Menu
 
Research menu
Jump to menu

Publications:  Prof Charles Knowles

Vollebregt PF, Hooper RL, Farmer AD, Miller J, Knowles CH, Scott SM(2020). Association between opioid usage and rectal dysfunction in constipation: A cross-sectional study of 2754 patients. Neurogastroenterology and Motility vol. 32, (7)
10.1111/nmo.13839
Dibley L, Hart A, Duncan J, Knowles CH, Kerry S, Lanz D, Madurasinghe VW, Wade T et al.(2020). Clinician Administered and Self-Report Survey Both Effective for Identifying Fecal Incontinence in Patients with Inflammatory Bowel Disease. Dig Dis Sci
10.1007/s10620-020-06418-9
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65330
El-Dhuwaib Y, Pandyan A, Knowles CH(2020). Epidemiological trends in surgery for rectal prolapse in England 2001-2012: an adult hospital population-based study. Colorectal Dis
10.1111/codi.15094
Cibert-Goton V, Kung VWS, McGuire C, Hockley JRF, Tranter MM, Dogra H, Belai A, Blackshaw LA et al.(2020). Functional and anatomical deficits in visceral nociception with age: a mechanism of silent appendicitis in the elderly?. Pain vol. 161, (4) 773-786.
10.1097/j.pain.0000000000001764
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65664
Lehur PA, Sørensen M, Dudding TC, Knowles CH, de Wachter S, Engelberg S, Matzel KE, European SNM Expert Group(2020). Programming Algorithms for Sacral Neuromodulation: Clinical Practice and Evidence-Recommendations for Day-to-Day Practice. Neuromodulation
10.1111/ner.13117
Vollebregt PF, Wiklendt L, Ang D, Dinning PG, Knowles CH, Scott SM (2020). Altered slow-wave pressure activity in low anterior resection syndrome: New mechanistic insight into pathophysiology?. NEUROGASTROENTEROLOGY AND MOTILITY. vol. 32,
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64762
Burgell RE, Vollebregt PF, Hooper RL, Knowles CH, Scott SM (2020). Clinical impact of rectal hyposensitivity: A cross-sectional study of 2876 patients with functional constipation. NEUROGASTROENTEROLOGY AND MOTILITY. vol. 32,
Vollebregt PF, Wiklendt L, Dinning PG, Knowles CH, Scott SM (2020). Coexistence of faecal incontinence with constipation: An underappreciated clinical problem in adults. A phenotyping study of 4027 patients.
De Wachter S, Knowles CH, Elterman DS, Kennelly MJ, Lehur PA, Matzel KE, Engelberg S, Van Kerrebroeck PEV(2020). New Technologies and Applications in Sacral Neuromodulation: An Update. Adv Ther vol. 37, (2) 637-643.
10.1007/s12325-019-01205-z
Chaichanavichkij P, Vollebregt PF, Scott SM, Knowles CH(2020). Botulinum toxin type A for the treatment of dyssynergic defaecation in adults: a systematic review. Colorectal Disease
10.1111/codi.15120
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65299
Carrington EV, Heinrich H, Knowles CH, Fox M, Rao S, Altomare DF, Bharucha AE, Burgell R et al.(2020). The international anorectal physiology working group (IAPWG) recommendations: Standardized testing protocol and the London classification for disorders of anorectal function. Neurogastroenterol Motil vol. 32, (1)
10.1111/nmo.13679
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59780
Haddow JB, Musbahi O, MacDonald TT, Knowles CH(2019). Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn's disease-related perianal fistula. World J Gastrointest Pathophysiol vol. 10, (4) 42-53.
10.4291/wjgp.v10.i4.42
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64573
Grossi U, Mercer-Jones M, Di Tanna GL, Knowles CH(2019). Recalled stapler device, high complication rate, non validated scoring system and misquote from the STARR surgeons. Techniques in Coloproctology vol. 23, (10) 1017-1018.
10.1007/s10151-019-02068-w
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64390
Knowles CH(2019). Quality evidence on interventions for faecal incontinence. Lancet Gastroenterol Hepatol vol. 4, (9) 659-660.
10.1016/S2468-1253(19)30225-0
Grossi U, Di Tanna GL, Heinrich H, Taylor SA, Knowles CH, Scott SM(2019). Letter: limitations of defecography among patients with refractory constipation. Authors' reply. Alimentary Pharmacology and Therapeutics vol. 50, (1) 112-113.
10.1111/apt.15309
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59316
Yiannakou Y, Etherson K, Close H, Kasim A, Mercer-Jones M, Plusa S, Maier R, Green S et al.(2019). A randomized double-blinded sham-controlled cross-over trial of tined-lead sacral nerve stimulation testing for chronic constipation. European Journal of Gastroenterology and Hepatology vol. 31, (6) 653-660.
10.1097/MEG.0000000000001379
Carrington EV, Knowles CH, Grossi U, Scott SM(2019). High-resolution Anorectal Manometry Measures Are More Accurate Than Conventional Measures in Detecting Anal Hypocontractility in Women With Fecal Incontinence. Clinical Gastroenterology and Hepatology vol. 17, (3) 477-485.e9.
10.1016/j.cgh.2018.06.037
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56271
Hooper R, Knowles C(2019). Improving the efficiency of individually randomized clinical trials by staggering the introduction of the intervention. Statistics in Medicine vol. 38, (1) 44-52.
10.1002/sim.7959
https://qmro.qmul.ac.uk/xmlui/handle/123456789/47463
VOLLEBREGT PF, RASIJEFF AMP, pares D, GROSSI U, CARRINGTON EV, KNOWLES CH, scott, SCOTT SM(2019). Functional anal canal length measurement using high‐resolution anorectal manometry to investigate anal sphincter dysfunction in patients with fecal incontinence or constipation. Neurogastroenterology and Motility
10.1111/nmo.13532
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54824
Grossi U, Di Tanna GL, Heinrich H, Taylor SA, Knowles CH, Scott SM(2018). Systematic review with meta-analysis: defecography should be a first-line diagnostic modality in patients with refractory constipation. Alimentary Pharmacology and Therapeutics vol. 48, (11-12) 1186-1201.
10.1111/apt.15039
https://qmro.qmul.ac.uk/xmlui/handle/123456789/52204
Knowles CH(2018). Human studies of anorectal sensory function. Ir J Med Sci vol. 187, (4) 1143-1147.
10.1007/s11845-018-1847-5
https://qmro.qmul.ac.uk/xmlui/handle/123456789/57003
Bhangu A, Minaya-Bravo AM, Gallo G, Glasbey JC, Kamarajah S, Pinkney T, El-Hussuna A, Battersby NJ et al.(2018). An international multicentre prospective audit of elective rectal cancer surgery; operative approach versus outcome, including transanal total mesorectal excision (TaTME). Colorectal Disease vol. 20, (S6) 33-46.
10.1111/codi.14376
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56928
Battersby N, Glasbey JC, Neary P, Negoi I, Kamarajah S, Sgro A, Bhangu A, Pinkney T et al.(2018). Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery. Colorectal Disease vol. 20, (S6) 58-68.
10.1111/codi.14361
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58099
Sánchez-Guillén L, Nepogodiev D, Sivrikoz E, van Elst T, Minaya A, Pata F, Glasbey J, Pinkney T et al.(2018). Safety of primary anastomosis following emergency left sided colorectal resection: an international, multi-centre prospective audit. Colorectal Disease vol. 20, 47-57.
10.1111/codi.14373
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56927
SANGER GJ, BROAD J, KUNG V, Palmer A, ELAHI S, Karami A, Darreh-Shori T, Ahmed S et al.(2018). Changes in neuromuscular structure and functions of human colon during ageing are region-dependent. Gut
10.1136/gutjnl-2018-316279
https://qmro.qmul.ac.uk/xmlui/handle/123456789/44826
Glasbey JC, Blanco-Colino R, Kelly M, Singh B, Bhangu A, Pinkney T, Poskus T, El-Hussuna A et al.(2018). Association of mechanical bowel preparation with oral antibiotics and anastomotic leak following left sided colorectal resection: an international, multi-centre, prospective audit. Colorectal Disease vol. 20, 15-32.
10.1111/codi.14362
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56916
van der Pool A, Rawlings A, Sánchez-Guillén L, Kuiper S, Negoi I, Buchs N, El-Hussuna A, Battersby NJ et al.(2018). The impact of conversion on the risk of major complication following laparoscopic colonic surgery: an international, multicentre prospective audit. Colorectal Disease vol. 20, 69-89.
10.1111/codi.14371
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56924
McAlees E, Vollebregt PF, Stevens N, Dudding TC, Emmanuel AV, Furlong PL, Hamdy S, Hooper RL et al.(2018). Efficacy and mechanism of sub-sensory sacral (optimised) neuromodulation in adults with faecal incontinence: Study protocol for a randomised controlled trial. Trials vol. 19, (1)
10.1186/s13063-018-2689-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55612
Thapar N, Saliakellis E, Benninga MA, Borrelli O, Curry J, Faure C, De Giorgio R, Gupte G et al.(2018). Paediatric Intestinal Pseudo-obstruction: Evidence and Consensus-based Recommendations From an ESPGHAN-Led Expert Group. J Pediatr Gastroenterol Nutr vol. 66, (6) 991-1019.
10.1097/MPG.0000000000001982
Leventi A, Clifford TFJ, Arnold A, Knowles CH, Martin JE(2018). A case of sigmoid volvulus. Gut
10.1136/gutjnl-2017-315465
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32030
Grossi U, Stevens N, McAlees E, Lacy-Colson J, Brown S, Dixon A, Di Tanna GL, Scott SM et al.(2018). Stepped-wedge randomised trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation: study protocol for a randomized controlled trial. Trials vol. 19, (1) 90-90.
