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Publications:  Prof Andrew Silver

Martin S(2019). MLH1 deficiency leads to deregulated mitochondrial metabolism. Cell Death and Disease vol. 10, 795-795.
10.1038/s41419-019-2018-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61511
Baker AM, Cross W, Curtius K, Al Bakir I, Choi CHR, Davis HL, Temko D, Biswas S et al.(2019). Evolutionary history of human colitis-associated colorectal cancer. Gut vol. 68, (6) 985-995.
10.1136/gutjnl-2018-316191
https://qmro.qmul.ac.uk/xmlui/handle/123456789/43331
Lewis A, Nijhuis A, Berti G, Felice C, Jeffrey R, Iqbal S, Pomeranc AB, Aldelemi S et al. (2019). Drugs that modulate histone acetylation disrupt TGF-beta-signalling and reduce collagen I expression in models of stricturing Crohn's disease. JOURNAL OF CROHNS & COLITIS. vol. 13, S38-S38.
Lewis A, Jeffrey R, Kumagai T, Hawkey CJ, Clark MM, Allez M, Satsangi J, Rogler G et al. (2019). Mucosal micoRNA profiles predict response to autologous stem-cell transplantation in Crohn's disease. JOURNAL OF CROHNS & COLITIS. vol. 13, S14-S14.
10.1093/ecco-jcc/jjy222.019
Lewis A, Nijhuis A, Berti G, Bishop CL, Feakins R, Lindsay JO, Silver A (2019). Pharmacological inhibition of the canonical WNT signalling pathway represents a potential novel therapy for fibrosis in Crohn's disease. JOURNAL OF CROHNS & COLITIS. vol. 13, S103-S104.
10.1093/ecco-jcc/jjy222.159
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65840
Bolland H, McIntyre A, Shams-Nateri A, Bishop C, Silver A (2018). eIF4A2 is a regulator of hypoxic translation and colorectal tumour cell survival. BRITISH JOURNAL OF CANCER. vol. 119, 23-23.
Mehta SJ, Lewis A, Nijhuis A, Jeffery R, Biancheri P, Di Sabatino A, Feakins R, Silver A et al.(2018). Epithelial down-regulation of the miR-200 family in fibrostenosing Crohn's disease is associated with features of epithelial to mesenchymal transition. J Cell Mol Med vol. 22, (11) 5617-5628.
10.1111/jcmm.13836
Baker A-M, Cross W, Curtius K, Choi C-HR, Al-Bakir I, Temko D, Martinez P, Williams M et al. (2018). The evolutionary history of human colitis-associated colorectal cancer. CANCER RESEARCH. vol. 78,
10.1158/1538-7445.AM2018-5368
Mehta SJ, Lewis A, Nijhuis A, Jeffery R, Feakins R, Silver A, Lindsay JO (2018). Epithelial to mesenchymal transition is a hallmark of fibrostenosing Crohn's disease and is associated with down regulation of the miR-200 family. JOURNAL OF CROHNS & COLITIS. vol. 12, S91-S92.
Rigoni A, Poulsom R, Jeffery R, Mehta S, Lewis A, Yau C, Giannoulatou E, Feakins R et al.(2017). Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans. Inflamm Bowel Dis vol. 24, (1) 136-148.
10.1093/ibd/izx024
https://qmro.qmul.ac.uk/xmlui/handle/123456789/41723
Bustos V, Nolan ÁM, Nijhuis A, Harvey H, Parker A, Poulsom R, McBryan J, Thomas W et al.(2017). GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions. Oncotarget vol. 8, (48) 84258-84275.
10.18632/oncotarget.20653
Shailes H, Bridge G, Foxler D, Sharp TV, Silver A, Martin SA (2017). Targeting APC loss using synthetic lethality in Colorectal Cancer. MOLECULAR CANCER THERAPEUTICS. vol. 16,
Adam J, Ramracheya R, Chibalina MV, Ternette N, Hamilton A, Tarasov AI, Zhang Q, Rebelato E et al.(2017). Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes. Cell Rep vol. 20, (13) 3135-3148.
10.1016/j.celrep.2017.08.093
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34663
Reissig K, Silver A, Hartig R, Schinlauer A, Walluscheck D, Guenther T, Siedentopf S, Ross J et al.(2017). Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding. Oxid Med Cell Longev vol. 2017, 9303158-9303158.
