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Publications:  Dr Jane Sosabowski

Martinez O, Sosabowski JK, Maher J, Papa S(2019). New Developments in Imaging Cell-based Therapy. J Nucl Med
10.2967/jnumed.118.213348
Zhai C, He S, Ye Y, Rangger C, Kaeopookum P, Summer D, Haas H, Kremser L et al.(2019). Rational Design, Synthesis and Preliminary Evaluation of Novel Fusarinine C-Based Chelators for Radiolabeling with Zirconium-89. Biomolecules vol. 9, (3)
10.3390/biom9030091
Klingler M, Summer D, Rangger C, Haubner R, Foster J, Sosabowski J, Virgolini I, Decristoforo C et al.(2018). DOTA-MGS5, a new cholecystokinin-2 receptor targeting peptide analog with optimized targeting profile for theranostic use. J Nucl Med
10.2967/jnumed.118.221283
Deshayes E, Ladjohounlou R, Le Fur P, Pichard A, Lozza C, Boudousq V, Sevestre S, Jarlier M et al.(2018). Radiolabeled Antibodies Against Müllerian-Inhibiting Substance Receptor, Type II: New Tools for a Theranostic Approach in Ovarian Cancer. J Nucl Med vol. 59, (8) 1234-1242.
10.2967/jnumed.118.208611
Klingler M, Decristoforo C, Rangger C, Summer D, Foster J, Sosabowski JK, von Guggenberg E(2018). Site-specific stabilization of minigastrin analogs against enzymatic degradation for enhanced cholecystokinin-2 receptor targeting. Theranostics vol. 8, (11) 2896-2908.
10.7150/thno.24378
Emami-Shahri N, Foster J, Kashani R, Gazinska P, Cook C, Sosabowski J, Maher J, Papa S(2018). Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells. Nature Communications vol. 9, (1) 1081-1081.
10.1038/s41467-018-03524-1
Tremoleda JL, Macholl S, Sosabowski JK(2018). Anesthesia and Monitoring of Animals During MRI Studies. Methods Mol Biol vol. 1718, 423-439.
10.1007/978-1-4939-7531-0_25
Costa PM, Wang JT-W, Morfin J-F, Khanum T, To W, Sosabowski J, Tóth E, Al-Jamal KT(2018). Functionalised Carbon Nanotubes Enhance Brain Delivery of Amyloid-Targeting Pittsburgh Compound B (PiB)-Derived Ligands. Nanotheranostics vol. 2, (2) 168-183.
10.7150/ntno.23125
Macholl S, Finucane CM, Hesterman J, Mather SJ, Pauplis R, Scully D, Sosabowski JK, Jouannot E(2017). High-throughput high-volume nuclear imaging for preclinical in vivo compound screening§. EJNMMI Res vol. 7, (1) 33-33.
10.1186/s13550-017-0281-4
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25485
Hodgins NO, Al-Jamal WT, Wang JT-W, Klippstein R, Costa PM, Sosabowski JK, Marshall JF, Maher J et al.(2017). Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy. J Control Release vol. 256, 141-152.
10.1016/j.jconrel.2017.04.025
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22659
Rudran B, Desai A, Luzarraga M, Hodivala-Dilke K, Foster J, Sosabowski J, Marshall J (2017). Development of non-invasive imaging of integrin alpha-v-beta-6 (alpha v beta 6)-positive lung cancers in advance of testing alpha v beta 6-targeted therapies. Lung Cancer. Conference: British Thoracic Oncology Group Conference 2017 (Dublin, Ireland) from: 25/01/2017 to: 27/01/2017, vol. 103, S4-S4.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25184
Dubey RD, Klippstein R, Wang JT-W, Hodgins N, Mei K-C, Sosabowski J, Hider RC, Abbate V et al.(2017). Novel Hyaluronic Acid Conjugates for Dual Nuclear Imaging and Therapy in CD44-Expressing Tumors in Mice In Vivo. Nanotheranostics vol. 1, (1) 59-79.
