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Publications:  Dr Gareth Pryce

von Kutzleben S, Pryce G, Giovannoni G et al. (2017) . Depletion of CD52-positive cells inhibits the development of central nervous system autoimmune disease, but deletes an immune-tolerance promoting CD8 T-cell population. Implications for secondary autoimmunity of alemtuzumab in multiple sclerosis.Immunology vol. 150, (4) 444-455.
10.1111/imm.12696
http://qmro.qmul.ac.uk/xmlui/handle/123456789/19408
Williams T, Pryce G, Giovannoni G et al. (2016) . VSN16R-A NOVEL TREATMENT FOR SPASTICITY IN EXPERIMENTAL MULTIPLE SCLEROSIS. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. vol. 87,
10.1136/jnnp-2016-315106.162
Baker D, Pryce G, Visintin C et al. (2016) . Big conductance calcium-activated potassium channel activation is a novel way to control spasticity without sedation. MULTIPLE SCLEROSIS JOURNAL. vol. 22, 380-381.
Sevastou I, Pryce G, Baker D et al. (2016) . Characterisation of Transcriptional Changes in the Spinal Cord of the Progressive Experimental Autoimmune Encephalomyelitis Biozzi ABH Mouse Model by RNA Sequencing.PLOS ONE vol. 11, (6) e0157754-e0157754.
10.1371/journal.pone.0157754
http://qmro.qmul.ac.uk/xmlui/handle/123456789/13513
Ummenthum K, Peferoen LAN, Finardi A et al. (2016) . Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease.Eur J Immunol vol. 46, (3) 701-711.
10.1002/eji.201545950
http://qmro.qmul.ac.uk/xmlui/handle/123456789/13679
Warne J, Pryce G, Hill JM et al. (2016) . Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis.J Biol Chem vol. 291, (9) 4356-4373.
10.1074/jbc.M115.700385
http://qmro.qmul.ac.uk/xmlui/handle/123456789/11312
Pryce G, Baker D (2015) . Cannabinoids fail to show evidence of slowing down the progression of multiple sclerosis.Evid Based Med vol. 20, (4)
10.1136/ebmed-2015-110198
Vainchtein I, Vinet J, Al-Izki S et al. (2015) . Microglia are involved in apoptotic clearance during chronic-relapsing EAE. GLIA. vol. 63, E353-E353.
Pryce G, Riddall DR, Selwood DL et al. (2015) . Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids.J Neuroimmune Pharmacol vol. 10, (2) 281-292.
10.1007/s11481-014-9575-8
Wu D, Cerutti C, Lopez-Ramirez MA et al. (2015) . Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation.J Cereb Blood Flow Metab vol. 35, (3) 412-423.
10.1038/jcbfm.2014.207
http://qmro.qmul.ac.uk/xmlui/handle/123456789/9649
Pryce G, Baker D (2015) . Endocannabinoids in Multiple Sclerosis and Amyotrophic Lateral Sclerosis.Handb Exp Pharmacol vol. 231, 213-231.
10.1007/978-3-319-20825-1_7
Von Kutzleben S, Pryce G, Chretien N et al. (2014) . Inhibition of relapsing experimental autoimmune encephalomyelitis in Biozzi ABH mice using a mouse CD52-specific monoclonal antibody. JOURNAL OF NEUROIMMUNOLOGY. vol. 275, 228-228.
10.1016/j.jneuroim.2014.08.611
Lopez-Ramirez MA, Wu D, Pryce G et al. (2014) . MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation.FASEB J vol. 28, (6) 2551-2565.
10.1096/fj.13-248880
http://qmro.qmul.ac.uk/xmlui/handle/123456789/7990
Pryce G, Visintin C, Ramagopalan SV et al. (2014) . Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists.FASEB J vol. 28, (1) 117-130.
10.1096/fj.13-239442
Mullen L, Rigby A, Sclanders M et al. (2014) . Latency can be conferred to a variety of cytokines by fusion with latency-associated peptide from TGF-β.Expert Opin Drug Deliv vol. 11, (1) 5-16.
10.1517/17425247.2013.839655
Al-Izki S, Pryce G, Hankey DJR et al. (2014) . Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis.Brain vol. 137, (Pt 1) 92-108.
10.1093/brain/awt324
http://qmro.qmul.ac.uk/xmlui/handle/123456789/9650
Hampton DW, Serio A, Pryce G et al. (2013) . Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis.Acta Neuropathol Commun vol. 1,
10.1186/2051-5960-1-84
http://qmro.qmul.ac.uk/xmlui/handle/123456789/18967
Pryce G, Cabranes A, Fernández-Ruiz J et al. (2013) . Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors.Mult Scler vol. 19, (14) 1896-1904.
