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Publications:  Prof Thomas MacDonald

Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X et al.(2019). Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. Cell Rep vol. 27, (5) 1461-1471.e4.
10.1016/j.celrep.2019.04.014
https://qmro.qmul.ac.uk/xmlui/handle/123456789/57415
Belarif L, Danger R, Kermarrec L, Nerrière-Daguin V, Pengam S, Durand T, Mary C, Kerdreux E et al.(2019). IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease. J Clin Invest vol. 130, 1910-1925.
10.1172/JCI121668
Reisdorf WC, Xie Q, Zeng X, Xie W, Rajpal N, Hoang B, Burgert ME, Kumar V et al.(2019). Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease. PLoS One vol. 14, (4)
10.1371/journal.pone.0215033
Garrido-Mesa N, Schroeder J-H, Stolarczyk E, Gallagher AL, Lo JW, Bailey C, Campbell L, Sexl V et al.(2019). T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function. Mucosal Immunol vol. 12, (1) 51-63.
10.1038/s41385-018-0092-6
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54755
Laudisi F, Di Fusco D, Dinallo V, Stolfi C, Di Grazia A, Marafini I, Colantoni A, Ortenzi A et al.(2019). The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation. Cell Mol Gastroenterol Hepatol vol. 7, (2) 457-473.
10.1016/j.jcmgh.2018.09.002
Crowe JS, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Clare S, Harcourt K, Reckless J et al.(2018). Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease. Sci Rep vol. 8, (1)
10.1038/s41598-018-23277-7
https://qmro.qmul.ac.uk/xmlui/handle/123456789/38084
Díaz-Jiménez D, Núñez L, De la Fuente M, Dubois-Camacho K, Sepúlveda H, Montecino M, Torres-Riquelme A, García-González P et al.(2017). A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis. Sci Rep vol. 7, (1)
10.1038/s41598-017-10465-0
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27963
Curciarello R, Docena GH, MacDonald TT(2017). The Role of Cytokines in the Fibrotic Responses in Crohn's Disease. Front Med (Lausanne) vol. 4, 126-126.
10.3389/fmed.2017.00126
Powell N, MacDonald TT(2017). Recent advances in gut immunology. Parasite Immunol vol. 39, (6)
10.1111/pim.12430
Wells JM, Brummer RJ, Derrien M, MacDonald TT, Troost F, Cani PD, Theodorou V, Dekker J et al.(2017). Homeostasis of the gut barrier and potential biomarkers. Am J Physiol Gastrointest Liver Physiol vol. 312, (3) G171-G193.
10.1152/ajpgi.00048.2015
Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA et al.(2017). Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. J Med Chem vol. 60, (4) 1247-1261.
10.1021/acs.jmedchem.6b01751
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39609
Foster M, Biancheri P, Fyfe M, MacDonald T, Rowley A, Sirohi S, Solanke Y, Webber S et al. (2017). The pharmacological profile of TOP1288, a narrow spectrum kinase inhibitor in clinical development as an anti-inflammatory treatment for ulcerative colitis. JOURNAL OF CROHNS & COLITIS. vol. 11, S95-S95.
Bron PA, Kleerebezem M, Brummer R-J, Cani PD, Mercenier A, MacDonald TT, Garcia-Ródenas CL, Wells JM(2017). Can probiotics modulate human disease by impacting intestinal barrier function?. Br J Nutr vol. 117, (1) 93-107.
10.1017/S0007114516004037
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34987
Giles EM, Sanders TJ, McCarthy NE, Lung J, Pathak M, MacDonald TT, Lindsay JO, Stagg AJ(2017). Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease. Mucosal Immunol vol. 10, (1) 184-193.
10.1038/mi.2016.44
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12894
König J, Wells J, Cani PD, García-Ródenas CL, MacDonald T, Mercenier A, Whyte J, Troost F et al.(2016). Human Intestinal Barrier Function in Health and Disease. Clin Transl Gastroenterol vol. 7, (10)
10.1038/ctg.2016.54
Biancheri P, Di Sabatino A, Rescigno M, Giuffrida P, Fornasa G, Tsilingiri K, Pender SLF, Papadia C et al.(2016). Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease. Gut vol. 65, (10) 1670-1680.
10.1136/gutjnl-2014-308876
Muthas D, Reznichenko A, Balendran CA, Böttcher G, Clausen IG, Kärrman Mårdh C, Ottosson T, Uddin M et al.(2016). Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications. Scand J Gastroenterol vol. 52, (2) 125-135.
10.1080/00365521.2016.1235224
Biancheri P, Foster MR, Fyfe MCT, MacDonald TT, Sirohi S, Solanke Y, Wood E, Rowley A et al.(2016). Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal Proinflammatory Immune Response in Ulcerative Colitis. Inflamm Bowel Dis vol. 22, (6) 1306-1315.
10.1097/MIB.0000000000000759
Haile PA, Votta BJ, Marquis RW, Bury MJ, Mehlmann JF, Singhaus R, Charnley AK, Lakdawala AS et al.(2016). The Identification and Pharmacological Characterization of 6-( tert -Butylsulfonyl)- N -(5-fluoro-1 H -indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. Journal of Medicinal Chemistry vol. 59, (10) 4867-4880.
10.1021/acs.jmedchem.6b00211
Canavan JB, Scottà C, Vossenkämper A, Goldberg R, Elder MJ, Shoval I, Marks E, Stolarczyk E et al.(2016). Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease. Gut vol. 65, (4) 584-594.
10.1136/gutjnl-2014-306919
De la Fuente M, MacDonald TT, Hermoso MA(2015). The IL-33/ST2 axis: Role in health and disease. Cytokine Growth Factor Rev vol. 26, (6) 615-623.
10.1016/j.cytogfr.2015.07.017
Biancheri P, Brezski RJ, Di Sabatino A, Greenplate AR, Soring KL, Corazza GR, Kok KB, Rovedatti L et al.(2015). Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease. Gastroenterology vol. 149, (6) 1564-1574.e3.
10.1053/j.gastro.2015.07.002
Powell N, Lo JW, Biancheri P, Vossenkämper A, Pantazi E, Walker AW, Stolarczyk E, Ammoscato F et al.(2015). Interleukin 6 Increases Production of Cytokines by Colonic Innate Lymphoid Cells in Mice and Patients With Chronic Intestinal Inflammation. Gastroenterology vol. 149, (2) 456-67.e15.
10.1053/j.gastro.2015.04.017
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9927
De Simone V, Franzè E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, Sica GS, Sileri P et al.(2015). Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene vol. 34, (27) 3493-3503.
10.1038/onc.2014.286
Goldberg R, Prescott N, Lord GM, MacDonald TT, Powell N(2015). The unusual suspects--innate lymphoid cells as novel therapeutic targets in IBD. Nat Rev Gastroenterol Hepatol vol. 12, (5) 271-283.