10.1155/2017/9303158
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27805
Lessel W, Silver A, Jechorek D, Guenther T, Roehl F-W, Kalinski T, Roessner A, Poehlmann-Nitsche A(2017). Inactivation of JNK2 as carcinogenic factor in colitis-associated and sporadic colorectal carcinogenesis. Carcinogenesis vol. 38, (5) 559-569.
10.1093/carcin/bgx032
Baker A-M, Davis CHRCH, Al-Bakir I, Martinez P, Temko D, Cross W, Williams M, Biswas S et al. (2017). MULTI-REGION EXOME SEQUENCING REVEALS THE CLONAL EVOLUTION OF COLITIS-ASSOCIATED COLORECTAL CANCER. GASTROENTEROLOGY. Conference: Pathological Society vol. 152, S983-S984.
10.1016/S0016-5085(17)33330-9
https://qmro.qmul.ac.uk/xmlui/handle/123456789/50083
Lewis A, Felice C, Kumagai T, Lai C, Singh K, Jeffery RR, Feakins R, Giannoulatou E et al.(2017). The miR-200 family is increased in dysplastic lesions in ulcerative colitis patients. PLoS One vol. 12, (3) e0173664-e0173664.
10.1371/journal.pone.0173664
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34604
Nijhuis A, Thompson H, Adam J, Parker A, Gammon L, Lewis A, Bundy JG, Tomoyoshi S et al.(2017). Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance. Human Molecular Genetics
10.1093/hmg/ddx059
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19445
Nijhuis A, Curciarello R, Mehta S, Feakins R, Bishop CL, Lindsay JO, Silver A(2017). MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8. Cell Tissue Res
10.1007/s00441-017-2576-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/20359
Lewis A, Felice C, Nihjuis A, Iqbal S, Mehta S, Feakins R, Armuzzi A, Silver A et al. (2017). Hypoacetylation of histone-3 is a hallmark of intestinal fibrosis in Crohn's disease. JOURNAL OF CROHNS & COLITIS. vol. 11, S17-S17.
Urban BC, Collard TJ, Eagle CJ, Southern SL, Greenhough A, Hamdollah-Zadeh M, Ghosh A, Poulsom R et al.(2016). BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling. Gut vol. 65, (7) 1151-1164.
10.1136/gutjnl-2014-308270
Walton S-J, Lewis A, Jeffery R, Thompson H, Feakins R, Giannoulatou E, Yau C, Lindsay JO et al.(2016). Familial adenomatous patients with desmoid tumours show increased expression of miR-34a in serum and high levels in tumours. Oncoscience vol. 3, (5-6) 173-185.
10.18632/oncoscience.312
Alzoubi S, Brody L, Rahman S, Mahul-Mellier A-L, Mercado N, Ito K, El-Bahrawy M, Silver A et al.(2016). Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer. Oncotarget vol. 7, (28) 44505-44521.
10.18632/oncotarget.9887
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34326
Santoro V, Jia R, Thompson H, Nijhuis A, Jeffery R, Kiakos K, Silver AR, Hartley JA et al.(2016). Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer. J Natl Cancer Inst vol. 108, (6)
10.1093/jnci/djv394
Suraweera N, Mouradov D, Li S, Jorissen RN, Hampson D, Ghosh A, Sengupta N, THAHA MA et al.(2016). Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer. Oncotarget
10.18632/oncotarget.9015
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12396
Nolan A, Bray I, Stallings R, Silver A, Thomas W, Harvey B(2016). Oestrogen and Hypoxia Modulate Gene Expression in Colorectal Cancer Cells Through Specific Microrna Regulation. IRISH JOURNAL OF MEDICAL SCIENCE vol. 185, S34-S34.
Rigoni A, Bongiovanni L, Burocchi A, Sangaletti S, Danelli L, Guarnotta C, Lewis A, Rizzo A et al.(2015). Mast cells infiltrating inflamed or transformed gut alternatively sustain mucosal healing or tumor growth. Cancer Research vol. 75, (18) 3760-3770.
10.1158/0008-5472.CAN-14-3767
Jawad N, Johnson C, Butterworth E, Saeed I, Feakins R, Rodriguez-Justo M, McDonald S, Wright N et al. (2015). DO INFLAMMATORY POLYPS SHOW FEATURES ASSOCIATED WITH THE EARLY STAGES OF MALIGNANT PROGRESSION?. GUT. vol. 64, A7-A7.
