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Publications:  Adrian Newland Cbe

Hallam S, Provan D, Newland AC (2013) . Immune thrombocytopenia -- what are the new treatment options?.Expert Opin Biol Ther vol. 13, (8) 1173-1185.
Kuter DJ, Bussel JB, Newland A et al. (2013) . Long-term treatment with romiplostim in patients with chronic immune thrombocytopenia: safety and efficacy.BRITISH JOURNAL OF HAEMATOLOGY vol. 161, (3) 411-423.
Rodeghiero F, Michel M, Gernsheimer T et al. (2013) . Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group.BLOOD vol. 121, (14) 2596-2606.
Doobaree IU, Provan AB, Nandigam RC et al. (2013) . The United Kingdom immune thrombocytopenic purpura registry.BRITISH JOURNAL OF HAEMATOLOGY vol. 161, 39-40.
Newland A (2012) . Thrombopoietin: too much or too little.Hematology vol. 17 Suppl 1, S166-S168.
Farren TW, Giustiniani J, Liu FT et al. (2011) . Differential and tumor-specific expression of CD160 in B-cell malignancies.Blood vol. 118, (8) 2174-2183.
Sarpatwari A, Bussel JB, Ahmed M et al. (2011) . Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults.Hematology vol. 16, (4) 243-248.
Stasi R, Newland AC (2011) . ITP: a historical perspective.Br J Haematol vol. 153, (4) 437-450.
Provan D, Newland AC, Consensus Grp (2011) . Guidelines for Immune Thrombocytopenia.NEW ENGL J MED vol. 364, (6) 580-581.
Newland A (2011) . What's new in the management of chronic primary immune thrombocytopenia in adults and the use of thrombopoietin receptor agonists.Med Princ Pract vol. 20, (4) 301-302.
Sarpatwari A, Provan D, Erqou S et al. (2010) . Autologous 111 In-labelled platelet sequestration studies in patients with primary immune thrombocytopenia (ITP) prior to splenectomy: a report from the United Kingdom ITP Registry.Br J Haematol vol. 151, (5) 477-487.
Stasi R, Newland A, Thornton P et al. (2010) . Should medical treatment options be exhausted before splenectomy is performed in adult ITP patients? A debate.ANN HEMATOL vol. 89, (12) 1185-1195.
Sarpatwari A, Watson S, Erqou S et al. (2010) . Health-related lifestyle in adults and children with primary immune thrombocytopenia (ITP).Br J Haematol vol. 151, (2) 189-191.
Molineux G, Newland A (2010) . Development of romiplostim for the treatment of patients with chronic immune thrombocytopenia: from bench to bedside.BRIT J HAEMATOL vol. 150, (1) 9-20.
Sarpatwari A, Bennett D, Logie JW et al. (2010) . Thromboembolic events among adult patients with primary immune thrombocytopenia in the United Kingdom General Practice Research Database.HAEMATOL-HEMATOL J vol. 95, (7) 1167-1175.
Provan D, Stasi R, Newland AC et al. (2010) . International consensus report on the investigation and management of primary immune thrombocytopenia.Blood vol. 115, (2) 168-186.
Sarpatwari A, Provan D, Sobnack R et al. (2009) . Autologous In-111-Labeled Platelet Sequestration Studies in Patients with Primary Immune Thrombocytopenia (ITP): A Report From the United Kingdom Registry. BLOOD. vol. 114, 950-950.
Bussel JB, Kuter DJ, Newland A et al. (2009) . Long-Term Efficacy and Safety of Romiplostim for the Treatment of Patients with Chronic Immune Thrombocytopenia (ITP): 5-Year Update From An Open-Label Extension Study. BLOOD. vol. 114, 285-285.
Newland A (2009) . Thrombopoietin receptor agonists in the treatment of thrombocytopenia.Curr Opin Hematol vol. 16, (5) 357-364.
Murphy MF, Allard S, Newland AC (2009) . Modernizing hospital transfusion laboratory services.TRANSFUSION MED vol. 19, (4) 153-155.
Pullarkat VA, Gernsheirner TB, Wasser JS et al. (2009) . Quantifying the reduction in immunoglobulin use over time in patients with chronic immune thrombocytopenic purpura receiving romiplostim (AMG 531).AM J HEMATOL vol. 84, (8) 538-540.
Newland A (2009) . Romiplostim: a breakthrough treatment for the management of immune thrombocytopenic purpura.EUR J HAEMATOL vol. 82, 20-25.