10.1038/nrgastro.2015.52
De Simone V, Ronchetti G, Franzè E, Colantoni A, Ortenzi A, Fantini MC, Rizzo A, Sica GS et al.(2015). Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis. Oncotarget vol. 6, (12) 9908-9923.
10.18632/oncotarget.3532
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11004
Di Sabatino A, Giuffrida P, Fornasa G, Salvatore C, Broglia F, Pasini A, Ammoscato F, Rescigno M et al. (2015). THYMIC STROMAL LYMPHOPOIETIN MODULATES TISSUE REMODELLING AND REPAIR IN NORMAL AND INFLAMED GUT. DIGESTIVE AND LIVER DISEASE. vol. 47, E182-E182.
Caruso R, Marafini I, Franzè E, Stolfi C, Zorzi F, Monteleone I, Caprioli F, Colantoni A et al.(2014). Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut. Mucosal Immunol vol. 7, (6) 1467-1479.
10.1038/mi.2014.35
Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R et al.(2014). In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts. Clin Sci (Lond) vol. 127, (5) 341-350.
10.1042/CS20140048
Vossenkämper A, Hundsrucker C, Page K, van Maurik A, Sanders TJ, Stagg AJ, Das L, MacDonald TT(2014). A CD3-specific antibody reduces cytokine production and alters phosphoprotein profiles in intestinal tissues from patients with inflammatory bowel disease. Gastroenterology vol. 147, (1) 172-183.
10.1053/j.gastro.2014.03.049
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5879
Rizzo A, De Mare V, Rocchi C, Stolfi C, Colantoni A, Neurath MF, Macdonald TT, Pallone F et al.(2014). Smad7 induces plasticity in tumor-infiltrating Th17 cells and enables TNF-alpha-mediated killing of colorectal cancer cells. Carcinogenesis vol. 35, (7) 1536-1546.
10.1093/carcin/bgu027
Cupi ML, Sarra M, Marafini I, Monteleone I, Franzè E, Ortenzi A, Colantoni A, Sica G et al.(2014). Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities. J Immunol vol. 192, (12) 6083-6091.
10.4049/jimmunol.1302238
Caruso R, Marafini I, Sedda S, Del Vecchio Blanco G, Giuffrida P, MacDonald TT, Corazza GR, Pallone F et al.(2014). Analysis of the cytokine profile in the duodenal mucosa of refractory coeliac disease patients. CLINICAL SCIENCE vol. 126, (5-6) 451-458.
10.1042/C520130478
Giuffrida P, Biancheri P, MacDonald TT(2014). Proteases and small intestinal barrier function in health and disease. Curr Opin Gastroenterol vol. 30, (2) 147-153.
10.1097/MOG.0000000000000042
Stolfi C, De Simone V, Colantoni A, Franzè E, Ribichini E, Fantini MC, Caruso R, Monteleone I et al.(2014). A functional role for Smad7 in sustaining colon cancer cell growth and survival. Cell Death Dis vol. 5,
10.1038/cddis.2014.49
Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque SS, Ghanbari A et al.(2014). Absence of a role for interleukin-13 in inflammatory bowel disease. Eur J Immunol vol. 44, (2) 370-385.
10.1002/eji.201343524
Kok K, Curciarello R, Giuffrida P, Joshi N, Biancheri P, MacDonald T(2014). Interactions between neutrophil elastase and biologics in IBD. JOURNAL OF CROHNS & COLITIS vol. 8, S85-S85.
10.1016/S1873-9946(14)60176-8
Biancheri P, Giuffrida P, Docena GH, MacDonald TT, Corazza GR, Di Sabatino A(2014). The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut. Cytokine Growth Factor Rev vol. 25, (1) 45-55.
10.1016/j.cytogfr.2013.11.001
Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Rüschendorf F, Warner TD, Kelsell DP et al.(2014). Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α. Gut vol. 63, (1) 96-104.
10.1136/gutjnl-2012-303581
Curciarello R, Steele A, Cooper D, MacDonald TT, Kruidenier L, Kudo T(2014). The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection. PLoS One vol. 9, (9)
10.1371/journal.pone.0107933
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18848
Biancheri P, Powell N, Monteleone G, Lord G, MacDonald TT(2013). The challenges of stratifying patients for trials in inflammatory bowel disease. Trends Immunol vol. 34, (11) 564-571.
10.1016/j.it.2013.08.002
Sarra M, Cupi ML, Bernardini R, Ronchetti G, Monteleone I, Ranalli M, Franzè E, Rizzo A et al.(2013). IL-25 prevents and cures fulminant hepatitis in mice through a myeloid-derived suppressor cell-dependent mechanism. Hepatology vol. 58, (4) 1436-1450.
10.1002/hep.26446
McCarthy NE, Bashir Z, Vossenkämper A, Hedin CR, Giles EM, Bhattacharjee S, Brown SG, Sanders TJ et al.(2013). Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells. J Immunol vol. 191, (5) 2752-2763.
10.4049/jimmunol.1202959
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5470
Vossenkämper A, Blair PA, Safinia N, Fraser LD, Das L, Sanders TJ, Stagg AJ, Sanderson JD et al.(2013). A role for gut-associated lymphoid tissue in shaping the human B cell repertoire. J Exp Med vol. 210, (9) 1665-1674.
10.1084/jem.20122465
https://qmro.qmul.ac.uk/xmlui/handle/123456789/5436
Biancheri P, Pender SL, Ammoscato F, Giuffrida P, Sampietro G, Ardizzone S, Ghanbari A, Curciarello R et al.(2013). The role of interleukin 17 in Crohn's disease-associated intestinal fibrosis. Fibrogenesis Tissue Repair vol. 6, (1)
10.1186/1755-1536-6-13
Di Sabatino A, Brunetti L, Biancheri P, Ciccocioppo R, Guerci M, Casella C, Vidali F, MacDonald TT et al.(2013). Mucosal changes induced by ischemia-reperfusion injury in a jejunal loop transplanted in oropharynx. INTERNAL AND EMERGENCY MEDICINE vol. 8, (4) 317-325.
10.1007/s11739-011-0615-6
Franzè E, Caruso R, Stolfi C, Sarra M, Cupi ML, Ascolani M, Sedda S, Antenucci C et al.(2013). High expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases. Inflamm Bowel Dis vol. 19, (3) 501-511.
10.1097/MIB.0b013e31828028e8
Biancheri P, Di Sabatino A, Rovedatti L, Giuffrida P, Calarota SA, Vetrano S, Vidali F, Pasini A et al.(2013). Effect of tumor necrosis factor-α blockade on mucosal addressin cell-adhesion molecule-1 in Crohn's disease. Inflamm Bowel Dis vol. 19, (2) 259-264.