10.1186/s13063-018-2456-3
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36527
Horrocks EJ, Chadi SA, Stevens NJ, Wexner SD, Knowles CH(2017). Factors Associated With Efficacy of Percutaneous Tibial Nerve Stimulation for Fecal Incontinence, Based on Post-Hoc Analysis of Data From a Randomized Trial. Clin Gastroenterol Hepatol vol. 15, (12) 1915-1921.e2.
10.1016/j.cgh.2017.06.032
https://qmro.qmul.ac.uk/xmlui/handle/123456789/26843
Matzel KE, Chartier-Kastler E, Knowles CH, Lehur PA, Muñoz-Duyos A, Ratto C, Rydningen MB, Sørensen M et al.(2017). Sacral Neuromodulation: Standardized Electrode Placement Technique. Neuromodulation vol. 20, (8) 816-824.
10.1111/ner.12695
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29623
KNOWLES CH(2017). Surgery for constipation: systematic review and practice recommendations: Results V: Sacral Nerve Stimulation. Colorectal Disease vol. 19, 92-100.
10.1111/codi.13780
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27483
Mercer-Jones MA, Brown SR, Knowles CH, Williams AB(2017). Position Statement by The Pelvic Floor Society on behalf of The Association of Coloproctology of Great Britain and Ireland on the use of mesh in ventral mesh rectopexy (VMR). Colorectal Dis
10.1111/codi.13893
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27423
Knowles CH, Grossi U, Horrocks EJ, Pares D, Vollebregt PF, Chapman M, Brown SR, Mercer-Jones M et al.(2017). Surgery for constipation: systematic review and clinical guidance: Paper 1: Introduction & Methods. Colorectal Dis vol. 19 Suppl 3, 5-16.
10.1111/codi.13774
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27405
Knowles CH, Grossi U, Horrocks EJ, Pares D, Vollebregt PF, Chapman M, Brown S, Mercer-Jones M et al.(2017). Surgery for constipation: systematic review and practice recommendations: Graded practice and future research recommendations. Colorectal Dis vol. 19 Suppl 3, 101-113.
10.1111/codi.13775
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27404
Knowles CH, Grossi U, Chapman M, Mason J, Brown S, Campbell K, Clarke A, Cruickshank N et al.(2017). Surgery for constipation: systematic review and practice recommendations: Results I: Colonic resection. Colorectal Disease vol. 19, 17-36.
10.1111/codi.13779
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27383
Grossi U, Knowles CH, Mason J, Lacy-Colson J, Brown SR, Campbell K, Chapman M, Clarke A et al.(2017). Surgery for constipation: systematic review and practice recommendations: Results II: Hitching procedures for the rectum (rectal suspension). Colorectal Disease vol. 19, 37-48.
10.1111/codi.13773
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27403
Mercer-Jones M, Grossi U, Pares D, Vollebregt PF, Mason J, Knowles CH, NIHR CapaCiTY working group, Pelvic floor Society(2017). Surgery for constipation: systematic review and practice recommendations: Results III: Rectal wall excisional procedures (Rectal Excision). Colorectal Dis vol. 19 Suppl 3, 49-72.
10.1111/codi.13772
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27385
Grossi U, Horrocks EJ, Mason J, Knowles CH, Williams AB, Brown S, Campbell K, Chapman M et al.(2017). Surgery for constipation: systematic review and practice recommendations: Results IV: Recto-vaginal reinforcement procedures. Colorectal Disease vol. 19, 73-91.
10.1111/codi.13781
https://qmro.qmul.ac.uk/xmlui/handle/123456789/27384
Carrington EV, Heinrich H, Knowles CH, Rao SS, Fox M, Scott SM, International Anorectal Physiology Working Party Group (IAPWG)(2017). Methods of anorectal manometry vary widely in clinical practice: Results from an international survey. Neurogastroenterol Motil vol. 29, (8)
10.1111/nmo.13016
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56595
Parés D, Drami I, Adams K, Grossi U, Suliman I, Knowles CH(2017). Use of the Harmonic scalpel for Delorme's procedure. Colorectal Disease vol. 19, (6) O232-O234.
10.1111/codi.13688
Devane LA, Lucking E, Evers J, Buffini M, Scott SM, Knowles CH, O'Connell PR, Jones JFX(2017). Altered defaecatory behaviour and faecal incontinence in a video-tracked animal model of pudendal neuropathy. Colorectal Dis vol. 19, (5) O162-O167.
10.1111/codi.13664
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56039
Hockley JRF, González-Cano R, McMurray S, Tejada-Giraldez MA, McGuire C, Torres A, Wilbrey AL, Cibert-Goton V et al.(2017). Visceral and somatic pain modalities reveal Na<inf>V</inf>1.7-independent visceral nociceptive pathways. Journal of Physiology vol. 595, (8) 2661-2679.
10.1113/JP272837
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19061
Emmett C, Close H, Mason J, Taheri S, Stevens N, Eldridge S, Norton C, Knowles C et al.(2017). Low-volume versus high-volume initiated trans-anal irrigation therapy in adults with chronic constipation: Study protocol for a randomised controlled trial. Trials vol. 18, (1)
10.1186/s13063-017-1882-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22588
Norton C, Emmanuel A, Stevens N, Scott SM, Grossi U, Bannister S, Eldridge S, Mason JM et al.(2017). Habit training versus habit training with direct visual biofeedback in adults with chronic constipation: study protocol for a randomised controlled trial. Trials vol. 18, (1) 139-139.
10.1186/s13063-017-1880-0
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22584
Fikree A, Aktar R, Morris JK, Grahame R, Knowles CH, Aziz Q(2017). The association between Ehlers-Danlos syndrome—hypermobility type and gastrointestinal symptoms in university students: a cross-sectional study. Neurogastroenterology and Motility vol. 29, (3)
10.1111/nmo.12942
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18434
Etherson KJ, Horrocks EJ, Scott SM, Knowles CH, Yiannakou Y(2017). A National Biofeedback Practitioners Service Evaluation: Focus on Chronic Idiopathic Constipation. Frontline Gastroenterol vol. 8, (1) 62-67.
10.1136/flgastro-2015-100660
McGuire C, Boundouki G, Hockley JR, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J et al.(2016). Ex vivo study of human visceral nociceptors. GUT Article 27654583, 1-11.
10.1136/gutjnl-2016-311629
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15894
Stevens N, Knowles C(2016). Risk based survey evidence supports electronic informed consent as a recruitment method for UK clinical trials. Journal of Clinical Epidemiology vol. 77, 134-136.
10.1016/j.jclinepi.2016.05.005
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15982
Jones J, Van de Putte D, De Ridder D, Knowles C, O'Connell R, Nelson D, Goessaert A-S, Everaert K(2016). A Joint Mechanism of Action for Sacral Neuromodulation for Bladder and Bowel Dysfunction?. Urology vol. 97, Article C, 13-19.
10.1016/j.urology.2016.05.032
Townsend DC, Carrington EV, Grossi U, Burgell RE, Wong JYJ, Knowles CH, Scott SM(2016). Pathophysiology of fecal incontinence differs between men and women: a case-matched study in 200 patients. Neurogastroenterology and Motility
10.1111/nmo.12858
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14510
Palit S, Thin N, Knowles CH, Lunniss PJ, Bharucha AE, Scott SM(2016). Diagnostic disagreement between tests of evacuatory function: a prospective study of 100 constipated patients. Neurogastroenterology and Motility
10.1111/nmo.12859
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14530
Rao SSC, Bharucha AE, Chiarioni G, Felt-Bersma R, Knowles C, Malcolm A, Wald A(2016). Anorectal Disorders. Gastroenterology vol. 150, (6) 1430-1442.e4.
10.1053/j.gastro.2016.02.009
Evers J, Devane L, Carrington EV, Scott SM, Knowles CH, O'Connell PR, Jones JFX(2016). Reversal of sensory deficit through sacral neuromodulation in an animal model of fecal incontinence. Neurogastroenterol Motil vol. 28, (5) 665-673.
10.1111/nmo.12762
Devane LA, Evers J, Scott MS, Knowles CH, O'Connell P, Jones JFX(2016). Acute lumbosacral nerve stimulation does not affect anorectal motor function in a rodent model. Neurogastroenterol Motil vol. 28, (3) 358-363.
10.1111/nmo.12733
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11973
Menys A, Butt S, Emmanuel A, Plumb AA, Fikree A, Knowles C, Atkinson D, Zarate N et al.(2016). Comparative quantitative assessment of global small bowel motility using magnetic resonance imaging in chronic intestinal pseudo-obstruction and healthy controls. Neurogastroenterology and Motility vol. 28, (3) 376-383.
10.1111/nmo.12735
Grossi U, Carrington EV, Bharucha AE, Horrocks EJ, Scott SM, Knowles CH(2016). Diagnostic accuracy study of anorectal manometry for diagnosis of dyssynergic defecation. Gut vol. 65, (3) 447-455.
10.1136/gutjnl-2014-308835
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6985
Evers J, Carrington EV, Scott SM, Knowles CH, O'Connell PR, Jones JFX (2016). The effect sacral neuromodulation on anal, perineal and rectal light-touch evoked potentials in the rat. IRISH JOURNAL OF MEDICAL SCIENCE. vol. 185, S93-S94.
Knowles CH, Horrocks EJ, Stevens N, Norton C, Eldridge S(2016). The CONFIDeNT trial - Authors' reply. Lancet vol. 387, (10019) 644-645.
10.1016/S0140-6736(15)01342-2
Knowles CH, Horrocks EJ, Stevens N, Norton C, Eldridge S(2016). The CONFIDeNT trial Reply. LANCET vol. 387, (10019) 644-645.
10.1016/S0140-6736(15)01342-2
Hockley JRF, Tranter MM, McGuire C, Bondouki G, Cibert-Goton V, Thaha MA, Blackshaw L, Michael GJ et al.(2016). P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors. Journal of Neuroscience vol. 36, (8) Article 26911685, 2364-2376.
