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Publications:  Prof Nicholas Lemoine

Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, de Giorgio A, Trabulo SM, Nguyen VTM et al.(2019). Author Correction: TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Nat Commun vol. 10, (1) 3738-3738.
10.1038/s41467-019-11752-2
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59879
Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, De Giorgio A, Trabulo SM, Nguyen VTM et al.(2018). TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Nature Communications vol. 9, (1)
10.1038/s41467-018-03962-x
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39324
Dayem Ullah AZ, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C(2018). SNPnexus: Assessing the functional relevance of genetic variation to facilitate the promise of precision medicine. Nucleic Acids Research vol. 46, (W1) W109-W113.
10.1093/nar/gky399
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A et al.(2018). A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. EMBO Mol Med
10.15252/emmm.201708304
https://qmro.qmul.ac.uk/xmlui/handle/123456789/42128
Marelli G, Howells A, Lemoine NR, Wang Y(2018). Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer. Frontiers in Immunology vol. 9, 866-866.
10.3389/fimmu.2018.00866
Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al.(2018). Erratum: Author Correction: Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent (Nature communications (2017) 8 1 (1395)). Nature communications vol. 9, (1)
10.1038/s41467-017-02205-9
https://qmro.qmul.ac.uk/xmlui/handle/123456789/40043
Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R et al.(2017). Splice variants as novel targets in pancreatic ductal adenocarcinoma. Scientific Reports vol. 7, (1)
10.1038/s41598-017-03354-z
https://qmro.qmul.ac.uk/xmlui/handle/123456789/24508
Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al.(2017). Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent. Nat Commun vol. 8, (1) 1395-1395.
10.1038/s41467-017-01385-8
https://qmro.qmul.ac.uk/xmlui/handle/123456789/33983
Marzec J, Dayem Ullah AZ, Pirrò S, Gadaleta E, Crnogorac-Jurcevic T, Lemoine NR, Kocher HM, Chelala C(2017). The Pancreatic Expression Database: 2018 update. Nucleic Acids Res vol. 46, (D1) D1107-D1110.
10.1093/nar/gkx955
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31471
Spurrell E, Gangeswaran R, Wang P, Cao F, Gao D, Feng B, Wold W, Tollefson A et al.(2017). Erratum: STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus [Journal of Virology, 88, 4, (2014) (2291-2300)] DOI: 10.1128/JVI.02829-13. Journal of Virology vol. 91, (20)
10.1128/JVI.00670-17
Howells A, Marelli G, Lemoine NR, Wang Y(2017). Oncolytic Viruses-Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer. Front Oncol vol. 7, 195-195.
10.3389/fonc.2017.00195
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34409
Glorioso JC, Lemoine N(2017). Gene therapy-from small beginnings to where we are now. Gene Ther vol. 24, (9) 495-496.
10.1038/gt.2017.23
Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al.(2017). 'Multi-omic' data analysis using O-miner. Brief Bioinform
10.1093/bib/bbx080
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36329
Webb ES, Liu P, BALEEIRO R, Lemoine NR, Yuan M, Wang Y(2017). Immune checkpoint inhibitors in cancer therapy. Journal of Biomedical Research
10.7555/JBR.31.20160168
Szlosarek PW, Steele JP, Nolan L, Gilligan D, Taylor P, Spicer J, Lind M, Mitra S et al.(2017). Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial. JAMA oncology vol. 3, (1) 58-66.
10.1001/jamaoncol.2016.3049
Szlosarek PW, Steele JP, Nolan L, Gilligan D, Taylor P, Spicer J, Lind M, Mitra S et al.(2017). Arginine deprivation with pegylated arginine deiminase in patients with argininosuccinate synthetase 1-deficient malignant pleural mesothelioma a randomized clinical trial. JAMA Oncology vol. 3, (1) E1-E9.
10.100l/jamaoncd.2016.3049
CRNOGORAC-JURCEVIC T, Dumartin L, Alrawashdeh W, Trabulo SM, Radon TP, Steiger K, Feakins RM, di Magliano MP et al.(2016). ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation. Oncogene
10.1038/onc.2016.459
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18288
Yuan M, Wang P, Chard LS, Lemoine NR, Wang Y(2016). A simple and efficient approach to construct mutant vaccinia virus vectors. Journal of Visualized Experiments vol. 2016, (116)
10.3791/54171
Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P et al.(2016). Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma. Journal of Pathology vol. 239, (3) 286-296.
10.1002/path.4727
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13271
Pantelidou C, Cherubini G, Lemoine NR, Halldén G(2016). The E1B19K-deleted oncolytic adenovirus mutant AdΔ19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11. Oncotarget vol. 7, (13) 15703-15724.
10.18632/oncotarget.7310
https://qmro.qmul.ac.uk/xmlui/handle/123456789/16702
Yuan M, Webb E, Lemoine NR, Wang Y(2016). CRISPR-Cas9 as a powerful tool for efficient creation of oncolytic viruses. Viruses vol. 8, (3)
10.3390/v8030072
Yaghchi CA, Zhang Z, Alusi G, Lemoine NR, Wang Y(2015). Vaccinia virus, a promising new therapeutic agent for pancreatic cancer. Immunotherapy vol. 7, (12) 1249-1258.
10.2217/imt.15.90
Radon TP, Massat NJ, Jones R, Alrawashdeh W, Dumartin L, Ennis D, Duffy SW, Kocher HM et al.(2015). Identification of a three-biomarker panel in urine for early detection of pancreatic adenocarcinoma. Clinical Cancer Research vol. 21, (15) 3512-3521.
10.1158/1078-0432.CCR-14-2467
Ahmed J, Yuan M, Li Y, Chu Y, Zhang Z, Gao D, Chard LS, Alusi G et al. (2015). A Promising Neo-Adjuvant Immuno-Therapeutic Agent for Preventing Cancer Recurrence and Metastasis After Surgery. MOLECULAR THERAPY. vol. 23, S166-S166.
10.1016/S1525-0016(16)34029-1
Ferguson M, Tysome J, Burns E, Whitehead M, Aksoy E, Clear A, Alusi G, Hiley C et al. (2015). Targeting Innate Host Immunity Through PI3K Delta for Enhancement of Systemic Delivery of Oncolytic Vaccinia Virus. MOLECULAR THERAPY. vol. 23, S258-S259.
10.1016/S1525-0016(16)34258-7
Yuan M, Gao X, Chard LS, Ali Z, Ahmed J, Li Y, Liu P, Lemoine NR et al.(2015). A marker-free system for highly efficient construction of vaccinia virus vectors using CRISPR Cas9. Molecular Therapy - Methods and Clinical Development vol. 2,
10.1038/mtm.2015.35
Hughes J, Wang P, Alusi G, Shi H, Chu Y, Wang J, Bhakta V, McNeish I et al.(2015). Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus. Gene Therapy
10.1038/gt.2015.13
Chard LS, Maniati E, Wang P, Zhang Z, Gao D, Wang J, Cao F, Ahmed J et al.(2015). A vaccinia virus armed with interleukin-10 Is a promising therapeutic agent for treatment of murine pancreatic cancer. Clinical Cancer Research vol. 21, (2) 405-416.
10.1158/1078-0432.CCR-14-0464
Yuan M, Zhang W, Wang J, Al Yaghchi C, Ahmed J, Chard L, Lemoine NR, Wang Y(2015). Efficiently editing the vaccinia virus genome by using the CRISPR-Cas9 system. Journal of Virology vol. 89, (9) 5176-5179.
10.1128/JVI.00339-15
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6978
Ibrahim AM, Wang Y, Lemoine NR(2015). Immune-checkpoint blockade: The springboard for immuno-combination therapy. Gene Therapy vol. 22, (11) 849-850.
10.1038/gt.2015.98
Hughes J, Wang P, Alusi G, Shi H, Chu Y, Wang J, Bhakta V, McNeish I et al.(2015). Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus. Gene Therapy vol. 22, (6) 476-484.
10.1038/gt.2015.13
Chard LS, Lemoine NR, Wang Y(2015). New role of Interleukin-10 in enhancing the antitumor efficacy of oncolytic vaccinia virus for treatment of pancreatic cancer. OncoImmunology vol. 4, (9) 1-3.