10.1097/MIB.0b013e31828100a4
Biancheri P, Di Sabatino A, Corazza GR, MacDonald TT(2013). Proteases and the gut barrier. CELL AND TISSUE RESEARCH vol. 351, (2) 269-280.
10.1007/s00441-012-1390-z
Monteleone I, Federici M, Sarra M, Franze E, Casagrande V, Zorzi F, Cavalera M, Rizzo A et al.(2012). Tissue Inhibitor of Metalloproteinase-3 Regulates Inflammation in Human and Mouse Intestine. GASTROENTEROLOGY vol. 143, (5) 1277-+.
10.1053/j.gastro.2012.07.016
MacDonald TT, Biancheri P, Sarra M, Monteleone G(2012). What's the next best cytokine target in IBD?. Inflamm Bowel Dis vol. 18, (11) 2180-2189.
10.1002/ibd.22967
Powell N, Walker AW, Stolarczyk E, Canavan JB, Gökmen MR, Marks E, Jackson I, Hashim A et al.(2012). The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells. Immunity vol. 37, (4) 674-684.
10.1016/j.immuni.2012.09.008
Monteleone I, MacDonald TT, Pallone F, Monteleone G(2012). The aryl hydrocarbon receptor in inflammatory bowel disease: linking the environment to disease pathogenesis. CURRENT OPINION IN GASTROENTEROLOGY vol. 28, (4) 310-313.
10.1097/MOG.0b013e328352ad69
Di Sabatino A, Biancheri P, Rovedatti L, MacDonald TT, Corazza GR(2012). Recent advances in understanding ulcerative colitis. INTERNAL AND EMERGENCY MEDICINE vol. 7, (2) 103-111.
10.1007/s11739-011-0719-z
Canavan JB, Afzali B, Scotta C, Fazekasova H, Edozie FC, Macdonald TT, Hernandez-Fuentes MP, Lombardi G et al.(2012). A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy. BLOOD vol. 119, (8) E57-E66.
10.1182/blood-2011-09-380048
Di Sabatino A, Biancheri P, Rovedatti L, MacDonald TT, Corazza GR(2012). New pathogenic paradigms in inflammatory bowel disease. INFLAMMATORY BOWEL DISEASES vol. 18, (2) 368-371.
10.1002/ibd.21735
MacDonald TT, Harper JI, Kelsell DP(2012). Inflammatory Bowel Disease and ADAM17 Deletion REPLY. NEW ENGLAND JOURNAL OF MEDICINE vol. 366, (2) 190-190.
10.1056/nejmc1113859
Stolfi C, Pallone F, Macdonald TT, Monteleone G(2012). Interleukin-21 in cancer immunotherapy Friend or foe?. ONCOIMMUNOLOGY vol. 1, (3) 351-354.
10.4161/onci.19122
MacDonald TT, Vossenkaemper A, Fantini M, Monteleone G(2012). Reprogramming the immune system in IBD. Dig Dis vol. 30, (4) 392-395.
10.1159/000338136
Rizzo A, Waldner MJ, Stolfi C, Sarra M, Fina D, Becker C, Neurath MF, Macdonald TT et al.(2011). Smad7 Expression in T cells Prevents Colitis- Associated Cancer. CANCER RESEARCH vol. 71, (24) 7423-7432.
10.1158/0008-5472.CAN-11-1895
Monteleone G, Pallone F, MacDonald TT(2011). Emerging immunological targets in inflammatory bowel disease. CURRENT OPINION IN PHARMACOLOGY vol. 11, (6) 640-645.
10.1016/j.coph.2011.09.013
Stolfi C, Rizzo A, Franze E, Rotondi A, Fantini MC, Sarra M, Caruso R, Monteleone I et al.(2011). Involvement of interleukin-21 in the regulation of colitis-associated colon cancer. J EXP MED vol. 208, (11) 2279-2290.
10.1084/jem.20111106
Blaydon DC, Biancheri P, Di W-L, Plagnol V, Cabral RM, Brooke MA, van Heel DA, Ruschendorf F et al.(2011). Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med vol. 365, (16) 1502-1508.
10.1056/NEJMoa1100721
Vossenkamper A, Fikree A, Fairclough PD, Aziz Q, MacDonald TT(2011). Colonic Lymphoid Nodular Hyperplasia in an Adolescent. Journal of Pediatric Gastroenterology and Nutrition vol. 53, (6) 684-686.
10.1097/MPG.0b013e318223650a
Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G, Vanoli A, Dainese E et al.(2011). The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease. MUCOSAL IMMUNOL vol. 4, (5) 574-583.
10.1038/mi.2011.18
MacDonald TT, Bell I, Monteleone G(2011). The opposing roles of IL-21 and TGFβ1 in chronic inflammatory bowel disease. Biochem Soc Trans vol. 39, (4) 1061-1066.
10.1042/BST0391061
Monteleone I, Rizzo A, Sarra M, Sica G, Sileri P, Biancone L, MacDonald TT, Pallone F et al.(2011). Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract. GASTROENTEROLOGY vol. 141, (1) 237-U324.
10.1053/j.gastro.2011.04.007
Macdonald TT(2011). New cytokine targets in inflammatory bowel disease. Gastroenterol Hepatol (N Y) vol. 7, (7) 474-476.
Vossenkämper A, Macdonald TT, Marchès O(2011). Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system. J Inflamm (Lond) vol. 8,
10.1186/1476-9255-8-11
Rovedatti L, Di Sabatino A, Knowles CH, Sengupta N, Biancheri P, Corazza GR, MacDonald TT(2011). Fibroblast activation protein expression in Crohn's disease strictures. Inflamm Bowel Dis vol. 17, (5) 1251-1253.
10.1002/ibd.21446
Sarra M, Caruso R, Cupi ML, Monteleone I, Stolfi C, Campione E, Diluvio L, Mazzotta A et al.(2011). IL-21 Promotes Skin Recruitment of CD4(+) Cells and Drives IFN-gamma-Dependent Epidermal Hyperplasia. J IMMUNOL vol. 186, (9) 5435-5442.
10.4049/jimmunol.1003326
MacDonald TT, Monteleone I, Fantini MC, Monteleone G(2011). Regulation of homeostasis and inflammation in the intestine. Gastroenterology vol. 140, (6) 1768-1775.
10.1053/j.gastro.2011.02.047
Fina D, Franze E, Rovedatti L, Corazza GR, Biancone L, Sileri PP, Sica G, MacDonald TT et al.(2011). Interleukin-25 production is differently regulated by TNF-alpha and TGF-beta 1 in the human gut. MUCOSAL IMMUNOL vol. 4, (2) 239-244.