10.1177/1352458513485982
Puentes F, van der Star BJ, Victor M et al. (2013) . Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis.Journal of Neuroinflammation vol. 10,
10.1186/1742-2094-10-118
http://qmro.qmul.ac.uk/xmlui/handle/123456789/7824
Baker D, Lidster K, Al-Izki S et al. (2013) . Animal models of progressive disability in MS.IRISH JOURNAL OF MEDICAL SCIENCE vol. 182, S5-S6.
Sisay S, Pryce G, Jackson SJ et al. (2013) . Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis.PLoS One vol. 8, (10)
10.1371/journal.pone.0076907
http://qmro.qmul.ac.uk/xmlui/handle/123456789/6281
Lopez-Ramirez MA, Wu D, Pryce G et al. (2012) . Endothelial miR-155 promotes blood brain barrier dysfunction in neuroinflammation. JOURNAL OF NEUROIMMUNOLOGY. vol. 253, 3-4.
Pryce G, Baker D (2012) . Potential control of multiple sclerosis by cannabis and the endocannabinoid system.CNS Neurol Disord Drug Targets vol. 11, (5) 624-641.
10.2174/187152712801661310
Gnanapavan S, Grant D, Pryce G et al. (2012) . Neurofilament a biomarker of neurodegeneration in autoimmune encephalomyelitis.Autoimmunity vol. 45, (4) 298-303.
10.3109/08916934.2012.654865
Baker D, Pryce G, Jackson SJ et al. (2012) . The biology that underpins the therapeutic potential of cannabis-based medicines for the control of spasticity in multiple sclerosis.Mult Scler Relat Disord vol. 1, (2) 64-75.
10.1016/j.msard.2011.11.001
Hilliard A, Stott C, Wright S et al. (2012) . Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis.ISRN Neurol vol. 2012,
10.5402/2012/802649
http://qmro.qmul.ac.uk/xmlui/handle/123456789/18983
Al-Izki S, Pryce G, O'Neill JK et al. (2012) . Practical guide to the induction of relapsing progressive experimental autoimmune encephalomyelitis in the Biozzi ABH mouse.Mult Scler Relat Disord vol. 1, (1) 29-38.
10.1016/j.msard.2011.09.001
Graves RS, Pryce G, Cabranes A et al. (2011) . Fatty acid amide hydrolase as a target for neuroprotection.MULTIPLE SCLEROSIS JOURNAL vol. 17, S431-S431.
Al-Izki S, Pryce G, Amor S et al. (2011) . Selective targeting of neuroprotection to MS lesions: sodium channel blockers in experimental autoimmune encephalomyelitis.MULTIPLE SCLEROSIS JOURNAL vol. 17, S209-S210.
Pryce G, Visintin C, Lutz B et al. (2011) . Selective targeting of spasticity by CNS-excluded cannabinoids.MULTIPLE SCLEROSIS JOURNAL vol. 17, S247-S247.
Baker D, Pryce G, Visintin C et al. (2011) . VSN16R a novel agent for the control of spasticity.MULTIPLE SCLEROSIS JOURNAL vol. 17, S243-S243.
Ayoub SS, Pryce G, Seed MP et al. (2011) . Paracetamol-induced hypothermia is independent of cannabinoids and transient receptor potential vanilloid-1 and is not mediated by AM404.Drug Metab Dispos vol. 39, (9) 1689-1695.
10.1124/dmd.111.038638
Al-Izki S, Pryce G, Jackson SJ et al. (2011) . Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis.Mult Scler vol. 17, (8) 939-948.
10.1177/1352458511400476
Al-Izki S, Pryce G, Giovannoni G et al. (2009) . Evaluating potential therapies for bladder dysfunction in a mouse model of multiple sclerosis with high-resolution ultrasonography.Mult Scler vol. 15, (7) 795-801.
10.1177/1352458509104594
Hampton DW, Anderson J, Pryce G et al. (2008) . An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.J NEUROIMMUNOL vol. 201, 200-211.
10.1016/j.jneuroim.2008.05.034
Jackson S, Al-Izik S, Pryce G et al. (2008) . Fingolimod reduces axonal loss in relapsing secondary progressive experimental autoimmune encephalomyelitis. MULTIPLE SCLEROSIS. vol. 14, S80-S81.
Parkes H, Shorter S, So PW et al. (2008) . High resolution 1H nuclear magnetic resonance spectroscopic-based metabolomic urine analysis of experimental autoimmune encephalitis, a model disease of multiple sclerosis. MULTIPLE SCLEROSIS. vol. 14, S86-S87.
Al-Izki S, Pryce G, Jackson S et al. (2008) . Neuroprotective effects of omega-3 fatty acids in a mouse model of multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY. vol. 197, 173-173.