10.1080/2162402X.2015.1038689
Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al.(2014). A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma. Genome Medicine vol. 6, (12)
10.1186/s13073-014-0105-3
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6841
Pantelidou C, Lemoine N, Hallden G (2014). Adenoviruses deleted in the anti-apoptotic E1B19K-gene synergise with DNA-damaging drugs through attenuation of DNA-damage repair responses and checkpoint activation in pancreatic cancer cells. HUMAN GENE THERAPY. vol. 25, A17-A17.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7021
Hughes J, Wang P, Alusi G, Bhakta V, Chu Y, Shi H, McNeish I, McCart A et al. (2014). Backbone selection for development of tumour-targeted oncolyti Vaccinia virus for cancer treatment. HUMAN GENE THERAPY. vol. 25, A22-A23.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6958
Ahmed J, Yuan M, Li Y, Chu Y, Shi H, Chard L, Alusi G, Lemoine N et al. (2014). A Novel Tumour Selective Oncolytic Vaccinia Virus Lacking the N1L Gene Enhances the Anti-Tumour Immune Response When Used as an Anticancer Therapeutic. MOLECULAR THERAPY. vol. 22, S248-S249.
Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Kocher HM, Grose RP(2014). Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion. EMBO Mol Med vol. 6, (4) 467-481.
10.1002/emmm.201302698
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13773
Allen MD, Luong P, Hudson C, Leyton J, Delage B, Ghazaly E, Cutts R, Yuan M et al.(2014). Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging. Cancer Res vol. 74, (3) 896-907.
10.1158/0008-5472.CAN-13-1702
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6977
Spurrell E, Gangeswaran R, Wang P, Cao F, Gao D, Feng B, Wold W, Tollefson A et al.(2014). STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus. J Virol vol. 88, (4) 2291-2300.
10.1128/JVI.02829-13
Dayem Ullah AZ, Cutts RJ, Ghetia M, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR, Chelala C(2014). The pancreatic expression database: recent extensions and updates. Nucleic Acids Res vol. 42, (Database issue) D944-D949.
10.1093/nar/gkt959
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18503
Szlosarek PW, Steele J, Sheaff M, Szyszko T, Ellis S, Nolan L, Taylor P, Gilligan D et al.(2013). A RANDOMISED PHASE II TRIAL OF PEGYLATED ARGININE DEIMINASE IN PATIENTS WITH MALIGNANT PLEURAL MESOTHELIOMA. JOURNAL OF THORACIC ONCOLOGY vol. 8, S308-S308.
Gadaleta E, Cutts RJ, Sangaralingam A, Lemoine NR, Chelala C(2013). An Integrated Systems Approach to the Study of Pancreatic Cancer. Systems Biology in Cancer Research and Drug Discovery,
Ahmed J, Yuan M, Alusi G, Lemoine NR, Wang Y(2013). The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent. Gene Therapy of Cancer: Translational Approaches from Preclinical Studies to Clinical Implementation: Third Edition,
Dayem Ullah AZ, Lemoine NR, Chelala C(2013). A practical guide for the functional annotation of genetic variations using SNPnexus. Brief Bioinform vol. 14, (4) 437-447.
10.1093/bib/bbt004
Chard LS, Maniati E, Wang P, Hughes J, Wang J, Denes B, Fodor I, Hagemann T et al. (2013). A Vaccinia Virus Armed with Interleukin-10 That Dampens Host Immunity to the Vctor but Not to Tumor Is a Promising Therapeutic Agent for Pancreatic Cancer. MOLECULAR THERAPY. vol. 21, S196-S196.
Hughes J, Wang P, Alusi G, Bhakta V, Chu Y, Shi H, McNeish I, McCart A et al. (2013). Lister Strain Vaccinia Virus Demonstrates Favourable Anti-Tumor Efficacy and Tumor-Selectivity Compared to Western Reserve Strain. MOLECULAR THERAPY. vol. 21, S216-S216.
Coleman S, Chioni A-M, Ghallab M, Lemoine N, Grose RP, Kocher H (2013). Nuclear Translocation of FGFR1 and FGF2 in Pancreatic Stellate Cells Is Necessary for Pancreatic Cancer Cell Invasion. GASTROENTEROLOGY. vol. 144, S98-S98.
Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR et al.(2013). S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells. Clin Exp Metastasis vol. 30, (3) 251-264.
10.1007/s10585-012-9532-y
Hiley CT, Chard LS, Gangeswaran R, Tysome JR, Briat A, Lemoine NR, Wang Y(2013). Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway. J Virol vol. 87, (5) 2781-2790.
10.1128/JVI.00854-12
Crnogorac-Jurcevic T, Chelala C, Barry S, Harada T, Bhakta V, Lattimore S, Jurcevic S, Bronner M et al.(2013). Molecular analysis of precursor lesions in familial pancreatic cancer. PLoS One vol. 8, (1)
10.1371/journal.pone.0054830
https://qmro.qmul.ac.uk/xmlui/handle/123456789/4930
Tysome JR, Lemoine NR, Wang Y(2013). Update on oncolytic viral therapy - targeting angiogenesis. Onco Targets Ther vol. 6, 1031-1040.
10.2147/OTT.S46974
Tysome JR, Li X, Wang S, Wang P, Gao D, Du P, Chen D, Gangeswaran R et al.(2012). A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity. Clin Cancer Res vol. 18, (24) 6679-6689.
10.1158/1078-0432.CCR-12-0979
Adam V, Ekblad M, Sweeney K, Müller H, Busch KH, Johnsen CT, Kang NR, Lemoine NR et al.(2012). Synergistic and Selective Cancer Cell Killing Mediated by the Oncolytic Adenoviral Mutant AdΔΔ and Dietary Phytochemicals in Prostate Cancer Models. Hum Gene Ther vol. 23, (9) 1003-1015.
10.1089/hum.2012.046
Delage B, Luong P, Maharaj L, O'Riain C, Syed N, Crook T, Hatzimichael E, Papoudou-Bai A et al.(2012). Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis. Cell Death Dis vol. 3,
10.1038/cddis.2012.83
Cutts RJ, Dayem Ullah AZ, Sangaralingam A, Gadaleta E, Lemoine NR, Chelala C(2012). O-miner: an integrative platform for automated analysis and mining of -omics data. Nucleic Acids Res vol. 40, (Web Server issue) W560-W568.
10.1093/nar/gks432
Dayem Ullah AZ, Lemoine NR, Chelala C(2012). SNPnexus: a web server for functional annotation of novel and publicly known genetic variants (2012 update). Nucleic Acids Res vol. 40, (Web Server issue) W65-W70.
10.1093/nar/gks364
Wang P, Jiang G, Chard L, Wang J, Gao D, Cao H, Lemoine NR, Wang Y (2012). A Rationally Designed Oncolytic Adenovirus, Ad-TD-IL-12, Cures Pancreatic Cancer in the Immunocompetent Syrian Hamster. MOLECULAR THERAPY. vol. 20, S131-S131.
Sweeney KG, Cheong SC, Lemoine NR, Hallden G(2012). A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells. CANCER RESEARCH vol. 72,
10.1158/1538-7445.AM2012-2712
Maya-Pineda HR, Miranda-Rota E, Lemoine NR, Hallden G(2012). Adenovirus E1A binding to p300 is essential for synergistic cell killing in combination with chemotherapeutic drugs in prostate cancer cells. CANCER RESEARCH vol. 72,
10.1158/1538-7445.AM2012-2713
Wong HH, Jiang G, Gangeswaran R, Wang P, Wang J, Yuan M, Wang H, Bhakta V et al.(2012). Modification of the early gene enhancer-promoter improves the oncolytic potency of adenovirus 11. Mol Ther vol. 20, (2) 306-316.
10.1038/mt.2011.242
Miranda E, Maya Pineda H, Öberg D, Cherubini G, Garate Z, Lemoine NR, Halldén G(2012). Adenovirus-mediated sensitization to the cytotoxic drugs docetaxel and mitoxantrone is dependent on regulatory domains in the E1ACR1 gene-region. PLoS One vol. 7, (10)
10.1371/journal.pone.0046617
https://qmro.qmul.ac.uk/xmlui/handle/123456789/4723
Ferguson MS, Lemoine NR, Wang Y(2012). Systemic delivery of oncolytic viruses: hopes and hurdles. Adv Virol vol. 2012,
10.1155/2012/805629
Cherubini G, Kallin C, Mozetic A, Hammaren-Busch K, Müller H, Lemoine NR, Halldén G(2011). The oncolytic adenovirus AdΔΔ enhances selective cancer cell killing in combination with DNA-damaging drugs in pancreatic cancer models. Gene Ther vol. 18, (12) 1157-1165.