10.7150/ntno.17896
Mohamed Suffian IFB, Wang JT-W, Hodgins NO, Klippstein R, Garcia-Maya M, Brown P, Nishimura Y, Heidari H et al.(2016). Engineering hepatitis B virus core particles for targeting HER2 receptors in vitro and in vivo. Biomaterials vol. 120, 126-138.
10.1016/j.biomaterials.2016.12.012
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34425
Denis-Bacelar AM, Cronin SE, Da Pieve C, Paul RL, Eccles SA, Spinks TJ, Box C, Hall A et al.(2016). Pre-clinical quantitative imaging and mouse-specific dosimetry for 111In-labelled radiotracers. EJNMMI Res vol. 6, (1)
10.1186/s13550-016-0238-z
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25482
Paillas S, Ladjohounlou R, Lozza C, Pichard A, Boudousq V, Jarlier M, Deshayes E, Sosabowski J et al. (2016). Localized irradiation of cell membrane by Auger electrons is cytotoxic through non-targeted effects involving p38 and JNK signaling pathways. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. vol. 43, S163-S164.
Spinks TJ, Flux G, Sosabowski J, Finucane C, Macholl S (2016). SPECT Characterisation and Quantification of Preclinical Scanners. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. vol. 43, S524-S524.
Denis-Bacelar AM, Cronin SE, Da Pieve C, Paul R, Eccles SA, Spinks T, Box C, Hall A et al. (2016). The effect of partial volume in quantitative pre-clinical imaging of In-111-labelled antibodies. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. vol. 43, S490-S490.
Paillas S, Ladjohounlou R, Lozza C, Pichard A, Boudousq V, Jarlier M, Sevestre S, Le Blay M et al.(2016). Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects. Antioxidants and Redox Signaling vol. 25, (8)
10.1089/ars.2015.6309
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15122
Al-Jamal KT, Bai J, Wang JT-W, Protti A, Southern P, Bogart L, Heidari H, Li X et al.(2016). Magnetic Drug Targeting: Preclinical in Vivo Studies, Mathematical Modeling, and Extrapolation to Humans. Nano Letters: a journal dedicated to nanoscience and nanotechnology
10.1021/acs.nanolett.6b02261
Emami-Shahri N, Foster J, Sosabowski J, Maher J, Papa S (2016). Dynamic SPECT imaging of PSMA-specific CAR T cells in mice bearing prostate cancer. CANCER RESEARCH. vol. 76,
10.1158/1538-7445.AM2016-2315
Cabana L, Bourgognon M, Wang JT-W, Protti A, Klippstein R, de Rosales RTM, Shah AM, Fontcuberta J et al.(2016). The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo. Small vol. 12, (21) 2893-2905.
10.1002/smll.201502721
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J et al.(2016). In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid. European Journal of Nuclear Medicine and Molecular Imaging
10.1007/s00259-016-3391-8
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12308
Kafa H, Wang JT-W, Rubio N, Klippstein R, Costa PM, Hassan HAFM, Sosabowski JK, Bansal SS et al.(2016). Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood-brain barrier in vitro and in vivo. J Control Release vol. 225, 217-229.
10.1016/j.jconrel.2016.01.031
Wang JT-W, Rubio N, Kafa H, Venturelli E, Fabbro C, Ménard-Moyon C, Da Ros T, Sosabowski JK et al.(2016). Kinetics of functionalised carbon nanotube distribution in mouse brain after systemic injection: Spatial to ultra-structural analyses. J Control Release vol. 224, 22-32.
10.1016/j.jconrel.2015.12.039
Bai J, Wang JT-W, Rubio N, Protti A, Heidari H, Elgogary R, Southern P, Al-Jamal WT et al.(2016). Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo. Theranostics vol. 6, (3) 342-356.
10.7150/thno.11918
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al. (2015). IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION. SHOCK. vol. 44, 24-25.
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al.(2015). T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION. Shock vol. 44 Suppl 2, 24-25.