10.1523/jneurosci.3369-15.2016
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12378
Carrington EV, Evers J, Scott SM, Knowles CH, O'Connell PR, Jones JFX(2015). Mechanically evoked cortical potentials: A physiological approach to assessment of anorectal sensory pathways. J Neurosci Methods vol. 256, 198-202.
10.1016/j.jneumeth.2015.09.006
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11974
Knowles CH(2015). Defecation: Colectomy for constipation-a time for renewed caution?. Nat Rev Gastroenterol Hepatol vol. 12, (12) 675-676.
10.1038/nrgastro.2015.191
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11971
Knowles CH, Horrocks EJ, Bremner SA, Stevens N, Norton C, O'Connell PR, Eldridge S, CONFIDeNT study group(2015). Percutaneous tibial nerve stimulation versus sham electrical stimulation for the treatment of faecal incontinence in adults (CONFIDeNT): a double-blind, multicentre, pragmatic, parallel-group, randomised controlled trial. Lancet vol. 386, (10004) 1640-1648.
10.1016/S0140-6736(15)60314-2
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11975
Rimmer CJ, Knowles CH, Lamparelli M, Durdey P, Lindsey I, Hunt L, Nugent K, Gill KA(2015). Short-term Outcomes of a Randomized Pilot Trial of 2 Treatment Regimens of Transcutaneous Tibial Nerve Stimulation for Fecal Incontinence. Diseases of the Colon and Rectum vol. 58, (10) 974-982.
10.1097/DCR.0000000000000444
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11976
Norton C, Dibley LB, Hart A, Duncan J, Emmanuel A, Knowles CH, Stevens N, Terry H et al.(2015). Faecal incontinence intervention study (FINS): self-management booklet information with or without nurse support to improve continence in people with inflammatory bowel disease: study protocol for a randomized controlled trial. Trials vol. 16,
10.1186/s13063-015-0962-0
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11110
Horrocks EJ, Bremner SA, Stevens N, Norton C, Gilbert D, O'Connell PR, Eldridge S, Knowles CH(2015). Double-blind randomised controlled trial of percutaneous tibial nerve stimulation versus sham electrical stimulation in the treatment of faecal incontinence: CONtrol of Faecal Incontinence using Distal NeuromodulaTion (the CONFIDeNT trial). Health Technol Assess vol. 19, (77) 1-164.
10.3310/hta19770
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11111
Thaha MA, Abukar AA, Thin NN, Ramsanahie A, Knowles CH(2015). Sacral nerve stimulation for faecal incontinence and constipation in adults. Cochrane Database of Systematic Reviews vol. 2015, (8)
10.1002/14651858.CD004464.pub3
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15365
Kung V, Broad J, Machesney M, THAHA MA, Knowles CH, Sanger G (2015). Preoperative chemotherapy does not appear to have short-term effects on human rectal neuromuscular functions. Gut. Conference: Digestive Disorders Federation 2015 (London, UK) from: 22/06/2015 to: 26/06/2015, vol. Suppl 1, A584-A584.
10.1136/gutjnl-2015-309861.1152
Dimidi E, Dibley L, Cotterill N, Knowles CH, Scott SM, Whelan K, Norton C (2015). AN EXPLORATORY QUALITATIVE STUDY INVESTIGATING PATIENTS' EXPERIENCES OF CONSTIPATION AND HOW THEIR SELF-REPORTED SYMPTOMS AND QUALITY OF LIFE COMPARE WITH CURRENTLY AVAILABLE VALIDATED MEASURES. GUT. vol. 64, A142-A143.
10.1136/gutjnl-2015-309861.296
Horrocks E, Bremner SA, Stevens N, Norton C, O'Connell PR, Eldridge S, Knowles CH (2015). DOUBLE BLIND RANDOMISED CONTROLLED TRIAL OF PERCUTANEOUS TIBIAL NERVE STIMULATION FOR THE TREATMENT OF FAECAL INCONTINENCE IN ADULTS. GUT. vol. 64, A4-A4.
10.1136/gutjnl-2015-309861.7
Bulmer DC, Botha CA, Wheeldon A, Grey K, Mein CA, Lee K, Knowles CH, Winchester WJ et al.(2015). Evidence of a role for GTP cyclohydrolase-1 in visceral pain. Neurogastroenterology and Motility vol. 27, (5) 656-662.
10.1111/nmo.12538
Horrocks E, Bremner SA, Stevens N, Norton C, Eldridge S, Knowles CH (2015). Double Blind Randomised Controlled Trial of Percutaneous Tibial Nerve Stimulation (PTNS) VS. Sham Electrical Stimulation in the Treatment of Faecal Incontinence. GASTROENTEROLOGY. vol. 148, S177-S177.
Horrocks EJ, Bremner SA, Stevens N, Norton C, O'Connell PR, Eldridge S, Knowles CH (2015). Double blind randomised controlled trial of percutaneous tibial nerve stimulation (PTNS) vs sham electrical stimulation in the treatment of faecal incontinence. (ISRCTN: 88559475). BRITISH JOURNAL OF SURGERY. vol. 102, 5-5.
Haddow JB, Musbahi O, Julka P, Knowles CH, Parsai A (2015). Dynamic contrast enhanced MRI to evaluate idiopathic and Crohn's perianal fistula: a pilot study. BRITISH JOURNAL OF SURGERY. vol. 102, 16-16.
Cibert-Goton V, Kung VW, Hockley JR, Blackshaw A, Knowles CH, Sanger GJ, Bulmer DC (2015). Evidence for Reduced Visceral Nociceptors Activation With Age During Appendicitis. GASTROENTEROLOGY. vol. 148, S924-S925.
Shamsiddinova A, Horrocks EJ, Mackenzie H, Scott SM, Knowles CH (2015). Fowler's syndrome of the anorectum?. BRITISH JOURNAL OF SURGERY. vol. 102, 38-38.
Botha C, Farmer AD, Nilsson M, Brock C, Gavrila AD, Drewes AM, Knowles CH, Aziz Q(2015). Preliminary report: modulation of parasympathetic nervous system tone influences oesophageal pain hypersensitivity. Gut vol. 64, (4) 611-617.
10.1136/gutjnl-2013-306698
Maeda Y, O'Connell PR, Lehur PA, Matzel KE, Laurberg S, Altomare DF, Baeten CGI, Buntzen S et al.(2015). Sacral nerve stimulation for faecal incontinence and constipation: A European consensus statement. Colorectal Disease vol. 17, (4) O74-O87.
10.1111/codi.12905
Altomare DF, Giuratrabocchetta S, Knowles CH, Duyos AM, Robert-Yap J, Matzel KE(2015). Long-term outcomes of sacral nerve stimulation for faecal incontinence. British Journal of Surgery vol. 102, (4)
10.1002/bjs.9740
Hayat JO, Gabieta-Somnez S, Yazaki E, Kang J-Y, Woodcock A, Dettmar P, Mabary J, Knowles CH et al.(2015). Pepsin in saliva for the diagnosis of gastro-oesophageal reflux disease. Gut vol. 64, (3) 373-380.
10.1136/gutjnl-2014-307049
https://qmro.qmul.ac.uk/xmlui/handle/123456789/28912
Thin NN, Taylor SJC, Bremner SA, Emmanuel AV, Hounsome N, Williams NS, Knowles CH(2015). Randomized clinical trial of sacral versus percutaneous tibial nerve stimulation in patients with faecal incontinence. British Journal of Surgery vol. 102, (4)
10.1002/bjs.9695
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7199
Thomas GP, Duelund-Jakobsen J, Dudding TC, Bradshaw E, Nicholls RJ, Alam A, Emmanuel A, Thin N et al.(2015). A double-blinded randomized multicentre study to investigate the effect of changes in stimulation parameters on sacral nerve stimulation for constipation. Colorectal Disease vol. 17, (11) 990-995.
10.1111/codi.12982
Fikree A, Aktar R, Grahame R, Hakim AJ, Morris JK, Knowles CH, Aziz Q(2015). Functional gastrointestinal disorders are associated with the joint hypermobility syndrome in secondary care: A case-control study. Neurogastroenterology and Motility vol. 27, (4) 569-579.
10.1111/nmo.12535
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9450
Grossi U, Hotouras A, Horrocks E, Allison M, Chan CL, Knowles CH(2015). Home-based percutaneous tibial nerve stimulation for fecal incontinence: Is it feasible?. Annals of Surgery vol. 261, (1)
10.1097/SLA.0000000000000887
Shribman SE, Noyce AJ, Martin JE, Giovannoni G, Knowles CH (2014). The distribution of alpha-synuclein in the enteric nervous system: An immunohistochemical study on colonic resections from 24 control and 4 Parkinson's disease patients. MOVEMENT DISORDERS. vol. 29, 1839-1839.
Hotouras A, Murphy J, Allison M, Curry A, Williams NS, Knowles CH, Chan CL(2014). Prospective clinical audit of two neuromodulatory treatments for fecal incontinence: sacral nerve stimulation (SNS) and percutaneous tibial nerve stimulation (PTNS). Surg Today vol. 44, (11) 2124-2130.
10.1007/s00595-014-0898-0
Hotouras A, Murphy J, Allison M, Curry A, Williams NS, Knowles CH, Chan CL(2014). Prospective clinical audit of two neuromodulatory treatments for fecal incontinence: sacral nerve stimulation (SNS) and percutaneous tibial nerve stimulation (PTNS). Surgery Today vol. 44, (11) 2124-2130.
10.1007/s00595-014-0898-0
Fikree A, Grahame R, Aktar R, Farmer AD, Hakim AJ, Morris JK, Knowles CH, Aziz Q(2014). A prospective evaluation of undiagnosed joint hypermobility syndrome in patients with gastrointestinal symptoms. Clin Gastroenterol Hepatol vol. 12, (10) 1680-87.e2.