10.1038/gt.2011.141
Dumartin L, Whiteman HJ, Weeks ME, Hariharan D, Dmitrovic B, Iacobuzio-Donahue CA, Brentnall TA, Bronner MP et al.(2011). AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D. Cancer Res vol. 71, (22) 7091-7102.
10.1158/0008-5472.CAN-11-1367
Gadaleta E, Cutts RJ, Kelly GP, Crnogorac-Jurcevic T, Kocher HM, Lemoine NR, Chelala C(2011). A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws. Nucleic Acids Res vol. 39, (18) 7900-7907.
10.1093/nar/gkr533
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18659
Bhattacharyya M, Francis J, Eddouadi A, Lemoine NR, Halldén G(2011). An oncolytic adenovirus defective in pRb-binding (dl922-947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine. Cancer Gene Ther vol. 18, (10) 734-743.
10.1038/cgt.2011.45
Tysome JR, Wang P, Alusi G, Briat A, Gangeswaran R, Wang J, Bhakta V, Fodor I et al.(2011). Lister vaccine strain of vaccinia virus armed with the endostatin-angiostatin fusion gene: an oncolytic virus superior to dl1520 (ONYX-015) for human head and neck cancer. Hum Gene Ther vol. 22, (9) 1101-1108.
10.1089/hum.2010.172
Gadaleta E, Lemoine NR, Chelala C(2011). Online resources of cancer data: barriers, benefits and lessons. Brief Bioinform vol. 12, (1) 52-63.
10.1093/bib/bbq010
Cutts RJ, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR, Chelala C(2011). The Pancreatic Expression database: 2011 update. Nucleic Acids Res vol. 39, (Database issue) D1023-D1028.
10.1093/nar/gkq937
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18435
Cutts RJ, Gadaleta E, Lemoine NR, Chelala C(2011). Using BioMart as a framework to manage and query pancreatic cancer data. Database (Oxford) vol. 2011,
10.1093/database/bar024
Dumartin L, Whiteman HJ, Weeks ME, Timms JF, Brentnall TA, Bronner MP, Brennan C, Lemoine NR et al.(2010). AGR2 Regulates the Invasion of Pancreatic Cancer Cells Through Cathepsins B and D. PANCREAS vol. 39, (8) 1318-1319.
Jiang G, Cao F, Ren G, Gao D, Bhakta V, Zhang Y, Cao H, Dong Z et al.(2010). PRSS3 promotes tumour growth and metastasis of human pancreatic cancer. Gut vol. 59, (11) 1535-1544.
10.1136/gut.2009.200105
Sweeney K, Cheong SC, Lemoine N, Hallden G (2010). A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells. HUMAN GENE THERAPY. vol. 21, 1398-1398.
Ekblad M, Oberg D, Lemoine N, Hallden G (2010). Development of an oncolytic adenovirus expressing the prodrug-converting enzyme CD/UPRT (Ad Delta Delta CU). HUMAN GENE THERAPY. vol. 21, 1473-1473.
Radhakrishnan S, Miranda E, Ekblad M, Holford A, Pizarro MT, Lemoine NR, Halldén G(2010). Efficacy of oncolytic mutants targeting pRb and p53 pathways is synergistically enhanced when combined with cytotoxic drugs in prostate cancer cells and tumor xenografts. Hum Gene Ther vol. 21, (10) 1311-1325.
10.1089/hum.2010.019
Cherubini G, Kalllin C, Mozetic A, Hammaren-Busch K, Muller H, Lemoine N, Hallden G (2010). Investigating a new potent and selective oncolytic adenovirus (Ad Delta Delta) in combination with chemotherapy. HUMAN GENE THERAPY. vol. 21, 1473-1474.
Mao XY, Yu YW, Boyd LK, Ren GP, Lin DM, Chaplin T, Kudahetti SC, Stankiewicz E et al.(2010). Distinct Genomic Alterations in Prostate Cancers in Chinese and Western Populations Suggest Alternative Pathways of Prostate Carcinogenesis. CANCER RES vol. 70, (13) 5207-5212.
10.1158/0008-5472.CAN-09-4074
Wong HH, Lemoine NR(2010). Novel therapies for pancreatic cancer: setbacks and progress. Future Oncol vol. 6, (7) 1061-1064.
10.2217/fon.10.70
Delage B, Fennell DA, Nicholson L, McNeish I, Lemoine NR, Crook T, Szlosarek PW(2010). Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer. Int J Cancer vol. 126, (12) 2762-2772.
10.1002/ijc.25202
Sziosarek PW, Delage B, O'Riain C, Hatzimichael E, Crook T, Calaminici M, Gribben JG, Lemoine N et al.(2010). Effect of inactivation of argininosuccinate synthetase on sensitivity of lymphomas to caspase-dependent apoptosis following treatment with arginine deiminase. JOURNAL OF CLINICAL ONCOLOGY vol. 28, (15)
Hiley CT, Yuan M, Lemoine NR, Wang Y(2010). Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours. Gene Ther vol. 17, (2) 281-287.
10.1038/gt.2009.132
Oberg D, Yanover E, Adam V, Sweeney K, Costas C, Lemoine NR, Halldén G(2010). Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant in prostate and pancreatic cancers. Clin Cancer Res vol. 16, (2) 541-553.
10.1158/1078-0432.CCR-09-1960
Wong HH, Lemoine NR, Wang Y(2010). Oncolytic viruses for cancer therapy: overcoming the obstacles. Viruses vol. 2, (1) 78-106.
10.3390/v2010078
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25475
Tysome JR, Lemoine NR, Wang YH(2009). Combination of anti-angiogenic therapy and virotherapy: Arming oncolytic viruses with anti-angiogenic genes. CURR OPIN MOL THER vol. 11, (6) 664-669.
Pardo OE, Latigo J, Jeffery RE, Nye E, Poulsom R, Spencer-Dene B, Lemoine NR, Stamp GW et al.(2009). The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo. Cancer Res vol. 69, (22) 8645-8651.
10.1158/0008-5472.CAN-09-1576
Peerlinck I, Merron A, Baril P, Conchon S, Martin-Duque P, Hindorf C, Burnet J, Quintanilla M et al.(2009). Targeted radionuclide therapy using a Wnt-targeted replicating adenovirus encoding the Na/I symporter. Clin Cancer Res vol. 15, (21) 6595-6601.
10.1158/1078-0432.CCR-09-0262
Tysome JR, Briat A, Alusi G, Cao F, Gao D, Yu J, Wang P, Yang S et al.(2009). Lister strain of vaccinia virus armed with endostatin-angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer. Gene Ther vol. 16, (10) 1223-1233.
10.1038/gt.2009.74
Seckl MJ, Pardo OE, Aboagye EO, Latigo J, Stamp G, Lemoine N, Spencer-Dean B(2009). The FGF receptor (FGFR) inhibitor PD0173074 blocks SCLC growth in vitro and in vivo. J THORAC ONCOL vol. 4, (9) S385-S385.
Wong HH, Lemoine NR(2009). Pancreatic cancer: molecular pathogenesis and new therapeutic targets (vol 6, pg 412, 2009). NAT REV GASTRO HEPAT vol. 6, (8) 440-440.
10.1038/nrgastro.2009.123
Wong HH, Lemoine NR(2009). Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Nat Rev Gastroenterol Hepatol vol. 6, (7) 412-422.
10.1038/nrgastro.2009.89
Wang Y, Gangeswaran R, Zhao X, Wang P, Tysome J, Bhakta V, Yuan M, Chikkanna-Gowda CP et al.(2009). CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells. J Clin Invest vol. 119, (6) 1604-1615.
10.1172/JCI37905
Wong HH, Gangeswaran R, Francis J, Lemoine NR, Wang Y (2009). Adenovirus 11 is an Alternative Oncolytic Virus Targeting Adenovirus 5-Insensitive Cancer and Shows Distinct E1A Gene Transcriptional Activity. MOLECULAR THERAPY. vol. 17, S235-S236.
Adam V, Oberg D, Lemoine N, Hallden G (2009). Prostate Cancer Targeting by Replication-Selective Adenoviral Mutants: Combination Treatments with Phytochemical Drugs. MOLECULAR THERAPY. vol. 17, S320-S320.
Tysome JR, Briat A, Hiley C, Gangeswaran R, Chikkanna-Gowda CP, Bhakta V, Alusi G, Trivedi K et al. (2009). Systemic Delivery of Lister Strain Vaccinia Virus to Tumors Is Facilitated by the Depletion of Macrophages in Immuno-Competent Mice. MOLECULAR THERAPY. vol. 17, S247-S247.