10.1136/gutjnl-2015-309861.12
Mehta S, Nijhuis A, Kumagai T, Lindsay J, Silver A(2015). Defects in the adherens junction complex (E-cadherin/ β-catenin) in inflammatory bowel disease. Cell Tissue Res vol. 360, (3) 749-760.
10.1007/s00441-014-1994-6
Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, Jaeger E, Lewis A et al.(2015). Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nat Med vol. 21, (1) 62-70.
10.1038/nm.3750
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15433
Lewis A, Nijhuis A, Mehta S, Kumagai T, Feakins R, Lindsay JO, Silver A(2015). Intestinal fibrosis in crohn's disease: Role of microRNAs as fibrogenic modulators, serum biomarkers, and therapeutic targets. Inflammatory Bowel Diseases vol. 21, (5) 1141-1150.
10.1097/MIB.0000000000000298
Lewis A, Mehta S, Hanna LN, Rogalski LA, Jeffery R, Nijhuis A, Kumagai T, Biancheri P et al.(2015). Low serum levels of microRNA-19 are associated with a stricturing Crohn's disease phenotype. Inflammatory Bowel Diseases vol. 21, (8) 1926-1934.
10.1097/MIB.0000000000000443
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23743
Felice C, Lewis A, Armuzzi A, Lindsay JO, Silver A(2015). Review article: selective histone deacetylase isoforms as potential therapeutic targets in inflammatory bowel diseases. Aliment Pharmacol Ther vol. 41, (1) 26-38.
10.1111/apt.13008
Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R et al.(2014). In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts. Clin Sci (Lond) vol. 127, (5) 341-350.
10.1042/CS20140048
MacFie TS, Poulsom R, Parker A, Warnes G, Boitsova T, Nijhuis A, Suraweera N, Poehlmann A et al.(2014). DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid. Inflamm Bowel Dis vol. 20, (3) 514-524.
10.1097/01.MIB.0000442012.45038.0e
Poehlmann A, Reissig K, Schönfeld P, Walluscheck D, Schinlauer A, Hartig R, Lessel W, Guenther T et al.(2013). Repeated H2 O2 exposure drives cell cycle progression in an in vitro model of ulcerative colitis. J Cell Mol Med vol. 17, (12) 1619-1631.
10.1111/jcmm.12150
Ogunkolade BW, Jones TA, Aarum J, Szary J, Owen N, Ottaviani D, Mumin MA, Patel S et al.(2013). BORIS/CTCFL is an RNA-binding protein that associates with polysomes. BMC Cell Biol vol. 14,
10.1186/1471-2121-14-52
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6448
Poehlmann A, Reissig K, Just A, Walluscheck D, Hartig R, Schinlauer A, Lessel W, Guenther T et al.(2013). Non-apoptotic function of caspases in a cellular model of hydrogen peroxide-associated colitis. J Cell Mol Med vol. 17, (7) 901-913.
10.1111/jcmm.12079
Mehta SJ, Silver AR, Lindsay JO(2013). Review article: strategies for the management of chronic unremitting ulcerative colitis. Aliment Pharmacol Ther vol. 38, (2) 77-97.
10.1111/apt.12345
Boitsova T, Rafferty H, Davis H, Bardella C, Gill P, East J, Tomlinson I, Chetty R et al. (2013). BONE MORPHOGENETIC PROTEIN (BMP) PATHWAY DYSREGULATION SUBVERTS ONCOGENE INDUCED SENESCENCE MECHANISMS IN THE SERRATED PATHWAY OF TUMOURIGENESIS. GUT. vol. 62, A200-A200.
10.1136/gutjnl-2013-304907.459
Sengupta N, Yau C, Sakthianandeswaren A, Mouradov D, Gibbs P, Suraweera N, Cazier J-B, Polanco-Echeverry G et al. (2013). Genome analysis of colorectal cancers in British Bangladeshis identifies early onset and a high prevalence of rbfox1 deletion compared to Caucasians. BRITISH JOURNAL OF SURGERY. vol. 100, 7-7.
Ghosh A, Lai C, McDonald S, Suraweera N, Sengupta N, Propper D, Dorudi S, Silver A(2013). HSP27 expression in primary colorectal cancers is dependent on mutation of KRAS and PI3K/AKT activation status and is independent of TP53. Exp Mol Pathol vol. 94, (1) 103-108.