10.1016/j.cgh.2014.01.014
Hockley JRF, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN et al.(2014). Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli. Pain vol. 155, (10) 1962-1975.
10.1016/j.pain.2014.06.015
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7130
Carrington EV, Evers J, Grossi U, Dinning PG, Scott SM, O'Connell PR, Jones JFX, Knowles CH(2014). A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation. Neurogastroenterol Motil vol. 26, (9) 1222-1237.
10.1111/nmo.12388
Broadhead A, Mcguire C, Reed D, Peiris M, Knowles CH, Kurtz CB, Silos-Santiago A, Bulmer D et al.(2014). Activation of guanylate cyclase C inhibits human and mouse intestinal afferent mechanosensitivity but not chemosensitivity. NEUROGASTROENTEROLOGY AND MOTILITY vol. 26, 32-32.
Evers J, Devane L, Carrington EV, Scott SM, Knowles CH, O'Connell PR, Jones JFX(2014). Effects of stimulation frequency and intensity in sacral neuromodulation on anorectal inputs to the somatosensory cortex in an experimental model. BRITISH JOURNAL OF SURGERY vol. 101, (10) 1317-1328.
10.1002/bjs.9587
Carrington EV, Grossi U, Knowles CH, Scott SM(2014). Normal values for high-resolution anorectal manometry: a time for consensus and collaboration. Neurogastroenterol Motil vol. 26, (9) 1356-1357.
10.1111/nmo.12364
Palit S, Bhan C, Lunniss PJ, Boyle DJ, Gladman MA, Knowles CH, Scott SM(2014). Evacuation proctography: a reappraisal of normal variability. Colorectal Dis vol. 16, (7) 538-546.
10.1111/codi.12595
Grossi U, Carrington EV, Scott SM, Knowles CH(2014). Sacral neuromodulation for anorectal dysfunction secondary to congenital imperforate anus: report of two cases. Int J Colorectal Dis vol. 29, (7) 889-890.
10.1007/s00384-014-1874-2
Etherson K, Horrocks E, Scott M, Knowles CH, Yiannakou Y(2014). PWE-172 A National Biofeedback Practitioners Service Evaluation. Gut vol. 63 Suppl 1,
10.1136/gutjnl-2014-307263.432
Kung VWS, Broad J, Sanger GJ, Knowles CH (2014). Gender- and regionally-specific decline in colonic neuromuscular activity with advanced age. BRITISH JOURNAL OF SURGERY. vol. 101, 3-3.
Hotouras A, Murphy J, Walsh U, Allison M, Curry A, Williams NS, Knowles C, Chan CL(2014). Outcome of percutaneous tibial nerve stimulation (PTNS) for fecal incontinence: a prospective cohort study. Ann Surg vol. 259, (5) 939-943.
10.1097/SLA.0b013e3182a6266c
Horrocks EJ, Jordan P, Burgell R, Scott SM, Knowles CH (2014). Post-partum defecatory dysfunction: a complex problem involving co-existing faecal incontinence and constipation. BRITISH JOURNAL OF SURGERY. vol. 101, 12-13.
Thin NN, Taylor SJC, Bremner SA, Hounsome N, Williams NS, Bannister S, Allison ME, Alam A et al. (2014). Prospective randomised mixed methods pilot trial of sacral and percutaneous tibial nerve stimulation for faecal incontinence. BRITISH JOURNAL OF SURGERY. vol. 101, 10-10.
Carrington EV, Horrocks EJ, Burgell R, Bjerke A, Connolly S, Scott SM, Jones JFX, O'Connell PR et al. (2014). Quality of anal evoked potential (AEP) recordings is reduced in patients with faecal incontinence (FI): evidence of central sensory pathway dysfunction?. BRITISH JOURNAL OF SURGERY. vol. 101, 11-11.
Thin NN, Taylor SJ, Bremner SA, Hounsome N, Bannister SM, Williams NS, Allison M, Emmanuel A et al. (2014). Randomised Mixed Methods Trial of Sacral and Percutaneous Tibial Nerve Stimulation for Faecal Incontinence. GASTROENTEROLOGY. vol. 146, S154-S154.
10.1016/S0016-5085(14)60549-7
Peiris M, Reed DE, Broadhead A, Knowles CH, Bulmer DC, Blackshaw A (2014). Role of Kv7 Potassium Channels in Excitation of Human Colonic Afferents. GASTROENTEROLOGY. vol. 146, S722-S722.
Townsend DC, Carrington EV, Burgell R, Horrocks EJ, Scott SM, Knowles CH (2014). Sex differences in features of anorectal dysfunction: a consecutive study of 100 males and 100 females presenting for investigation of faecal incontinence. BRITISH JOURNAL OF SURGERY. vol. 101, 36-36.
Carrington EV, Tangenberg E, Horrocks E, Palit S, Knowles CH, Scott SM (2014). Squeeze Profile - A Novel and Improved Measure of Anal Function Using High-Resolution Anal Manometry. GASTROENTEROLOGY. vol. 146, S714-S714.
Hotouras A, Murphy J, Abeles A, Allison M, Williams NS, Knowles CH, Chan CL(2014). Symptom distribution and anorectal physiology results in male patients with rectal intussusception and prolapse. Journal of Surgical Research vol. 188, (1) 298-302.
10.1016/j.jss.2013.12.008
Hotouras A, Murphy J, Abeles A, Allison M, Williams NS, Knowles CH, Chan CL(2014). Symptom distribution and anorectal physiology results in male patients with rectal intussusception and prolapse. J Surg Res vol. 188, (1) 298-302.
10.1016/j.jss.2013.12.008
Fikree A, Aktar R, Farmer AD, Grahame R, Knowles CH, Aziz Q (2014). The Joint Hypermobility Syndrome Is Associated With Functional Dyspepsia and Gastro-Oesophageal Reflux Disorders and Identifies A Subgroup With Multiple Extra-Intestinal Symptoms and Worse Quality of Life. GASTROENTEROLOGY. vol. 146, S264-S264.
Shribman SE, Noyce AJ, Martin JE, Giovannoni G, Knowles CH (2014). The distribution of alpha-synuclein in the enteric nervous system: An immunohistochemical study on colonic resections from 24 control and 4 Parkinson's disease patients. MOVEMENT DISORDERS. vol. 29, S31-S32.
Carrington EV, Brokjaer A, Craven H, Zarate N, Horrocks EJ, Palit S, Jackson W, Duthie GS et al.(2014). Traditional measures of normal anal sphincter function using high-resolution anorectal manometry (HRAM) in 115 healthy volunteers. Neurogastroenterol Motil vol. 26, (5) 625-635.
10.1111/nmo.12307
Horrocks EJ, Scott SM, Burgell RE, Carrington EV, Yerragorla P, Knowles CH (2014). Under-recognised co-existence of constipation and faecal incontinence in the adult population: a large single-centre experience. BRITISH JOURNAL OF SURGERY. vol. 101, 45-45.
Hockley JRF, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN et al.(2014). Multiple roles for Na<inf>V</inf>1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli. Pain vol. 155, (10) 1962-1975.
10.1016/j.pain.2014.06.015
Noyce AJ, Bestwick JP, Silveira-Moriyama L, Hawkes CH, Knowles CH, Hardy J, Giovannoni G, Nageshwaran S et al.(2014). PREDICT-PD: Identifying risk of Parkinson's disease in the community: methods and baseline results. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY vol. 85, (1) 31-37.
10.1136/jnnp-2013-305420
https://qmro.qmul.ac.uk/xmlui/handle/123456789/41483
Farmer AD, Coen SJ, Kano M, Naqvi H, Paine PA, Scott SM, Furlong PL, Lightman SL et al.(2014). Psychophysiological responses to visceral and somatic pain in functional chest pain identify clinically relevant pain clusters. Neurogastroenterol Motil vol. 26, (1) 139-148.
10.1111/nmo.12245
Horrocks EJ, Thin N, Thaha MA, Taylor SJC, Norton C, Knowles CH(2014). Systematic review of tibial nerve stimulation to treat faecal incontinence. British Journal of Surgery
10.1002/bjs.9391
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39607
Haddow JB, Adwan H, Clark SE, Tayeh S, Antonowicz SS, Jayia P, Chicken DW, Wiggins T et al.(2014). Use of the surgical Apgar score to guide postoperative care. Annals of the Royal College of Surgeons of England vol. 96, (5) 352-358.
10.1308/003588414X13946184900840
Broad J, Kung VWS, Boundouki G, Aziz Q, De Maeyer JH, Knowles CH, Sanger GJ(2013). Cholinergic interactions between donepezil and prucalopride in human colon: potential to treat severe intestinal dysmotility. Br J Pharmacol vol. 170, (6) 1253-1261.
10.1111/bph.12397
Farmer AD, Coen SJ, Kano M, Paine PA, Shwahdi M, Jafari J, Kishor J, Worthen SF et al.(2013). Psychophysiological responses to pain identify reproducible human clusters. Pain vol. 154, (11) 2266-2276.
10.1016/j.pain.2013.05.016
Thin NN, Horrocks EJ, Hotouras A, Palit S, Thaha MA, Chan CLH, Matzel KE, Knowles CH(2013). Systematic review of the clinical effectiveness of neuromodulation in the treatment of faecal incontinence. British Journal of Surgery vol. 100, (11) 1430-1447.
10.1002/bjs.9226
Hotouras A, Murphy J, Thin NN, Allison M, Horrocks E, Williams NS, Knowles CH, Chan CL(2013). Outcome of sacral nerve stimulation for fecal incontinence in patients refractory to percutaneous tibial nerve stimulation. Dis Colon Rectum vol. 56, (7) 915-920.
10.1097/DCR.0b013e31827f0697
Lahiri RP, Abeles A, Burnand KM, Alazawi W, Bhattacharya S, Foster GR, Knowles CH(2013). A cross sectional study of colonic diverticulosis in the London Bangladeshi population. United European Gastroenterol J vol. 1, (3) 191-197.