Leitner S, Sweeney K, Oberg D, Davies D, Miranda E, Lemoine NR, Halldén G(2009). Oncolytic adenoviral mutants with E1B19K gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumor efficacy in vivo. Clin Cancer Res vol. 15, (5) 1730-1740.
10.1158/1078-0432.CCR-08-2008
Chelala C, Khan A, Lemoine NR(2009). SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms. Bioinformatics vol. 25, (5) 655-661.
10.1093/bioinformatics/btn653
Marinov M, Ziogas A, Pardo OE, Tan LT, Dhillon T, Mauri FA, Lane HA, Lemoine NR et al.(2009). AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001. Clin Cancer Res vol. 15, (4) 1277-1287.
10.1158/1078-0432.CCR-08-2166
Chelala C, Lemoine NR, Hahn SA, Crnogorac-Jurcevic T(2009). A web-based platform for mining pancreatic expression datasets. Pancreatology vol. 9, (4) 340-343.
10.1159/000212082
Harada T, Chelala C, Crnogorac-Jurcevic T, Lemoine NR(2009). Genome-wide analysis of pancreatic cancer using microarray-based techniques. Pancreatology vol. 9, (1-2) 13-24.
10.1159/000178871
Tysome JR, Briat A, Alusi G, Cao F, Yu J, Wang P, Yang S, Dong Z et al.(2009). Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancerVaccine strain of vaccinia virus for cancer therapy. Gene Therapy vol. 16, (10) 1223-1233.
10.1038/gt.2009.74
Antonello D, Gobbo S, Corbo V, Sipos B, Lemoine NR, Scarpa A(2009). Update on the molecular pathogenesis of pancreatic tumors other than common ductal adenocarcinoma. Pancreatology vol. 9, (1-2) 25-33.
10.1159/000178872
Yuan M, Tomlinson V, Lara R, Holliday D, Chelala C, Harada T, Gangeswaran R, Manson-Bishop C et al.(2008). Yes-associated protein (YAP) functions as a tumor suppressor in breast. Cell Death Differ vol. 15, (11) 1752-1759.
10.1038/cdd.2008.108
Adam V, Lemoine N, Hallden G (2008). Prostate cancer targeting by replication-selective adenoviral mutants: combination treatments with phytochemical drugs. HUMAN GENE THERAPY. vol. 19, 1165-1165.
Peerlinck I, Amini-Nik S, Phillips RK, Iggo R, Lemoine NR, Tejpar S, Vassaux G(2008). Therapeutic potential of replication-selective oncolytic adenoviruses on cells from familial and sporadic desmoid tumors. Clin Cancer Res vol. 14, (19) 6187-6192.
10.1158/1078-0432.CCR-08-0410
Weeks ME, Hariharan D, Petronijevic L, Radon TR, Whiteman HJ, Kocher HM, Timms JF, Lemoine NR et al.(2008). Analysis of the urine proteome in patients with pancreatic ductal adenocarcinoma. PROTEOM CLIN APPL vol. 2, (7-8) 1047-1057.
10.1002/prca.200780164
Montiel-Equihua CA, Martín-Duque P, de la Vieja A, Quintanilla M, Burnet J, Vassaux G, Lemoine NR(2008). Targeting sodium/iodide symporter gene expression for estrogen-regulated imaging and therapy in breast cancer. Cancer Gene Ther vol. 15, (7) 465-473.
10.1038/cgt.2008.6
Lemoine NR(2008). The clinician-scientist: a rare breed under threat in a hostile environment. Dis Model Mech vol. 1, (1) 12-14.
10.1242/dmm.000752
Baird SK, Aerts JL, Eddaoudi A, Lockley M, Lemoine NR, McNeish IA(2008). Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer. Oncogene vol. 27, (22) 3081-3090.
10.1038/sj.onc.1210977
Baird SK, Ingemarsdotter CK, Eddaoudi A, Lockley M, Lemoine NR, McNeish IA (2008). Oncolytic adenoviral mutants define a novel mode of programmed cell death in ovarian cancer. HUMAN GENE THERAPY. vol. 19, 399-399.
Adam VS, Lemoine N, Hallden G (2008). Prostate cancer targeting by replication-selective adenoviral mutants: Combination treatments with phytochemical drugs. HUMAN GENE THERAPY. vol. 19, 419-419.
Harada T, Chelala C, Bhakta V, Chaplin T, Caulee K, Baril P, Young BD, Lemoine NR(2008). Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays. Oncogene vol. 27, (13) 1951-1960.
10.1038/sj.onc.1210832
Wong HH, Lemoine NR(2008). Biological approaches to therapy of pancreatic cancer. Pancreatology vol. 8, (4-5) 431-461.
10.1159/000151536
Cheong SC, Wang Y, Meng J-H, Hill R, Sweeney K, Kirn D, Lemoine NR, Halldén G(2008). E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models. Cancer Gene Ther vol. 15, (1) 40-50.
10.1038/sj.cgt.7701099
Danovi SA, Wong HH, Lemoine NR(2008). Targeted therapies for pancreatic cancer. Br Med Bull vol. 87, 97-130.
10.1093/bmb/ldn027
Marinov M, Ziogas A, Pardo OE, Tan LT, Lane HA, Lemoine NR, Zangemeister-Wittke U, Seckl MJ et al.(2007). Akt/mTOR pathway activation and Bcl-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001 (Everolimus). MOL CANCER THER vol. 6, (12) 3409S-3409S.
Aiuti A, Bachoud-Levi AC, Blesch A, Brenner MK, Cattaneo F, Chiocca EA, Gao G, High KA et al.(2007). Progress and prospects: gene therapy clinical trials (part 2) (vol 14, pg 1555, 2007). GENE THER vol. 14, (24) 1754-1754.
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Chelala C, Hahn SA, Whiteman HJ, Barry S, Hariharan D, Radon TP, Lemoine NR, Crnogorac-Jurcevic T(2007). Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets. BMC GENOMICS vol. 8, Article 439,
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Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D(2007). Cytotoxic action of phorbol esters on human pancreatic cancer cells. INT J CANCER vol. 121, (7) 1445-1454.
10.1002/ijc.22869
Cheong SC, Lemoine N, Hallden G (2007). Inhibition of androgen receptor signaling pathways in prostate cancer cells by adenoviral vectors expressing Hey1. HUMAN GENE THERAPY. vol. 18, 1004-1004.
Whiteman HJ, Weeks ME, Dowen SE, Barry S, Timms JF, Lemoine NR, Crnogorac-Jurcevic T(2007). The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D. Cancer Res vol. 67, (18) 8633-8642.
10.1158/0008-5472.CAN-07-0545
Mahon PC, Baril P, Bhakta V, Chelala C, Caulee K, Harada T, Lemoine NR(2007). S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer. Cancer Res vol. 67, (14) 6786-6795.
10.1158/0008-5472.CAN-07-0440
Lopes RB, Gangeswaran R, McNeish IA, Wang YH, Lemoine NR(2007). Expression of the IAP protein family is dysregulated in pancreatic cancer cells and is important for resistance to chemotherapy. INT J CANCER vol. 120, (11) 2344-2352.
10.1002/ijc.22554
Radhakrishnan S, Hallden G, Chinegwundoh F, Lemoine N (2007). Synergistic enhancement of prostate cancer cell death by combination therapy of adenovirus and chemotherapy. BJU INTERNATIONAL. vol. 99, 28-28.
Sheikh AA, Vimalachandran D, Thompson CC, Jenkins RE, Nedjadi T, Shekouh A, Campbell F, Dodson A et al. (2007). The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells. PROTEOMICS. vol. 7, 1929-1940.
10.1002/pmic.200700072
Pandha H, Rigg A, John J, Lemoine N(2007). Loss of expression of antigen-presenting molecules in human pancreatic cancer and pancreatic cancer cell lines. CLIN EXP IMMUNOL vol. 148, (1) 127-135.
10.1111/j.1365-2249.2006.03289.x
Radhakrishnan S, Hallden GK, Chinegwundoh F, Lemoine N (2007). Synergistic enhancement of cell death by combination therapy with adenovirus and chemotherapy. JOURNAL OF UROLOGY. vol. 177, 182-183.
10.1016/S0022-5347(18)30788-2
Baril P, Gangeswaran R, Mahon PC, Caulee K, Kocher HM, Harada T, Zhu M, Kalthoff H et al.(2007). Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway. Oncogene vol. 26, (14) 2082-2094.
