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Publications:  Prof Graham Hitman

Smit RAJ, Trompet S, Leong A, Goodarzi MO, Postmus I, Warren H, Theusch E, Barnes MR et al.(2019). Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study. Pharmacogenomics Journal
10.1038/s41397-019-0125-x
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62179
Bhowmik B, Siddique T, Majumder A, Mdala I, Hossain IA, Hassan Z, Jahan I, Moreira NCDV et al.(2019). Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in Bangladesh. BMC Pregnancy and Childbirth vol. 19, (1)
10.1186/s12884-019-2571-5
Cripps MJ, Bagnati M, Jones TA, Ogunkolade BW, Sayers SR, Caton PW, Hanna K, Billacura MP et al.(2020). Identification of a subset of trace amine-associated receptors and ligands as potential modulators of insulin secretion. Biochemical Pharmacology vol. 171,
10.1016/j.bcp.2019.113685
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61413
Martineau AR, Thummel KE, Wang Z, Jolliffe DA, Boucher BJ, Griffin SJ, Forouhi NG, Hitman GA(2019). Differential Effects of Oral Boluses of Vitamin D<inf>2</inf> vs Vitamin D<inf>3</inf> on Vitamin D Metabolism: A Randomized Controlled Trial. Journal of Clinical Endocrinology and Metabolism vol. 104, (12) 5831-5839.
10.1210/jc.2019-00207
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59234
Thangaratinam S, Khan K, Al Wattar B, Dodds J, PLACZEK A, Beresford L, Spyreli E, Moore A et al.(2019). Mediterranean-style diet in pregnant women with metabolic risk factors (ESTEEM): a pragmatic multicentre randomised trial. PLoS Medicine vol. 16, (7)
10.1371/journal.pmed.1002857
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59317
Lau EYM, Carroll EC, Callender LA, Hood GA, Berryman V, Pattrick M, Finer S, Hitman GA et al.(2019). Type 2 diabetes is associated with the accumulation of senescent T cells. Clinical & Experimental Immunology
10.1111/cei.13344
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58984
Daley B, Hitman G, Fenton N, McLachlan S(2019). Assessment of the methodological quality of local clinical practice guidelines on the identification and management of gestational diabetes. BMJ Open vol. 9, (6) e027285-e027285.
10.1136/bmjopen-2018-027285
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58216
Preston JL, Berryman VR, Hancock A, Pattrick M, Worthington A, Hitman GA, Hood GA(2019). Developing patient and public involvement and engagement (PPIE) in diabetes research: a local approach. Practical Diabetes vol. 36, (3) 81-85.
10.1002/pdi.2220
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58283
MIHAYLOVA BA(2019). Efficacy and safety of statin therapy in older people: meta-analysis of individual participant data from 28 randomised controlled trials. Lancet407-415.
10.1016/S0140-6736(18)31942-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55109
Fottrell E, Ahmed N, Nahar B, Shaha SK, Kuddus A, Grijalva-Eternod CS, Nahar T, Fall C et al.(2018). Growth and body composition of children aged 2-4 years after exposure to community mobilisation women's groups in Bangladesh. Journal of Epidemiology and Community Health vol. 72, (10) 888-895.
10.1136/jech-2017-210134
https://qmro.qmul.ac.uk/xmlui/handle/123456789/42963
Beveridge LA, Khan F, Struthers AD, Armitage J, Barchetta I, Bressendorff I, Cavallo MG, Clarke R et al.(2018). Effect of vitamin D supplementation on markers of vascular function: A systematic review and individual participant meta- analysis. Journal of the American Heart Association vol. 7, (11)
10.1161/JAHA.117.008273
https://qmro.qmul.ac.uk/xmlui/handle/123456789/41643
Riaz M, Shaikh F, Fawwad A, Hakeem R, Shera AS, Hitman GA, Bhowmik B, do Vale Moreira NC et al.(2018). Maternal Nutrition during Early Pregnancy and Cardiometabolic Status of Neonates at Birth. J Diabetes Res vol. 2018, 7382946-7382946.
