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Publications:  Prof Richard Leslie

Mishra R, Åkerlund M, Cousminer DL, Ahlqvist E, Bradfield JP, Chesi A, Hodge KM, Guy VC et al.(2020). Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC. Diabetes Care vol. 43, (2) 418-425.
10.2337/dc19-0986
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62219
Leslie R, Vartak T(2019). Allostasis and the origins of adult-onset diabetes. Diabetologia vol. 63, (2) 261-265.
10.1007/s00125-019-05048-9
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62519
Leslie RD, Vartak T(2019). C-peptide persistence in type 1 diabetes: 'Not drowning, but waving'?. BMC Medicine vol. 17, (1)
10.1186/s12916-019-1415-5
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62741
Cardona A, Day FR, Perry JRB, Loh M, Chu AY, Lehne B, Paul DS, Lotta LA et al.(2019). Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study. Diabetes
10.2337/db18-0290
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61088
Leslie RD, Jerram ST(2019). Looking back and looking forward: A brief history of research into type 1 diabetes. Diabetes - Metabolism: Research and Reviews vol. 35, (6)
10.1002/dmrr.3196
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63061
Xiang Y, Huang G, Zhu Y, Zuo X, Liu X, Feng Q, Li X, Yang T et al.(2019). Identification of autoimmune type 1 diabetes and multiple organ-specific autoantibodies in adult-onset non-insulin-requiring diabetes in China: A population-based multicentre nationwide survey. Diabetes, Obesity and Metabolism vol. 21, (4) 893-902.
10.1111/dom.13595
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58765
Leslie RD, Grant SFA(2018). The Dynamic Origins of Type 1 Diabetes. Diabetes Care vol. 41, (12) 2441-2443.
10.2337/dci18-0034
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58958
Cousminer DL, Ahlqvist E, Mishra R, Andersen MK, Chesi A, Hawa MI, Davis A, Hodge KM et al. (2018). First genome-wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes. Diabetes Care. vol. 41, 2396-2403.
10.2337/dc18-1032
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58959
Niu X, Luo S, Li X, Xie Z, Xiang Y, Huang G, Lin J, Yang L et al.(2018). Identification of a distinct phenotype of elderly latent autoimmune diabetes in adults: LADA China Study 8. Diabetes - Metabolism: Research and Reviews vol. 35, (1) e3068-e3068.
10.1002/dmrr.3068
https://qmro.qmul.ac.uk/xmlui/handle/123456789/60010
Mishra R, Hodge KM, Cousminer DL, Leslie RD, Grant SFA(2018). A Global Perspective of Latent Autoimmune Diabetes in Adults. Trends in Endocrinology and Metabolism vol. 29, (9) 638-650.
10.1016/j.tem.2018.07.001
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62721
Achenbach P, Hawa MI, Krause S, Lampasona V, Jerram ST, Williams AJK, Bonifacio E, Ziegler AG et al.(2018). Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes: Action LADA 12. Diabetologia vol. 61, (7) 1644-1649.
10.1007/s00125-018-4605-3
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58677
Ibrahim M, Tuomilehto J, Aschner P, Beseler L, Cahn A, Eckel RH, Fischl AH, Guthrie G et al.(2018). Global status of diabetes prevention and prospects for action: A consensus statement. Diabetes - Metabolism: Research and Reviews vol. 34, (6)
10.1002/dmrr.3021
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62769
Pozzilli P, Leslie RD, Peters AL, Buzzetti R, Shankar SS, Milicevic Z, Pavo I, Lebrec J et al.(2018). Dulaglutide treatment results in effective glycaemic control in latent autoimmune diabetes in adults (LADA): A post-hoc analysis of the AWARD-2, -4 and -5 Trials. Diabetes, Obesity and Metabolism vol. 20, (6) 1490-1498.
10.1111/dom.13237
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62740
Napoli N, Strollo R, Defeudis G, Leto G, Moretti C, Zampetti S, D'Onofrio L, Campagna G et al.(2018). Serum Sclerostin and Bone Turnover in Latent Autoimmune Diabetes in Adults. Journal of Clinical Endocrinology and Metabolism vol. 103, (5) 1921-1928.
10.1210/jc.2017-02274
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62238
Leslie RD, Lernmark Å(2018). Genetic risk scores in adult-onset type 1 diabetes. The Lancet Diabetes and Endocrinology vol. 6, (3) 168-169.
10.1016/S2213-8587(18)30039-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58764
Leslie RD, Grant SFA(2018). Teasing Diabetes Apart, One Locus at a Time. Diabetes Care vol. 41, (2) 224-226.
10.2337/dci17-0046
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62244
Jerram ST, Dang MN, Leslie RD(2017). The Role of Epigenetics in Type 1 Diabetes. Current Diabetes Reports vol. 17, (10)
10.1007/s11892-017-0916-x
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61359
Toniolo A, Leslie RD(2017). Diabetes, the TYK2 Gene and the Interferon Response: In Search for Environmental Causes. EBioMedicine vol. 24, 18-19.
10.1016/j.ebiom.2017.09.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34316
Jerram ST, Leslie RD(2017). The Genetic Architecture of Type 1 Diabetes. Genes (Basel) vol. 8, (8)
10.3390/genes8080209
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34408
Hernández M, López C, Real J, Valls J, Ortega-Martinez de Victoria E, Vázquez F, Rubinat E, Granado-Casas M et al.(2017). Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes. Cardiovascular Diabetology vol. 16, (1)
10.1186/s12933-017-0576-9
Mishra R, Chesi A, Cousminer DL, Hawa MI, Bradfield JP, Hodge KM, Guy VC, Hakonarson H et al.(2017). Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes. BMC Med vol. 15, (1) 88-88.