10.1038/sj.onc.1210009
Neesse A, Gangeswaran R, Luettges J, Feakins R, Weeks ME, Lemoine NR, Crnogorac-Jurcevic T(2007). Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells. Oncogene vol. 26, (11) 1533-1545.
10.1038/sj.onc.1209961
Harada T, Baril P, Gangeswaran R, Kelly G, Chelala C, Bhakta V, Caulee K, Mahon PC et al.(2007). Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation. Br J Cancer vol. 96, (2) 373-382.
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Thompson CC, Ashcroft FJ, Patel S, Saraga G, Vimalachandran D, Prime W, Campbell F, Dodson A et al.(2007). Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility. GUT vol. 56, (1) 95-106.
10.1136/gut.2005.083691
Neesse A, Gangeswaran R, Luettges J, Feakins R, Weeks ME, Lemoine NR, Crnogorac-Jurcevic T(2006). Sperm associated antigen 1 (spag1) is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells. PANCREAS vol. 33, (4) 485-486.
10.1097/00006676-200611000-00166
Vimalachandran D, Sheikh A, Tweedle E, Khattak I, Thompson CC, Jenkins RE, Nedjadi T, Shekouh A et al.(2006). The expression of S100A8 in tumour-associated monocytes is directly associated with the Smad4 status of pancreatic cancer cells. PANCREAS vol. 33, (4) 506-506.
10.1097/00006676-200611000-00233
Leyton J, Lockley M, Aerts JL, Baird SK, Aboagye EO, Lemoine NR, McNeish IA(2006). Quantifying the activity of adenoviral E1A CR2 deletion mutants using renilla luciferase bioluminescence and 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography imaging. Cancer Res vol. 66, (18) 9178-9185.
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Capurso G, Lattimore S, Crnogorac-Jurcevic T, Panzuto F, Milione M, Bhakta V, Campanini N, Swift SM et al.(2006). Gene expression profiles of progressive pancreatic endocrine tumours and their liver metastases reveal potential novel markers and therapeutic targets. ENDOCR-RELAT CANCER vol. 13, (2) 541-558.
10.1677/erc.1.01153
Khan SA, Taylor-Robinson SD, Carmichael PL, Habib N, Lemoine NR, Thomas HC(2006). Analysis of p53 mutations for a mutational signature in human intrahepatic cholangiocarcinoma. Int J Oncol vol. 28, (5) 1269-1277.
Martin-Duque P, Quintanilla M, McNeish I, Lopes R, Romero J, Romero D, Lemoine NR, Cajal SRY et al.(2006). Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo. INT J MOL MED vol. 17, (5) 841-847.
Bhattacharrya M, Lemoine NR(2006). Gene therapy developments for pancreatic cancer. BEST PRACT RES CL GA vol. 20, (2) 285-298.
10.1016/j.bpg.2005.10.004
Chernajovsky Y, Layward L, Lemoine N(2006). Controversy - Fighting cancer with oncolytic viruses. BRIT MED J vol. 332, (7534) 170-172.
10.1136/bmj.332.7534.170
Chernajovsky Y, Layward L, Lemoine N(2006). Fighting cancer with oncolytic viruses. BMJ vol. 332, (7534) 170-172.
10.1136/bmj.332.7534.170
Lockley M, Fernandez M, Wang Y, Li NF, Conroy S, Lemoine N, McNeish I(2006). Activity of the adenoviral E1A deletion mutant dl922-947 in ovarian cancer: comparison with E1A wild-type viruses, bioluminescence monitoring, and intraperitoneal delivery in icodextrin. Cancer Res vol. 66, (2) 989-998.
10.1158/0008-5472.CAN-05-2691
Vassaux G, Nitcheu J, Jezzard S, Lemoine NR(2006). Bacterial gene therapy strategies. J Pathol vol. 208, (2) 290-298.
10.1002/path.1865
Martin-Duque P, Quintanilla M, McNeish I, Lopes R, Romero J, Romero D, Lemoine NR, Cajal SRY et al. (2005). Radio- and chemo-sensitization by caspase-1 in vitro and in vivo. CLINICAL CANCER RESEARCH. vol. 11, 8996S-8996S.
Arencibia JM, Del Rio M, Bonnin A, Lopes R, Lemoine NR, López-Barahona M(2005). Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation. Int J Oncol vol. 27, (6) 1617-1623.
Crnogorac-Jurcevic T, Gangeswaran R, Bhakta V, Capurso G, Lattimore S, Akada M, Sunamura M, Prime W et al.(2005). Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma. Gastroenterology vol. 129, (5) 1454-1463.
10.1053/j.gastro.2005.08.012
Smith PG, Oakley F, Fernandez M, Mann DA, Lemoine NR, Whitehouse A(2005). Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging. Gene Ther vol. 12, (19) 1465-1476.
10.1038/sj.gt.3302543
Vimalachandran CD, Watson R, Thompson CC, Greenhalf W, Yan L, Prime W, Campbell F, Dodson A et al. (2005). High nuclear A100A6 (calcyclin) is significantly associated with poor survival in pancreatic cancer patients. BRITISH JOURNAL OF SURGERY. vol. 92, 1313-1314.
Liu T-C, Wang Y, Hallden G, Brooks G, Francis J, Lemoine NR, Kirn D(2005). Functional interactions of antiapoptotic proteins and tumor necrosis factor in the context of a replication-competent adenovirus. Gene Ther vol. 12, (17) 1333-1346.
10.1038/sj.gt.3302555
Lemoine NR(2005). Silencing RNA: a novel treatment for pancreatic cancer?. GUT vol. 54, (9) 1215-1216.
10.1136/gut.2005.067108
Lopes R, Castro I, Pontes P, Candeias J, Lemoine NR, Sambade C(2005). Expression profile of survivin in acute leukaemias: the importance of differential splicing. Leukemia vol. 19, (7) 1284-1286.
10.1038/sj.leu.2403765
Petralia GA, Lemoine NR, Kakkar AK(2005). Mechanisms of disease: the impact of antithrombotic therapy in cancer patients. Nat Clin Pract Oncol vol. 2, (7) 356-363.
10.1038/ncponc0225
Buluwela L, Pike J, Mazhar D, Kamalati T, Hart SM, Al-Jehani R, Yahaya H, Patel N et al.(2005). Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-alpha and the transcriptional repressor PLZF (vol 12, pg 452, 2005). GENE THER vol. 12, (10) 862-862.
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Vimalachandran D, Greenhalf W, Thompson C, Luttges J, Prime W, Campbell F, Dodson A, Watson R et al.(2005). High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients. CANCER RES vol. 65, (8) 3218-3225.
10.1158/0008-5472.CAN-04-4311
Akada M, Crnogorac-Jurcevic T, Lattimore S, Mahon P, Lopes R, Sunamura M, Matsuno S, Lemoine NR(2005). Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer. CLIN CANCER RES vol. 11, (8) 3094-3101.
10.1158/1078-0432.CCR-04-1785
Lemoine NR(2005). Antithrombotic therapy in cancer. J Clin Oncol vol. 23, (10) 2119-2120.
10.1200/JCO.2005.10.975
Capurso G, Lattimore S, Crnogorac-Jurcevic T, Panzuto F, Milione M, Bhakta V, Bordi C, Lemoine NR et al. (2005). Gene expression profiles of non-functioning primary and metastatic pancreatic endocrine tumours (pets) reveal potential new markers and targets for therapy. GASTROENTEROLOGY. vol. 128, A483-A483.
Buluwela L, Pike J, Mazhar D, Kamalati T, Hart SM, Al-Jehani R, Yahaya H, Patel N et al.(2005). Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-alpha and the transcriptional repressor PLZF (vol 12, pg 452, 2005). GENE THER vol. 12, (6) 552-552.
10.1038/sj.gt.3302506
Buluwela L, Pike J, Mazhar D, Kamalati T, Hart SM, Al-Jehani R, Yahaya H, Patel N et al.(2005). Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-alpha and the transcriptional repressor PLZF. Gene Ther vol. 12, (5) 452-460.
10.1038/sj.gt.3302421
Wang Y, Xue S-A, Hallden G, Francis J, Yuan M, Griffin BE, Lemoine NR(2005). Virus-associated RNA I-deleted adenovirus, a potential oncolytic agent targeting EBV-associated tumors. Cancer Res vol. 65, (4) 1523-1531.