10.1155/2018/7382946
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39904
Griffin SJ, Bethel MA, Holman RR, Khunti K, Wareham N, Brierley G, Davies M, Dymond A et al.(2018). Metformin in non-diabetic hyperglycaemia: the GLINT feasibility RCT. Health Technol Assess vol. 22, (18) 1-64.
10.3310/hta22180
https://qmro.qmul.ac.uk/xmlui/handle/123456789/38883
Miettinen ME, Smart MC, Kinnunen L, Keinänen-Kiukaanniemi S, Moilanen L, Puolijoki H, Saltevo J, Oksa H et al.(2018). The effect of age and gender on the genetic regulation of serum 25-hydroxyvitamin D - the FIN-D2D population-based study. J Steroid Biochem Mol Biol vol. 178, 229-233.
10.1016/j.jsbmb.2017.12.018
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36346
Amaefule CE, Drymoussi Z, Dodds J, Sweeney L, Pizzo E, Daru J, Robson J, Poston L et al.(2018). Effectiveness and acceptability of myoinositol nutritional supplement in the prevention of gestational diabetes (EMmY): A protocol for a randomised, placebo-controlled, double-blind pilot trial. BMJ Open vol. 8, (9)
10.1136/bmjopen-2018-022831
https://qmro.qmul.ac.uk/xmlui/handle/123456789/43283
Miettinen ME, Smart MC, Kinnunen L, Harjutsalo V, Reinert-Hartwall L, Ylivinkka I, Surcel H-M, Lamberg-Allardt C et al.(2017). Genetic determinants of serum 25-hydroxyvitamin D concentration during pregnancy and type 1 diabetes in the child. PLoS One vol. 12, (10) e0184942-e0184942.
10.1371/journal.pone.0184942
https://qmro.qmul.ac.uk/xmlui/handle/123456789/28804
Al Wattar BH, Dodds J, Placzek A, Spyreli E, Higgins S, Moore A, Hooper R, Beresford L et al.(2017). Mediterranean diet based intervention in pregnancy to improve maternal and fetal outcomes: Methodological challenges and lessons learned from the multicentre ESTEEM study. Contemporary Clinical Trials Communications vol. 6, 72-77.
10.1016/j.conctc.2017.02.012
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22386
Finer S, Lowe R, Ogunkolade W, Bhowmik B, Hussain A, Khan AKA, Rakyan V, Hitman GA (2017). The influence of maternal and offspring environment on genome-wide methylation of the offspring in Bangladesh. Manchester Central, Manchester , from: 08/03/2017 to: 10/03/2017, vol. 34, pp. 20-21. Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,
10.1111/dme.8_13303
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55373
Hanna K, Bagnati M, Ogunkolade BW, Marshall C, Bugliani M, Marchetti P, Caton PW, Ball GR et al. (2017). Role of tumour necrosis factor receptor 5 in glucolipotoxic islet cell death. DIABETIC MEDICINE. vol. 34, 47-47.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56401
Finer S, LOWE R, Ogunkolade BW, Pervin S, Mathews C, Smart M, Alam DS, Hitman GA(2016). Is famine exposure during developmental life in rural Bangladesh associated with a metabolic and epigenetic signature in young adulthood? A historical cohort study. BMJ Open
10.1136/bmjopen-2016-011768
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18154
Deedwania PC, Pedersen TR, DeMicco DA, Breazna A, Betteridge DJ, Hitman GA, Durrington P, Neil A et al.(2016). Differing predictive relationships between baseline LDL-C, systolic blood pressure, and cardiovascular outcomes. Int J Cardiol vol. 222, 548-556.