10.1186/s12916-017-0846-0
https://qmro.qmul.ac.uk/xmlui/handle/123456789/33988
Leslie RD, Jerram ST(2017). Stratifying diabetes: Desperately seeking specificity. Diabetes vol. 66, (4) 801-803.
10.2337/dbi16-0074
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62240
Paul DS, Teschendorff AE, Dang MAN, Lowe R, Hawa MI, Ecker S, Beyan H, Cunningham S et al.(2016). Increased DNA methylation variability in type 1 diabetes across three immune effector cell types. Nat Commun vol. 7, 13555-13555.
10.1038/ncomms13555
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22321
Stunnenberg HG, Abrignani S, Adams D, de Almeida M, Altucci L, Amin V, Amit I, Antonarakis SE et al.(2016). The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. Cell vol. 167, (5) 1145-1149.
10.1016/j.cell.2016.11.007
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64204
Schloot NC, Pham MN, Hawa MI, Pozzilli P, Scherbaum W, Schott M, Kolb H, Hunter S et al.(2016). Inverse relationship between organ-specific autoantibodies and systemic immune mediators in type 1 diabetes and type 2 diabetes: Action LADA 11. Diabetes Care vol. 39, (11) 1932-1939.
10.2337/dc16-0293
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22373
Yang Z, Wong A, Kuh D, Paul DS, Rakyan VK, Leslie RD, Zheng SC, Widschwendter M et al.(2016). Correlation of an epigenetic mitotic clock with cancer risk. Genome Biology vol. 17, (1)
10.1186/s13059-016-1064-3
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22365
Leslie RD, Jerram S(2016). Variation and the spice of life. Am J Clin Nutr vol. 104, (4) 955-956.
10.3945/ajcn.116.143313
https://qmro.qmul.ac.uk/xmlui/handle/123456789/60080
Østergaard JA, Laugesen E, Leslie RD(2016). Should There be Concern About Autoimmune Diabetes in Adults? Current Evidence and Controversies. Curr Diab Rep vol. 16, (9) 82-82.
10.1007/s11892-016-0780-0
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59939
Leslie RD, Palmer J, Schloot NC, Lernmark A(2016). Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment. Diabetologia vol. 59, (1) 13-20.
10.1007/s00125-015-3789-z
Dang MN, Bradford CM, Pozzilli P, Leslie RD(2016). Methylation analysis in distinct immune cell subsets in type 1 diabetes. Methods in Molecular Biology vol. 1433, 143-151.
10.1007/7651_2015_286
Hernandez M, Mollo A, Marsal JR, Esquerda A, Capel I, Puig-Domingo M, Pozzilli P, de Leiva A et al.(2015). Insulin secretion in patients with latent autoimmune diabetes (LADA): Half way between type 1 and type 2 diabetes: Action LADA 9. BMC Endocrine Disorders vol. 15, (1)
10.1186/1472-6823-15-1
Xiang Y, Huang G, Shan Z, Pan L, Luo S, Yang L, Shi L, Li Q et al.(2015). Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5. Acta Diabetologica vol. 52, (6) 1121-1127.
10.1007/s00592-015-0799-8
Wang B, Hawa MI, Rijsdijk FV, Fain PR, Paschou SA, Boehm BO, Steck AK, Snieder H et al.(2015). Heritability of thyroid peroxidase autoantibody levels in type 1 diabetes: evidence from discordant twin pairs. Diabetologia vol. 58, (9) 2079-2086.
10.1007/s00125-015-3664-y
O'Hare JP, Millar-Jones D, Hanif W, Hicks D, Leslie RD, Bain SC, Barnett AH(2015). The revised NICE draft guideline for type 2 diabetes: Still a long way to go. The Lancet Diabetes and Endocrinology vol. 3, (9) 679-680.
10.1016/S2213-8587(15)00288-0
Li X, Liu L, Xiang Y, Huang G, Leslie RD, Zhou Z(2015). Latent autoimmune diabetes in adults with low-titer GAD antibodies: similar disease progression with type 2 diabetes: A Nationwide, multicenter prospective study (LADA China Study 3). Diabetes care 2015;38:16-21. Diabetes Care vol. 38, (3)
10.2337/dc14-2861
Lauria A, Barker A, Schloot N, Hosszufalusi N, Ludvigsson J, Mathieu C, Mauricio D, Nordwall M et al.(2015). BMI is an important driver of β-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children. Eur J Endocrinol vol. 172, (2) 107-113.
10.1530/EJE-14-0522
Migdalis I, Leslie D, Mavrogiannaki A, Papanas N, Valensi P, Vlassara H(2015). Diabetes Mellitus 2014. Int J Endocrinol vol. 2015,
10.1155/2015/845759
Liu L, Li X, Xiang Y, Huang G, Lin J, Yang L, Zhao Y, Yang Z et al.(2015). Latent autoimmune diabetes in adults with low-titer gad antibodies: Similar disease progression with type 2 diabetes :A nationwide, multicenter prospective study (lada china study 3). Diabetes Care vol. 38, (1) 16-21.
10.2337/dc14-1770
Laugesen E, Østergaard JA, Leslie RDG(2015). Latent autoimmune diabetes of the adult: Current knowledge and uncertainty. Diabetic Medicine vol. 32, (7) 843-852.
10.1111/dme.12700
O'Hare JP, Hanif W, Millar-Jones D, Bain S, Hicks D, Leslie RD, Barnett AH(2015). NICE guidelines for Type 2 diabetes: Revised but still not fit for purpose. Diabetic Medicine vol. 32, (11) 1398-1403.