10.1016/j.yexmp.2012.09.001
Sengupta N, Yau C, Sakthianandeswaren A, Mouradov D, Gibbs P, Suraweera N, Cazier J, Polanco-Echeverry G et al.(2013). Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion. Molecular Cancer Article 1,
10.1186/1476-4598-12-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6439
Macfie T, Parker A, Nijhuis A, Boitsova T, Suraweera N, Jeffery R, Poulsom R, Lindsay J et al.(2012). 5-ASA ENHANCES DUOX2 EXPRESSION IN ACTIVE ULCERATIVE COLITIS: A RISK FOR COLORECTAL CANCER?. GUT vol. 61, A401-A402.
10.1136/gutjnl-2012-302514d.255
Jawad N, Graham T, Novelli M, Rodriguez-Justo M, Feakins R, Silver A, Wright N, McDonald S(2012). ARE PSEUDOPOLYPS THE SOURCE OF TUMORIGENIC MUTATIONS IN ULCERATIVE COLITIS?. GUT vol. 61, A236-A236.
10.1136/gutjnl-2012-302514c.124
Nijhuis A, Biancheri P, Lai C, Ghosh A, Boitsova T, Chan C, MacDonald T, Lindsay J et al.(2012). MICRORNA EXPRESSION PROFILING IN STRICTURING CROHN'S DISEASE IDENTIFIES MIR-34A AS A FUNCTIONALLY RELEVANT INFLUENCE ON DISEASE PHENOTYPE. GUT vol. 61, A167-A168.
10.1136/gutjnl-2012-302514b.229
Biancheri P, Nijhuis A, Lai C, Ghosh A, Feakins R, Chan C, Di Sabatino A, Corazza GR et al. (2012). Differential MicroRNA Expression Profiles in Crohn's Disease Strictured Versus Non-Strictured Intestine. GASTROENTEROLOGY. vol. 142, S877-S877.
Silver A, Sengupta N, Propper D, Wilson P, Hagemann T, Patel A, Parker A, Ghosh A et al.(2012). A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers. Int J Cancer vol. 130, (5) 1082-1092.
10.1002/ijc.26104
Silver AR, Sengupta N, Propper D, Wilson P, Hagemann T, Patel A, Parker A, Ghosh A et al. (2012). Genomic Profiling of Genetic Events in Colorectal Cancer: Identifying Subgroups with Distinct Phenotype-Genotype Associations. JOURNAL OF PATHOLOGY. vol. 226, S6-S6.
Lai C, Robinson J, Clark S, Stamp G, Poulsom R, Silver A(2011). Elevation of WNT5A expression in polyp formation in Lkb1+/- mice and Peutz-Jeghers syndrome. J Pathol vol. 223, (5) 584-592.
10.1002/path.2835
McDonald SL, Silver AR(2011). On target? Strategies and progress in the development of therapies for colorectal cancer targeted against WNT signalling. COLORECTAL DIS vol. 13, (4) 360-369.
10.1111/j.1463-1318.2009.02149.x
Patel HS, Silver AR, Levine T, Williams G, Northover JM(2010). Human papillomavirus infection and anal dysplasia in renal transplant recipients. Br J Surg vol. 97, (11) 1716-1721.
10.1002/bjs.7218
Elsaba TMA, Martinez-Pomares L, Robins AR, Crook S, Seth R, Jackson D, McCart A, Silver AR et al.(2010). The Stem Cell Marker CD133 Associates with Enhanced Colony Formation and Cell Motility in Colorectal Cancer. PLOS ONE vol. 5, (5) Article ARTN e10714,
10.1371/journal.pone.0010714
Sengupta N, MacFie TS, MacDonald TT, Pennington D, Silver AR(2010). Cancer immunoediting and "spontaneous" tumor regression. Pathol Res Pract vol. 206, (1) 1-8.
10.1016/j.prp.2009.10.001
Kuester D, Guenther T, Biesold S, Hartmann A, Bataille F, Ruemmele P, Peters B, Meyer F et al.(2010). Aberrant methylation of DAPK in long-standing ulcerative colitis and ulcerative colitis-associated carcinoma. PATHOLOGY RESEARCH AND PRACTICE vol. 206, (9) 616-624.