10.1016/j.ijcard.2016.07.201
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15128
Kage A, Cowan F, Kempley S, Finer S, Hogg M, Hitman G, Shah D (2016). HEAD CIRCUMFERENCE IS DIRECTLY RELATED TO SPECIFIC LINEAR MEASUREMENTS OF CEREBRAL STRUCTURES IN A LOCAL EAST LONDON POPULATION OF WELL NEWBORNS OF SOUTH ASIAN DIASPORA. EUROPEAN JOURNAL OF PEDIATRICS. vol. 175, 1676-1676.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19359
Al Wattar B, DODDS JP, Placzek A, Spyreli E, Moore A, Hooper R, Beresford L, Roseboom T et al.(2016). Effect of simple, targeted diet in pregnant women with metabolic risk factors on maternal and fetal outcomes (ESTEEM): study protocol for a pragmatic multicentre randomised trial. BMJ Open vol. 6, (10) Article BMJ Open 2016;6:e01, 1-10.
10.1136/bmjopen-2016-013495
https://qmro.qmul.ac.uk/xmlui/handle/123456789/16264
Smit RA, Postmus I, Trompet S, Barnes MR, Warren H, Arsenault BJ, Chasman DI, Cupples LA et al.(2016). Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment. Pharmacogenomics vol. 17, (15) 1621-1628.
10.2217/pgs-2016-0091
https://qmro.qmul.ac.uk/xmlui/handle/123456789/16224
Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE et al.(2016). Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. Journal of Medical Genetics
10.1136/jmedgenet-2016-103966
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15127
Rayanagoudar G, Hashi AA, Zamora J, Khan KS, Hitman GA, Thangaratinam S(2016). Quantification of the type 2 diabetes risk in women with gestational diabetes: a systematic review and meta-analysis of 95,750 women. Diabetologia
10.1007/s00125-016-3927-2
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12246
Forouhi NG, Menon RK, Sharp SJ, Mannan N, Timms PM, Martineau AR, Rickard AP, Boucher BJ et al.(2016). Effects of vitamin D<inf>2</inf> or D<inf>3</inf> supplementation on glycaemic control and cardiometabolic risk among people at risk of type 2 diabetes: Results of a randomized double-blind placebo-controlled trial. Diabetes, Obesity and Metabolism vol. 18, (4) 392-400.
10.1111/dom.12625
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12380
Deshmukh H, Chasman D, Trompet S, Li X, Sun F, Hitman G, Colhoun H (2016). Meta-analysis of genome-wide association studies to assess C-reactive protein response to statin therapy. LANCET. vol. 387, 37-37.
Livingstone SJ, Looker HC, Akbar T, Betteridge DJ, Durrington PN, Hitman GA, Neil HAW, Fuller JH et al.(2016). Effect of atorvastatin on glycaemia progression in patients with diabetes: an analysis from the Collaborative Atorvastatin in Diabetes Trial (CARDS). Diabetologia vol. 59, (2) 299-306.
10.1007/s00125-015-3802-6
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12384
Bagnati M, Ogunkolade BW, Marshall C, Tucci C, Hanna K, Jones TA, Bugliani M, Nedjai B et al.(2016). Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation. Cell Death and Disease vol. 7, (8)
10.1038/cddis.2016.203
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15134
Rayanagoudar G, Moore M, Zamora J, Hanson P, Huda MSB, Hitman GA, Thangaratinam S(2015). Postpartum care of women with gestational diabetes: Survey of healthcare professionals. European Journal of Obstetrics and Gynecology and Reproductive Biology vol. 194, 236-240.
10.1016/j.ejogrb.2015.09.019
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15725
Huda MSB, Hitman GA(2015). C-peptide: should we be testing this routinely in the Type 1 diabetes clinic?. Diabet Med vol. 32, (10) 1259-1260.