10.1111/dme.12952
Juhl CB, Bradley U, Holst JJ, Leslie RD, Yderstraede KB, Hunter S, Consortium ALADA(2014). Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and Type 2 diabetes: Action LADA 8. DIABETIC MEDICINE vol. 31, (8) 941-945.
10.1111/dme.12434
Hawa MI, Buchan AP, Ola T, Wun CC, DeMicco DA, Bao W, Betteridge DJ, Durrington PN et al.(2014). LADA and CARDS: a prospective study of clinical outcome in established adult-onset autoimmune diabetes. Diabetes Care vol. 37, (6) 1643-1649.
10.2337/dc13-2383
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7009
Zhao Y, Yang L, Xiang Y, Liu L, Huang G, Long Z, Li X, Leslie RD et al.(2014). Dipeptidyl peptidase 4 inhibitor sitagliptin maintains β-cell function in patients with recent-onset latent autoimmune diabetes in adults: one year prospective study. J Clin Endocrinol Metab vol. 99, (5) E876-E880.
10.1210/jc.2013-3633
Barker A, Lauria A, Schloot N, Hosszufalusi N, Ludvigsson J, Mathieu C, Mauricio D, Nordwall M et al.(2014). Age-dependent decline of β-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study. Diabetes Obes Metab vol. 16, (3) 262-267.
10.1111/dom.12216
Hayes DF, Markus HS, Leslie RD, Topol EJ(2014). Personalized medicine: risk prediction, targeted therapies and mobile health technology. BMC MEDICINE vol. 12, Article ARTN 37,
10.1186/1741-7015-12-37
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22441
Hawa MI, Kolb H, Schloot N, Beyan H, Paschou SA, Buzzetti R, Mauricio D, De Leiva A et al.(2014). Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: Action LADA 7 (Diabetes Care (2013) 36, (908-913)). Diabetes Care vol. 37, (5)
10.2337/dc14-er05
Leslie RDG, Bradford C(2014). Autoimmune diabetes: Caught in a NET. Diabetes vol. 63, (12) 4018-4020.
10.2337/db14-1382
Migdalis I, Leslie D, Papanas N, Valensi P, Vlassara H(2014). Diabetes mellitus. Int J Endocrinol vol. 2014,
10.1155/2014/108419
Bradford CM, Hawa M, Sumaria N, Dang MN, Beyan H, Davies G, Jensen H, Tsang V et al. (2013). Understanding auto-antigen expression and regulation in human medullary thymic epithelial cells (mTECs). IMMUNOLOGY. vol. 140, 187-187.
Hitman GA, Leslie RD, Holt RIG(2013). GLP-1-based diabetes therapies; trial by media. Diabetic Medicine vol. 30, (10) 1147-1147.
10.1111/dme.12299
Paschou SA, Leslie RD(2013). Personalizing guidelines for diabetes management: twilight or dawn of the expert?. BMC Med vol. 11,
10.1186/1741-7015-11-161
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23121
Xiang Y, Zhou Z, Deng C, Leslie RD(2013). Latent autoimmune diabetes in adults in Asians: Similarities and differences between East and West. Journal of Diabetes vol. 5, (2) 118-126.
10.1111/1753-0407.12029
Gemma C, Ramagopalan SV, Down TA, Beyan H, Hawa MI, Holland ML, Hurd PJ, Giovannoni G et al.(2013). Inactive or moderately active human promoters are enriched for inter-individual epialleles. Genome Biol vol. 14, (5)
10.1186/gb-2013-14-5-r43
https://qmro.qmul.ac.uk/xmlui/handle/123456789/4899
Lowe R, Gemma C, Beyan H, Hawa MI, Bazeos A, Leslie RD, Montpetit A, Rakyan VK et al.(2013). Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies. Epigenetics : official journal of the DNA Methylation Society vol. 8, (4) 445-454.
10.4161/epi.24362
Lowe R, Gemma C, Beyan H, Hawa MI, Bazeos A, Leslie RD, Montpetit A, Rakyan VK et al.(2013). Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies. Epigenetics vol. 8, (4) 445-454.
10.4161/epi.24362
Chiu SWY, Leslie RDG, Beyan H(2013). Non-genetic factors in the pathogenesis of type 1 diabetes. Diabetes and Viruses, vol. 9781461440512,
Leslie RDG, Ho-Le L, Beyan H(2013). Viruses and autoimmune diabetes: A history. Diabetes and Viruses, vol. 9781461440512,
Zhou Z, Xiang Y, Ji L, Jia W, Ning G, Huang G, Yang L, Lin J et al.(2013). Frequency, immunogenetics, and clinical characteristics of latent autoimmune diabetes in China (LADA China Study): A nationwide, multicenter, clinic-based cross-sectional study. Diabetes vol. 62, (2) 543-550.
10.2337/db12-0207
Merger SR, Leslie RD, Boehm BO(2013). The broad clinical phenotype of Type 1 diabetes at presentation. Diabetic Medicine vol. 30, (2) 170-178.
10.1111/dme.12048
Leslie RDG(2013). Type 1 diabetes reviews series. Diabetic Medicine vol. 30, (2)
10.1111/dme.12098
Beyan H, Down TA, Ramagopalan SV, Uvebrant K, Nilsson A, Holland ML, Gemma C, Giovannoni G et al.(2012). Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans. Genome Res vol. 22, (11) 2138-2145.
10.1101/gr.134304.111
Beyan H, Wen L, Leslie RD(2012). Guts, germs, and meals: the origin of type 1 diabetes. Curr Diab Rep vol. 12, (5) 456-462.