10.1016/j.prp.2010.05.004
Patel H, Silver A, Levine T, Williams G, Northover J(2010). Prevalence of human papillomavirus types and risk factors for anal dysplasia in renal transplant patients. British Journal of Surgery vol. 97, Article PMID:20730855, 1716-1721.
Robinson J, Lai C, Martin A, Nye E, Tomlinson I, Silver A(2009). Oral rapamycin reduces tumour burden and vascularization in Lkb1(+/-) mice. J Pathol vol. 219, (1) 35-40.
10.1002/path.2562
McDonald SL, Silver A(2009). The opposing roles of Wnt-5a in cancer. Br J Cancer vol. 101, (2) 209-214.
10.1038/sj.bjc.6605174
Howarth K, Ranta S, Winter E, Teixeira A, Schaschl H, Harvey JJ, Rowan A, Jones A et al.(2009). A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk. BMC MED GENET vol. 10, Article 54,
10.1186/1471-2350-10-54
Pollard P, Deheragoda M, Segditsas S, Lewis A, Rowan A, Howarth K, Willis L, Nye E et al.(2009). The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression. Gastroenterology vol. 136, (7)
10.1053/j.gastro.2009.02.058
Elahi E, Suraweera N, Volikos E, Haines J, Brown N, Davidson G, Churchman M, Ilyas M et al.(2009). Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice. PLoS One vol. 4, (2)
10.1371/journal.pone.0004388
Rashid S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynee-Jones R et al.(2009). Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis. Br J Cancer vol. 100, (10) 1666-1673.
10.1038/sj.bjc.6605026
Segditsas S, Sieber O, Deheragoda M, East P, Rowan A, Jeffery R, Nye E, Clark S et al.(2008). Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice. HUM MOL GENET vol. 17, (24) 3864-3875.
10.1093/hmg/ddn286
Robinson J, Nye E, Stamp G, Silver A(2008). Osteogenic tumours in Lkb1-deficient mice. Exp Mol Pathol vol. 85, (3) 223-226.
10.1016/j.yexmp.2008.07.005
Vickaryous N, Polanco-Echeverry G, Morrow S, Suraweera N, Thomas H, Tomlinson I, Silver A(2008). Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome. Br J Cancer vol. 99, (10) 1726-1728.
10.1038/sj.bjc.6604737
Sengupta N, Banerjea A, Suraweera N, Hammond L, Silver A, Dorudi S (2008). Copy number and methylation analysis of microsatellite and chromosome stable colorectal cancers associated with poor outcome. DISEASES OF THE COLON & RECTUM. vol. 51, 643-643.
McCart AE, Vickaryous NK, Silver A(2008). Apc mice: Models, modifiers and mutants. PATHOL RES PRACT vol. 204, (7) 479-490.
10.1016/j.prp.2008.03.004
Sengupta N, Gill KA, MacFie TS, Lai CS, Suraweera N, Mcdonald S, Silver A(2008). Management of colorectal cancer: a role for genetics in prevention and treatment?. Pathol Res Pract vol. 204, (7) 469-477.
10.1016/j.prp.2008.03.003
Patel H, Polanco-Echeverry G, Segditsas S, Volikos E, McCart A, Lai C, Guenther T, Zaitoun A et al.(2007). Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma. Int J Cancer vol. 121, (12) 2668-2673.
10.1002/ijc.23028
Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, Spain S, Penegar S, Chandler I et al.(2007). A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. NAT GENET vol. 39, (8) 984-988.
10.1038/ng2085
Carvajal-Carmona LG, Howarth KM, Lockett M, Polanco-Echeverry GM, Volikos E, Gorman M, Barclay E, Martin L et al.(2007). Molecular classification and genetic pathways in hyperplastic polyposis syndrome. J Pathol vol. 212, (4) 378-385.
10.1002/path.2187
Suraweera N, Latchford A, McCart A, Rogers P, Spain S, Sieber O, Phillips R, Tomlinson I et al.(2007). Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP. J MED GENET vol. 44, (8) 541-544.
10.1136/jmg.2007.049965
Monahan KJ, Thomas HJ, Silver AR, Tomlinson IP, Phillips RK (2007). Polyposis families without mutations have a less severe phenotype. GUT. vol. 56, A24-A24.