10.1038/mi.2010.68
Di Sabatino A, Rovedatti L, Vetrano S, Vidali F, Biancheri P, Rescigno M, Danese S, MacDonald TT et al.(2011). Involvement of CD40-CD40 Ligand in Uncomplicated and Refractory Celiac Disease. AM J GASTROENTEROL vol. 106, (3) 519-527.
10.1038/ajg.2010.450
Di Sabatino A, Calarota SA, Vidali F, MacDonald TT, Corazza GR(2011). Role of IL-15 in immune-mediated and infectious diseases. CYTOKINE GROWTH F R vol. 22, (1) 19-33.
10.1016/j.cytogfr.2010.09.003
Monteleone G, Pallone F, MacDonald TT, Chimenti S, Costanzo A(2011). Psoriasis: from pathogenesis to novel therapeutic approaches. CLIN SCI vol. 120, (1-2) 1-11.
10.1042/CS20100163
Monteleone G, Pallone F, MacDonald TT(2010). Interleukin-25: A two-edged sword in the control of immune-inflammatory responses. CYTOKINE GROWTH F R vol. 21, (6) 471-475.
10.1016/j.cytogfr.2010.05.001
Macdonald TT(2010). Inside the microbial and immune labyrinth: totally gutted. Nat Med vol. 16, (11) 1194-1195.
10.1038/nm1110-1194
Di Sabatino A, Biancheri P, Piconese S, Rosado MM, Ardizzone S, Rovedatti L, Ubezio C, Massari A et al.(2010). Peripheral Regulatory T Cells and Serum Transforming Growth Factor-beta: Relationship with Clinical Response to Infliximab in Crohn's Disease. INFLAMM BOWEL DIS vol. 16, (11) 1891-1897.
10.1002/ibd.21271
Powell N, Canavan JB, MacDonald TT, Lord GM(2010). Transcriptional regulation of the mucosal immune system mediated by T-bet. Mucosal Immunol vol. 3, (6) 567-577.
10.1038/mi.2010.53
Docena G, Rovedatti L, Kruidenier L, Fanning A, Leakey NAB, Knowles CH, Lee K, Shanahan F et al.(2010). Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease. Clin Exp Immunol vol. 162, (1) 108-115.
10.1111/j.1365-2249.2010.04203.x
Sarra M, Pallone F, MacDonald TT, Monteleone G(2010). IL-23/IL-17 Axis in IBD. INFLAMM BOWEL DIS vol. 16, (10) 1808-1813.
10.1002/ibd.21248
Vossenkämper A, Marchès O, Fairclough PD, Warnes G, Stagg AJ, Lindsay JO, Evans PC, Luong LA et al.(2010). Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE. J Immunol vol. 185, (7) 4118-4127.
10.4049/jimmunol.1000500
Günther U, Bateman AC, Beattie RM, Bauer M, MacDonald TT, Kaskas BA(2010). Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease. Histopathology vol. 57, (3) 427-435.
10.1111/j.1365-2559.2010.03652.x
Sarra M, Monteleone I, Stolfi C, Fantini MC, Sileri P, Sica G, Tersigni R, Macdonald TT et al.(2010). Interferon-gamma-expressing Cells Are a Major Source of Interleukin-21 in Inflammatory Bowel Diseases. INFLAMM BOWEL DIS vol. 16, (8) 1332-1339.
10.1002/ibd.21238
MacDonald TT, Bell I(2010). Probiotics and the immune response to vaccines. Proc Nutr Soc vol. 69, (3) 442-446.
10.1017/S0029665110001758
MacDonald TT(2010). Cytokine regulation of intestinal epithelial cell proliferation. Expert Rev Clin Immunol vol. 6, (4) 531-535.
10.1586/eci.10.42
Epstein J, Sanderson IR, Macdonald TT(2010). Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies. Br J Nutr vol. 103, (11) 1545-1557.
10.1017/S0007114509993667
Sarra M, Pallone F, Macdonald TT, Monteleone G(2010). Targeting Interleukin-21 in Immune-Mediated Pathologies. CURR DRUG TARGETS vol. 11, (5) 645-649.
10.2174/138945010791011910
Epstein J, Docena G, MacDonald TT, Sanderson IR(2010). Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. Br J Nutr vol. 103, (6) 824-832.
10.1017/S0007114509992510
Monteleone I, Sarra M, Blanco GDV, Paoluzi OA, Franze E, Fina D, Fabrizi A, MacDonald TT et al.(2010). Characterization of IL-17A-Producing Cells in Celiac Disease Mucosa. J IMMUNOL vol. 184, (4) 2211-2218.
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Sengupta N, MacFie TS, MacDonald TT, Pennington D, Silver AR(2010). Cancer immunoediting and "spontaneous" tumor regression. Pathol Res Pract vol. 206, (1) 1-8.
10.1016/j.prp.2009.10.001
Stolfi C, Sarra M, Caruso R, Fantini MC, Fina D, Pellegrini R, Palmieri G, MacDonald TT et al.(2010). Inhibition of Colon Carcinogenesis by 2-Methoxy-5-Amino-N-Hydroxybenzamide, a Novel Derivative of Mesalamine. GASTROENTEROLOGY vol. 138, (1) 221-230.
10.1053/j.gastro.2009.08.062
Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles CH, Rampton DS, Corazza GR, Monteleone G et al.(2009). Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut vol. 58, (12) 1629-1636.
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MacDonald TT, Di Sabatino A(2009). The immunologic basis for gastrointestinal food allergy. Curr Opin Gastroenterol vol. 25, (6) 521-526.
10.1097/MOG.0b013e3283306236
Gordon JN, Prothero JD, Thornton CA, Pickard KM, Di Sabatino A, Goggin PM, Pender SL, MacDonald TT(2009). CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-alpha and MMP-3 production in patients with inflammatory bowel disease. J CROHNS COLITIS vol. 3, (3) 175-182.
10.1016/j.crohns.2009.03.001
Caruso R, Botti E, Sarra M, Esposito M, Stolfi C, Diluvio L, Giustizieri ML, Pacciani V et al.(2009). Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. NAT MED vol. 15, (9) 1013-1015.
10.1038/nm.1995
Di Sabatino A, Saarialho-Kere U, Buckley MG, Gordon JN, Biancheri P, Rovedatti L, Corazza GR, Macdonald TT et al.(2009). Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohn's disease patients treated with infliximab. Eur J Gastroenterol Hepatol vol. 21, (9) 1049-1055.
10.1097/MEG.0b013e3283293d0f
Di Sabatino A, Rovedatti L, Kaur R, Spencer JP, Brown JT, Morisset VD, Biancheri P, Leakey NAB et al.(2009). Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease. J Immunol vol. 183, (5) 3454-3462.
10.4049/jimmunol.0802887
MacDonald TT, Vossenkamper A, Di Sabatino A(2009). Antigen presenting cells and T cell interactions in the gastrointestinal tract. Mol Nutr Food Res vol. 53, (8) 947-951.