10.1111/dme.12953
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15613
Miettinen ME, Smart MC, Kinnunen L, Mathews C, Harjutsalo V, Surcel H-M, Lamberg-Allardt C, Tuomilehto J et al.(2015). Maternal VDR variants rather than 25-hydroxyvitamin D concentration during early pregnancy are associated with type 1 diabetes in the offspring. Diabetologia vol. 58, (10) 2278-2283.
10.1007/s00125-015-3675-8
https://qmro.qmul.ac.uk/xmlui/handle/123456789/10889
Soedamah-Muthu SS, Livingstone SJ, Charlton-Menys V, Betteridge DJ, Hitman GA, Neil HAW, Bao W, DeMicco DA et al.(2015). Effect of atorvastatin on C-reactive protein and benefits for cardiovascular disease in patients with type 2 diabetes: analyses from the Collaborative Atorvastatin Diabetes Trial. Diabetologia vol. 58, (7) 1494-1502.
10.1007/s00125-015-3586-8
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14893
Greenhalgh T, Clinch M, Afsar N, Choudhury Y, Sudra R, Campbell-Richards D, Claydon A, Hitman GA et al.(2015). Socio-cultural influences on the behaviour of South Asian women with diabetes in pregnancy: Qualitative study using a multi-level theoretical approach. BMC Medicine vol. 13, (1)
10.1186/s12916-015-0360-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9752
Adaikalakoteswari A, Finer S, Voyias PD, Mccarthy CM, Vatish M, Moore J, Smart-Halajko M, Bawazeer N et al.(2015). Vitamin b<inf>12</inf> insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of srebf1 and ldlr genes. Clinical Epigenetics vol. 7, (1)
10.1186/s13148-015-0046-8
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6970
Rogozi¿ska E, Chamillard M, Hitman GA, Khan KS, Thangaratinam S(2015). Nutritional manipulation for the primary prevention of gestational diabetes mellitus: A meta-analysis of randomised studies. PLoS ONE vol. 10, (2)
10.1371/journal.pone.0115526
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7072
Hillman SL, Finer S, Smart MC, Mathews C, Lowe R, Rakyan VK, Hitman GA, Williams DJ(2015). Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates. Epigenetics vol. 10, (1) 50-61.
10.4161/15592294.2014.989741
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15595
Fulcher J, O'Connell R, Voysey M, Emberson J, Blackwell L, Mihaylova B, Simes J, Collins R et al.(2015). Efficacy and safety of LDL-lowering therapy among men and women: Meta-analysis of individual data from 174 000 participants in 27 randomised trials. The Lancet vol. 385, (9976) 1397-1405.
10.1016/S0140-6736(14)61368-4
Hood GA, Chowdhury TA, Griffiths CJ, Hood RKE, Mathews C, Hitman GA(2015). The Mela Study: exploring barriers to diabetes research in black and minority ethnic groups. Prim Health Care Res Dev vol. 16, (1) 53-60.
10.1017/S1463423614000061
Finer S, Mathews C, Lowe R, Smart M, Hillman S, Foo L, Sinha A, Williams D et al.(2014). Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring. Human Molecular Genetics vol. 24, (11) 3021-3029.
10.1093/hmg/ddv013
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7020
Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K et al.(2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun vol. 5,
10.1038/ncomms6068
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6802
Trompet S, Postmus I, Deshmukh HA, Barnes MR, Psaty BM, Tardif JC, Hitman G, Krauss RM et al. (2014). Pharmacogenetic GWAS meta-analysis of LDL cholesterol response to statins. EUROPEAN HEART JOURNAL. vol. 35, 370-370.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6689
Finer S, Iqbal S, Ogunkolade WB, Mathews C, Lowe R, Smart M, Rakyan VK, Alam DS et al.(2014). Variation in phenotype and DNA methylation is detectable in an observational cohort of young adult Bangladeshis exposed to famine during in utero and postnatal life. DIABETOLOGIA vol. 57, S105-S106.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7120
Boekholdt SM, Hovingh GK, Mora S, Arsenault BJ, Amarenco P, Pedersen TR, LaRosa JC, Waters DD et al.(2014). Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials. J Am Coll Cardiol vol. 64, (5) 485-494.