Stasi R, Sarpatwari A, Segal JB et al. (2009) . Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systematic review.BLOOD vol. 113, (6) 1231-1240.
Sarpatwari A, Watson S, Anderson H et al. (2008) . Health-Related Lifestyle among Adult & Pediatric Patients with Idiopathic Thrombocytopenic Purpura in the United Kingdom. BLOOD. vol. 112, 1178-1178.
Kuter DJ, Bussel JB, Newland A et al. (2008) . Long-Term Treatment with Romiplostim in Patients with Chronic Immune Thrombocytopenic Purpura (ITP): 3-Year Update from An Open-Label. BLOOD. vol. 112, 154-154.
Sarpatwari A, Bennett D, Logie JW et al. (2008) . Thromboembolic Events among Adult Patients with Idiopathic Thrombocytopenic Purpura in the United Kingdom General Practice Research Database. BLOOD. vol. 112, 1167-1167.
Liu FT, Agrawal SG, Movasaghi Z et al. (2008) . Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib.Blood vol. 112, (9) 3835-3846.
Provan D, Newland AC, Amadori S et al. (2008) . Rituximab in the treatment of autoimmune haematological disorders.BRIT J HAEMATOL vol. 143, (2) 294-294.
Yu M, Liu FT, Newland AC et al. (2008) . The alpha-5 helix of Bax is sensitive to ubiquitin-dependent degradation.Biochem Biophys Res Commun vol. 371, (1) 10-15.
Liu FT, Agrawal SG, Gribben JG et al. (2008) . Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL.Blood vol. 111, (5) 2797-2805.
Agrawal SG, Liu FT, Wiseman C et al. (2008) . Increased proteasomal degradation of Bax is a common feature of poor prognosis chronic lymphocytic leukemia.Blood vol. 111, (5) 2790-2796.
Kuter DJ, Bussel JB, Lyons RM et al. (2008) . Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial.LANCET vol. 371, (9610) 395-403.
Newland A (2008) . Emerging strategies to treat chronic immune thrombocytopenic purpura. Eur J Haematol Suppl. 27-33.
Provan D, Butler T, Evangelista ML et al. (2007) . Activity and safety profile of low-dose rituximab for the treatment of autoimmune cytopenias in adults.HAEMATOL-HEMATOL J vol. 92, (12) 1695-1698.
Agrawal SG, Liu FT, Wiseman C et al. (2007) . Bax degradation activity is a novel poor prognosis marker of chronic lymphocytic leukemia. BLOOD. vol. 110, 908A-908A.
Bussel JB, Kuter DJ, de Wolf JTM et al. (2007) . Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura: 2-year update. BLOOD. vol. 110, 174A-175A.
Pullarkat V, Gernsheimer TB, de Wolf JTM et al. (2007) . Reduction in immunoglobulin (IVIG or anti D) use in patients with chronic immune thrombocytopenic purpura (ITP) receiving AMG 531: Results from two phase 3 randomized placebo-controlled trials. BLOOD. vol. 110, 392A-393A.
Tsitsikas DA, Giustiniani J, Skipper A et al. (2007) . Universal CD160 expression and the CD5+23+/CD5+19+ ratio in chronic lymphocytic leukemia simpify identification of atypical cases from CD23+ mantle cell lymphoma. BLOOD. vol. 110, 243B-243B.
Farren T, Giustiniani J, Johansson U et al. (2007) . Using CD160 as a novel approach to the assessment of minimal residual disease (MRD) in chronic lymphocytic leukaemia (CLL). BLOOD. vol. 110, 606A-606A.
Jahnke U, Higginbottom K, Newland AC et al. (2007) . Cell death in leukemia: passenger protein regulation by topoisomerase inhibitors.Biochem Biophys Res Commun vol. 361, (4) 928-933.
Higginbottom K, Jahnke U, Newland AC et al. (2007) . New alternative phosphorylation sites on the cyclin dependent kinase 1/cyclin a complex in p53-deficient human cells treated with etoposide: possible association with etoposide-induced apoptosis.Apoptosis vol. 12, (10) 1847-1855.
Newland A (2007) . Thrombopoietin mimetic agents in the management of immune thrombocytopenic purpura.SEMIN HEMATOL vol. 44, (4) S35-S45.
Provan D, Newland AC (2007) . Romiplostim.DRUG FUTURE vol. 32, (9) 781-787.
Aledort LM, Salama A, Kovaleva L et al. (2007) . Efficacy and safety of intravenous anti-D immunoglobulin (Rhophylac((R))) in chronic immune thrombocytopenic purpura.HEMATOLOGY vol. 12, (4) 289-295.
