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Publications:  Dr John Viles

Barritt JD, Younan ND, Viles JH (2017) . N-Terminally Truncated Amyloid-β(11-40/42) Cofibrillizes with its Full-Length Counterpart: Implications for Alzheimer's Disease.Angew Chem Int Ed Engl vol. 56, (33) 9816-9819.
10.1002/anie.201704618
http://qmro.qmul.ac.uk/xmlui/handle/123456789/25927
Shahzad R, Jones MR, Viles JH et al. (2016) . Endocytosis of the tachykinin neuropeptide, neurokinin B, in astrocytes and its role in cellular copper uptake.J Inorg Biochem vol. 162, 319-325.
10.1016/j.jinorgbio.2016.02.027
Matheou CJ, Younan ND, Viles JH (2016) . The Rapid Exchange of Zinc2+ Enables Trace Levels to Profoundly Influence Amyloid-β Misfolding and Dominates Assembly Outcomes in Cu2+/Zn2+ Mixtures.Journal of Molecular Biology vol. 428, (14) 2832-2846.
10.1016/j.jmb.2016.05.017
http://qmro.qmul.ac.uk/xmlui/handle/123456789/13507
Gu M, Viles JH (2016) . Methionine oxidation reduces lag-times for Amyloid-β(1–40) fibre formation but generates highly fragmented fibres.Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
10.1016/j.bbapap.2016.04.009
http://qmro.qmul.ac.uk/xmlui/handle/123456789/12385
Barritt JD, Viles JH (2015) . Truncated Amyloid-β(11-40/42) from Alzheimer Disease Binds Cu2+ with a Femtomolar Affinity and Influences Fiber Assembly.J Biol Chem vol. 290, (46) 27791-27802.
10.1074/jbc.M115.684084
http://qmro.qmul.ac.uk/xmlui/handle/123456789/11005
Younan ND, Viles JH (2015) . A Comparison of Three Fluorophores for the Detection of Amyloid Fibers and Prefibrillar Oligomeric Assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid).Biochemistry vol. 54, (28) 4297-4306.
10.1021/acs.biochem.5b00309
http://qmro.qmul.ac.uk/xmlui/handle/123456789/11006
Nasica-Labouze J, Nguyen PH, Sterpone F et al. (2015) . Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Chem Rev vol. 115, (9) 3518-3563.
10.1021/cr500638n
Matheou CJ, Younan ND, Viles JH (2015) . Cu²⁺ accentuates distinct misfolding of Aβ₁₋₄₀ and Aβ₁₋₄₂ peptides, and potentiates membrane disruption.Biochem J vol. 466, (2) 233-242.
10.1042/BJ20141168
http://qmro.qmul.ac.uk/xmlui/handle/123456789/11007
Jones CE, Otara CB, Younan ND et al. (2014) . Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides S1 and S2.Biochim Biophys Acta vol. 1844, (10) 1842-1850.
10.1016/j.bbapap.2014.08.001
http://qmro.qmul.ac.uk/xmlui/handle/123456789/6407
Stanyon HF, Cong X, Chen Y et al. (2014) . Developing predictive rules for coordination geometry from visible circular dichroism of copper(II) and nickel(II) ions in histidine and amide main-chain complexes.FEBS J vol. 281, (17) 3945-3954.
10.1111/febs.12934
http://qmro.qmul.ac.uk/xmlui/handle/123456789/11008
Stanyon HF, Patel K, Begum N et al. (2014) . Copper(II) sequentially loads onto the N-terminal amino group of the cellular prion protein before the individual octarepeats.Biochemistry vol. 53, (24) 3934-3999.
10.1021/bi500643b
http://qmro.qmul.ac.uk/xmlui/handle/123456789/11269
Otara CB, Jones CE, Younan ND et al. (2014) . Structural analysis of the starfish SALMFamide neuropeptides S1 and S2: the N-terminal region of S2 facilitates self-association.Biochim Biophys Acta vol. 1844, (2) 358-365.