10.1007/s11892-012-0298-z
Rajendram R, Fraser-Bell S, Kaines A, Michaelides M, Hamilton RD, Esposti SD, Peto T, Egan C et al.(2012). A 2-year prospective randomized controlled trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic macular edema: 24-month data: report 3. Arch Ophthalmol vol. 130, (8) 972-979.
10.1001/archophthalmol.2012.393
Strom A, Menart B, Simon MC, Pham MN, Kolb H, Roden M, Pozzilli P, Leslie RDG et al.(2012). Cellular interferon-γ and interleukin-13 immune reactivity in type 1, type 2 and latent autoimmune diabetes: Action LADA 6. Cytokine vol. 58, (2) 148-151.
10.1016/j.cyto.2012.01.002
Beyan H, Riese H, Hawa MI, Beretta G, Davidson HW, Hutton JC, Burger H, Schlosser M et al.(2012). Glycotoxin and autoantibodies are additive environmentally determined predictors of type 1 diabetes: a twin and population study. Diabetes vol. 61, (5) 1192-1198.
10.2337/db11-0971
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19765
Pham MN, Hawa MI, Roden M, Schernthaner G, Pozzilli P, Buzzetti R, Scherbaum WA, Seissler J et al.(2012). Increased serum concentrations of adhesion molecules but not of chemokines in patients with Type2 diabetes compared with patients with Type1 diabetes and latent autoimmune diabetes in adult age: Action LADA5. Diabetic Medicine vol. 29, (4) 470-478.
10.1111/j.1464-5491.2011.03546.x
Leslie RD, Ludvigsson J(2012). The viral aetiology of diabetes: A tribute to Keith Taylor (1929-2012). Diabetic Medicine vol. 29, (4)
10.1111/j.1464-5491.2012.03614.x
Adams D, Altucci L, Antonarakis SE, Ballesteros J, Beck S, Bird A, Bock C, Boehm B et al.(2012). BLUEPRINT to decode the epigenetic signature written in blood. NATURE BIOTECHNOLOGY vol. 30, (3) 224-226.
10.1038/nbt.2153
Bizzarri C, Pinto RM, Pitocco D, Astorri E, Cappa M, Hawa M, Giannone G, Palermo A et al.(2012). Diabetes-related autoantibodies in children with acute lymphoblastic leukemia. Diabetes Care vol. 35, (3)
10.2337/dc11-1946
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19616
Ludvigsson J, Krisky D, Casas R, Battelino T, Castaño L, Greening J, Kordonouri O, Otonkoski T et al.(2012). GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus. New England Journal of Medicine vol. 366, (5) 433-442.
10.1056/NEJMoa1107096
Pham MN, Hawa MI, Pfleger C, Roden M, Schernthaner G, Pozzilli P, Buzzetti R, Scherbaum WA et al.(2012). Erratum: Pro- and anti-inflammatory cytokines in latent autoimmune diabetes in adults, type 1 and type 2 diabetes patients: Action LADA 4 (Diabetologia DOI: 10.1007/s00125-011-2088-6). Diabetologia vol. 55, (2)
10.1007/s00125-011-2375-2
Hawa MI, Kolb H, Schloot N, Beyan H, Paschou SA, Buzzetti R, Mauricio D, De Leiva A et al.(2012). Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: Action LADA 7. Diabetes Care
10.2337/dc12-0931
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18410
Leslie RD, Lansang MC, Coppack S(2012). Diabetes: Clinician's desk reference.
Leslie RD, Beyan H(2011). Metabolomics makes a mark: early changes associated with autoimmune diabetes. Diabetes vol. 60, (11) 2688-2690.
10.2337/db11-1177
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22550
Hadavi S, Noyce AJ, Leslie RD, Giovannoni G(2011). Stiff person syndrome. Pract Neurol vol. 11, (5) 272-282.
10.1136/practneurol-2011-000071
Leslie RD(2011). Towards secondary prevention of Type 1 diabetes. DIABETIC MED vol. 28, (10) 1140-1140.
10.1111/j.1464-5491.2011.03418.x
Rakyan VK, Beyan H, Down TA, Hawa MI, Maslau S, Aden D, Daunay A, Busato F et al.(2011). Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet vol. 7, (9)
10.1371/journal.pgen.1002300
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5415
Leslie D (2011). Type 1 Diabetes-Not All in the Genes. JOURNAL OF MEDICAL VIROLOGY. vol. 83, 1670-1670.
10.1002/jmv.22065
Xiang Y, Zhou P, Li X, Huang G, Liu Z, Xu A, Leslie RD, Zhou Z(2011). Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China. Diabetes Care vol. 34, (7) 1639-1641.
10.2337/dc11-0039
Pham MN, Hawa MI, Pfleger C, Roden M, Schernthaner G, Pozzilli P, Buzzetti R, Scherbaum W et al.(2011). Pro- and anti-inflammatory cytokines in latent autoimmune diabetes in adults, type 1 and type 2 diabetes patients: Action LADA 4. Diabetologia vol. 54, (7) 1630-1638.
10.1007/s00125-011-2088-6
Beyan H, Rakyan VK, Down TA, Hawa MI, Maslau S, Wallace C, Aden D, Mein CA et al. (2010). Identification of type 1 diabetes-associated methylation variable positions that precede disease diagnosis. DIABETOLOGIA. vol. 53, S145-S146.
10.1371/journal.pgen.1002300
Beyan H, Drexhage RC, van der Heul Nieuwenhuijsen L, de Wit H, Padmos RC, Schloot NC, Drexhage HA, Leslie RD(2010). Monocyte gene-expression profiles associated with childhood-onset type 1 diabetes and disease risk: a study of identical twins. Diabetes vol. 59, (7) 1751-1755.