10.1097/01.shk.0000472079.77136.27
Paillas S, Desai A, Quetier I, Marshall J, Pouget J, Sosabowski J (2015). Targeted Radionuclide Therapy using high-LET particle emitter-labeled vectors against alpha-v-beta6-expressing cancers. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. vol. 42, S201-S201.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/10035
Rycroft D, Sosabowski J, Coulstock E, Davies M, Morrey J, Friel S(2015). Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Alpha (vol 2, e0117847, 2015). PLOS ONE vol. 10, (4) Article ARTN e0124463,
10.1371/journal.pone.0124463
Tremoleda JL, Sosabowski J(2015). Imaging technologies and basic considerations for welfare of laboratory rodents. LAB ANIMAL vol. 44, (3) 101-109.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/8256
Tremoleda JL, Sosabowski J(2015). Imaging technologies and basic considerations for welfare of laboratory rodents. Lab Anim (NY) vol. 44, (3) 97-105.
10.1038/laban.665
Goldstein R, Sosabowski J, Livanos M, Leyton J, Vigor K, Bhavsar G, Nagy-Davidescu G, Rashid M et al.(2015). Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging. Eur J Nucl Med Mol Imaging vol. 42, (2) 288-301.
10.1007/s00259-014-2940-2
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15124
Pujatti PB, Foster JM, Finucane C, Hudson CD, Burnet JC, Pasqualoto KFM, Mengatti J, Mather SJ et al.(2015). Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models. Appl Radiat Isot vol. 96, 91-101.
10.1016/j.apradiso.2014.11.006
Rycroft D, Sosabowski J, Coulstock E, Davies M, Morrey J, Friel S, Kelly F, Hamatake R et al.(2015). Pharmacokinetic characteristics, pharmacodynamic effect and in vivo antiviral efficacy of liver-targeted interferon alpha. PLoS One vol. 10, (2)
10.1371/journal.pone.0117847
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15123
Parente-Pereira AC, Shmeeda H, Whilding LM, Zambirinis CP, Foster J, van der Stegen SJC, Beatson R, Zabinski T et al.(2014). Adoptive immunotherapy of epithelial ovarian cancer with Vγ9Vδ2 T cells, potentiated by liposomal alendronic acid. J Immunol vol. 193, (11) 5557-5566.
10.4049/jimmunol.1402200
Roosenburg S, Laverman P, Joosten L, Cooper MS, Kolenc-Peitl PK, Foster JM, Hudson C, Leyton J et al.(2014). PET and SPECT imaging of a radiolabeled minigastrin analogue conjugated with DOTA, NOTA, and NODAGA and labeled with (64)Cu, (68)Ga, and (111)In. Mol Pharm vol. 11, (11) 3930-3937.
10.1021/mp500283k
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6698
Wang JT-W, Fabbro C, Venturelli E, Ménard-Moyon C, Chaloin O, Da Ros T, Methven L, Nunes A et al.(2014). The relationship between the diameter of chemically-functionalized multi-walled carbon nanotubes and their organ biodistribution profiles in vivo. Biomaterials vol. 35, (35) 9517-9528.
10.1016/j.biomaterials.2014.07.054
Da Pieve C, Cronin SE, Paul RL, Denis-Bacelar AM, Frisch KJ, Hall A, Sosabowski JK, Spinks T et al. (2014). Pre-clinical image-based dosimetry using HER2 targeting In-111 labelled antibodies. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. vol. 41, S281-S281.
Wang JTW, Cabana L, Bourgognon M, Kafa H, Protti A, Venner K, Shah AM, Sosabowski JK et al.(2014). Magnetically decorated multiwalled carbon nanotubes as dual mri and spect contrast agents. Advanced Functional Materials vol. 24, (13) 1880-1894.
10.1002/adfm.201302892
Allen MD, Luong P, Hudson C, Leyton J, Delage B, Ghazaly E, Cutts R, Yuan M et al.(2014). Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging. Cancer Res vol. 74, (3) 896-907.