10.1016/j.bbapap.2013.10.013
http://qmro.qmul.ac.uk/xmlui/handle/123456789/6403
Younan ND, Sarell CJ, Davies P et al. (2013) . The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers.FASEB J vol. 27, (5) 1847-1858.
10.1096/fj.12-222588
http://qmro.qmul.ac.uk/xmlui/handle/123456789/17639
Viles JH (2012) . Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases.COORDINATION CHEMISTRY REVIEWS vol. 256, (19-20) 2271-2284.
10.1016/j.ccr.2012.05.003
http://qmro.qmul.ac.uk/xmlui/handle/123456789/11270
Younan ND, Nadal RC, Davies P et al. (2012) . Methionine oxidation perturbs the structural core of the prion protein and suggests a generic misfolding pathway.J Biol Chem vol. 287, (34) 28263-28275.
10.1074/jbc.M112.354779
Stanyon HF, Viles JH (2012) . Human serum albumin can regulate amyloid-β peptide fiber growth in the brain interstitium: implications for Alzheimer disease.J Biol Chem vol. 287, (33) 28163-28168.
10.1074/jbc.C112.360800
Younan ND, Klewpatinond M, Davies P et al. (2011) . Copper(II)-induced secondary structure changes and reduced folding stability of the prion protein.J Mol Biol vol. 410, (3) 369-382.
10.1016/j.jmb.2011.05.013
Davies P, Wang X, Sarell CJ et al. (2011) . The synucleins are a family of redox-active copper binding proteins.Biochemistry vol. 50, (1) 37-47.
10.1021/bi101582p
Sarell CJ, Wilkinson SR, Viles JH (2010) . Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease.J Biol Chem vol. 285, (53) 41533-41540.
10.1074/jbc.M110.171355
Wright HM, Wyatt PB, Viles JH (2010) . Is oxidation the trigger of the Amyloid Cascade?: A synthesis of 2-oxo-histidine for incorporation into the Amyloid beta sequence.J PEPT SCI vol. 16, 66-66.
Nadal RC, Davies P, Brown DR et al. (2009) . Evaluation of copper2+ affinities for the prion protein.Biochemistry vol. 48, (38) 8929-8931.
10.1021/bi9011397
Sarell CJ, Syme CD, Rigby SEJ et al. (2009) . Copper(II) binding to amyloid-beta fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Abeta oligomeric form.Biochemistry vol. 48, (20) 4388-4402.
10.1021/bi900254n
O'Sullivan DBD, Jones CE, Abdelraheim SR et al. (2009) . Dynamics of a truncated prion protein, PrP(113-231), from (15)N NMR relaxation: order parameters calculated and slow conformational fluctuations localized to a distinct region.Protein Sci vol. 18, (2) 410-423.
10.1002/pro.44
Viles JH, Klewpatinond M, Nadal RC (2008) . Copper and the structural biology of the prion protein.Biochem Soc Trans vol. 36, (Pt 6) 1288-1292.
10.1042/BST0361288
Nadal RC, Rigby SEJ, Viles JH (2008) . Amyloid beta-Cu2+ complexes in both monomeric and fibrillar forms do not generate H2O2 catalytically but quench hydroxyl radicals.Biochemistry vol. 47, (44) 11653-11664.
10.1021/bi8011093
Brazier MW, Davies P, Player E et al. (2008) . Manganese binding to the prion protein.J Biol Chem vol. 283, (19) 12831-12839.
10.1074/jbc.M709820200
Klewpatinond M, Davies P, Bowen S et al. (2008) . Deconvoluting the Cu2+ binding modes of full-length prion protein.J BIOL CHEM vol. 283, (4) 1870-1881.
10.1074/jbc.M708472200
Klewpatinond M, Viles JH (2007) . Fragment length influences affinity for Cu2+ and Ni2+ binding to His(96) or His(111) of the prion protein and spectroscopic evidence for a multiple histidine binding only at low pH.BIOCHEM J vol. 404, 393-402.