Will O, Carvajal-Carmona LG, Gorman P, Howarth KM, Jones AM, Polanco-Echeverry GM, Chinaleong JA, Gunther T et al.(2007). Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenorna phenotype without extraintestinal cancer. GASTROENTEROLOGY vol. 132, (2) 527-530.
10.1053/j.gastro.2006.11.043
Latchford A, Volikos E, Johnson V, Rogers P, Suraweera N, Tomlinson I, Phillips R, Silver A(2007). APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'. HUM MOL GENET vol. 16, (1) 78-82.
10.1093/hmg/ddl442
SILVER A, Northover J, Patel H(2007). Anal cancer in renal transplant patients. Int J Colorectal Dis vol. 16, (1) 1-5.
10.1007/s00384-005-0023-3
Patel HS, Silver ARJ, Northover JMA(2007). Anal cancer in renal transplant patients. Int J Colorectal Dis vol. 22, (1) 1-5.
10.1007/s00384-005-0023-3
Suraweera N, Haines J, McCart A, Rogers P, Latchford A, Coster M, Polanco-Echeverry G, Guenther T et al.(2006). Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice. Hum Mol Genet vol. 15, (23) 3429-3435.
10.1093/hmg/ddl419
Suraweera N, Robinson J, Volikos E, Guenther T, Talbot I, Tomlinson I, Silver A(2006). Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines. Int J Cancer vol. 119, (8) 1837-1842.
10.1002/ijc.22046
Sieber OM, Segditsas S, Knudsen AL, Zhang J, Luz J, Rowan AJ, Spain SL, Thirlwell C et al.(2006). Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation. Gut vol. 55, (10) 1440-1448.
10.1136/gut.2005.087106
Kuester D, El-Rifai W, Guenther T, Hartmann A, Tannapfel A, Meyer F, Bohr URM, Biesold S et al. (2006). Aberrant promoter methylation pattern in ulcerative colitis-associated carcinomas compared to sporadic colorectal carcinomas. MODERN PATHOLOGY. vol. 19, 61-62.
Kuester D, El-Rifai W, Guenther T, Hartmann A, Tannapfel A, Meyer F, Bohr URM, Biesold S et al. (2006). Potential protective role of glutathione peroxidase-x3 in the inflammation-driven pathologv of ulcerative colitis and its frequent promoter hypermethylation in ulcerative colitis-associated carcinoma. MODERN PATHOLOGY. vol. 19, 62-62.
Tomlinson I, SILVER A, Volikos E, Robinson J, Aaltonen L, Aittomoki K, Mecklin J-P, Moeslein G et al.(2006). Lkb1 exonic and whole-gene deletions are a common cause of Peutz-Jeghers syndrome. J Med Genet vol. 43, (5) e18-e18.
10.1136/jmg.2005.039875
Monahan KJ, Emmanouil V, Phillips RK, Huw TJ, Silver AR, Tomlinson IP (2006). The genotype-phenotype relationship of polyposis families reveals clinically distinct subgroups. GASTROENTEROLOGY. vol. 130, A152-A152.
McCart A, Latchford A, Volikos E, Rowan A, Tomlinson I, Silver A(2006). A novel exon duplication event leading to a truncating germ-fine mutation of the APC gene in a Familial Adenomatous Polyposis family. FAM CANCER vol. 5, (2) 205-208.
10.1007/s10689-006-7471-y
Rowan A, Halford S, Gaasenbeek M, Kemp Z, Sieber O, Volikos E, Douglas E, Fiegler H et al.(2005). Refining molecular analysis in the pathways of colorectal carcinogenesis. Clin Gastroenterol Hepatol vol. 3, (11) 1115-1123.
10.1016/s1542-3565(05)00618-x
Johnson V, Lipton LR, Cummings C, Eftekhar Sadat AT, Izatt L, Hodgson SV, Talbot IC, Thomas HJW et al.(2005). Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families. J Med Genet vol. 42, (10) 756-762.
10.1136/jmg.2005.031245
Tomlinson I, SILVER A, Volikos E, Eftekhar Sadat A, Johnson V, Halford S, Truninger K, Talbot I et al.(2005). Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in the hereditary non-polyposis colorectal cancer syndrome. Gut vol. 54, 264-267.