10.1158/0008-5472.CAN-04-3113
Missiaglia E, Donadelli M, Palmieri M, Crnogorac-Jurcevic T, Scarpa A, Lemoine NR(2005). Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway. Oncogene vol. 24, (1) 199-211.
10.1038/sj.onc.1208018
Wang Y, Thorne S, Hannock J, Francis J, Au T, Reid T, Lemoine N, Kirn D et al.(2005). A novel assay to assess primary human cancer infectibility by replication-selective oncolytic adenoviruses. Clin Cancer Res vol. 11, (1) 351-360.
10.1158/1078-0432.ccr-04-2548
Stoll V, Calleja V, Vassaux G, Downward J, Lemoine NR(2005). Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer. Gut vol. 54, (1) 109-116.
10.1136/gut.2004.046706
Dowen SE, Crnogorac-Jurcevic T, Gangeswaran R, Hansen M, Eloranta JJ, Bhakta V, Brentnall TA, Luttges J et al.(2005). Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. AM J PATHOL vol. 166, (1) 81-92.
10.1016/S0002-9440(10)62234-1
Capurso G, Crnogorac-Jurcevic T, Milione M, Panzuto F, Campanini N, Dowen SE, Di Florio A, Sette C et al.(2005). Peanut-like 1 (septin 5) gene expression in normal and neoplastic human endocrine pancreas. Neuroendocrinology vol. 81, (5) 311-321.
10.1159/000088449
McNeish IA, Lopes R, Bell SJ, McKay TR, Fernandez M, Lockley M, Wheatley SP, Lemoine NR(2005). Survivin interacts with Smac/DIABLO in ovarian carcinoma cells but is redundant in Smac-mediated apoptosis. Exp Cell Res vol. 302, (1) 69-82.
10.1016/j.yexcr.2004.08.029
Savage P, Cowburn P, Clemens D, Hurley T, Laguda B, Martin-Duque P, Vassaux G, Lemoine NR(2004). Suicide gene therapy conversion of ethanol to acetaldehyde mediated by human beta 2 alcohol dehydrogenase. CANCER GENE THER vol. 11, (12) 774-781.
10.1038/sj.cgt.7700764
Petrovska L, Aspinall RJ, Barber L, Clare S, Simmons CP, Stratford R, Khan SA, Lemoine NR et al.(2004). Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene. CELL MICROBIOL vol. 6, (11) 1071-1084.
10.1111/j.1462-5822.2004.00419.x
Missiaglia E, Blaveri E, Terris B, Wang Y-H, Costello E, Neoptolemos JP, Crnogorac-Jurcevic T, Lemoine NR(2004). Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis. Int J Cancer vol. 112, (1) 100-112.
10.1002/ijc.20376
Pike J, Holmes D, Kamalati T, Davies D, Tolhurst R, Mazhar D, Fishpool S, al-Jehani R et al.(2004). Silencing of androgen-regulated genes using a fusion of AR with the PLZF transcriptional repressor. Oncogene vol. 23, (45) 7561-7570.
10.1038/sj.onc.1208030
Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD et al.(2004). Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells (vol 23, pg 7600, 2003). MOL CELL BIOL vol. 24, (15) 6887-6887.
10.1128/mcb.24.15.6887.2004
Critchley RJ, Jezzard S, Radford KJ, Goussard S, Lemoine NR, Grillot-Courvalin C, Vassaux G(2004). Potential therapeutic applications of recombinant, invasive E. coli. Gene Ther vol. 11, (15) 1224-1233.
10.1038/sj.gt.3302281
Groot-Wassink T, Aboagye EO, Wang Y, Lemoine NR, Keith WN, Vassaux G(2004). Noninvasive imaging of the transcriptional activities of human telomerase promoter fragments in mice. Cancer Res vol. 64, (14) 4906-4911.
10.1158/0008-5472.CAN-04-0426
Leslie J, McFaul C, Earl J, Azadeh B, Prime W, Bartsch D, Harada T, Lemoine N et al. (2004). Identification of a familial pancreatic cancer gene by focusing haplotype analysis using LOH in sporadic cancer. BRITISH JOURNAL OF CANCER. vol. 91, S31-S31.
Wang Y, Faux SP, Hallden G, Kirn DH, Houghton CE, Lemoine NR, Patrick G(2004). Interleukin-1beta and tumour necrosis factor-alpha promote the transformation of human immortalised mesothelial cells by erionite. Int J Oncol vol. 25, (1) 173-178.
Vimalachandran D, Watson R, Shekouh A, Thompson C, Campbell F, Prime W, Crngorac-Jurcevic T, Lemoine N et al. (2004). The calcium binding protein s100A6 (calcyclin) as a prognostic indicator in pancreatic cancer. BRITISH JOURNAL OF CANCER. vol. 91, S32-S32.
Liu T-C, Hallden G, Wang Y, Brooks G, Francis J, Lemoine N, Kirn D(2004). An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factor-enhanced cancer selectivity and enhanced oncolytic potency. Mol Ther vol. 9, (6) 786-803.
10.1016/j.ymthe.2004.03.017
Burn J, Lemoine N, O'Toole L(2004). Assessing cancer risk. Expert Rev Anticancer Ther vol. 4 Suppl 1, S13-S17.
10.1586/14737140.4.5.s13
Kakkar AK, Levine MN, Kadziola Z, Lemoine NR, Low V, Patel HK, Rustin G, Thomas M et al.(2004). Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS). J Clin Oncol vol. 22, (10) 1944-1948.
10.1200/JCO.2004.10.002
Madhusudan S, Tamir A, Bates N, Flanagan E, Gore ME, Barton DPJ, Harper P, Seckl M et al.(2004). A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/neu oncogene. Clin Cancer Res vol. 10, (9) 2986-2996.
10.1158/1078-0432.ccr-03-0291
Yaohe, Pen H, Jennelle, Gunnel, Shao-an, Grriffin BE, Lemoine NR (2004). Anti-CD22 immunolipoplexes enhance transduction of adenovirus in B lymphoma cells independent on adenovirus' receptor but do not enhance the cytotoxicity of oncolytic adenovirus. MOLECULAR THERAPY. vol. 9, S171-S172.
Liu TC, Wang YH, Hallden G, Francis J, Brooks G, Lemoine N, Kirn D (2004). Oncolytic adenovirus E1B-19kD deletion and E3B retention results in both enhanced potency and tumor necrosis factor-mediated selectivity. MOLECULAR THERAPY. vol. 9, S109-S109.
Hill RJ, Hallden GK, Wang YH, Francis J, Simpson C, Kirn DH, Lemoine NR (2004). The gene expression and function of adenoviral E3-genes in murine tumour cell lines. MOLECULAR THERAPY. vol. 9, S374-S375.
Wang YH, Xue SA, Hallden G, Francis J, Griffin BE, Lemoine NR (2004). VAI deleted adenovirus as an oncolytic agent targeting human EBV-associated tumours. MOLECULAR THERAPY. vol. 9, S230-S230.
Lemoine NR, McNeish IA(2004). Gene transfer: Bax to the future for cancer therapy. Gut vol. 53, (4) 478-479.
10.1136/gut.2003.030312
Marani M, Hancock D, Lopes R, Tenev T, Downward J, Lemoine NR(2004). Role of Bim in the survival pathway induced by Raf in epithelial cells. Oncogene vol. 23, (14) 2431-2441.
10.1038/sj.onc.1207364
McNeish IA, Bell SJ, Lemoine NR(2004). Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes. Gene Ther vol. 11, (6) 497-503.
10.1038/sj.gt.3302238
Groot-Wassink T, Aboagye EO, Wang Y, Lemoine NR, Reader AJ, Vassaux G(2004). Quantitative imaging of Na/I symporter transgene expression using positron emission tomography in the living animal. Mol Ther vol. 9, (3) 436-442.
10.1016/j.ymthe.2003.12.001
Capurso G, Delle Fave G, Lemoine N(2004). Re: Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. J Natl Cancer Inst vol. 96, (1)
10.1093/jnci/djh018
Brown NL, Lemoine NR(2004). Clinical trials with GDEPT: cytosine deaminase and 5-fluorocytosine. Methods Mol Med vol. 90, 451-457.
10.1385/1-59259-429-8:451
Nasir FA, Patel HK, Scully MF, Fareed J, Lemoine NR, Kakkar AK (2003). The low molecular weight heparins dalteparin sodium inhibits angiogenesis and induces apoptosis in an experimental tumour model. BLOOD. vol. 102, 808A-808A.