Auer RL, Dighiero G, Goldin LR et al. (2007) . Trinucleotide repeat dynamic mutation identifying susceptibility in familial and sporadic chronic lymphocytic leukaemia.Br J Haematol vol. 136, (1) 73-79.
Newland A, Caulier MT, Kappers-Klunne M et al. (2006) . An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura.Br J Haematol vol. 135, (4) 547-553.
NEWLAND AC, Provan D, Amadori S et al. (2006) . Long-term observation of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis treated with rituximab.Rheumatology (Oxford). vol. 45, 1432-1436.
Stasi R, Amadori S, Osborn J et al. (2006) . Borderline thrombocytopenia or mild idiopathic thrombocytopenic purpura? Reply.PLOS MED vol. 3, (8) Article e365, 1435-1435.
Mcelwaine SM, Johansson U, Kenny D et al. (2006) . Global gene expression profiling in patients diagnosed with idiopathic thrombocytopenia (ITP) using affymetrix gene expression arrays. BRITISH JOURNAL OF HAEMATOLOGY. vol. 133, 32-33.
Stasi R, Amadori S, Osborn J et al. (2006) . Long-term outcome of otherwise healthy individuals with incidentally discovered borderline, thrombocytopenia.PLOS MED vol. 3, (3) Article e24, 388-394.
NEWLAND AC, Provan D, Moss AJ et al. (2006) . Efficacy of mycophenolate mofetil as single-agent therapy for refractory immune thrombocytopenic purpura.Am J Hematol. vol. 81, 19-25.
Johansson U, Lawson C, Dabare M et al. (2005) . Human peripheral blood monocytes express protease receptor-2 and respond to receptor activation by production of IL-6, IL-8, and IL-1{beta}.J Leukoc Biol vol. 78, (4) 967-975.
Newland A, Provan D, Myint S (2005) . Preventing severe infection after splenectomy - Risk of malaria and meningitis increases with asplenia - Reply.BRIT MED J vol. 331, (7516) 576-576.
Newland A, Provan D, Myint S (2005) . Preventing severe infection after splenectomy - Patients should know the risks, be immunised, and take prophylactic antibiotics.BRIT MED J vol. 331, (7514) 417-418.
Stasi R, Amadori S, Littlewood TJ et al. (2005) . Management of cancer-related anemia with erythropoietic agents: Doubts, certainties, and concerns.ONCOLOGIST vol. 10, (7) 539-554.
Cotter F, Su B, Corbo M et al. (2005) . GCS-100 a novelgalectin-3 antagonist and caspase9 activating therapy for indolent B-cell malignancies. ANNALS OF ONCOLOGY. vol. 16, 70-70.
Auer R, Costagli A, Newland A et al. (2005) . Zebrafish in vivo modelling of the 11Q23 region of deletion in chronic lymphatic leukaemia. ANNALS OF ONCOLOGY. vol. 16, 87-87.
Auer RL, Starczynski J, McElwaine S et al. (2005) . Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia.Genes Chromosomes Cancer vol. 43, (1) 1-10.
Johansson U, Macey MG, Kenny D et al. (2005) . The role of natural killer T (NKT) cells in immune thrombocytopenia: is strong in vitro NKT cell activity related to the development of remission?.BRIT J HAEMATOL vol. 129, (4) 564-565.
Newland AC, Provan AB, Caulier MT et al. (2005) . An open-label, unit dose-finding study evaluating the safety and platelet response of a novel thrombopoietic protein (AMG531) in thrombocytopenic adult patients (Pts) with immune thrombocytopenic purpura (ITP). BRITISH JOURNAL OF HAEMATOLOGY. vol. 129, 43-43.
Auer RL, Costagli A, Newland AC et al. (2005) . Definition and zebrafish modelling of the 11 q23 critical region of deletion in CLL. BRITISH JOURNAL OF HAEMATOLOGY. vol. 129, 25-26.
Auer RL, Su B, Corbo M et al. (2005) . GCS-100, a Galectin 3 antagonist, is a novel caspase-9 apoptosis activating agent for the treatment of indolent B-cell malignancies. BRITISH JOURNAL OF HAEMATOLOGY. vol. 129, 5-5.
Stasi R, Amadori S, Newland AC et al. (2005) . Infliximab chimeric antitumor necrosis factor-alpha monoclonal antibody as potential treatment for myelodysplastic syndromes.LEUKEMIA LYMPHOMA vol. 46, (4) 509-516.