Anderson JM, Hampton DW, Patani R et al. (2008) . Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis.BRAIN vol. 131, 1736-1748.
10.1093/brain/awn119
East E, Gveri¿ D, Baker D et al. (2008) . Chronic relapsing experimental allergic encephalomyelitis (CREAE) in plasminogen activator inhibitor-1 knockout mice: the effect of fibrinolysis during neuroinflammation.Neuropathol Appl Neurobiol vol. 34, (2) 216-230.
10.1111/j.1365-2990.2007.00889.x
Croxford JL, Pryce G, Jackson SJ et al. (2008) . Cannabinoid-mediated neuroprotection, not immuno suppression, may be more relevant to multiple sclerosis.J NEUROIMMUNOL vol. 193, (1-2) 120-129.
10.1016/j.jneuroim.2007.10.024
Baker D, Pryce G (2008) . The endocannabinoid system and multiple sclerosis.Curr Pharm Des vol. 14, (23) 2326-2336.
10.2174/138161208785740036
Baker D, Jackson SJ, Pryce G (2007) . Cannabinoid control of neuroinflammation related to multiple sclerosis.Br J Pharmacol vol. 152, (5) 649-654.
10.1038/sj.bjp.0707458
Maresz K, Pryce G, Ponomarev ED et al. (2007) . Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.NAT MED vol. 13, (4) 492-497.
10.1038/nm1561
Pryce G, Baker D (2007) . Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors.BRIT J PHARMACOL vol. 150, (4) 519-525.
10.1038/sj.bjp.0707003
Baker D, Croxford JL, Pryce G et al. (2006) . Cannabinoid-mediated immunosuppression in experimental allergic encephalomyelitis. JOURNAL OF NEUROIMMUNOLOGY. vol. 178, 90-91.
Cabranes A, Pryce G, Baker D et al. (2006) . Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice.BRAIN RES vol. 1107, 199-205.
10.1016/j.brainres.2006.06.001
Bilsland LG, Dick JRT, Pryce G et al. (2006) . Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice.FASEB J vol. 20, (7) 1003-+.
10.1096/fj.05-4743fje
Baker D, Pryce G, Croxford JL et al. (2006) . Cannabinoid-mediated immunosuppression in experimental allergic encephalomyelitits. CURRENT TOPICS IN NEUROIMMUNOLOGY. Editors: Tabira, T, Yamamura, T, Kira, J, 109-116.
Cristino L, De Petrocellis L, Pryce G et al. (2006) . Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain.NEUROSCIENCE vol. 139, (4) 1405-1415.
10.1016/j.neuroscience.2006.02.074
Baker D, Pryce G, Davies WL et al. (2006) . In silico patent searching reveals a new cannabinoid receptor.Trends Pharmacol Sci vol. 27, (1) 1-4.
10.1016/j.tips.2005.11.003
Ligresti A, Cascio MG, Pryce G et al. (2006) . New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis.BRIT J PHARMACOL vol. 147, (1) 83-91.
10.1038/sj.bjp.0706418
de Lago E, Fernandez-Ruiz J, Ortega-Gutierrez S et al. (2006) . UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.EUR NEUROPSYCHOPHARM vol. 16, (1) 7-18.
10.1016/j.euroneuro.2005.06.001
Heijmans N, Smith PA, Morris-Downes MM et al. (2005) . Encephalitogenic and tolerogenic potential of altered peptide ligands of MOG and PLP in Biozzi ABH mice.J NEUROIMMUNOL vol. 167, (1-2) 23-33.
10.1016/j.jneuroim.2005.06.005
East E, Baker D, Pryce G et al. (2005) . A role for the plasminogen activator system in inflammation and neurodegeneration in the central nervous system during experimental allergic encephalomyelitis.Am J Pathol vol. 167, (2) 545-554.
10.1016/S0002-9440(10)62996-3
Pryce G, O'Neill JK, Croxford JL et al. (2005) . Autoimmune tolerance eliminates relapses but fails to halt progression in a model of multiple sclerosis.J NEUROIMMUNOL vol. 165, (1-2) 41-52.
10.1016/j.jneuroim.2005.04.009
Smith PA, Morris-Downes M, Heijmans N et al. (2005) . Epitope spread is not critical for the relapse and progression of MOG 8-21 induced EAE in Biozzi ABH mice.J NEUROIMMUNOL vol. 164, (1-2) 76-84.
10.1016/j.jneuroim.2005.04.006
Jackson SJ, Diemel LT, Pryce G et al. (2005) . Cannabinoids and neuroprotection in CNS inflammatory disease. J Neurol Sci. vol. 233, 21-25.