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Monteleone G, Pallone F, Macdonald TT(2009). Interleukin-21 as a new therapeutic target for immune-mediated diseases. TRENDS PHARMACOL SCI vol. 30, (8) 441-447.
10.1016/j.tips.2009.05.006
Caruso R, Sarra M, Stolfi C, Rio A, Fina D, Fantini MC, Pallone F, MacDonald TT et al.(2009). Interleukin-25 Inhibits Interleukin-12 Production and Th1 Cell-Driven Inflammation in the Gut. GASTROENTEROLOGY vol. 136, (7) 2270-2279.
10.1053/j.gastro.2009.02.049
Di Sabatino A, Jackson CL, Pickard KM, Buckley M, Rovedatti L, Leakey NAB, Picariello L, Cazzola P et al.(2009). Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures. Gut vol. 58, (6) 777-789.
10.1136/gut.2008.149096
Di Sabatino A, Rovedatti L, Rosado MM, Carsetti R, Corazza GR, MacDonald TT(2009). Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin alpha4beta7-positive T cells in blood. Hum Pathol vol. 40, (5) 699-704.
10.1016/j.humpath.2008.10.014
Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G(2009). Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3. Blood vol. 113, (15) 3512-3519.
10.1182/blood-2008-08-172767
Monteleone G, Pallone F, Macdonald TT(2009). Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease. CYTOKINE GROWTH F R vol. 20, (2) 185-191.
10.1016/j.cytogfr.2009.02.002
Fantini MC, Rizzo A, Fina D, Caruso R, Sarra M, Stolfi C, Becker C, Macdonald TT et al.(2009). Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology vol. 136, (4) 1308-e3.
10.1053/j.gastro.2008.12.053
Chuang S-L, Hayes PJ, Ogundipe E, Haddad M, MacDonald TT, Fell JM(2009). Cow's milk protein-specific T-helper type I/II cytokine responses in infants with necrotizing enterocolitis. Pediatr Allergy Immunol vol. 20, (1) 45-52.
10.1111/j.1399-3038.2008.00729.x
Hemrajani C, Marches O, Wiles S, Girard F, Dennis A, Dziva F, Best A, Phillips AD et al.(2008). Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut. Infect Immun vol. 76, (11) 4804-4813.
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Monteleone G, Boirivant M, Pallone F, MacDonald TT (2008). TGF-beta1 and Smad7 in the regulation of IBD. Mucosal Immunol. vol. 1 Suppl 1, S50-S53.
10.1038/mi.2008.55
Dennis A, Kudo T, Kruidenier L, Girard F, Crepin VF, MacDonald TT, Frankel G, Wiles S(2008). The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium. Infect Immun vol. 76, (11) 4978-4988.
10.1128/IAI.00736-08
Fina D, Pallone F, Macdonald TT, Monteleone G(2008). Role of neutrophil recruitment in the amelioration of experimental colitis by genetic ablation of interleukin-21 - Reply. GASTROENTEROLOGY vol. 135, (4) 1426-1427.
10.1053/j.gastro.2008.08.026
Di Sabatino A, Miceli E, Dhaliwal W, Biancheri P, Salerno R, Cantoro L, Vanoli A, De Vincenzi M et al.(2008). Distribution, proliferation, and function of Paneth cells in uncomplicated and complicated adult celiac disease. Am J Clin Pathol vol. 130, (1) 34-42.
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Fina D, Sarra M, Caruso R, Del Vecchio Blanco G, Pallone F, MacDonald TT, Monteleone G(2008). Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease. Gut vol. 57, (7) 887-892.
10.1136/gut.2007.129882
MacDonald TT(2008). The gut is still the biggest lymphoid organ in the body. MUCOSAL IMMUNOL vol. 1, (4) 246-247.
10.1038/mi.2008.17
Monteleone G, Pallone F, MacDonald TT(2008). Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses. Trends Immunol vol. 29, (6) 290-294.
10.1016/j.it.2008.02.008
Di Sabatino A, Pickard KM, Rampton D, Kruidenier L, Rovedatti L, Leakey NAB, Corazza GR, Monteleone G et al.(2008). Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa. Gut vol. 57, (5) 605-612.
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Caprioli F, Sarra M, Caruso R, Stolfi C, Fina D, Sica G, MacDonald TT, Pallone F et al.(2008). Autocrine regulation of interleukin-21 production in human peripheral blood and intestinal T lymphocytes. GASTROENTEROLOGY vol. 134, (4) A2-A2.
Di Sabatino A, Rovedatti L, Biancheri P, Rosado M, Cantoro L, Carsetti R, Corazza GR, MacDonald TT(2008). Mucosal addressin cell adhesion molecule-1 in celiac disease. GASTROENTEROLOGY vol. 134, (4) A519-A519.
Fina D, Sarra M, Fantini MC, Rizzo A, Caruso R, Caprioli F, Stolfi C, Cardolini I et al.(2008). Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology vol. 134, (4) 1038-1048.
10.1053/j.gastro.2008.01.041
Fantini MC, Rizzo A, Fina D, Sarra M, Caruso R, Becker C, Pallone F, Macdonald TT et al.(2008). T cell-specific Smad7 over-expression reduces regulatory T cell-mediated control of colitis. GASTROENTEROLOGY vol. 134, (4) A72-A73.
Fantini MC, Monteleone G, MacDonald TT(2008). IL-21 comes of age as a regulator of effector T cells in the gut. Mucosal Immunol vol. 1, (2) 110-115.
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Caprioli F, Sarra M, Caruso R, Stolfi C, Fina D, Sica G, MacDonald TT, Pallone F et al.(2008). Autocrine regulation of IL-21 production in human T lymphocytes. J Immunol vol. 180, (3) 1800-1807.
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Caruso R, Fina D, Paoluzi OA, Del Vecchio Blanco G, Stolfi C, Rizzo A, Caprioli F, Sarra M et al.(2008). IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa. Eur J Immunol vol. 38, (2) 470-478.
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Gordon JN, Pickard KM, Di Sabatino A, Prothero JD, Pender SLF, Goggin PM, MacDonald TT (2008). Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease. Inflamm Bowel Dis. vol. 14, 195-203.
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Gordon JN, Pickard KM, Di Sabatino A, Prothero JD, Pender SL, Goggin PM, MacDonald T(2008). Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease. Inflamm Bowel Dis vol. 14, (2) 195-203.
10.1002/ibd.20302
Blumberg RS, MacDonald TT(2008). Mucosal immunology: a frontier no longer. MUCOSAL IMMUNOL vol. 1, (1) 3-3.
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Sengupta N, MacDonald TT(2007). The role of matrix metalloproteinases in stromal/epithelial interactions in the gut. Physiology (Bethesda) vol. 22, 401-409.