10.1042/BJ20061893
Klewpatinond M, Viles JH (2007) . Empirical rules for rationalising visible circular dichroism of Cu2+ and Ni2+ histidine complexes: Applications to the prion protein.FEBS LETT vol. 581, (7) 1430-1434.
10.1016/j.febslet.2007.02.068
O'Sullivan DBD, Jones CE, Abdelraheim SR et al. (2007) . NMR characterization of the pH 4 beta-intermediate of the prion protein: the N-terminal half of the protein remains unstructured and retains a high degree of flexibility.Biochem J vol. 401, (2) 533-540.
10.1042/BJ20060668
Nadal RC, Abdelraheim SR, Brazier MW et al. (2007) . Prion protein does not redox-silence Cu2+, but is a sacrificial quencher of hydroxyl radicals.Free Radic Biol Med vol. 42, (1) 79-89.
10.1016/j.freeradbiomed.2006.09.019
Syme CD, Viles JH (2006) . Solution 1H NMR investigation of Zn2+ and Cd2+ binding to amyloid-beta peptide (Abeta) of Alzheimer's disease.Biochim Biophys Acta vol. 1764, (2) 246-256.
10.1016/j.bbapap.2005.09.012
Garnett AP, Jones CE, Viles JH (2006) . A survey of diamagnetic probes for copper2+ binding to the prion protein. 1H NMR solution structure of the palladium2+ bound single octarepeat.Dalton Trans (3) 509-518.
10.1039/b511553a
Otara CB, Jones CE, Melarange R et al. (2005) . Tertiary structure and activity of SALMFamide neuropeptides.COMP BIOCHEM PHYS A vol. 141, (3) S161-S161.
Jones CE, Klewpatinond M, Abdelraheim SR et al. (2005) . Probing copper2+ binding to the prion protein using diamagnetic nickel2+ and 1H NMR: the unstructured N terminus facilitates the coordination of six copper2+ ions at physiological concentrations.J Mol Biol vol. 346, (5) 1393-1407.
10.1016/j.jmb.2004.12.043
Jones CE, Abdelraheim SR, Brown DR et al. (2004) . Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein.J Biol Chem vol. 279, (31) 32018-32027.
10.1074/jbc.M403467200
Syme CD, Nadal RC, Rigby SEJ et al. (2004) . Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques.J Biol Chem vol. 279, (18) 18169-18177.
10.1074/jbc.M313572200
Garnett AP, Viles JH (2003) . Copper binding to the octarepeats of the prion protein. Affinity, specificity, folding, and cooperativity: insights from circular dichroism.J Biol Chem vol. 278, (9) 6795-6802.
10.1074/jbc.M209280200
Dyson HJ, Wright PE, Mo HP et al. (2002) . Structure and dynamics of prion and doppel proteins.ABSTR PAP AM CHEM S vol. 223, C35-C35.
Dyson HJ, Mo HP, Viles JH et al. (2002) . Structure and dynamics of prion and Doppel proteins.BIOPHYS J vol. 82, (1) 169A-169A.
Viles JH, Duggan BM, Zaborowski E et al. (2001) . Potential bias in NMR relaxation data introduced by peak intensity analysis and curve fitting methods.J BIOMOL NMR vol. 21, (1) 1-9.
10.1023/A:1011966718826
Viles JH, Donne D, Kroon G et al. (2001) . Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics.BIOCHEMISTRY-US vol. 40, (9) 2743-2753.
10.1021/bi002898a
Viles JH, Cohen FE, Prusiner SB et al. (1999) . Copper binding to the prion protein: structural implications of four identical cooperative binding sites.Proc Natl Acad Sci U S A vol. 96, (5) 2042-2047.
10.1073/pnas.96.5.2042
Viles JH, Patel SU, Mitchell JB et al. (1998) . Design, synthesis and structure of a zinc finger with an artificial beta-turn.J Mol Biol vol. 279, (4) 973-986.