Johansson U, Kenny D, Provan D et al. (2005) . Selective reduction of plasmacytoid DCs in peripheral blood from ITP patients. BRITISH JOURNAL OF HAEMATOLOGY. vol. 129, 9-9.
NEWLAND AC, Provan D, Stipa E et al. (2005) . Helicobacter pylori eradication in the management of patients with idiopathic thrombocytopenic purpura.Am J Med. vol. 118, 414-419.
Aledort LM, Salama A, Kovaleva L et al. (2004) . An open label, multi center study on the efficacy and safety of a liquid, ready-to-use intravenously administered anti-D immunoglobulin in patients with chronic immune thrombocytopenic purpura. BLOOD. vol. 104, 72B-72B.
Cotter FE, Su B, Corbo M et al. (2004) . GCS-100, a Galectin 3 antagonist, is a novel caspase-9 apoptosis activating agent for the treatment of indolent B-cell malignancies. BLOOD. vol. 104, 898A-898A.
Hao JH, Yu M, Liu FT et al. (2004) . Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells.Cancer Res vol. 64, (10) 3607-3616.
Johansson U, Macey MG, Kenny D et al. (2004) . Alpha-galactosylceramide-driven expansion of human natural killer T cells is inhibited by prednisolone treatment.Br J Haematol vol. 125, (3) 400-404.
Liu FT, Goff LK, Hao JH et al. (2004) . Increase in the ratio of mitochondrial Bax/Bcl-XL induces Bax activation in human leukemic K562 cell line.Apoptosis vol. 9, (3) 377-384.
NEWLAND AC, Provan D, Amadori R et al. (2004) . Comparison of rHuEpo plus rHuG-CSF and supportive care: apples to oranges.Blood vol. 104,
Provan D, Newland A (2003) . Idiopathic thrombocytopenic purpura in adults. J Pediatr Hematol Oncol. vol. 25 Suppl 1, S34-S38.
Feng WY, Liu FT, Patwari Y et al. (2003) . BH3-domain mimetic compound BH3I-2 ' induces rapid damage to the inner mitochondrial membrane prior to the cytochrome c release from mitochondria.BRIT J HAEMATOL vol. 121, (2) 332-340.
Jia L, Patwari Y, Kelsey SM et al. (2003) . Role of Smac in human leukaemic cell apoptosis and proliferation.ONCOGENE vol. 22, (11) 1589-1599.
Hough RE, Lorigan PC, Poynton C et al. (2003) . A phase II protection study of BB-10010 in patients with high grade non-Hodgkin's lymphoma undergoing intensive chemotherapy.INT J ONCOL vol. 22, (2) 421-424.
Provan D, Newland A, Norfolk D et al. (2003) . Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy.BRIT J HAEMATOL vol. 120, (4) 574-596.
Fu WN, Bertoni F, Kelsey SM et al. (2003) . Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia.ONCOGENE vol. 22, (3) 451-455.
NEWLAND AC, Provan D, MeaD AJ (2003) . Adult idiopathic thrombocytopenic purpura.Hematology vol. 8, 345-357.
JIA L, Newland AC, Liu FT (2003) . Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia.Biochem. Biophys. Res. Commun vol. 310, (3) 856-962.
Macey M, McCarthy D, Azam U et al. (2003) . Ethylenediaminetetraacetic acid plus. citrate-theophylfine-adenosine-dipyridamole (EDTA-CTAD): A novel anticoagulant for the flow cytometric assessment of platelet and neutrophil activation ex vivo in whole blood.CYTOM PART B-CLIN CY vol. 51B, (1) 30-40.
NEWLAND AC, Provan D, Williams MA et al. (2003) . In vitro cytotoxic effects of stabilizing sugars within human intravenous immunoglobulin preparations against the human macrophage THP-1 cell-line.Hematology vol. 8, 285-294.
JIA L, Newland AC, Liu FT et al. (2003) . Potential mechanisms of leukemia cell resistance to TRAIL-induced apoptosis.Apoptosis vol. 8, 601-607.
Provan D, Newland A (2002) . Fifty years of idiopathic thrombocytopenic purpura (ITP): management of refractory itp in adults.Br J Haematol vol. 118, (4) 933-944.
Newland A (2002) . Progress in the treatment of acute myeloid leukaemia in adults. Int J Hematol. vol. 76 Suppl 1, 253-258.
ALLEN PD, Newland AC, Higginbottom K et al. (2002) . Etoposide-Mediated Deregulation of the G2M Checkpoint in Myeloid Leukaemic Cell Lines Results in Loss of Cell Survival.Br J. Haemat vol. 119, 956-964.
