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Publications:  Prof Richard Pickersgill

Gu S, Vladimir VE, Shaw R et al. (2017) . The role of intrinsic disorder and dynamics in the assembly and function of the type II secretion system.BBA - Proteins and Proteomics
Gu S, Sushko O, Deery E et al. (2015) . Crystal structure of CobK reveals strand-swapping between Rossmann-fold domains and molecular basis of the reduced precorrin product trap.Sci Rep vol. 5,
Sushko O, Qiu J, Dubrovka R et al. (2015) . Sub-terahertz spectroscopy as a probe for protein stability in an ionic environment. IRMMW-THz 2015 - 40th International Conference on Infrared, Millimeter, and Terahertz Waves.
Ali S, Søndergaard CR, Teixeira S et al. (2015) . Structural insights into the loss of catalytic competence in pectate lyase activity at low pH.FEBS Lett vol. 589, (21) 3242-3246.
Pang A, Frank S, Brown I et al. (2014) . Structural insights into higher order assembly and function of the bacterial microcompartment protein PduA.J Biol Chem vol. 289, (32) 22377-22384.
Lawrence AD, Taylor SL, Scott A et al. (2014) . FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR).Biosci Rep vol. 34, (4)
Palmer DJ, Schroeder S, Lawrence AD et al. (2014) . The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway.MOLECULAR MICROBIOLOGY vol. 93, (2) 247-261.
Terali K, Beavil RL, Pickersgill RW et al. (2013) . The effect of the adaptor protein Isd11 on the quaternary structure of the eukaryotic cysteine desulphurase Nfs1.Biochem Biophys Res Commun vol. 440, (2) 235-240.
Rehman S, Gu S, Shevchik VE et al. (2013) . Anatomy of secretin binding to the Dickeya dadantii type II secretion system pilotin.Acta Crystallogr D Biol Crystallogr vol. 69, (Pt 8) 1381-1386.
Pang A, Liang M, Prentice MB et al. (2012) . Substrate channels revealed in the trimeric Lactobacillus reuteri bacterial microcompartment shell protein PduB.Acta Crystallogr D Biol Crystallogr vol. 68, (Pt 12) 1642-1652.
Deery E, Schroeder S, Lawrence AD et al. (2012) . An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis.NATURE CHEMICAL BIOLOGY vol. 8, (11) 933-940.
Wang X, Pineau C, Gu S et al. (2012) . Cysteine Scanning Mutagenesis and Disulfide Mapping Analysis of Arrangement of GspC and GspD Protomers within the Type 2 Secretion System.JOURNAL OF BIOLOGICAL CHEMISTRY vol. 287, (23) 19082-19093.
Gu S, Kelly G, Wang X et al. (2012) . Solution structure of homology region (HR) domain of type II secretion system.J Biol Chem vol. 287, (12) 9072-9080.
Martin JE, Chowdhury ATMD, McElwaine S et al. (2012) . Intestinal Glycogen Storage Disease, and the Molecular Basis of Pseudo-obstruction with Polyglucosan Bodies. JOURNAL OF PATHOLOGY. vol. 226, S24-S24.
Pickersgill RW (2012) . Pathology: A Structural Biologist's View. JOURNAL OF PATHOLOGY. vol. 226, S7-S7.
Gu S, Rehman S, Wang X et al. (2012) . Structural and functional insights into the pilotin-secretin complex of the type II secretion system.PLoS Pathog vol. 8, (2)
Pang A, Warren MJ, Pickersgill RW (2011) . Structure of PduT, a trimeric bacterial microcompartment protein with a 4Fe-4S cluster-binding site.Acta Crystallogr D Biol Crystallogr vol. 67, (Pt 2) 91-96.
Romao CV, Ladakis D, Lobo SAL et al. (2011) . Evolution in a family of chelatases facilitated by the introduction of active site asymmetry and protein oligomerization.P NATL ACAD SCI USA vol. 108, (1) 97-102.
Brocklehurst K, Gul S, Pickersgill RW (2010) . Substrate Recognition.Amino Acids, Peptides and Proteins in Organic Chemistry, vol. 2,
Seyedarabi A, Hutchison T, To TT et al. (2010) . Cloning, purification and preliminary crystallographic analysis of cobalamin methyltransferases from Rhodobacter capsulatus.Acta Crystallogr Sect F Struct Biol Cryst Commun vol. 66, (Pt 12) 1652-1656.
Seyedarabi A, Sullivan JA, Sasakawa C et al. (2010) . A disulfide driven domain swap switches off the activity of Shigella IpaH9.8 E3 ligase.FEBS Lett vol. 584, (19) 4163-4168.
Shala K, Yang B, TT T et al. (2010) . Millimeter wave spectroscopy of glucose and a calcium-binding protein using a vector network analyser. Conference: 35th IRMMW-THZ Internation Conference, 2010 (Rome, Italy) from: 05/09/2010 to: 10/09/2010, 1-2.
Login FH, Fries M, Wang XH et al. (2010) . A 20-residue peptide of the inner membrane protein OutC mediates interaction with two distinct sites of the outer membrane secretin OutD and is essential for the functional type II secretion system in Erwinia chrysanthemi.Molecular Microbiology vol. 76, (4) 944-955.