10.1006/jmbi.1998.1764
Donne DG, Viles JH, Groth D et al. (1997) . Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible.Proc Natl Acad Sci U S A vol. 94, (25) 13452-13457.
10.1073/pnas.94.25.13452
Sadler PJ, Viles JH (1996) . <sup>1</sup>H and <sup>113</sup>Cd NMR Investigations of Cd<sup>2+</sup> and Zn<sup>2+</sup> Binding Sites on Serum Albumin: Competition with Ca<sup>2+</sup>, Ni<sup>2+</sup>, Cu<sup>2+</sup>, and Zn<sup>2+</sup>.Inorganic Chemistry vol. 35, (15) 4490-4496.
Viles JH, Mitchell JB, Gough SL et al. (1996) . Multiple solution conformations of the integrin-binding cyclic pentapeptide cyclo(-Ser-D-Leu-Asp-Val-Pro-). Analysis of the (phi, psi) space available to cyclic pentapeptides.Eur J Biochem vol. 242, (2) 352-362.
10.1111/j.1432-1033.1996.0352r.x
Sadler PJ, Viles JH (1996) . 1H and (113)Cd NMR Investigations of Cd(2+) and Zn(2+) Binding Sites on Serum Albumin: Competition with Ca(2+), Ni(2+), Cu(2+), and Zn(2+).Inorg Chem vol. 35, (15) 4490-4496.
10.1021/ic951005d
Harris R, Patel SU, Sadler PJ et al. (1996) . Observation of albumin resonances in proton nuclear magnetic resonance spectra of human blood plasma: N-terminal assignments aided by use of modified recombinant albumin.Analyst vol. 121, (7) 913-922.
10.1039/an9962100913
Doyle PM, Harris JC, Moody CM et al. (1996) . Solution structure of a biologically active cyclic LDV peptide analogue containing a type II' beta-turn mimetic.Int J Pept Protein Res vol. 47, (6) 427-436.
10.1111/j.1399-3011.1996.tb01093.x
Jones DT, Moody CM, Uppenbrink J et al. (1996) . Towards meeting the Paracelsus Challenge: The design, synthesis, and characterization of paracelsin-43, an α-helical protein with over 50% sequence identity to an all-β protein.Proteins: Structure, Function and Genetics vol. 24, (4) 502-513.
10.1002/(SICI)1097-0134(199604)24:4&lt;502::AID-PROT9&gt;3.0.CO;2-F
Jones DT, Moody CM, Uppenbrink J et al. (1996) . Towards meeting the Paracelsus Challenge: The design, synthesis, and characterization of paracelsin-43, an alpha-helical protein with over 50% sequence identity to an all-beta protein.Proteins vol. 24, (4) 502-513.
10.1002/(SICI)1097-0134(199604)24:4<502::AID-PROT9>3.0.CO;2-F
Sadler PJ, Tucker A, Viles JH (1994) . Involvement of a lysine residue in the N-terminal Ni2+ and Cu2+ binding site of serum albumins. Comparison with Co2+, Cd2+ and Al3+.Eur J Biochem vol. 220, (1) 193-200.
10.1111/j.1432-1033.1994.tb18614.x
Patel SU, Sadler PJ, Tucker A et al. (1993) . Direct Detection of Albumin in Human Blood Plasma by <sup>1</sup>H NMR Spectroscopy. Complexation of Nickel<sup>2+</sup>.Journal of the American Chemical Society vol. 115, (20) 9285-9286.
10.1021/ja00073a053
PATEL SU, SADLER PJ, TUCKER A et al. (1993) . PROTON NMR DETECTION OF ALBUMIN IN INTACT HUMAN BLOOD-PLASMA. JOURNAL OF CELLULAR BIOCHEMISTRY. 298-298.
BAKER MD. Ion Channel Formation by Amyloid-β42 Oligomers but not Amyloid-β40 in Cellular Membranes.Journal of Biological Chemistry
10.1074/jbc.M116.762526
http://qmro.qmul.ac.uk/xmlui/handle/123456789/21600
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