Macey M, Azam U, McCarthy D et al. (2002) . Evaluation of the anticoagulants EDTA and citrate, theophylline, adenosine, and dipyridamole (CTAD) for assessing platelet activation on the ADVIA 120 Hematology System.CLIN CHEM vol. 48, (6) 891-899.
Liu FT, Kelsey SM, Newland AC et al. (2002) . Liposomal encapsulation diminishes daunorubicin-induced generation of reactive oxygen species, depletion of ATP and necrotic cell death in human leukaemic cells.Br J Haematol vol. 117, (2) 333-342.
Cummings M, Siitonen T, Higginbottom K et al. (2002) . p53-mediated downregulation of Chk1 abrogates the DNA damage-induced G2M checkpoint in K562 cells, resulting in increased apoptosis.BRIT J HAEMATOL vol. 116, (2) 421-428.
Newland AC (2002) . Treatment of adults with autoimmune thrombocytopenic purpura.Lancet vol. 359, (9300) 4-5.
Liu FT, Kelsey SM, Newland AC et al. (2001) . Generation of reactive oxygen species is not involved in idarubicin-induced apoptosis in human leukaemic cells.Br J Haematol vol. 115, (4) 817-825.
Partheniou F, Kelsey SM, Srinivasula SM et al. (2001) . c-IAP1 blocks TNFalpha-mediated cytotoxicity upstream of caspase-dependent and -independent mitochondrial events in human leukemic cells.Biochem Biophys Res Commun vol. 287, (1) 181-189.
Stanworth SJ, Newland AC (2001) . Stem cells: progress in research and edging towards the clinical setting.CLIN MED vol. 1, (5) 378-382.
Jia L, Patwari Y, Srinivasula SM et al. (2001) . Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis.Oncogene vol. 20, (35) 4817-4826.
Jia L, Srinivasula SM, Liu FT et al. (2001) . Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells.BLOOD vol. 98, (2) 414-421.
McBride NC, Cavenagh JD, Ward MC et al. (2001) . Liposomal daunorubicin (daunoxome) in combination with cyclophosphamide, vincristine and prednisolone (COPA) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.LEUKEMIA LYMPHOMA vol. 42, (1-2) 89-98.
Jia L, Patwari Y, Kelsey SM et al. (2001) . Trail-induced apoptosis in Type I leukemic cells is not enhanced by overexpression of bax.Biochem Biophys Res Commun vol. 283, (5) 1037-1045.
Yin Y, Allen PD, Jia L et al. (2001) . 8-Cl-adenosine mediated cytotoxicity and sensitization of T-lymphoblastic leukemia cells to TNFalpha-induced apoptosis is via inactivation of NF-kappaB.Leuk Res vol. 25, (5) 423-431.
Fu WN, Kelsey SM, Newland AC et al. (2001) . Apaf-1XL is an inactive isoform compared with Apaf-1L.Biochem Biophys Res Commun vol. 282, (1) 268-272.
Newland AC, Burton I, Cavenagh JD et al. (2001) . Vigam-S, a solvent/detergent-treated intravenous immunoglobulin, in idiopathic thrombocytopenic purpura.TRANSFUSION MED vol. 11, (1) 37-44.
Gilston V, Williams MA, Newland AC et al. (2001) . Hydrogen peroxide and tumour necrosis factor-alpha induce NF-kappa B-DNA binding in primary human T lymphocytes in addition to T cell lines.FREE RADICAL RES vol. 35, (6) 681-691.
Newland AC, Mantsch HH, JIA L et al. (2001) . Quantitative determination of apoptosis on leukaemic cells by infrared spectroscopy.Apoptosis vol. 6, 267-276.
Wu YL, Jiang XR, Lillington DM et al. (2000) . Upregulation of lipocortin 1 inhibits tumour necrosis factor-induced apoptosis in human leukaemic cells: a possible mechanism of resistance to immune surveillance.BRIT J HAEMATOL vol. 111, (3) 807-816.
Chapman ES, Azam U, Webb L et al. (2000) . The use of the anticoagulant CTAD for the assessment of ex vivo platelet activation on the ADVIA 120 Haematology System.BLOOD vol. 96, (11) 52B-52B.
Shamash J, O'Doherty CA, Oliver RTD et al. (2000) . Should high-dose chemotherapy be used to consolidate second or third line treatment in relapsing germ cell tumours?.ACTA ONCOL vol. 39, (7) 857-863.
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