Wang Y, Hallden G, Hill R, Anand A, Liu T-C, Francis J, Brooks G, Lemoine N et al.(2003). E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models. Nat Biotechnol vol. 21, (11) 1328-1335.
10.1038/nbt887
Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD et al.(2003). Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells. Mol Cell Biol vol. 23, (21) 7600-7610.
10.1128/mcb.23.21.7600-7610.2003
Shekouh AR, Thompson CC, Prime W, Campbell F, Hamlett J, Herrington CS, Lemoine NR, Crnogorac-Jurcevic T et al.(2003). Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma. Proteomics vol. 3, (10) 1988-2001.
10.1002/pmic.200300466
Wang Y, Groot-Wassink T, Lemoine NR, Vassaux G(2003). Cellular characterization of the tropism of recombinant adenovirus for the adrenal glands. Eur J Clin Invest vol. 33, (9) 794-798.
10.1046/j.1365-2362.2003.01216.x
Crnogorac-Jurcevic T, Missiaglia E, Blaveri E, Gangeswaran R, Jones M, Terris B, Costello E, Neoptolemos JP et al.(2003). Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent. J Pathol vol. 201, (1) 63-74.
10.1002/path.1418
Halldén G, Hill R, Wang Y, Anand A, Liu T-C, Lemoine NR, Francis J, Hawkins L et al.(2003). Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy. Mol Ther vol. 8, (3) 412-424.
10.1016/s1525-0016(03)00199-0
Lemoine NR, Kirby RB(2003). UK cash for gene therapy: government pledges support. Gene Ther vol. 10, (17) 1405-1406.
10.1038/sj.gt.3302119
Radford KJ, Jackson AM, Wang J-H, Vassaux G, Lemoine NR(2003). Recombinant E. coli efficiently delivers antigen and maturation signals to human dendritic cells: presentation of MART1 to CD8+ T cells. Int J Cancer vol. 105, (6) 811-819.
10.1002/ijc.11149
Zhu G, Reynolds L, Crnogorac-Jurcevic T, Gillett CE, Dublin EA, Marshall JF, Barnes D, D'Arrigo C et al.(2003). Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer. Oncogene vol. 22, (24) 3742-3748.
10.1038/sj.onc.1206428
McNeish IA, Bell S, McKay T, Tenev T, Marani M, Lemoine NR(2003). Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway. Exp Cell Res vol. 286, (2) 186-198.
10.1016/s0014-4827(03)00073-9
McKay TR, Bell S, Tenev T, Stoll V, Lopes R, Lemoine NR, McNeish IA(2003). Procaspase 3 expression in ovarian carcinoma cells increases survivin transcription which can be countered with a dominant-negative mutant, survivin T34A; a combination gene therapy strategy. Oncogene vol. 22, (23) 3539-3547.
10.1038/sj.onc.1206417
Groot-Wassink T, Barthel H, Lemoine NR, Vassaux G(2003). Sodium iodide symporter: a new strategy to target cancer?. Lancet vol. 361, (9372) 1905-1906.
10.1016/S0140-6736(03)13510-6
Liu TC, Wang YH, Hallden G, Anand A, Lemoine NR, Kirn DH (2003). Adenoviral E1B-19kD deletion results in enhanced oncolytic effect and reduced toxicity in an immunocompetent murine tumor. MOLECULAR THERAPY. vol. 7, S416-S416.
Wang YH, Francis J, Griffin BE, Lemoine NLR, Xue SA (2003). Cytotoxicity of replication-competent adenovirus to lymphoproliferative disorders correlates with expression of heparan sulfate. MOLECULAR THERAPY. vol. 7, S359-S359.
Hill RJ, Hallden GK, Lemoine NR, Kirn DH (2003). In vitro screening of murine carcinoma cell lines for testing of replication-competent oncolytic adenoviruses. MOLECULAR THERAPY. vol. 7, S362-S362.
Aspinali RJ, Clare S, Goulding D, Goldin RD, Lemoine NR, Dougan G (2003). Microbiology and cellular pathology of infection with sifA-mutant Salmonella typhimurium. GASTROENTEROLOGY. vol. 124, A484-A484.
10.1016/S0016-5085(03)82448-4
Crnogorac-Jurcevic T, Lemoine NR (2003). Molecular profiles of pancreatic adenocarcinoma. GUT. vol. 52, A36-A36.
Khan SA, Taylor-Robinson SD, Carmichael PL, Habib N, Lemoine N, Thomas HC (2003). Novel p53 mutations but lack of a mutational fingerprint in human intrahepatic cholangiocarcinoma. GUT. vol. 52, A32-A32.
Liu TC, Hallden G, Anand A, Wang YH, Lemoine N, Kirn D (2003). Adenovirus E1B-19kD gene deletion enhances oncolytic virus efficacy and selectivity. CANCER GENE THERAPY. vol. 10, S20-S20.
Lemoine NR(2002). Risks and benefits of gene therapy for immunodeficiency: a reality check. GENE THER vol. 9, (23) 1561-1562.
10.1038/sj.gt.3301924
Kakkar AK, Kadziola Z, Williamson RCN, Levine MN, Low V, Lemoine NR, Fragmin Adv Malignancy Outcome (2002). Low molecular weight heparin (LMWH) therapy and survival in advanced cancer. BLOOD. vol. 100, 148A-148A.
Radford KJ, Higgins DE, Pasquini S, Cheadle EJ, Carta L, Jackson AM, Lemoine NR, Vassaux G(2002). A recombinant E. coli vaccine to promote MHC class I-dependent antigen presentation: application to cancer immunotherapy. GENE THER vol. 9, (21) 1455-1463.
10.1038/sj.gt.3301812
Campbell NJH, Lemoine NR, Glorioso JC(2002). Information overload? Take the 'Progress and Prospects' cure. Gene Ther vol. 9, (20)
10.1038/sj.gt.3301873
Groot-Wassink T, Aboagye EO, Glaser M, Lemoine NR, Vassaux G(2002). Adenovirus biodistribution and noninvasive imaging of gene expression in vivo by positron emission tomography using human sodium/iodide symporter as reporter gene. Hum Gene Ther vol. 13, (14) 1723-1735.
10.1089/104303402760293565
Crnogorac-Jurcevic T, Efthimiou E, Nielsen T, Loader J, Terris B, Stamp G, Baron A, Scarpa A et al.(2002). Expression profiling of microdissected pancreatic adenocarcinomas. Oncogene vol. 21, (29) 4587-4594.
10.1038/sj.onc.1205570
Harrington K, Alvarez-Vallina L, Crittenden M, Gough M, Chong H, Diaz RM, Vassaux G, Lemoine N et al.(2002). Cells as vehicles for cancer gene therapy: The missing link between targeted vectors and systemic delivery?. HUM GENE THER vol. 13, (11) 1263-1280.
10.1089/104303402760128504
McNeish IA, Bell S, McKay T, Tenev T, Stoll V, Lemoine NR(2002). Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis predominantly via a caspase-9-mediated pathway and enhances sensitivity to cisplatin and paclitaxel. BRIT J CANCER vol. 86, S20-S21.
Marani M, Tenev T, Hancock D, Downward J, Lemoine NR(2002). Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Mol Cell Biol vol. 22, (11) 3577-3589.
10.1128/mcb.22.11.3577-3589.2002
Tagawa T, Manvell M, Brown N, Keller M, Perouzel E, Murray KD, Harbottle RP, Tecle M et al.(2002). Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu (mu) and plasmid DNA. GENE THER vol. 9, (9) 564-576.
10.1038/sj.gt.3301686
Terris B, Blaveri E, Crnogorac-Jurcevic T, Jones M, Missiaglia E, Ruszniewski P, Sauvanet A, Lemoine NR(2002). Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas. AM J PATHOL vol. 160, (5) 1745-1754.
10.1016/S0002-9440(10)61121-2
Lemoine NR(2002). The power to deliver: stem cells in gene therapy. Gene Ther vol. 9, (10) 603-605.
10.1038/sj.gt.3301769
Savage P, Cowburn P, Clayton A, Man S, McMichael A, Lemoine N, Epenetos A, Ogg G(2002). Induction of viral and tumour specific CTL responses using antibody targeted HLA class I peptide complexes. Br J Cancer vol. 86, (8) 1336-1342.
10.1038/sj.bjc.6600223
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7223
Savage P, Cowburn P, Clayton A, Man S, Lawson T, Ogg G, Lemoine N, McMichael A et al.(2002). Anti-viral cytotoxic T cells inhibit the growth of cancer cells with antibody targeted HLA class I/peptide complexes in SCID mice. Int J Cancer vol. 98, (4) 561-566.