10.1152/physiol.00027.2007
Fantini MC, Rizzo A, Fina D, Caruso R, Becker C, Neurath MF, Macdonald TT, Pallone F et al.(2007). IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells. Eur J Immunol vol. 37, (11) 3155-3163.
10.1002/eji.200737766
Fantini MC, Monteleone G, Macdonald TT(2007). New players in the cytokine orchestra of inflammatory bowel disease. Inflamm Bowel Dis vol. 13, (11) 1419-1423.
10.1002/ibd.20212
Macdonald TT, Domizio P(2007). Autistic enterocolitis: is it a histopathological entity?. Histopathology vol. 51, (4) 552-553.
10.1111/j.1365-2559.2007.02805.x
Di Sabatino A, Pickard KM, Gordon JN, Salvati V, Mazzarella G, Beattie RM, Vossenkaemper A, Rovedatti L et al.(2007). Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease. Gastroenterology vol. 133, (4) 1175-1187.
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https://qmro.qmul.ac.uk/xmlui/handle/123456789/2040
Di Sabatino A, Pender SLF, Jackson CL, Prothero JD, Gordon JN, Picariello L, Rovedatti L, Docena G et al.(2007). Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies. Gastroenterology vol. 133, (1) 137-149.
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Caruso R, Fina D, Peluso I, Fantini MC, Tosti C, Del Vecchio Blanco G, Paoluzi OA, Caprioli F et al.(2007). IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J Immunol vol. 178, (9) 5957-5965.
10.4049/jimmunol.178.9.5957
Lottaz D, Buri C, Monteleone G, Rösmann S, Macdonald TT, Sanderson IR, Sterchi EE(2007). Compartmentalised expression of meprin in small intestinal mucosa: enhanced expression in lamina propria in coeliac disease. Biol Chem vol. 388, (3) 337-341.
10.1515/BC.2007.038
MacDonald TT, Domizio P(2007). Autistic enterocolitis; is it a histopathological entity?. Histopathology vol. 50, (3) 371-379.
10.1111/j.1365-2559.2007.02606.x
Peluso I, Fantini MC, Fina D, Caruso R, Boirivant M, MacDonald TT, Pallone F, Monteleone G(2007). IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes. J Immunol vol. 178, (2) 732-739.
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Caruso R, Fina D, Peluso I, Stolfi C, Fantini MC, Gioia V, Caprioli F, Del Vecchio Blanco G et al.(2007). A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. Gastroenterology vol. 132, (1) 166-175.
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Monteleone G, Caruso R, Fina D, Peluso I, Gioia V, Stolfi C, Fantini MC, Caprioli F et al.(2006). Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut vol. 55, (12) 1774-1780.
10.1136/gut.2006.093187
Boirivant M, Pallone F, Di Giacinto C, Fina D, Monteleone I, Marinaro M, Caruso R, Colantoni A et al.(2006). Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis. Gastroenterology vol. 131, (6) 1786-1798.
10.1053/j.gastro.2006.09.016
Wiles S, Pickard KM, Peng K, MacDonald TT, Frankel G(2006). In vivo bioluminescence imaging of the murine pathogen Citrobacter rodentium. Infect Immun vol. 74, (9) 5391-5396.
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Pender SLF, Li CKF, Di Sabatino A, MacDonald TT, Buckley MG (2006). Role of macrophage metalloelastase in gut inflammation. Ann N Y Acad Sci. vol. 1072, 386-388.
10.1196/annals.1326.019
Caruso R, Pallone F, Fina D, Gioia V, Peluso I, Caprioli F, Stolfi C, Perfetti A et al.(2006). Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation. Am J Pathol vol. 169, (1) 268-278.
10.2353/ajpath.2006.050841
MacDonald TT, Di Sabatino A(2006). The exposure of infants to Lactobacillus rhamnosus GG in Finland. J Pediatr Gastroenterol Nutr vol. 42, (5) 476-478.
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MacDonald TT(2006). The significance of ileocolonic lymphoid nodular hyperplasia in children with autistic spectrum disorder. Eur J Gastroenterol Hepatol vol. 18, (5) 569-571.
10.1097/00042737-200605000-00023
Fina D, Peluso I, Caruso R, Valentina G, Stolfi C, MacDonald TT, Pallone F, Monteleone G (2006). Regulation of matrix metalloproteinases synthesis by interleukin-21 in human intestinal fibroblasts. INFLAMMATORY BOWEL DISEASES. vol. 12, S24-S24.
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MacDonald TT(2006). Decoy receptor springs to life and eases fibrosis. Nat Med vol. 12, (1) 13-14.
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Kruidenier L, MacDonald TT, Collins JE, Pender SLF, Sanderson IR(2006). Myofibroblast matrix metalloproteinases activate the neutrophil chemoattractant CXCL7 from intestinal epithelial cells. Gastroenterology vol. 130, (1) 127-136.
10.1053/j.gastro.2005.09.032
MacDonald TT, Monteleone G(2006). Overview of role of the immune system in the pathogenesis of inflammatory bowel disease. Adv Exp Med Biol vol. 579, 98-107.
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Mundy R, MacDonald TT, Dougan G, Frankel G, Wiles S(2005). Citrobacter rodentium of mice and man. Cell Microbiol vol. 7, (12) 1697-1706.
10.1111/j.1462-5822.2005.00625.x
Monteleone G, Del Vecchio Blanco G, Monteleone I, Fina D, Caruso R, Gioia V, Ballerini S, Federici G et al.(2005). Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease. Gastroenterology vol. 129, (5) 1420-1429.
10.1053/j.gastro.2005.09.005
MacDonald TT, Gordon JN(2005). Bacterial regulation of intestinal immune responses. Gastroenterol Clin North Am vol. 34, (3) 401-viii.
10.1016/j.gtc.2005.05.012
Prasad S, Mingrino R, Kaukinen K, Hayes KL, Powell RM, MacDonald TT, Collins JE(2005). Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Lab Invest vol. 85, (9) 1139-1162.
10.1038/labinvest.3700316
Gordon JN, MacDonald TT(2005). Osteopontin: a new addition to the constellation of cytokines which drive T helper cell type 1 responses in Crohn's disease. GUT vol. 54, (9) 1213-1215.
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Pender SL-F, Chance V, Whiting CV, Buckley M, Edwards M, Pettipher R, MacDonald TT(2005). Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model. Gut vol. 54, (8) 1114-1120.
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MacDonald TT, Di Sabatino A, Gordon JN(2005). Immunopathogenesis of Crohn's disease. JPEN J Parenter Enteral Nutr vol. 29, (4 Suppl) S118-S124.
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Gordon JN, Di Sabatino A, Macdonald TT(2005). The pathophysiologic rationale for biological therapies in inflammatory bowel disease. Curr Opin Gastroenterol vol. 21, (4) 431-437.