10.1177/2050640613489282
Fikree A, Aziz Q, Ahmed M, Mohammed S, Knowles CH, Scott M (2013). JOINT HYPERMOBILITY SYNDROME, RECTAL HYPOSENSITIVITY AND SEVERE CONSTIPATION IN YOUNG NULLIPAROUS FEMALES. GUT. vol. 62, A98-A98.
10.1136/gutjnl-2013-304907.216
Fikree A, Aktar R, Gillespie KV, Glasgow LE, Morris JK, Farmer A, Grahame R, Knowles CH et al. (2013). THE ASSOCIATION OF THE JOINT HYPERMOBILITY SYNDROME WITH FUNCTIONAL GASTROINTESTINAL DISORDERS - AN INTERESTING NEW FINDING THAT MAY EXPLAIN AETIOLOGY. GUT. vol. 62, A97-A97.
10.1136/gutjnl-2013-304907.214
McGuire C, Harrington AM, Hubball A, McPhail H, Peiris M, Bulmer DC, Knowles CH, Blackshaw LA (2013). Anatomical Sensory Nerve Markers in Human Gut. GASTROENTEROLOGY. vol. 144, S56-S56.
Athanasakos EP, Kemal KI, Malliwal RS, Scott SM, Williams NS, Aziz Q, Ward HC, Knowles CH(2013). Clinical and psychosocial functioning in adolescents and young adults with anorectal malformations and chronic idiopathic constipation. Br J Surg vol. 100, (6) 832-839.
10.1002/bjs.9111
Bulmer DC, Botha CA, Winchester W, Blackshaw LA, Knowles CH, Aziz Q (2013). Healthy Volunteers With the Pain Protective GTP Cyclohydrolase-1 Haplotype Who Sensitise to Oesophageal Acidification Possess Significantly Higher Pain Thresholds. GASTROENTEROLOGY. vol. 144, S935-S935.
McGuire C, Boundouki G, Peiris M, Blackshaw LA, Knowles CH, Bulmer DC (2013). Identification of a Distinct Population of Human Visceral Nociceptors. GASTROENTEROLOGY. vol. 144, S670-S670.
Hockley JR, Cibert-Goton V, Boundouki G, Wood J, Knowles CH, Baker MD, Winchester W, Bulmer DC (2013). Mechanotransduction in Mouse Visceral Afferent Fibres Is Modulated by Nav1.9. GASTROENTEROLOGY. vol. 144, S935-S935.
Peiris M, Masding A, Galanakis V, Bulmer DC, Knowles CH, Blackshaw LA (2013). Specific Pathways of Nutrient Activation in Human and Mouse Enteroendocrine Eells. GASTROENTEROLOGY. vol. 144, S374-S374.
Fikree A, Aktar R, Glasgow LE, Gillespie KV, Farmer AD, Grahame R, Morris JK, Knowles CH et al. (2013). The Association Between Functional Gastrointestinal Disorders and the Joint Hypermobility Syndrome - Connective Tissue Is the Missing Link!. GASTROENTEROLOGY. vol. 144, S539-S539.
Fikree A, Aktar R, Wellstead G, Morris JK, Knowles CH, Grahame R, Aziz Q (2013). The Association Between Gastrointestinal Symptoms and the Joint Hypermobility Syndrome in a Population of University Students. GASTROENTEROLOGY. vol. 144, S732-S732.
Knowles CH, Lindberg G, Panza E, De Giorgio R(2013). New perspectives in the diagnosis and management of enteric neuropathies. Nat Rev Gastroenterol Hepatol vol. 10, (4) 206-218.
10.1038/nrgastro.2013.18
Aiken AM, Haddow JB, Symons NRA, Kaptanis S, Katz-Summercorn AC, Debnath D, Dent H, Tayeh S et al.(2013). Use of antibiotic prophylaxis in elective inguinal hernia repair in adults in London and south-east England: A cross-sectional survey. Hernia vol. 17, (5) 657-664.
10.1007/s10029-013-1061-3
Martin JE, Duraisamy Y, West M, Chowdhury DATM, Rahman M, Rowberry P, Broad J, Minassian B et al. (2013). Glycogen metabolism pathway defects produce gastrointestinal myopathy with polyglucosan bodies: an explanation for the neuropathology and symptoms of gastrointestinal neuromuscular disorder. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. vol. 39, 25-25.
Kondo T, Oshima T, Tomita T, Fukui H, Watari J, Okada H, Kikuchi S, Sasako M et al.(2013). Prostaglandin E-2 mediates acid-induced heartburn in healthy volunteers. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY vol. 304, (6) G568-G573.
10.1152/ajpgi.00276.2012
Sanger GJ, Broad J, Kung V, Knowles CH(2013). Translational neuropharmacology: the use of human isolated gastrointestinal tissues. Br J Pharmacol vol. 168, (1) 28-43.
10.1111/j.1476-5381.2012.02198.x
Bryant C, Lunniss PJ, Knowles CH, Thaha MA, Chan CLH(2012). Anterior resection syndrome. Lancet Oncology vol. 13, (9) e403-e408.
10.1016/S1470-2045(12)70236-X
Hotouras A, Thaha MA, Boyle DJ, Allison ME, Currie A, Knowles CH, Chan CLH(2012). Short-term outcome following percutaneous tibial nerve stimulation for faecal incontinence: a single-centre prospective study. Colorectal Dis vol. 14, (9) 1101-1105.
10.1111/j.1463-1318.2011.02906.x
Hubball AW, Lang B, Souza MAN, Curran OD, Martin JE, Knowles CH(2012). Voltage-gated potassium channel (K(v) 1) autoantibodies in patients with chagasic gut dysmotility and distribution of K(v) 1 channels in human enteric neuromusculature (autoantibodies in GI dysmotility). Neurogastroenterol Motil vol. 24, (8) 719-e344.
10.1111/j.1365-2982.2012.01924.x
Hotouras A, Allison M, Currie A, Knowles CH, Chan CLC, Thaha MA(2012). Percutaneous Tibial Nerve Stimulation (PTNS) for faecal incontinence: a video demonstration. Diseases of the Colon and Rectum vol. 6, (55) 711-713.
10.1097/DCR.0b013e31824e68e8
Botha CA, Knowles CH, Aziz Q (2012). Anxiety and Sympathetic Nervous System Activation are Associated With the Development of Human Esophageal Pain Hypersensitivity. GASTROENTEROLOGY. vol. 142, S290-S290.
Duraisamy Y, West M, Knowles CH, Akman HO, DiMauro S, Rahman MM, Minassian B, Martin J (2012). Glycogen Metabolism Defects Produce Gastrointestinal Myopathy With Polyglucosan Bodies. GASTROENTEROLOGY. vol. 142, S897-S897.
Peiris M, Atiba MA, Hubball A, Bulmer DC, Knowles CH, Blackshaw LA (2012). Molecular Aspects of Nutrient Sensing in the Human Gastrointestinal Tract. GASTROENTEROLOGY. vol. 142, S199-S199.
Palit S, Thin NN, Knowles CH, Scott SM, Lunniss PJ (2012). Prospective comparison of balloon expulsion, anorectal manometry and evacuation proctography for the diagnosis of evacuatory dysfunction. BRITISH JOURNAL OF SURGERY. vol. 99, 28-28.
Noyce A, Silveira-Moriyama L, Lees AJ, Schrag A, Bestwick J, Hawkes CH, Giovannoni G, Hardy J et al. (2012). A PILOT STUDY OF AN ALGORITHM DESIGNED TO IDENTIFY PARKINSON'S DISEASE IN THE EARLY, NON-MOTOR PHASE. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. vol. 83,
10.1136/jnnp-2011-301993.161
Noyce A, Bestwick J, Hawkes CH, Knowles CH, Hardy J, Lees AJ, Silveira-Moriyama L, Giovannoni G et al. (2012). AN ALGORITHM TO IDENTIFY INDIVIDUALS AT HIGH-RISK OF PARKINSON'S DISEASE IN THE COMMUNITY. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. vol. 83,
10.1136/jnnp-2011-301993.162
Martin JE, Chowdhury ATMD, McElwaine S, Fikree A, Minassian B, Broad J, Knowles CH, Allen L et al. (2012). Intestinal Glycogen Storage Disease, and the Molecular Basis of Pseudo-obstruction with Polyglucosan Bodies. JOURNAL OF PATHOLOGY. vol. 226, S24-S24.
Panza E, Knowles CH, Graziano C, Thapar N, Burns AJ, Seri M, Stanghellini V, De Giorgio R(2012). Genetics of human enteric neuropathies. PROGRESS IN NEUROBIOLOGY vol. 96, (2) 176-189.
10.1016/j.pneurobio.2012.01.001
Chua YC, Ng KS, Sharma A, Jafari J, Surguy S, Yazaki E, Knowles CH, Aziz Q(2012). Randomised clinical trial: pregabalin attenuates the development of acid-induced oesophageal hypersensitivity in healthy volunteers - a placebo-controlled study. Aliment Pharmacol Ther vol. 35, (3) 319-326.
10.1111/j.1365-2036.2011.04955.x
KNOWLES CH, Knowles CH, Thin N, Gill K, Bhan C, Grimmer K, Lunniss PJ, Williams NS et al.(2012). Prospective randomized double-blind study of temporary sacral nerve stimulation in patients with rectal evacuatory dysfunction and rectal hyposensitivity. Annals of Surgery vol. 255, (4) 643-649.
10.1097/SLA.0b013e318247d49f
MURPHY J, Knowles CH, Bhan C, Scott SM, Williams NS, Lunniss PJ(2012). The effects of age and parity on anal sphincter function and morphology in 999 symptomatic female patients with colorectal dysfunction. Dis. Col. Rect. vol. 3, (55) 286-293.