10.2337/db09-1433
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23125
Michaelides M, Kaines A, Hamilton RD, Fraser-Bell S, Rajendram R, Quhill F, Boos CJ, Xing W et al.(2010). A Prospective Randomized Trial of Intravitreal Bevacizumab or Laser Therapy in the Management of Diabetic Macular Edema (BOLT Study) 12-Month Data: Report 2. OPHTHALMOLOGY vol. 117, (6) 1078-U76.
10.1016/j.ophtha.2010.03.045
Beyan H, Rakyan VK, Down TA, Maslau S, Hawa MI, Boehm BO, Beck S, Leslie RD (2010). Whole-Genome Identification and Functional Analysis of Type 1 Diabetes-Associated Epigenetic Variation. DIABETES. vol. 59, A56-A56.
Pozzilli P, Leslie RD, Chan J, De Fronzo R, Monnier L, Raz I, Del Prato S(2010). The A1C and ABCD of glycaemia management in type 2 diabetes: a physician's personalized approach. Diabetes Metab Res Rev vol. 26, (4) 239-244.
10.1002/dmrr.1092
Rakyan VK, Down TA, Maslau S, Andrew T, Yang T-P, Beyan H, Whittaker P, McCann OT et al.(2010). Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res vol. 20, (4) 434-439.
10.1101/gr.103101.109
Leslie RD(2010). Predicting adult-onset autoimmune diabetes: clarity from complexity. Diabetes vol. 59, (2) 330-331.
10.2337/db09-1620
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25551
Cernea S, Raz I, Herold KC, Hirshberg B, Roep BO, Schatz DA, Alexander Fleming G, Pozzilli P et al.(2009). Challenges in developing endpoints for type 1 diabetes intervention studies. Diabetes/Metabolism Research and Reviews vol. 25, (8) 694-704.
10.1002/dmrr.1002
Beyan H, Riese H, Hawa MI, Beretta G, Davidson HW, Hutton JC, Snieder H, Boehm BO et al. (2009). Common and unique environmental events associated with innate and adaptive immunity in type 1 diabetes. DIABETOLOGIA. vol. 52, S197-S198.
Leslie RDG, Cohen RM(2009). Biologic variability in plasma glucose, hemoglobin A1c, and advanced glycation end products associated with diabetes complications. J Diabetes Sci Technol vol. 3, (4) 635-643.
10.1177/193229680900300403
Leslie RD, Hawa MI, Schloot N, Sarti C, Williams R, Buzzetti R, Alemanno I, Kolb H et al. (2009). Frequency and Phenotypic Characteristics of Autoimmune Diabetes in Adult European Patients with Diabetes. DIABETES. vol. 58, A258-A258.
Pozzilli P, Leslie RD(2009). New prospects for immunotherapy at diagnosis of type 1 diabetes. DIABETES-METAB RES vol. 25, (4) 299-301.
10.1002/dmrr.970
Beyan H, Buckley LR, Bustin SA, Yousaf N, Pozzilli P, Leslie RD(2009). Altered monocyte cyclo-oxygenase response in non-obese diabetic mice. Clin Exp Immunol vol. 155, (2) 304-310.
10.1111/j.1365-2249.2008.03825.x
Padmos RC, Schloot NC, Beyan H, Ruwhof C, Staal FJT, de Ridder D, Aanstoot HJ, Lam-Tse WK et al.(2009). LADA Consortium: Distinct monocyte gene-expression profiles in autoimmune diabetes. (vol 57, pg 2768, 2008). DIABETES vol. 58, (1) 296-296.
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Pozzilli P, Lunadei M, Frati L, Leslie RDG, Farthing M(1996). From Erasmus to Socrates: Should mobility move from students to teachers? [13]. Lancet vol. 347, (9017)
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Hardman TC, Dubrey SW, Leslie RDG, Lant AF(1996). Kinetic behavior of the erythrocyte sodium-lithium countertransporter in nonnephropathic diabetic twins. Metabolism: Clinical and Experimental vol. 45, (10) 1203-1207.
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Peakman M, Leslie RDG, Alviggi L, Hawa M, Vergani D(1996). Persistent activation of CD8<sup>+</sup> T-cells characterizes prediabetic twins. Diabetes Care vol. 19, (11) 1177-1184.
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Lohmann T, Leslie RDG, Londei M (1996). T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes. Journal of Autoimmunity. vol. 9, 385-389.
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Lo SSS, Leslie RDG, Sutton MSJ(1995). Effects of type 1 diabetes mellitus on cardiac function: A study of monozygotic twins. Heart vol. 73, (5) 450-455.
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Pozzilli P, Buzzetti R, Giovannini C, Gragnoli C, Leslie RDG(1995). New and old trends for treating organ-specific autoimmune endocrinopathies. Journal of Endocrinology vol. 145, (2) 195-199.
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Rowe RE, Leslie RDG(1995). Twin studies in insulin dependent diabetes and other autoimmune diseases. Diabetes/Metabolism Reviews vol. 11, (2) 121-135.
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Orrell RW, Lane RJ, Maitland J, Leslie RD(1994). Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus. Lancet vol. 344, (8917)
Lohmann T, Londei M, Leslie RDG, Hawa M, Geysen M, Rodda S(1994). Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus. The Lancet vol. 343, (8913) 1607-1608.