10.1158/0008-5472.CAN-13-1702
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6977
van der Stegen SJC, Davies DM, Wilkie S, Foster J, Sosabowski JK, Burnet J, Whilding LM, Petrovic RM et al.(2013). Preclinical in vivo modeling of cytokine release syndrome induced by ErbB-retargeted human T cells: identifying a window of therapeutic opportunity?. J Immunol vol. 191, (9) 4589-4598.
10.4049/jimmunol.1301523
Goldstein R, Tolner B, Leyton J, Livanos M, Bhavsar G, Vigor K, Nagy G, Mather S et al. (2013). Pre-clinical developments of the G3 Designed ankyrin repeat protein (DARPin) for invivo assessment of HERZ expression. CANCER RESEARCH. vol. 73,
10.1158/1538-7445.AM2013-3912
Goldstein R, Sosabowski J, Vigor K, Chester K, Meyer T(2013). Developments in single photon emission computed tomography and PET-based HER2 molecular imaging for breast cancer. Expert Rev Anticancer Ther vol. 13, (3) 359-373.
10.1586/era.13.11
Coulstock E, Sosabowski J, Ove¿ka M, Prince R, Goodall L, Mudd C, Sepp A, Davies M et al.(2013). Liver-targeting of interferon-alpha with tissue-specific domain antibodies. PLoS One vol. 8, (2)
10.1371/journal.pone.0057263
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5241
Wang JT-W, Cabana L, Bourgognon M, Kafa H, Protti A, Venner K, Shah AM, Sosabowski JK et al.(2013). Magnetically Decorated Multiwalled Carbon Nanotubes as Dual MRI and SPECT Contrast Agents. Advanced Functional Materials
10.1002/adfm.201302892
Rangger C, Helbok A, Sosabowski J, Kremser C, Koehler G, Prassl R, Andreae F, Virgolini IJ et al.(2013). Tumor targeting and imaging with dual-peptide conjugated multifunctional liposomal nanoparticles. Int J Nanomedicine vol. 8, 4659-4671.
10.2147/IJN.S51927
Joosten L, Sosabowski JK, Cooper MS, Foster J, Burnet J, Oyen WJG, Boerman OC, Blower PJ et al. (2012). PET and SPECT Imaging of a CCK2 Receptor-Binding Peptide Comparing Various Chelators and Radionuclides. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. vol. 39, S241-S241.
von Guggenberg E, Rangger C, Sosabowski J, Laverman P, Reubi J-C, Virgolini IJ, Decristoforo C(2012). Preclinical evaluation of radiolabeled DOTA-derivatized cyclic minigastrin analogs for targeting cholecystokinin receptor expressing malignancies. Mol Imaging Biol vol. 14, (3) 366-375.
10.1007/s11307-011-0506-2
Laverman P, Sosabowski JK, Boerman OC, Oyen WJG(2012). Radiolabelled peptides for oncological diagnosis. Eur J Nucl Med Mol Imaging vol. 39 Suppl 1, S78-S92.
10.1007/s00259-011-2014-7
Rangger C, Helbok A, von Guggenberg E, Sosabowski J, Radolf T, Prassl R, Andreae F, Thurner GC et al.(2012). Influence of PEGylation and RGD loading on the targeting properties of radiolabeled liposomal nanoparticles. Int J Nanomedicine vol. 7, 5889-5900.
10.2147/IJN.S36847
Laverman P, Joosten L, Eek A, Roosenburg S, Peitl PK, Maina T, Mäcke H, Aloj L et al.(2011). Comparative biodistribution of 12 ¹¹¹In-labelled gastrin/CCK2 receptor-targeting peptides. Eur J Nucl Med Mol Imaging vol. 38, (8) 1410-1416.
10.1007/s00259-011-1806-0
Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowski JK et al.(2011). Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607. Eur J Nucl Med Mol Imaging vol. 38, (8) 1426-1435.