10.1097/DCR.0b013e31823fe7f1
Hotouras A, Thaha MA, Boyle D, Allison M, Currie A, Knowles CH, Chan CLH(2011). Short-term outcomes following percutaneous tibial nerve stimulation (PTNS) for faecal incontinence: A single-centre prospective study. Colorectal Disease
10.1111/j.1463-1318.2011.02906.x
Knowles CH, Martin JE(2011). Enteric neuromuscular pathology update. Gastroenterol Clin North Am vol. 40, (4) 695-713.
10.1016/j.gtc.2011.09.007
Knowles CH, De Giorgio R, IWG(2011). The London Classification of gastrointestinal neuromuscular pathology: a little more flexibility would be wise ... response. GUT vol. 60, (10) 1437-1438.
10.1136/gut.2010.224444
Scott SM, Knowles CH(2011). Constipation: Dried plums (prunes) for the treatment of constipation. Nat Rev Gastroenterol Hepatol vol. 8, (6) 306-307.
10.1038/nrgastro.2011.82
Martin JE, Chowdhury AH, McElwaine S, Fikree A, Broad J, Knowles CH, Allen L, Bevan S et al. (2011). A Novel Phenotype of Glycogen Storage Disease Presenting as Gastrointestinal Neuromuscular Disease. GASTROENTEROLOGY. vol. 140, S705-S705.
Noyce AJ, Bestwick J, Hawkes CH, Schrag A, Knowles CH, Hardy J, Lees AJ, Giovannoni G et al. (2011). A pilot study of an algorithm designed to identify Parkinson's disease in the early, non-motor phase. MOVEMENT DISORDERS. vol. 26, S54-S54.
Noyce AJ, Bestwick J, Hawkes CH, Knowles CH, Hardy J, Lees AJ, Silveira-Moriyama L, Giovannoni G et al. (2011). An algorithm to identify individuals at high-risk of Parkinson's disease in the community. MOVEMENT DISORDERS. vol. 26, S54-S55.
Carrington EV, Burgell R, Lelic D, Surguy S, Drewes AM, Aziz Q, Knowles CH, Scott SM (2011). Assessment of Rectal Afferent Neuronal Function Using Evoked Potentials in Patients With Constipation and Rectal Hyposensitivity - A Pilot Study. GASTROENTEROLOGY. vol. 140, S530-S530.
Botha CA, Naqvi H, Chua YC, Knowles CH, Aziz Q (2011). Effect of Autonomic Modulation on Human Esophageal Pain Hypersensitivity. GASTROENTEROLOGY. vol. 140, S164-S164.
Rovedatti L, Di Sabatino A, Knowles CH, Sengupta N, Biancheri P, Corazza GR, MacDonald TT(2011). Fibroblast activation protein expression in Crohn's disease strictures. Inflamm Bowel Dis vol. 17, (5) 1251-1253.
10.1002/ibd.21446
Palit S, Thin NN, Knowles CH, Scott SM (2011). Prospective Comparison of Balloon Expulsion, Anorectal Manometry and Evacuation Proctography for the Diagnosis of Rectal Evacuatory Disorder. GASTROENTEROLOGY. vol. 140, S609-S609.
Broad J, Mukerjee S, Boundouki G, Hughes F, Mannur KR, Knowles CH, Dukes GE, Sanger GJ (2011). Regionally-Dependent Responses to Both Nerve Stimulation and to Motilin in Human Isolated Esophagus, Stomach, Small and Large Intestine. GASTROENTEROLOGY. vol. 140, S479-S480.
Broad J, Hubball A, Souza M, Boundouki G, Knowles CH, Sanger GJ (2011). Serum but Not IgG From Patients With Chagas' Disease Relax Naive Human Colon Muscle Without Directly Interfering With Motor Nerve Functions. GASTROENTEROLOGY. vol. 140, S282-S282.
Carrington EV, Burgell R, Lelic D, Surguy S, Drewes A, Aziz Q, Knowles CH, Scott SM (2011). Assessment of rectal afferent neuronal function using evoked potentials in patients with constipation and rectal hyposensation - A pilot study. BRITISH JOURNAL OF SURGERY. vol. 98, 43-44.
Botha CA, Naqvi H, Chua YC, Knowles CH, Aziz Q (2011). EFFECT OF AUTONOMIC MODULATION ON HUMAN OESOPHAGEAL PAIN HYPERSENSITIVITY. GUT. vol. 60,
10.1136/gut.2011.239301.53
Chua YC, Hubball A, Peiris M, Ng KS, Hughes SF, Chinaleong J, Preston S, Patel B et al. (2011). OESOPHAGEAL EPITHELIAL ASIC3 IS ASSOCIATED WITH INCREASE IN SEVERITY OF SYMPTOMS IN PATIENTS WITH GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD). GUT. vol. 60, A171-A171.
10.1136/gut.2011.239301.363
Carrington EV, Knowles CH(2011). The influence of sacral nerve stimulation on anorectal dysfunction. Colorectal Dis vol. 13 Suppl 2, 5-9.
10.1111/j.1463-1318.2010.02518.x
Thin NN, Carrington EV, Grimmer K, Knowles CH(2011). Advancement anoplasty and sacral nerve stimulation: an effective combination for radiation-induced anal stenosis. Int J Colorectal Dis vol. 26, (2) 211-213.
10.1007/s00384-010-1088-1
Knowles CH, Farrugia G(2011). Gastrointestinal neuromuscular pathology in chronic constipation. Best Pract Res Clin Gastroenterol vol. 25, (1) 43-57.
10.1016/j.bpg.2010.12.001
Peiris M, Bulmer DC, Baker MD, Boundouki G, Sinha S, Hobson A, Lee K, Aziz Q et al.(2011). Human visceral afferent recordings: preliminary report. Gut vol. 60, (2) 204-208.
10.1136/gut.2010.221820
Knowles CH, Veress B, Kapur RP, Wedel T, Farrugia G, Vanderwinden J-M, Geboes K, Smith VV et al.(2011). Quantitation of cellular components of the enteric nervous system in the normal human gastrointestinal tract--report on behalf of the Gastro 2009 International Working Group. Neurogastroenterol Motil vol. 23, (2) 115-124.
10.1111/j.1365-2982.2010.01657.x
Nastro P, Knowles CH, McGrath A, Heyman B, Porrett TRC, Lunniss PJ(2010). Complications of intestinal stomas. Br J Surg vol. 97, (12) 1885-1889.
10.1002/bjs.7259
Boundouki G, Peiris M, Baker MD, Bulmer DC, Aziz Q, Hobson A, Sinha S, Lee K et al.(2010). A novel in vitro model of visceral pain using the human appendix. BRITISH JOURNAL OF SURGERY vol. 97, 31-32.
Chua YC, Ng KS, Sharma A, Jafari J, Surguy S, Yazaki E, Julu PO, Knowles CH et al.(2010). Pregabalin prevents development of visceral hyperalgesia to oesophageal acid infusion in healthy volunteers. BRITISH JOURNAL OF SURGERY vol. 97, 1-1.
Bhan C, Prosser K, Gill K, Boyle DJ, Mottahadeh M, Williams NS, Lunniss PJ, Scott SM et al. (2010). Prospective randomized double-blind placebo-controlled crossover study of sacral nerve stimulation in patients with severe rectal evacuatory dysfunction allied to rectal hyposensitivity. BRITISH JOURNAL OF SURGERY. vol. 97, 33-33.
Docena G, Rovedatti L, Kruidenier L, Fanning A, Leakey NAB, Knowles CH, Lee K, Shanahan F et al.(2010). Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease. Clin Exp Immunol vol. 162, (1) 108-115.
10.1111/j.1365-2249.2010.04203.x
Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Lindberg G, Martin JE et al.(2010). The London Classification of gastrointestinal neuromuscular pathology: report on behalf of the Gastro 2009 International Working Group. Gut vol. 59, (7) 882-887.
10.1136/gut.2009.200444
Chua YC, Ng KS, Jafari J, Sharma A, Surguy S, Yazaki E, Julu PO, Knowles CH et al. (2010). Pregabalin Prevents Development of Esophageal Hypersensitivity to Esophageal Acid Infusion in Healthy Volunteers. GASTROENTEROLOGY. vol. 138, S134-S134.
Chua YC, Ng KS, Sharma A, Jafari J, Surguy S, Yazaki E, Julu PO, Knowles CH et al. (2010). ACID-INDUCED OESOPHAGEAL HYPERSENSITIVITY IS INHIBITED BY PREGABALIN TREATMENT. GUT. vol. 59, A25-A25.
10.1136/gut.2009.208975i
Broad J, Boundouki G, Knowles CH, Sanger GJ (2010). CHARACTERISATION OF MOTOR NERVE RESPONSES TO ELECTRICAL FIELD STIMULATION IN HUMAN ISOLATED COLON. GUT. vol. 59, A140-A140.
10.1136/gut.2009.209049d
Zarate N, Farmer AD, Grahame R, Mohammed SD, Knowles CH, Scott SM, Aziz Q(2010). Unexplained gastrointestinal symptoms and joint hypermobility: is connective tissue the missing link?. Neurogastroenterol Motil vol. 22, (3) 252-e78.
10.1111/j.1365-2982.2009.01421.x
De Giorgio R, Ricciardiello L, Naponelli V, Selgrad M, Piazzi G, Felicani C, Serra M, Fronzoni L et al. (2010). Chronic Intestinal Pseudo-Obstruction Related to Viral Infections. TRANSPLANTATION PROCEEDINGS. vol. 42, 9-14.
10.1016/j.transproceed.2009.12.014
Kondo T, Oshima T, Obata K, Sakurai J, Knowles CH, Matsumoto T, Noguchi K, Miwa H(2010). Role of transient receptor potential A1 in gastric nociception. Digestion vol. 82, (3) 150-155.