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Tun RYM, Peakman M, Alviggi L, Hussain MJ, lo SSS, Shattock M, Pyke DA, Bottazzo GF et al.(1994). Importance of persistent cellular and humoral immune changes before diabetes develops: Prospective study of identical twins. BMJ vol. 308, (6936)
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Tun RYM, Smith MD, Lo SSS, Rook GAW, Lydyard P, Leslie RDG(1994). Antibodies to Heat Shock Protein 65 kD in Type 1 Diabetes Mellitus. Diabetic Medicine vol. 11, (1) 66-70.
10.1111/j.1464-5491.1994.tb00232.x
Smerdon RA, Peakman M, Hussain MJ, Wong FS, Watkins PJ, Leslie RDG, Vergani D(1994). CD5<sup>+</sup> B-cells at the onset of type I diabetes and in the prediabetic period. Diabetes Care vol. 17, (7) 657-664.
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Leslie RDG, Elliott RB(1994). Early environmental events as a cause of IDDM: Evidence and implications. Diabetes vol. 43, (7) 843-850.
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Dubrey S, Akhras F, Song GJ, Hardman T, Travill C, Hynd J, Noble MIM, Lo SSS et al.(1994). Exercise electrocardiography and aortic Doppler velocimetry in asymptomatic identical twins discordant for type 1 (insulin dependent) diabetes. British Heart Journal vol. 71, (4) 341-348.
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Peakman M, Alviggi L, Hussain MJ, Lo SSS, Hawa M, Leslie RDG, Vergani D(1994). Increased expression of T-cell markers of immunological memory associated with protection from type I diabetes: A study of identical twins. Diabetes vol. 43, (5) 712-717.
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Pozzilli P, Leslie RDG(1994). Infections and Diabetes: Mechanisms and Prospects for Prevention. Diabetic Medicine vol. 11, (10) 935-941.
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Fava D, Leslie RDG, Pozzilli P(1994). Relationship between dairy product consumption and incidence of IDDM in childhood in Italy. Diabetes Care vol. 17, (12) 1488-1490.
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Dubrey SW, Reaveley DR, Seed M, Lane DA, Ireland H, O'Donnell M, O'Connor B, Noble MI et al.(1994). Risk factors for cardiovascular disease in IDDM: A study of identical twins. Diabetes vol. 43, (6) 831-835.
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Leslie RDG, Hawa M (1994). Twin studies in auto-immune disease. Acta Geneticae Medicae et Gemellologiae. vol. 43, 71-81.
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Leslie RD, Pozzilli P(1994). Type I diabetes masquerading as type II diabetes. Possible implications for prevention and treatment. Diabetes care vol. 17, (10) 1214-1219.
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Lo SSS, John Sutton MS, Leslie RDG(1993). Information on type 1 diabetes mellitus and QT interval from identical twins. The American Journal of Cardiology vol. 72, (3) 305-309.
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Leslie RDG, Pyke DA, Braun MM, Caporaso N, Duffy DL, Macdonald AM(1993). Twin studies in medical research. The Lancet vol. 341, (8857) 1418-1419.
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Tun RYM, Leslie RDG(1993). Autoimmunity to glutamic acid decarboxylase in insulin-dependent diabetes. Saudi Medical Journal vol. 14, (2) 98-102.
Peakman M, Leslie RDG, Vergani D(1993). Immunological studies on type 1 diabetes in identical twins. Archives of Disease in Childhood vol. 69, (1) 97-99.
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Smerdon RA, Peakman M, Hussain MJ, Alviggi L, Watkins PJ, Leslie RDG, Vergani D(1993). Increase in simultaneous coexpression of naive and memory lymphocyte markers at diagnosis of IDDM. Diabetes vol. 42, (1) 127-133.
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Leslie RDG(1993). Metabolic changes in diabetes. Eye (Basingstoke) vol. 7, (2) 205-208.
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Leslie RDG, Carotenuto P, Pozzilli P (1993). New developments in non‐specific and semi‐specific immunosuppression in type I diabetes. Diabetes/Metabolism Reviews. vol. 9, 257-267.
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Lo SS, Hawa M, Pyke DA, Leslie RDG(1992). Erratum: Altered Islet Beta-cell function before the onset of Type 1 (insulin-dependent) diabetes mellitus (Diabetologia, Volume 35, Number 3, March 1992 (pp 277-282)). Diabetologia vol. 35, (11)
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Lo SSS, Hawa M, Beer SF, Pyke DA, Leslie RDG(1992). Altered islet Beta-cell function before the onset of Type 1 (insulin-dependent) diabetes mellitus. Diabetologia vol. 35, (3) 277-282.
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Christie MR, Tun RYM, Lo SSS, Cassidy D, Brown TJ, Hollands J, Shattock M, Bottazzo GF et al.(1992). Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: Studies with identical twins. Diabetes vol. 41, (7) 782-787.
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Leslie RDG, Lo S, Millward BA, Honour J, Pyke DA(1991). Decreased growth velocity before IDDM onset. Diabetes vol. 40, (2) 211-216.
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Leslie RDG, Pyke DA(1991). Escaping insulin dependent diabetes. British Medical Journal vol. 302, (6785) 1103-1104.
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Lo SSS, Tun RYM, Leslie RDG(1991). Non‐genetic Factors Causing Type 1 Diabetes. Diabetic Medicine vol. 8, (7) 609-618.
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Lo SSS, Tun RYM, Hawa M, Leslie RDG(1991). Studies of diabetic twins. Diabetes/Metabolism Reviews vol. 7, (4) 223-238.
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Beer SF, Heaton DA, Alberti KGMM, Pyke DA, Leslie RDG(1990). Impaired glucose tolerance precedes but does not predict insulin-dependent diabetes mellitus: a study of identical twins. Diabetologia vol. 33, (8) 497-502.