10.1007/s00259-011-1818-9
Aloj L, Aurilio M, Rinaldi V, D'ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R et al.(2011). Comparison of the binding and internalization properties of 12 DOTA-coupled and ¹¹¹In-labelled CCK2/gastrin receptor binding peptides: a collaborative project under COST Action BM0607. Eur J Nucl Med Mol Imaging vol. 38, (8) 1417-1425.
10.1007/s00259-011-1816-y
Finucane CM, Murray I, Sosabowski JK, Foster JM, Mather SJ(2011). Quantitative Accuracy of Low-Count SPECT Imaging in Phantom and In Vivo Mouse Studies. Int J Mol Imaging vol. 2011,
10.1155/2011/197381
Naqvi SAR, Sosabowski JK, Nagra SA, Ishfaq MM, Mather SJ, Matzow T(2011). Radiopeptide internalisation and externalization assays: cell viability and radioligand integrity. Appl Radiat Isot vol. 69, (1) 68-74.
10.1016/j.apradiso.2010.09.005
Sosabowski J, Finucane C, Foster J, Ellison D, Burnet J, Mather S (2010). Comparison Of 111-In Labelled CCK2-Receptor Targeting Peptides Using Nanospect/CT Imaging, A Collaborative Project Under COST BM0607. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. vol. 37, S268-S268.
Naqvi SAR, Matzow T, Finucane C, Nagra SA, Ishfaq MM, Mather SJ, Sosabowski J(2010). Insertion of a lysosomal enzyme cleavage site into the sequence of a radiolabeled neuropeptide influences cell trafficking in vitro and in vivo. Cancer Biother Radiopharm vol. 25, (1) 89-95.
10.1089/cbr.2009.0666
Sosabowski JK, Matzow T, Foster JM, Finucane C, Ellison D, Watson SA, Mather SJ(2009). Targeting of CCK-2 receptor-expressing tumors using a radiolabeled divalent gastrin peptide. J Nucl Med vol. 50, (12) 2082-2089.
10.2967/jnumed.109.064808
Sosabowski J, Matzow T, Foster J, Mather S(2009). TARGETING OF CCK2 RECEPTOR EXPRESSING TUMOURS USING AN 111IN-LABELLED MINIGASTRIN DIMER. J LABELLED COMPD RAD vol. 52, S327-S327.
Sosabowski JK, Lee M, Dekker BA, Simmons BP, Singh S, Beresford H, Hagan SA, McKenzie AJ et al.(2007). Formulation development and manufacturing of a gastrin/CCK-2 receptor targeting peptide as an intermediate drug product for a clinical imaging study. Eur J Pharm Sci vol. 31, (2) 102-111.
10.1016/j.ejps.2007.02.007
Mather SJ, McKenzie AJ, Sosabowski JK, Morris TM, Ellison D, Watson SA(2007). Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy. J Nucl Med vol. 48, (4) 615-622.
10.2967/jnumed.106.037085
Sosabowski JK, Mather SJ(2006). Conjugation of DOTA-like chelating agents to peptides and radiolabeling with trivalent metallic isotopes. Nat Protoc vol. 1, (2) 972-976.
10.1038/nprot.2006.175
Whelan AN, Elaridi J, Smith SV, Mulder RJ, Robinson AJ, Sosabowski J(2005). SYNTHESIS OF DICARBA ANALOGUES OF OCTREOTIDE USING TANDEM HOMOGENEOUS CATALYSIS. J LABELLED COMPD RAD vol. 48, S238-S238.
Sosabowski J, Melendez-Alafort L, Mather S(2003). Radiolabelling of peptides for diagnosis and therapy of non-oncological diseases. Q J NUCL MED vol. 47, (4) 223-237.
Fowkes RC, Sidhu KK, Sosabowski JK, King P, Burrin JM(2003). Absence of pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein alpha-subunit gene in LbetaT2 gonadotrophs reveals disrupted cAMP-mediated gene transcription. J Mol Endocrinol vol. 31, (2) 263-278.
10.1677/jme.0.0310263
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