10.1159/000310836
Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles CH, Rampton DS, Corazza GR, Monteleone G et al.(2009). Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut vol. 58, (12) 1629-1636.
10.1136/gut.2009.182170
Martin JE, Hester TW, Aslam H, Sinha S, Knowles CH(2009). Discordant practice and limited histopathological assessment in gastrointestinal neuromuscular disease. GUT vol. 58, (12) 1703-1705.
10.1136/gut.2009.184572
Knowles CH, Dinning PG, Pescatori M, Rintala R, Rosen H(2009). Surgical management of constipation. NEUROGASTROENT MOTIL vol. 21, 62-71.
10.1111/j.1365-2982.2009.01405.x
Di Sabatino A, Rovedatti L, Kaur R, Spencer JP, Brown JT, Morisset VD, Biancheri P, Leakey NAB et al.(2009). Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease. J Immunol vol. 183, (5) 3454-3462.
10.4049/jimmunol.0802887
Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Gershon MD, Hutson J et al.(2009). Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta Neuropathol vol. 118, (2) 271-301.
10.1007/s00401-009-0527-y
Boyle DJ, Knowles CH, Lunniss PJ, Scott SM, Williams NS, Gill KA(2009). Efficacy of sacral nerve stimulation for fecal incontinence in patients with anal sphincter defects. Dis Colon Rectum vol. 52, (7) 1234-1239.
10.1007/DCR.0b013e31819f7400
Rovedatti L, Kudo T, Biancheri P, Rampton DS, Sengupta N, Knowles CH, Monteleone G, Corazza GR et al. (2009). Differential Regulation of Interleukin-17 and Interferon-gamma Production in Inflammatory Bowel Disease. GASTROENTEROLOGY. vol. 136, A258-A258.
Farmer AD, Zarate-Lopez N, Mohammed S, Scott SM, Knowles CH, Grahame R, Aziz Q (2009). JOINT HYPERMOBILITY AND FUNCTIONAL GASTROINTESTINAL DISORDERS: IS CONNECTIVE TISSUE THE MISSING LINK?. RHEUMATOLOGY. vol. 48, I95-I95.
De Giorgio R, Knowles CH(2009). Acute colonic pseudo-obstruction. BRIT J SURG vol. 96, (3) 229-239.
10.1002/bjs.6480
Knowles CH, Aziz Q(2009). Basic and clinical aspects of gastrointestinal pain. Pain vol. 141, (3) 191-209.
10.1016/j.pain.2008.12.011
Knowles CH, Martin JE(2009). New techniques in the tissue diagnosis of gastrointestinal neuromuscular diseases. World J Gastroenterol vol. 15, (2) 192-197.
10.3748/wjg.15.192
Hubball A, Martin JE, Lang B, De Giorgio R, Knowles CH(2009). The role of humoral autoimmunity in gastrointestinal neuromuscular diseases. Prog Neurobiol vol. 87, (1) 10-20.
10.1016/j.pneurobio.2008.09.011
Zarate N, Knowles CH, Yazaki E, Lunnis PJ, Scott SM(2009). Clinical presentation and patterns of slow transit constipation do not predict coexistent upper gut dysmotility. Dig Dis Sci vol. 54, (1) 122-131.
10.1007/s10620-008-0324-9
Karling P, Abrahamsson H, Dolk A, Hallbook O, Hellstrom PM, Knowles CH, Kjellstrom L, Lindberg G et al.(2009). Function and dysfunction of the colon and anorectum in adults: Working team report of the Swedish Motility Group (SMoG). SCAND J GASTROENTERO vol. 44, (6) 646-660.
10.1080/00365520902718713
Knowles AM, Knowles CH, Scott SM, Lunniss P(2008). Effects of age and gender on three-dimensional endoanal ultrasonography measurements: development of normal ranges. TECH COLOPROCTOL vol. 12, (4) 323-329.
10.1007/s10151-008-0443-5
Loosemore M, Knowles CH, Whyte GP(2008). Amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies. BRIT J SPORT MED vol. 42, (11) 864-867.
10.1136/bmj.39342.690220.55
Williams NS, Murphy J, Knowles C, Chan C, Ahmed S(2008). Letter in response to colorectal disease article on intersphincteric resection. Colorectal Disease vol. 10, (7)
10.1111/j.1463-1318.2008.01531.x
Gladman MA, Knowles CH(2008). Surgical treatment of patients with constipation and fecal incontinence. GASTROENTEROL CLIN N vol. 37, (3) 605-+.
10.1016/j.gtc.2008.06.009
Gladman MA, Knowles CH(2008). Novel concepts in the diagnosis, pathophysiology and management of idiopathic megabowel. COLORECTAL DIS vol. 10, (6) 531-538.
10.1111/j.1463-1318.2007.01457.x
Knowles CH, Veress B, Tornblom H, Wallace S, Paraskeva P, Darzi A, Martin JE, Nyberg B et al.(2008). Safety and diagnostic yield of laparoscopically assisted full-thickness bowel biospy. NEUROGASTROENT MOTIL vol. 20, (7) 774-779.
10.1111/j.1365-2982.2008.01099.x
Williams NS, Murphy J, Knowles CH(2008). Anterior Perineal PlanE for Ultra-low Anterior Resection of the Rectum (the APPEAR technique): a prospective clinical trial of a new procedure. Ann Surg vol. 247, (5) 750-758.
10.1097/SLA.0b013e31816b2ee3
Knowles CH, Aziz Q(2008). Visceral hypersensitivity in non-erosive reflux disease. Gut vol. 57, (5) 674-683.
10.1136/gut.2007.127886
Docena GH, Fanning A, Rovedatti L, Di Sabatino A, Leakey NA, Knowles CH, Lee K, Shanahan F et al.(2008). Activation and modulation of the MAP kinase pathway in IBD. GASTROENTEROLOGY vol. 134, (4) A647-A647.
Matthews PJ, Knowles CH, Chua YC, Delaney C, Hobson AR, Aziz Q(2008). Effects of the concentration and frequency of acid infusion on the development and maintenance of esophageal hyperalgesia in a human volunteer model. Am J Physiol Gastrointest Liver Physiol vol. 294, (4) G914-G917.
10.1152/ajpgi.00445.2007
Gooneratne ML, Facer P, Knowles CH, Chan CL, Lunniss PJ, Scott SM, Anand P, Williams NS(2008). Normalization of substance P levels in rectal mucosa of patients with faecal incontinence treated successfully by sacral nerve stimulation. BRITISH JOURNAL OF SURGERY vol. 95, (4) 477-483.
10.1002/bjs.5905
Knowles CH, De Giorgio R(2008). Observations on a vestigial organ: a potential surrogate for enteric neuromesenchymal disease. NEUROGASTROENT MOTIL vol. 20, (4) 263-268.
10.1111/j.1365-2982.2008.01090.x
Irving PM, Macey MG, Feakins RM, Knowles CH, Frye JN, Liyanage SH, Dorudi S, Williams NS et al. (2008). Platelet-leucocyte aggregates form in the mesenteric vasculature in patients with ulcerative colitis. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY. vol. 20, 283-289.
10.1097/MEG.0b013e3282f246c2
Zarate N, Knowles CH, Newell M, Garvie NW, Gladman MA, Lunniss PJ, Scott SM(2008). In patients with slow transit constipation, the pattern of colonic transit delay does not differentiate between those with and without impaired rectal evacuation. AM J GASTROENTEROL vol. 103, (2) 427-434.
10.1111/j.1572-0241.2007.01675.x
Knowles CH(2007). New horizons in the pathogenesis of gastrointestinal neuromuscular disease. J Pediatr Gastroenterol Nutr vol. 45 Suppl 2, S97-102.
10.1097/MPG.0b013e31812e6569
Loosemore M, Knowles CH, Whyte GP(2007). Amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies. BRIT MED J vol. 335, (7624) 809-812.
10.1136/bmj.39342.690220.55
Bowen S, Ateh DD, Deinhardt K, Bird MM, Price KM, Baker CS, Robson JC, Swash M et al.(2007). The phagocytic capacity of neurones. Eur J Neurosci vol. 25, (10) 2947-2955.
10.1111/j.1460-9568.2007.05554.x
Murphy J, Hammond TM, Knowles CH, Scott SM, Lunniss PJ, Williams NS(2007). Does anastomotic technique influence anorectal function after sphincter-saving rectal cancer resection? A systematic review of evidence from randomized trials. J AM COLL SURGEONS vol. 204, (4) 673-680.
10.1016/j.jamcollsurg.2007.01.008
Donaldson J, Knowles CH, Clark SK, Renfrew I, Lobo MD(2007). Rectus sheath haematoma associated with low molecular weight heparin: a case series. ANN ROY COLL SURG vol. 89, (3) 309-312.
10.1308/003588407X179152
Tornblom H, Lang B, Clover L, Knowles CH, Vincent A, Lindberg G(2007). Autoantibodies in patients with gut motility disorders and enteric neuropathy. SCAND J GASTROENTERO vol. 42, (11) 1289-1293.
10.1080/00365520701396216
Scott SM, Knowles CH, Wang D, Yazaki E, Picon L, Wingate DL, Lindberg G(2006). The nocturnal jejunal migrating motor complex: defining normal ranges by study of 51 healthy adult volunteers and meta-analysis. NEUROGASTROENT MOTIL vol. 18, (10) 927-935.
10.1111/j.1365-2982.2006.00824.x
KNOWLES CH, Cross F, Wilson A, West A, Konig T(2006). Stabbing: data support public perception. BMJ vol. 333,
10.1136/bmj.333.7569.652
Hammond TM, Knowles CH, Porrett T, Lunniss PJ(2006). The Snug Seton: short and medium term results of slow fistulotomy for idiopathic anal fistulae. COLORECTAL DIS vol. 8, (4) 328-337.