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Johnston C, Millward BA, Leslie RDG, Pyke DA, Bottazzo GF(1990). Are thyrogastric autoantibodies associated with an increased susceptibility to developing type 1 (insulin-dependent) diabetes? a study in identical twins. Autoimmunity vol. 6, (3) 195-201.
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Peakman M, Hussain MJ, Millward BA, Leslie RDG, Vergani D(1990). Effect of Initiation of Insulin Therapy on T‐lymphocyte Activation in Type 1 Diabetes. Diabetic Medicine vol. 7, (4) 327-330.
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Leslie RDG, Lazarus NR, Vergani D(1989). Aetiology of insulin-dependent diabetes. British Medical Bulletin vol. 45, (1) 58-72.
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Heaton DA, Lazarus NR, Pyke DA, Leslie RDG(1989). B-cell responses to intravenous glucose and glucagon in non-diabetic twins of patients with Type 1 (insulin-dependent) diabetes mellitus. Diabetologia vol. 32, (11) 814-817.
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Johnston C, Millward BA, Hoskins P, Leslie RDG, Bottazzo GF, Pyke DA(1989). Islet-cell antibodies as predictors of the later development of Type 1 (insulin-dependent) diabetes - A study in identical twins. Diabetologia vol. 32, (6) 382-386.
10.1007/BF00277263
Leslie RDG, Lazarus NR, Vergani D(1989). Events leading to insulin-dependent diabetes. Clinical Science vol. 76, (2) 119-124.
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Hammer MR, John PN, Flynn MD, Bellingham AJ, Leslie RDG(1989). Glycated fibrinogen: A new index of short-term diabetic control. Annals of Clinical Biochemistry vol. 26, (1) 58-62.
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Olmos P, A'Hern R, Heaton DA, Millward BA, Risley D, Pyke DA, Leslie RDG(1988). The significance of the concordance rate for Type 1 (insulin-dependent) diabetes in identical twins. Diabetologia vol. 31, (10) 747-750.
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Heaton DA, Millward BA, Gray IP, Tun Y, Hales CN, Pyke DA, Leslie RDG(1988). Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of Type 1 (insulin-dependent) diabetic patients. Diabetologia vol. 31, (3) 182-184.
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Johnston C, Alviggi L, Millward BA, Leslie RDG, Pyke DA, Vergani D(1988). Alterations in T-lymphocyte subpopulations in type I diabetes. Exploration of genetic influence in identical twins. Diabetes vol. 37, (11) 1484-1488.
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Millward A, Hussain MJ, Peakman M, Pyke DA, Leslie RDG, Vergani D(1988). Characterization of islet cell antibody in insulin dependent diabetes: evidence for IgG1 subclass restriction and polyclonality. Clinical and Experimental Immunology vol. 71, (2) 353-356.
Leslie RDG, Ganash A, Volkmann HP, Hanning I, Alberti KGMM(1988). Insensitivity to insulin in offspring of non-insulin dependent diabetic patients. Diabetes, Nutrition and Metabolism - Clinical and Experimental vol. 1, (3) 235-237.
Senaldi G, Millward BA, Hussain MJ, Pyke DA, Leslie RDG, Vergani D(1988). Low serum haemolytic function of the fourth complement component (C4) in insulin dependent diabetes. Journal of Clinical Pathology vol. 41, (10) 1114-1116.
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Hussain MJ, Alviggi L, Millward BA, Leslie RDG, Pyke DA, Vergani D(1987). Evidence that the reduced number of natural killer cells in Type 1 (insulin-dependent) diabetes may be genetically determined. Diabetologia vol. 30, (12) 907-911.
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Senaldi G, Millward BA, Hussein MJ, Pyke D, Leslie RDG, Vergani D(1987). Complement in Type 1 (insulin-dependent) diabetes. Diabetologia vol. 30, (10)
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Heaton DA, Millward BA, Tun Y, Pyke DA, Leslie RDG, Gray P, Hales CN(1987). Evidence of β cell dysfunction which does not lead on to diabetes: A study of identical twins of insulin dependent diabetics. British Medical Journal (Clinical research ed.) vol. 294, (6565) 145-146.
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Millward BA, Welsh KI, Leslie RDG, Pyke DA, Demaine AG(1987). T cell receptor beta chain polymorphisms are associated with insulin-dependent diabetes. Clinical and Experimental Immunology vol. 70, (1) 152-157.
Ferner RE, Jarrett RJ, Leslie RDG, O'Rahilly SP, Nugent Z, Rudenski AS, Hosker JP, Turner RC(1986). BETA-CELL FUNCTION IN TYPE II DIABETES. The Lancet vol. 328, (8507) 628-629.
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Leslie RD(1986). Metabolic abnormalities in children of non-insulin dependent diabetics. British Medical Journal (Clinical research ed.) vol. 293, (6551) 840-842.
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Pyke DA, Hoskins PJ, Leslie RD(1985). Monozygotic twins and genetic aspects of diabetes. Journees annuelles de diabetologie de l"Hotel-Dieu121-133.
Leslie RDG, Pyke DA, Denman AM(1985). IMMUNOSUPPRESSIVE THERAPY IN DIABETES. The Lancet vol. 325, (8427)
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Wilkin T, Armitage M, Casey C, Pyke DA, Hoskins PJ, Rodier M, Diaz JL, Leslie RDG(1985). VALUE OF INSULIN AUTOANTIBODIES AS SERUM MARKERS FOR INSULIN-DEPENDENT DIABETES MELLITUS. The Lancet vol. 325, (8427) 480-482.