10.1016/j.jns.2005.03.002
Pryce G, Baker D (2005) . Emerging properties of cannabinoid medicines in management of multiple sclerosis.Trends Neurosci vol. 28, (5) 272-276.
10.1016/j.tins.2005.03.006
Gegg ME, Harry R, Hankey D et al. (2005) . Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction.J IMMUNOL vol. 174, (4) 2327-2335.
10.4049/jimmunol.174.4.2327
Jackson SJ, Pryce G, Diemel LT et al. (2005) . Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation.Neuroscience vol. 134, (1) 261-268.
10.1016/j.neuroscience.2005.02.045
Pryce G, Jackson SM, Hankey DRJ et al. (2004) . Cannabinoids are neuroprotective: dissociation of true neuroprotection from protection secondary to immunosuppression. JOURNAL OF NEUROIMMUNOLOGY. vol. 154, 78-78.
Pryce G, O'Neill JK, Hankey DRJ et al. (2004) . Immunological tolerance that eliminates relapses, fails to halt secondary progression in a chronic multiple sclerosis model. JOURNAL OF NEUROIMMUNOLOGY. vol. 154, 62-62.
East E, Baker D, Pryce G et al. (2004) . The role of plasminogen activators in experimental allergic encephalomyelitis: inflammation and axonal pathology. JOURNAL OF NEUROIMMUNOLOGY. vol. 154, 167-167.
de Lago E, Ligresti A, Ortar G et al. (2004) . In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake.EUR J PHARMACOL vol. 484, (2-3) 249-257.
10.1016/j.ejphar.2003.11.027
Wilkinson JD, Whalley BJ, Baker D et al. (2003) . Medicinal cannabis: is Delta(9)-tetrahydrocannabinol necessary for all its effects?.J PHARM PHARMACOL vol. 55, (12) 1687-1694.
10.1211/0022357022304
Pryce G, Ahmed Z, Hankey DJR et al. (2003) . Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.BRAIN vol. 126, 2191-2202.
10.1093/brain/awg224
East E, Baker D, Pryce GM et al. (2003) . The role of plasminogen activators in experimental allergic encephalomyelitis. GLIA. 40-40.
Greenwood J, Walters CE, Pryce G et al. (2003) . Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis.FASEB J vol. 17, (8) 905-907.
10.1096/fj.02-1014fje
Pryce G, Giovannoni G, Baker D (2003) . Mifepristone or inhibition of 11 beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice.NEUROSCI LETT vol. 341, (2) 164-166.
10.1016/S0304-3940(03)00159-9
Petzold A, Baker D, Pryce G et al. (2003) . Quantification of neurodegeneration by measurement of brain-specific proteins.J Neuroimmunol vol. 138, (1-2) 45-48.
10.1016/S0165-5728(03)00092-4
Baker D, Pryce G, Giovannoni G et al. (2003) . The therapeutic potential of cannabis.LANCET NEUROL vol. 2, (5) 291-298.
10.1016/S1474-4422(03)00381-8
Baker D, Pryce G (2003) . The therapeutic potential of cannabis in multiple sclerosis.Expert Opin Investig Drugs vol. 12, (4) 561-567.
10.1517/13543784.12.4.561
Ahmed Z, Doward AI, Pryce G et al. (2002) . A role for caspase-1 and-3 in the pathology of experimental allergic encephalomyelitis - Inflammation versus degeneration.AM J PATHOL vol. 161, (5) 1577-1586.
10.1016/S0002-9440(10)64436-7
Walters CE, Pryce G, Hankey DJR et al. (2002) . Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis.J IMMUNOL vol. 168, (8) 4087-4094.
10.4049/jimmunol.168.8.4087
Brooks JW, Pryce G, Bisogno T et al. (2002) . Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB1/CB2 receptors.EUR J PHARMACOL vol. 439, (1-3) 83-92.
10.1016/S0014-2999(02)01369-9
Ahmed Z, Gveric D, Pryce G et al. (2001) . Myelin/axonal pathology in interleukin-12 induced serial relapses of experimental allergic encephalomyelitis in the Lewis rat.Am J Pathol vol. 158, (6) 2127-2138.
10.1016/S0002-9440(10)64684-6
Baker D, Pryce G, Croxford JL et al. (2001) . Endocannabinoids control spasticity in a multiple sclerosis model.FASEB J vol. 15, (2) 300-302.
10.1096/fj.00-0399fje
Peferoen LAN, Breur M, van de Berg S et al.. Ageing and recurrent episodes of neuroinflammation promote progressive eae in biozzi abh mice.Immunology
10.1111/imm.12644
http://qmro.qmul.ac.uk/xmlui/handle/123456789/13480
BAKER D, Marta M, Pryce G et al.. Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis.eBiomedicne
10.1016/j.ebiom.2017.01.042
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