10.1111/j.1463-1318.2005.00926.x
KNOWLES CH, Maroney NL(2006). Innovation and teamwork: introducing multidisciplinary team ward rounds. Nursing Management vol. 13, 28-31.
10.7748/nm2006.04.13.1.28.c2047
LUNNISS PJ, Williams NS, Knowles CH, Scott SM, Dvorkin LS(2005). Rectal intussusception: characterization of symptomatology. Dis Colon Rectum vol. 48, 824-831.
Knowles CH, Silk DBA, Darzi A, Veress B, Feakins R, Raimundo AH, Crompton T, Browning EC et al.(2004). Deranged smooth muscle alpha-actin as a biomarker of intestinal pseudo-obstruction: a controlled multinational case series. Gut vol. 53, (11) 1583-1589.
10.1136/gut.2003.037275
Knowles CH, Silk DBA, Darzi A, Feakins R, Raimundo AH, Veress B, Crompton T, Lindberg G et al.(2004). Deranged smooth muscle alpha-actin: A bio-marker of intestinal pseudo-obstruction. A controlled multinational case series and ontological study. GUT vol. 53, A29-A30.
Dvorkin LEES, Chan CHRISTOPHERL, Knowles CHARLESH, Williams NORMANS, Lunniss PETERJ, Scott MS(2004). Anal sphincter morphology in patients with full-thickness rectal prolapse. Diseases of the Colon and Rectum vol. 47, (2) 198-203.
10.1007/s10350-003-0035-4
Lunniss PJ, WILLIAMS NS, Knowles CH, Scott SM, Dvorkin LS, Chan CLH(2004). Anal sphincter morphology in patients with full-thickness rectal prolapse. Diseases of the Colon and Rectum. vol. 47, (2) 198-203.
10.1007/s10350-003-0035-4
GLADMAN MA, Knowles CH, Payne JG(2004). Intraoperative culture in appendicitis: historical practice challenged. Ann Royal Coll Surg Eng vol. 86, 196-201.
10.1308/003588404323043346
Haq AI, Gladman MA, Knowles CH, Payne JG (2003). Evaluation of intraoperative bacterial cultures in 721 patients with acute appendicitis. BRITISH JOURNAL OF SURGERY. vol. 90, 34-34.
Scott SM, Picon L, Knowles CH, Fourquet F, Yazaki E, Williams NS, Lunniss PJ, Wingate DL(2003). Automated quantitative analysis of nocturnal jejunal motor activity identifies abnormalities in individuals and subgroups of patients with slow transit constipation. Am J Gastroenterol vol. 98, (5) 1123-1134.
10.1111/j.1572-0241.2003.07419.x
Chan CLH, Scott SM, Birch MJ, Knowles CH, Williams NS, Lunniss PJ(2003). Rectal heat thresholds: a novel test of the sensory afferent pathway. Dis Colon Rectum vol. 46, (5) 590-595.
10.1097/01.DCR.0000059331.62627.6F
Knowles CH, Nickols CD, Feakins R, Martin JE(2003). A systematic analysis of polyglucosan bodies in the human gastrointestinal tract in health and disease. Acta Neuropathol vol. 105, (4) 410-413.
10.1007/s00401-002-0662-1
Lunniss PJ, KNOWLES CH, Porrett T(2003). Creation of a treatment protocol for nurse-led management of anal fissure. Colorectal Dis vol. 5, (1) 63-72.
10.1046/j.1463-1318.2003.00406.x
Lunniss PJ, KNOWLES CH, Scott SM, Kamm MA, Lindberg G, Glia A, Rayner C(2003). Idiopathic slow-transit constipation: an almost exclusively female disorder. Dis Colon Rectum vol. 46, (2) 1716-1717.
Chen B, Knowles CH, Scott M, Anand P, Williams NS, Milbrandt J, Tam PKH(2002). Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations. NEUROGASTROENT MOTIL vol. 14, (5) 513-517.
10.1046/j.1365-2982.2002.00354.x
Lunniss PJ, KNOWLES CH, Scott SM, Allison ME, Legg PE(2002). Level of classification performance of KESS (symptom scoring system for constipation) validated in a prospective series of 105 patients. Dis Colon Rectum vol. 45, (6) 842-843.
Mukherjee D, Khela MK, Castillo FD, Scott SM, Knowles CH, Yazaki E, Evans DF, Kadirkamanathan SS(2002). Estimation of bolus transport and clearance in an oesophageal model using multichannel intraluminal impedance (MII): Validation study with gamma scintigraphy (GS). GASTROENTEROLOGY vol. 122, (4) A357-A358.
MARTIN JE, Knowles CH, Clover L, Lang B(2002). A role for autoantibodies in some cases of acquired non-paraneoplastic gut dysmotility. Scand J Gastroenterol vol. 37, 166-170.
Knowles CH, Lang B, Clover L, Scott SM, Gotti C, Vincent A, Martin JE(2002). A role for autoantibodies in some cases of acquired non-paraneoplastic gut dysmotility. Scand J Gastroenterol vol. 37, (2) 166-170.
10.1080/003655202753416821
Facer P, Knowles CH, Tam PKH, Ford AP, Dyer N, Baecker PA, Anand P (2001). Novel capsaicin (VR1) and purinergic (P2X(3)) receptors in Hirschsprung's intestine. JOURNAL OF PEDIATRIC SURGERY. vol. 36, 1679-1684.
10.1053/jpsu.2001.27959
Williams NS, KNOWLES CH, Anand P, Birch R, Smith JA, Yiangou Y, Facer P, Sangameswaran L et al.(2001). Increased acid-sensing ion channel ASIC-3 in inflamed human intestine. Eur J Gastroent and Hepatology vol. 13, (8) 891-896.
KNOWLES CH, Sampietre SN, de Souza LJ, Machado MC, Monteiro Cunha JE, Leite KR, Assis RS, Jancar S(2001). Effect of platelet-activating factor antagonists (BN-52021, WEB-2170, and BB-882) on bacterial translocation in acute pancreatitis. J Gastrointest Surg vol. 5, (4) 364-370.
Chan CLH, Yiangou Y, Facer P, Dyer NHC, Knowles CH, Williams NS, Anand P(2001). Increased capsaicin receptor VR1-immunoreactivity in acute inflammatory bowel disease. BRIT J SURG vol. 88, 10-10.
Knowles CH, Lang B, Clover L, Scott M, Gotti C, Vincent A, Martin JE(2001). A role for autoantibodies in some cases of acquired non-paraneoplastic gut dysmotility. GASTROENTEROLOGY vol. 120, (5) A750-A750.
Facer P, Knowles CH, Thomas PK, Tam PKH, Williams NS, Anand P (2001). Decreased tyrosine kinase C expression may reflect developmental abnormalities in Hirschsprung's disease and idiopathic slow-transit constipation. BRITISH JOURNAL OF SURGERY. vol. 88, 545-552.
10.1046/j.1365-2168.2001.01731.x
Williams NS, KNOWLES CH, Chan CL, Yiangou Y, Facer P, Anand P, Dyer NH(2001). Vanilloid receptor 1 immunoreactivity in inflamed human bowel. Lancet vol. 357, (9265) 1338-1339.
10.1016/S0140-6736(00)04503-7
CLH C, Scott SM, Knowles CH, Lunniss PJ(2001). Exaggerated rectal adaptation - another cause of outlet obstruction. Colorectal Disease vol. 3, (2) 141-141.
10.1111/j.1463-1318.2001.00222.x
Scott SM, Knowles CH, Newell M, Garvie N, Williams NS, Lunniss PJ(2001). Scintigraphic assessment of colonic transit in women with slow-transit constipation arising de novo and following pelvic surgery or childbirth. Br J Surg vol. 88, (3) 405-411.
10.1046/j.1365-2168.2001.01699.x
Knowles CH, Nickols CD, Scott SM, Bennett NI, de Oliveira RB, Chimelli L, Feakins R, Williams NS et al.(2001). Smooth muscle inclusion bodies in slow transit constipation. J PATHOL vol. 193, (3) 390-397.
10.1002/1096-9896(2000)9999:9999
Cheng W, Au DK, Knowles CH, Anand P, Tam PK(2001). Hirschsprung's disease: a more generalised neuropathy?. J Pediatr Surg vol. 36, (2) 296-300.
10.1053/jpsu.2001.20695
Williams NS, KNOWLES CH, Chan CL, Anand P, Facer P, Baecker PA, Ford AP, Yiangou Y(2001). ATP-gated ion channel P2X(3) is increased in human inflammatory bowel disease. Neurogastroenterol Motil vol. 13, (4) 365-369.
Lunniss PJ, Williams NS, KNOWLES CH, Scott SM, Garvie N, Newell M(2001). Scintigraphic assessment of colonic transit in women with slow-transit constipation arising de novo and following pelvic surgery or childbirth. Br J Surg vol. 88, (3) 405-411.
Lunniss PJ, KNOWLES CH, Scott SM(2001). Slow transit constipation: a disorder of pelvic autonomic nerves?. Digestive Diseases and Sciences. vol. 46, (2) 389-401.
Knowles CH, Eccersley AJ, Scott SM, Walker SM, Reeves B, Lunniss PJ(2000). Linear discriminant analysis of symptoms in patients with chronic constipation: validation of a new scoring system (KESS). Diseases of the Colon and Rectum vol. 43, (10) 1419-1426.
10.1007/BF02236639
Knowles CH, Gayther SA, Scott M, Ramus S, Anand P, Williams NS, Ponder BA(2000). Idiopathic slow-transit constipation is not associated with mutations of the RET proto-oncogene or GDNF. Diseases of the Colon and Rectum vol. 6, (43) 851-857.
10.1007/BF02238026
KNOWLES CH, Scott M, LUNNISS PJ(1999). Outcome of colectomy for slow transit constipation. Annals of Surgery vol. 5, (230) 627-638.
Return to top