10.1136/gut.2004.048132
Tomlinson I, SILVER A, Suraweera N, Wilding J, Cabuy E, Bodmer W, Sieber O, Slijepcevic P et al.(2005). Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice. Proc. Natl. Acad. Sci. USA vol. 102, 2868-2873.
10.1073/pnas.0500039102
Tomlinson I, SILVER A, Robinson J, Rogers PA, Johnson V, Houlston RS, Thomas HJW, Evans DG et al.(2005). Evidence for an association between compound heterozygosity for germ-line mutations in the haemochromatosis (HFE) gene and increased risk of colorectal cancer. Cancer Epidemiology Biomarkers and Prevention vol. 14, 1460-1463.
10.1158/1055-9965.EPI-04-0672
Tomlinson I, SILVER A, Suraweera N, Meijne E, Moody J, Carvajal-Carmona LG, Yoshida K, Pollard P et al.(2005). Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia. Oncogene vol. 24, 3678-3683.
10.1038/sj.onc.1208422
Sieber OM, Howarth KM, Thirlwell C, Rowan A, Mandir N, Goodlad RA, Gilkar A, Spencer-Dene B et al.(2004). Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (Apc(Min/+)) mice. CANCER RES vol. 64, (24) 8876-8881.
10.1158/0008-5472.CAN-04-2958
Suraweera N, Zampeli E, Rogers P, Atkin W, Forbes A, Harbord M, Silver A(2004). NCF1 (p47phox) and ncf1 pseudogenes are not associated with inflammatory bowel disease. Inflamm Bowel Dis vol. 10, (6) 758-762.
10.1097/00054725-200411000-00010
Kemp Z, Thirlwell C, Sieber O, Silver A, Tomlinson I(2004). An update on the genetics of colorectal cancer. HUM MOL GENET vol. 13, R177-R185.
10.1093/hmg/ddh247
Tomlinson I, SILVER A, Phillips R, Philp C, Bassett P, Neale K, Gallagher M, Sturt N(2004). Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis (FAP) independent of the germline APC mutation. Gut vol. 53, 1832-1836.
10.1136/gut.2004.042705
SILVER A, Phillips R, Latchford A(2004). Familial adenomatous polyposis associated desmoid disease. CME J Gastroenterology, Hepatology & Nutrition vol. 6, (1) 22-27.
SILVER A, Degg N, Weil M, Coster M, Ellender M, Cox R, Haines J, Edwards A et al.(2003). Adenoma multiplicity in Irradiated ApcMin mice is modified by chromosome 16 segments from BALB/c. Cancer Research vol. 63, 2361-2363.
SILVER A, Cox R, Bouffler S(2002). Mechanistic and genetic studies of radiation tumorigenesis in the mouse--implications for low dose risk estimation. Journal of Radiological Protection vol. 22, (3A) A11-A16.
SILVER A, Cox R, Edwards A, Haines J, Clark D, Moody J, Meijne E, Finnon R(2002). A major breakpoint cluster domain in murine radiation-induced acute myeloid leukaemia. Mol. Carcinog. vol. 34, 64-71.
SILVER A, Moody J, Haines J, Meijne E, Edwards A, Newbold R, Parris C, Cox R et al.(2002). Functional evidence from microcell-mediated chromosome transfer of myeloid leukaemia supressor genes on human chromosomes 7 and 11. Genes, Chrom. & Cancer vol. 34, 390-397.
SILVER A, Edwards A, Spanjer S, Bouffler S, Wilding J, Moody J, Huiskamp R, Cox R et al.(2001). Analysis of loss of heterozygosity in lymphoma and leukaemia arising in F1 hybrid mice locates a common region of chromosome 4 loss. Genes, Chrom. & Cancer vol. 31, 373-381.
SILVER A, Neville A, O'Hare M, Davies D, Alsop A, Jat P, Moody J, Atherton A et al.(2001). Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells. Proc. Natl. Acad. Sci. USA vol. 98, 646-651.
SILVER A, Ullrich R, Long S, McCarthy M, Weil M, Yu Y, Okayasu R, Cox R et al.(2001). Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA PKcs) gene. Cancer Research vol. 61, 1820-1824.
Finnon P, SILVER A, Bouffler S, Slijepcevic A, Wong H-P(2001). Long but dysfunctional telomeres correlate with chromosomal radiosensitivity in a mouse AML cell line. Int. J. Rad Biol. vol. 77, 1151-1162.
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