10.1002/ijc.10219
Pasquini S, Peralta S, Missiaglia E, Carta L, Lemoine NR(2002). Prime-boost vaccines encoding an intracellular idiotype/GM-CSF fusion protein induce protective cell-mediated immunity in murine pre-B cell leukemia. Gene Ther vol. 9, (8) 503-510.
10.1038/sj.gt.3301677
Aspinall RJ, Simmons CP, Petrovska L, Clare S, Khan S, Stratford R, Shea J, Holden DW et al.(2002). Selective delivery of antigen to the class I MHC pathway by SifA-mutant Salmonella typhimurium - An assessment of vaccine vector potential. GASTROENTEROLOGY vol. 122, (4) A535-A535.
Missiaglia E, Moore PS, Williamson J, Lemoine NR, Falconi M, Zamboni G, Scarpa A(2002). Sex chromosome anomalies in pancreatic endocrine tumors. Int J Cancer vol. 98, (4) 532-538.
10.1002/ijc.10223
Lemoine N(2002). 10th International Conference on Gene Therapy of Cancer. 13-15 December, 2001, Sidney Kimmel Cancer Center, San Diego, CA, USA. Expert Rev Anticancer Ther vol. 2, (1) 9-11.
10.1586/14737140.2.1.9
Scarpa A, Orlandini S, Moore PS, Lemoine NR, Beghelli S, Baron A, Falconi M, Zamboni G(2002). Dpc4 is expressed in virtually all primary and metastatic pancreatic endocrine carcinomas. VIRCHOWS ARCH vol. 440, (2) 155-159.
10.1007/s00428-001-0569-6
Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW et al.(2002). The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J Biol Chem vol. 277, (1) 439-444.
10.1074/jbc.M109784200
Terris B, Blaveri E, Crnogorac-Jurcevic T, Jones M, Missiaglia E, Lemoine N(2002). Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas. LAB INVEST vol. 82, (1) 294A-295A.
Sirivatanauksorn Y, Sirivatanauksorn V, Lemoine NR(2002). DNA fingerprinting from cells captured by laser microdissection. Methods Enzymol vol. 356, 289-294.
10.1016/s0076-6879(02)56942-1
Glorioso J, Lemoine N(2002). Electronic submission, review and tracking system for gene therapy. GENE THER vol. 9, (1) 1-1.
10.1038/sj.gt.3301649
Hawkins LK, Lemoine NR, Kirn D(2002). Oncolytic biotherapy: a novel therapeutic platform. LANCET ONCOL vol. 3, (1) 17-26.
10.1016/s1470-2045(01)00618-0
Crnogorac-Jurcevic T, Nielsen TO, Lemoine NR(2002). RT-PCR from laser-capture microdissected samples. Methods Mol Biol vol. 193, 197-204.
10.1385/1-59259-283-X:197
Sirivatanauksorn V, Sirivatanauksorn Y, McKie AB, Lemoine NR(2002). Use of DNA fingerprinting to detect genetic rearrangements in human cancer. Methods Mol Med vol. 68, 107-114.
10.1385/1-59259-135-3:107
El-Hariry I, Pignatelli M, Lemoine NR(2001). FGF-1 and FGF-2 regulate the expression of E-cadherin and catenins in pancreatic adenocarcinoma. Int J Cancer vol. 94, (5) 652-661.
10.1002/ijc.1515
Moore PS, Sipos B, Orlandini S, Sorio C, Real FX, Lemoine NR, Gress T, Bassi C et al.(2001). Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch vol. 439, (6) 798-802.
10.1007/s004280100474
Lemoine NR, Tenev T, McNeish L, Stoll V, Marani M, Vassaux G(2001). Targeting suicide genes for cancer gene therapy. CANCER GENE THER vol. 8, S17-S17.
Rigg AS, Lemoine NR(2001). Adenoviral delivery of TIMP1 or TIMP2 can modify the invasive behavior of pancreatic cancer and can have a significant antitumor effect in vivo. CANCER GENE THER vol. 8, (11) 869-878.
10.1038/sj.cgt.7700387
Crnogorac-Jurcevic T, Efthimiou E, Capelli P, Blaveri E, Baron A, Terris B, Jones M, Tyson K et al.(2001). Gene expression profiles of pancreatic cancer and stromal desmoplasia. Oncogene vol. 20, (50) 7437-7446.
10.1038/sj.onc.1204935
Lemoine N(2001). Genome medicine: gene therapy for the new millennium. IDrugs vol. 4, (11) 1247-1249.
Lemoine N(2001). Tumor-selective transcriptional targeting for cancer gene therapy. CANCER GENE THER vol. 8, (9) 691-691.
Lemoine N(2001). American Society of Gene Therapy - Fourth Annual Meeting. Emerging technologies. 30 May-3 June 2001, Seattle, WA, USA. IDrugs vol. 4, (8) 901-903.
Madhusudan S, Bates N, Flanagan E, Charnock FMC, Gore M, Barton DPJ, Harper, Karapetis C et al.(2001). A multicentre phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with epithelial overian cancer overexpressing HER-2/neu. BRIT J CANCER vol. 85, 26-26.
Sirivatanauksorn Y, Sirivatanauksorn V, Lemoine NR, Williamson RC, Davidson BR(2001). Genomic homogeneity in fibrolamellar carcinomas. Gut vol. 49, (1) 82-86.
10.1136/gut.49.1.82
El-Hariry I, Pignatelli M, Lemoine NR(2001). FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines. BRIT J CANCER vol. 84, (12) 1656-1663.
10.1054/bjoc.2001.1813
McNeish IA, Tenev T, Bell S, Marani M, Vassaux G, Lemoine N(2001). Herpes simplex virus thymidine kinase/ganciclovir-induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells. CANCER GENE THER vol. 8, (4) 308-319.
10.1038/sj.cgt.7700305
Ariaens A, Taniguchi T, Crnogorac-Jurcevic T, Lemoine NR(2001). Investigation of expression profiles associated with factor VIIa activation of TF signalling and TIMP1 upregulation in human pancreatic adenocarcinoma cells. J PATHOL vol. 193, 27A-27A.
Tenev T, Marani M, McNeish I, Lemoine NR(2001). Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors. CELL DEATH DIFFER vol. 8, (3) 256-264.
10.1038/sj.cdd.4400808
Ghaneh P, Greenhalf W, Humphreys M, Wilson D, Zumstein L, Lemoine NR, Neoptolemos JP(2001). Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo. Gene Ther vol. 8, (3) 199-208.
10.1038/sj.gt.3301394
Efthimiou E, Crnogorac-Jurcevic T, Lemoine NR(2001). Inherited predisposition to pancreatic cancer. GUT vol. 48, (2) 143-147.
10.1136/gut.48.2.143
Sirivatanauksorn V, Sirivatanauksorn Y, Gorman PA, Davidson JM, Sheer D, Moore PS, Scarpa A, Edwards PAW et al.(2001). Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping. INT J CANCER vol. 91, (3) 350-358.
10.1002/1097-0215(200002)9999:9999<::aid-ijc1049>3.3.co;2-3
Moore PS, Orlandini S, Zamboni G, Capelli P, Rigaud G, Falconi M, Bassi C, Lemoine NR et al.(2001). Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. BRIT J CANCER vol. 84, (2) 253-262.
10.1054/bjoc.2000.1567
Efthimiou E, Crnogorac-Jurcevic T, Lemoine NR(2001). Pancreatic cancer genetics. Pancreatology vol. 1, (6) 571-575.
10.1159/000055865
Zhao J, Tenev T, Martins LM, Downward J, Lemoine NR(2000). The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner. J CELL SCI vol. 113, (23) 4363-4371.
Taniguchi T, Lemoine NR (2000). Application of suppression subtractive hybridisation for identification of genes regulated by the TF-FVIIa pathway in pancreatic cancer. MOLECULAR PATHOGENESIS OF PANCREATIC CANCER. Editors: Gress, TM, vol. 41, 57-59.
Vassaux G, Lemoine NR(2000). Gene therapy for carcinoma of the breast - Genetic toxins. BREAST CANCER RES vol. 2, (1) 22-27.
10.1186/bcr25
Lemoine NR, Sirivatanauksorn V, Crnogorac-Jurcevic T (2000). Molecular profile of pancreatic cancer. MOLECULAR PATHOGENESIS OF PANCREATIC CANCER. Editors: Gress, TM, vol. 41, 4-16.
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