Seyedarabi A, To TT, Ali S et al. (2010) . Structural insights into substrate specificity and the anti beta-elimination mechanism of pectate lyase.Biochemistry vol. 49, (3) 539-546.
Heldt D, Frank S, Seyedarabi A et al. (2009) . Structure of a trimeric bacterial microcompartment shell protein, EtuB, associated with ethanol utilization in Clostridium kluyveri.BIOCHEM J vol. 423, 199-207.
Brindley AA, Pickersgill RW, Partridge JC et al. (2008) . Enzyme sequence and its relationship to hyperbaric stability of artificial and natural fish lactate dehydrogenases.PLoS One vol. 3, (4)
Lawrence AD, Deery E, McLean KJ et al. (2008) . Identification, characterization, and structure/function analysis of a corrin reductase involved in adenosylcobalamin biosynthesis.J BIOL CHEM vol. 283, (16) 10813-10821.
Fries M, Ihrig J, Brocklehurst K et al. (2007) . Molecular basis of the activity of the phytopathogen pectin methylesterase.EMBO J vol. 26, (17) 3879-3887.
Frank S, Deery E, Brindley AA et al. (2007) . Elucidation of substrate specificity in the cobalamin (vitamin B12) biosynthetic methyltransferases. Structure and function of the C20 methyltransferase (CbiL) from Methanothermobacter thermautotrophicus.J Biol Chem vol. 282, (33) 23957-23969.
Ooi A, Hussain S, Seyedarabi A et al. (2006) . Structure of internalin C from Listeria monocytogenes.Acta Crystallogr D Biol Crystallogr vol. 62, (Pt 11) 1287-1293.
Opaleye O, Rose R-S, Whittaker MM et al. (2006) . Structural and spectroscopic studies shed light on the mechanism of oxalate oxidase.J Biol Chem vol. 281, (10) 6428-6433.
Graham CE, Brocklehurst K, Pickersgill RW et al. (2006) . Characterization of retinaldehyde dehydrogenase 3.Biochem J vol. 394, (Pt 1) 67-75.
Frank S, Brindley AA, Deery E et al. (2005) . Anaerobic synthesis of vitamin B12: characterization of the early steps in the pathway.Biochem Soc Trans vol. 33, (Pt 4) 811-814.
Okuda J, Toyotome T, Kataoka N et al. (2005) . Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responses.BIOCHEM BIOPH RES CO vol. 333, (2) 531-539.
Jenkins J, Shevchik VE, Hugouvieux-Cotte-Pattat N et al. (2004) . The crystal structure of pectate lyase Pel9A from Erwinia chrysanthemi.J BIOL CHEM vol. 279, (10) 9139-9145.
Pickersgill RW (2003) . A primordial structure underlying amyloid.STRUCTURE vol. 11, (2) 137-138.
PICKERSGILL RW, Jenkins JA (2003) . The structures and active sites of pectinases. Advances in pectin and pectinase research. Editors: Voragen, AGJ, Voragen, F, Schols, H, Visser, R et al., Conference: International symposium on pectins and pectinases (2nd) (Rotterdam, The Netherlands) from: 05/2001 to: 05/2001, 267-278.
Pickersgill RW (2002) . Complex cell signaling molecules from ancient molecular glue.STRUCTURE vol. 10, (10) 1287-1288.
Woo EJ, Marshall J, Bauly J et al. (2002) . Crystal structure of auxin-binding protein 1 in complex with auxin.EMBO J vol. 21, (12) 2877-2885.
Palomäki T, Pickersgill R, Riekki R et al. (2002) . A putative three-dimensional targeting motif of polygalacturonase (PehA), a protein secreted through the type II (GSP) pathway in Erwinia carotovora.Mol Microbiol vol. 43, (3) 585-596.
Lo Leggio L, Kalogiannis S, Eckert K et al. (2001) . Substrate specificity and subsite mobility in T. aurantiacus xylanase 10A.FEBS Lett vol. 509, (2) 303-308.
Jenkins J, Pickersgill R (2001) . The architecture of parallel beta-helices and related folds.PROG BIOPHYS MOL BIO vol. 77, (2) 111-175.
Hogg D, Woo EJ, Bolam DN et al. (2001) . Crystal structure of mannanase 26A from Pseudomonas cellulosa and analysis of residues involved in substrate binding.J Biol Chem vol. 276, (33) 31186-31192.
Teixeira S, Lo Leggio L, Pickersgill R et al. (2001) . Anisotropic refinement of the structure of Thermoascus aurantiacus xylanase I.ACTA CRYSTALLOGR D vol. 57, 385-392.
Jenkins J, Mayans O, Smith D et al. (2001) . Three-dimensional structure of Erwinia chrysanthemi pectin methylesterase reveals a novel esterase active site.J Mol Biol vol. 305, (4) 951-960.
GARNETT JA, Gu, S, Shevchik VE et al.. The role of intrinsic disorder and dynamics in the assembly and function of the type II secretion system.BBA - Proteins and Proteomics
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