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Hoskins PJ, Leslie RDG, Pyke DA(1985). Height at diagnosis of diabetes in children: A study in identical twins. British Medical Journal (Clinical research ed.) vol. 290, (6464) 278-280.
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Alviggi L, Hoskins PJ, Pyke DA, Johnston C, Tee DEH, Leslie RDG, Vergani D(1984). PATHOGENESIS OF INSULIN-DEPENDENT DIABETES: A ROLE FOR ACTIVATED T LYMPHOCYTES. The Lancet vol. 324, (8393) 4-6.
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Johnston C, Owerbach D, Leslie RDG, Pyke DA, Nerup J(1984). MASON-TYPE DIABETES AND DNA INSERTION POLYMORPHISM. The Lancet vol. 323, (8371)
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Leslie RDG(1984). Clinical significance of chlorpropamide-alcohol flushing in NIDDM vasculopathy. Practical Cardiology vol. 10, (12) 79-90.
Wiles PG, Hoskins P, Leslie RDG, Pyke DA(1984). Prevalence of chlorpropamide alcohol flushing. British Medical Journal vol. 288, (6413) 328-329.
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Leslie RDG(1983). Causes of insulin dependent diabetes. British Medical Journal vol. 287, (6384) 5-6.
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Leslie RDG, Eff C, Barnett AH, Spiliopoulos AJ, Pyke DA, Stubbs WA, Alberti KG(1982). Opiate receptors and the metabolic response to intravenous glucose. Diabete et Metabolisme vol. 8, (3) 235-239.
Leslie RDG, Pyke DA(1982). Diabetic retinopathy in identical twins. Diabetes vol. 31, (1) 19-21.
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Harris M, Leslie RDG(1981). Chlorpropamide-alcohol flushing and diabetes - Report of an International Workshop, 13-14 June 1980, Washington, USA. Diabetologia vol. 21, (4) 422-424.
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Barnett AH, Leslie RDG, Pyke DA(1981). Chlorpropamide-alcohol flushing and proteinuria in non-insulin-dependent diabetics. British Medical Journal (Clinical research ed.) vol. 282, (6263) 522-523.
10.1136/bmj.282.6263.522
Stubbs SM, Leslie RDG, John PN(1981). Fetal macrosomia and maternal diabetic control in pregnancy. British Medical Journal (Clinical research ed.) vol. 282, (6262) 439-440.
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Barnett AH, Eff C, Leslie RDG, Pyke DA(1981). Diabetes in identical twins - A study of 200 pairs. Diabetologia vol. 20, (2) 87-93.
10.1007/BF00262007
Green IC, Perrin D, Pedley KC, Leslie RDG, Pyke DA(1980). Effect of enkephalins and morphine on insulin secretion from isolated rat islets. Diabetologia vol. 19, (2) 158-161.
10.1007/BF00421864
Leslie RDG, Bellamy D, Pyke DA(1980). Asthma induced by enkephalin. British Medical Journal vol. 280, (6206) 16-18.
10.1136/bmj.280.6206.16
Young BJJ, Clark CJM, Hamblin TJ, Mallya RK, Leslie RDG(1979). Anti-keratin antibodies in rheumatoid arthritis. British Medical Journal vol. 2, (6182) 97-99.
10.1136/bmj.2.6182.97
Leslie RDG, Pyke DA, John PN, White JM(1979). How quickly can haemoglobin A<inf>1</inf> increase?. British Medical Journal vol. 2, (6181)
10.1136/bmj.2.6181.19
Leslie RDG, Barnett AH, Pyke DA(1979). CHLORPROPAMIDE ALCOHOL FLUSHING AND DIABETIC RETINOPATHY. The Lancet vol. 313, (8124) 997-999.
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Leslie RDG, Pyke DA, John PN, White JM(1979). FAST GLYCOSYLATION OF HÆMOGLOBIN. The Lancet vol. 313, (8119) 773-774.
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Leslie RDG, Pyke DA, Stubbs WA(1979). SENSITIVITY TO ENKEPHALIN AS A CAUSE OF NON-INSULIN DEPENDENT DIABETES. The Lancet vol. 313, (8112) 341-343.
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Leslie RDG, Pyke DA(1979). Letter to the editor. Diabetologia vol. 16, (2)
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Pyke DA, Leslie RDG(1978). Chlorpropamide-alcohol flushing: A definition of its relation to non-insulin-dependent diabetes. British Medical Journal vol. 2, (6151) 1521-1522.
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Leslie RDG, Pyke DA(1978). Chlorpropamide-alcohol flushing: A dominantly inherited trait associated with diabetes. British Medical Journal vol. 2, (6151) 1519-1521.
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Leslie RDG, Mackay JD(1978). Intravenous insulin infusion in diabetic emergencies. British Medical Journal vol. 2, (6148)
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Leslie RDG, John PN, Pyke DA, White JM(1978). HÆMOGLOBIN A<inf>1</inf> IN DIABETIC PREGNANCY. The Lancet vol. 312, (8097) 958-959.
10.1016/S0140-6736(78)92525-4
Essex NL, Leslie R, Mackay JD, Stubbs SM(1978). Regulating blood glucose concentration in diabetes during labour. British Medical Journal vol. 2, (6142)
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Leslie RDG, Pyke DA(1978). Chlorpropamide-alcohol flushing and maturity onset diabetes. Diabetologia vol. 15, (3)
Leslie RDG, Pyke DA(1978). Chlorpropamide-induced flushing after alcohol: A genetic marker for a specific type of early onset diabetes?. Quarterly Journal of Medicine vol. 47, (188) 567-568.
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