eur J Immunol vol. 35, (8) 2471-2476.
10.1002/eji.200526296
van Heel DA, Hunt K, Greco L, Wijmenga C(2005). Genetics in coeliac disease. Best Pract Res Clin Gastroenterol vol. 19, (3) 323-339.
10.1016/j.bpg.2005.01.001
van Heel DA, Ghosh S, Butler M, Hunt KA, Lundberg AMC, Ahmad T, McGovern DPB, Onnie C et al.(2005). Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet vol. 365, (9473) 1794-1796.
10.1016/S0140-6736(05)66582-8
McGovern DPB, Hysi P, Ahmad T, van Heel DA, Moffatt MF, Carey A, Cookson WOC, Jewell DP(2005). Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease. Hum Mol Genet vol. 14, (10) 1245-1250.
10.1093/hmg/ddi135
Hunt KA, McGovern DPB, Kumar PJ, Ghosh S, Travis SPL, Walters JRF, Jewell DP, Playford RJ et al.(2005). A common CTLA4 haplotype associated with coeliac disease. Eur J Hum Genet vol. 13, (4) 440-444.
10.1038/sj.ejhg.5201357
Pierik M, Yang H, Barmada MM, Cavanaugh JA, Annese V, Brant SR, Cho JH, Duerr RH et al.(2005). The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction. Inflamm Bowel Dis vol. 11, (1) 1-7.
10.1097/00054725-200501000-00001
Ghosh S, van Heel D, Playford RJ(2004). Probiotics in inflammatory bowel disease: is it all gut flora modulation?. Gut vol. 53, (5) 620-622.
10.1136/gut.2003.034249
https://qmro.qmul.ac.uk/xmlui/handle/123456789/958
Owens DW, Wilson NJ, Hill AJM, Rugg EL, Porter RM, Hutcheson AM, Quinlan RA, van Heel D et al.(2004). Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients. J Cell Sci vol. 117, (Pt 10) 1989-1999.
10.1242/jcs.01043
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