Brittan M, Chance V, Elia G, Poulsom R, Alison MR, MacDonald TT, Wright NA(2005). A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts. Gastroenterology vol. 128, (7) 1984-1995.
10.1053/j.gastro.2005.03.028
Gunther U, Holloway JA, Gordon JN, Knight A, Chance V, Hanley NA, Wilson DI, French R et al.(2005). Phenotypic characterization of CD3-7+ cells in developing human intestine and an analysis of their ability to differentiate into T cells. J Immunol vol. 174, (9) 5414-5422.
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Macdonald TT, Monteleone G(2005). Immunity, inflammation, and allergy in the gut. Science vol. 307, (5717) 1920-1925.
10.1126/science.1106442
Monteleone G, Monteleone I, Fina D, Vavassori P, Del Vecchio Blanco G, Caruso R, Tersigni R, Alessandroni L et al.(2005). Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology vol. 128, (3) 687-694.
10.1053/j.gastro.2004.12.042
Pender SLF, MacDonald TT(2004). Matrix metalloproteinases and the gut - new roles for old enzymes. Curr Opin Pharmacol vol. 4, (6) 546-550.
10.1016/j.coph.2004.06.005
Salmela MT, Pender SLF, Karjalainen-Lindsberg M-L, Puolakkainen P, Macdonald TT, Saarialho-Kere U(2004). Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing. Scand J Gastroenterol vol. 39, (11) 1095-1104.
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Li CKF, Pender SLF, Pickard KM, Chance V, Holloway JA, Huett A, Gonçalves NS, Mudgett JS et al.(2004). Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice. J Immunol vol. 173, (8) 5171-5179.
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Monteleone G, Pallone F, MacDonald TT(2004). Smad7 in TGF-beta-mediated negative regulation of gut inflammation. Trends Immunol vol. 25, (10) 513-517.
10.1016/j.it.2004.07.008
Pender SLF, Croucher PJP, Mascheretti S, Prothero JD, Fisher SA, MacDonald TT, Schreiber S, Ye S(2004). Transmission disequilibrium test of stromelysin-1 gene variation in relation to Crohn's disease. J Med Genet vol. 41, (9)
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Monteleone I, Monteleone G, Del Vecchio Blanco G, Vavassori P, Cucchiara S, MacDonald TT, Pallone F(2004). Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa. Gut vol. 53, (8) 1090-1095.
10.1136/gut.2003.030551
Pickard KM, Bremner AR, Gordon JN, MacDonald TT(2004). Immune responses. BEST PRACT RES CL GA vol. 18, (2) 271-285.
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Pickard KM, Bremner AR, Gordon JN, MacDonald TT(2004). Microbial-gut interactions in health and disease. Immune responses. Best Pract Res Clin Gastroenterol vol. 18, (2) 271-285.
10.1016/j.bpg.2003.10.009
Monteleone G, Del Vecchio Blanco G, Palmieri G, Vavassori P, Monteleone I, Colantoni A, Battista S, Spagnoli LG et al.(2004). Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection. Gastroenterology vol. 126, (3) 674-682.
10.1053/j.gastro.2003.11.048
Mimura T, Bateman AC, Lee RL, Johnson PA, MacDonald TT, Pender SLF, McDonald PJ, Talbot IC et al.(2004). Up-regulation of collagen and tissue inhibitors of matrix metalloproteinase in colonic diverticular disease - Reply. DIS COLON RECTUM vol. 47, (3) 379-379.
Mimura T, Bateman AC, Lee RL, Johnson PA, McDonald PJ, Talbot IC, Kamm MA, MacDonald TT et al. (2004). Up-regulation of collagen and tissue inhibitors of matrix metalloproteinase in colonic diverticular disease. Dis Colon Rectum. vol. 47, 371-378.
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Monteleone G, Mann J, Monteleone I, Vavassori P, Bremner R, Fantini M, Del Vecchio Blanco G, Tersigni R et al.(2004). A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation. J Biol Chem vol. 279, (6) 3925-3932.
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MacDonald TT, Monteleone G (2004). The Smad signalling pathway in Crohn's disease and ulcerative colitis. MECHANISMS OF INTESTINAL INFLAMMATION: IMPLICATIONS FOR THERAPEUTIC INTERVENTION IN IBD. Editors: Duchmann, R, Blumberg, RS, Neurath, MF, Scholmerich, J et al., vol. 133, 133-136.
Macdonald TT(2003). A mouse model of intestinal fibrosis?. Gastroenterology vol. 125, (6) 1889-1892.
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Gordon JN, MacDonald TT(2003). Biological therapy in Crohn's disease. Hosp Med vol. 64, (12) 708-712.
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Simmons CP, Clare S, Ghaem-Maghami M, Uren TK, Rankin J, Huett A, Goldin R, Lewis DJ et al.(2003). Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium. Infect Immun vol. 71, (9) 5077-5086.
10.1128/iai.71.9.5077-5086.2003
Salvati VM, MacDonald TT, del Vecchio Blanco G, Mazzarella G, Monteleone I, Vavassori P, Auricchio S, Pallone F et al.(2003). Enhanced expression of interferon regulatory factor-1 in the mucosa of children with celiac disease. Pediatr Res vol. 54, (3) 312-318.
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Pender SLF, Braegger C, Gunther U, Monteleone G, Meuli M, Schuppan D, Macdonald TT(2003). Matrix metalloproteinases in necrotising enterocolitis. Pediatr Res vol. 54, (2) 160-164.
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Mazzarella G, MacDonald TT, Salvati VM, Mulligan P, Pasquale L, Stefanile R, Lionetti P, Auricchio S et al.(2003). Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions. Am J Pathol vol. 162, (6) 1845-1855.
10.1016/S0002-9440(10)64319-2
Veitch AM, Higgins LM, Bajaj-Elliot M, Farthing MJG, MacDonald TT(2003). Impaired rejection and mucosal injury of small intestinal allografts lacking the interferon-gamma receptor. Int J Exp Pathol vol. 84, (3) 107-113.
10.1046/j.1365-2613.2003.00342.x
Gonçalves NS, Hale C, Dougan G, Frankel G, MacDonald TT(2003). Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences. Infect Immun vol. 71, (5) 2960-2965.
10.1128/iai.71.5.2960-2965.2003
Hauer AC, Riederer M, Griessl A, Rosegger H, MacDonald TT(2003). Cytokine production by cord blood mononuclear cells stimulated with cows milk proteins in vitro: interleukin-4 and transforming growth factor beta-secreting cells detected in the CD45RO T cell population in children of atopic mothers. Clin Exp Allergy vol. 33, (5) 615-623.
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MacDonald TT(2003). The mucosal immune system. Parasite Immunol vol. 25, (5) 235-246.
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MacDonald TT, Frankel G, Dougan G, Goncalves NS, Simmons C(2003). Host defences to Citrobacter rodentium. Int J Med Microbiol vol. 293, (1) 87-93.
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Monteleone G, Holloway J, Salvati VM, Pender SL-F, Fairclough PD, Croft N, MacDonald TT(2003). Activated STAT4 and a functional role for IL-12 in human Peyer's patches. J Immunol vol. 170, (1) 300-307.
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MacDonald TT, Mazzarella G, Salvati VM, Mulligan P, Pasquale L, Stefanile R, Lionetti P, Troncone R et al. (2003). Signal transducer and activator of transcription 1 (STAT1) and suppressor of cytokine signalling 1 (SOCS1) in coeliac disease. Coeliac Disease. Editors: CerfBensussan, N, Brousse, N, CaillatZucman, S, Cellier, C et al., 89-96.
Salmela MT, MacDonald TT, Black D, Irvine B, Zhuma T, Saarialho-Kere U, Pender SLF(2002). Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation. Gut vol. 51, (4) 540-547.
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MacDonald TT(2002). Suppressor T cells, rebranded as regulatory T cells, emerge from the wilderness bearing surface markers. Gut vol. 51, (3) 311-312.
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MacDonald TT (2002). The biochemical basis of immune enteropathy. J Pediatr Gastroenterol Nutr. vol. 34 Suppl 1, S27-S30.
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Monteleone G, MacDonald TT, Salvati VM, Mulligan P, Pasquale L, Stefanile R, Lionetti P, Troncone R et al.(2002). Activation of signal transducer and activator of transcription 1 in celiac disease. GASTROENTEROLOGY vol. 122, (4) A386-A386.
Li CKF, Goncalves NS, Bachler M, Chance V, Mudgett J, Dougan G, Frankel G, Pender SLF et al.(2002). Critical role of stromelysin-1 (MMP-3) in mucosal T cell responses during Citrobacter rodentium infection in mice. GASTROENTEROLOGY vol. 122, (4) A272-A272.
Chance V, Goncalves NS, Li CKF, Frankel G, Dougan G, Pender SLF, MacDonald TT(2002). Matrix metalloproteinases in Citrobacter rodentium infected TNF receptor (p55) knockout mice. GASTROENTEROLOGY vol. 122, (4) A273-A273.
Simmons CP, Goncalves NS, Ghaem-Maghami M, Bajaj-Elliott M, Clare S, Neves B, Frankel G, Dougan G et al.(2002). Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma. J Immunol vol. 168, (4) 1804-1812.
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Salvati VM, MacDonald TT, Bajaj-Elliott M, Borrelli M, Staiano A, Auricchio S, Troncone R, Monteleone G(2002). Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease. Gut vol. 50, (2) 186-190.
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Gonçalves NS, Ghaem-Maghami M, Monteleone G, Frankel G, Dougan G, Lewis DJ, Simmons CP, MacDonald TT(2001). Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis. Infect Immun vol. 69, (11) 6651-6659.
10.1128/IAI.69.11.6651-6659.2001
Shaida A, Kenyon G, Devalia J, Davies RJ, MacDonald TT, Pender SL(2001). Matrix metalloproteinases and their inhibitors in the nasal mucosa of patients with perennial allergic rhinitis. J Allergy Clin Immunol vol. 108, (5) 791-796.
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Monteleone G, Kumberova A, Croft NM, McKenzie C, Steer HW, MacDonald TT(2001). Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J Clin Invest vol. 108, (4) 601-609.
10.1172/JCI12821
Jones CA, Vance GH, Power LL, Pender SL, Macdonald TT, Warner JO(2001). Costimulatory molecules in the developing human gastrointestinal tract: a pathway for fetal allergen priming. J Allergy Clin Immunol vol. 108, (2) 235-241.
10.1067/mai.2001.117178
Monteleone G, Pender SL, Wathen NC, MacDonald TT(2001). Interferon-alpha drives T cell-mediated immunopathology in the intestine. Eur J Immunol vol. 31, (8) 2247-2255.
10.1002/1521-4141(200108)31:8<2247::AID-IMMU2247>3.0.CO;2-4
Salvati VM, Bajaj-Elliott M, Poulsom R, Mazzarella G, Lundin KE, Nilsen EM, Troncone R, MacDonald TT(2001). Keratinocyte growth factor and coeliac disease. Gut vol. 49, (2) 176-181.
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MacDonald TT, Monteleone G(2001). IL-12 and Th1 immune responses in human Peyer's patches. Trends Immunol vol. 22, (5) 244-247.
10.1016/S1471-4906(01)01892-0
Veitch AM, Kelly P, Zulu I, MacDonald TT, Farthing MJ(2001). Lack of evidence for small intestinal mucosal T-cell activation as a pathogenic mechanism in African HIV-associated enteropathy. Dig Dis Sci vol. 46, (5) 1133-1138.
10.1023/A:1010738818127
Salmela MT, Pender SLF, Reunala T, MacDonald T, Saarialho-Kere U(2001). Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis. GUT vol. 48, (4) 496-502.
10.1136/gut.48.4.496
Monteleone G, Pender SLF, Alstead E, Hauer AC, Lionetti P, McKenzie C, MacDonald TT(2001). Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease (vol 48, pg 425, 2001). GUT vol. 48, (4) 584-584.
Goncalves N, Simmons CP, Ghaem-Maghami M, Monteleone G, Frankel G, Dougan G, MacDonald TT(2001). Increased susceptibility of TNFRp55 deficient mice to Citrobacter rodentium (mouse EPEC) infection. GUT vol. 48, A75-A75.
Monteleone G, Pender SL, Alstead E, Hauer AC, Lionetti P, McKenzie C, MacDonald TT(2001). Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease. Gut vol. 48, (3) 425-429.
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MacDonald TT, Nagata S, Fairclough PD, McKenzie C (2001). Mucosal immunity - A key to tolerance. NEW CONCEPTS IN PATHOLOGY AND TREATMENT OF AUTOIMMUNE DISORDERS. Editors: Pozzilli, C, Pozzilli, P, Kapp, JF, 89-99.
MacDonald TT (2001). Targets for inflammatory bowel disease - biological therapy. IBD AND SALICYLATES - 5. Editors: Modigliani, R, vol. 24, 61-65.
Macdonald TT(2001). The worm turns on Helicobacter pylori. Gut vol. 48, (1) 10-11.
10.1136/gut.48.1.10
Fell JME, Paintin M, Donnet-Hughes A, Arnaud-Battandier F, MacDonald TT, Walker-Smith JA (1999). Remission induced by a new specific oral polymeric diet in children with Crohn's disease. INFLAMMATORY BOWEL DISEASES. Editors: Bistrian, BR, WalkerSmith, JA, vol. 2, 187-198.
10.1159/000061787
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