10.1016/j.jacc.2014.02.615
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6690
Hawa MI, Buchan AP, Ola T, Wun CC, DeMicco DA, Bao W, Betteridge DJ, Durrington PN et al.(2014). LADA and CARDS: a prospective study of clinical outcome in established adult-onset autoimmune diabetes. Diabetes Care vol. 37, (6) 1643-1649.
10.2337/dc13-2383
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7009
Finer S, Mathews C, Smart M, Hillman S, Foo L, Lowe R, Rakyan V, Hitman G (2014). Maternal Gestational Diabetes Is Associated with Genome-Wide Methylation Variation in Placenta and Cord Blood of Exposed Offspring. DIABETES. vol. 63, A56-A56.
Hillman SL, Finer S, Smart MC, Rakyan V, Hitman GA, Williams DJ(2014). Identification of Novel DNA Methylation Profiles Associated with Gene Regulation and Metabolic Pathways in Growth Restricted Offspring. REPRODUCTIVE SCIENCES vol. 21, (3) 166A-166A.
Finer S, Saravanan P, Hitman G, Yajnik C(2014). The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity. Diabet Med vol. 31, (3) 263-272.
10.1111/dme.12390
Finer S, Iqbal S, Mathews C, Ogunkolade BW, Smart M, Alam D, Hitman G(2014). DNA methylation variants in young adult off spring exposed to famine during postnatal life in Bangladesh. LANCET vol. 383, 48-48.
Hitman GA, Finer S(2014). To tweet or not to tweet. Diabet Med vol. 31, (2)
10.1111/dme.12394
Callejo D, Diaz-Cuervo H, Cuervo J, Rebollo P, Hussain A, Hitman GA(2013). EARLY LIFE DETERMINANTS OF METABOLIC SYNDROME AND DIABETES MELLITUS IN SOUTH ASIAN POPULATION LIVING IN EUROPE: A SYSTEMATIC REVIEW. VALUE IN HEALTH vol. 16, (7) A434-A435.
10.1016/j.jval.2013.08.642
Menon RK, Rickard AP, Mannan N, Timms PM, Sharp SJ, Martineau A, Boucher BJ, Chowdhury TA et al.(2013). The effects of vitamin D₂ or D₃ supplementation on glycaemic control and related metabolic parameters in people at risk of type 2 diabetes: protocol of a randomised double-blind placebo-controlled trial. BMC Public Health vol. 13,
10.1186/1471-2458-13-999
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14650
Hitman GA, Leslie RD, Holt RIG(2013). GLP-1-based diabetes therapies; trial by media. Diabetic Medicine vol. 30, (10) 1147-1147.
10.1111/dme.12299
Boekholdt SM, Arsenault BJ, Hovingh GK, Mora S, Pedersen TR, Larosa JC, Welch KMA, Amarenco P et al.(2013). Levels and changes of HDL cholesterol and apolipoprotein A-I in relation to risk of cardiovascular events among statin-treated patients: a meta-analysis. Circulation vol. 128, (14) 1504-1512.
10.1161/CIRCULATIONAHA.113.002670
Deshmukh H, McKeigue PM, Looker HC, Van Zuydam N, Ahlqvist E, Hitman GA, Palmer CNA, Colhoun HM et al. (2013). Genome-wide association study for circulating levels of soluble receptor for advanced glycation end-products (sRAGE). DIABETOLOGIA. vol. 56, S77-S77.
Huertas-Vazquez A, Nelson CP, Guo X, Reinier K, Uy-Evanado A, Teodorescu C, Ayala J, Jerger K et al.(2013). Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease. PLoS ONE vol. 8, (4)
10.1371/journal.pone.0059905
Albrechtsen A, Grarup N, Li Y, Sparso T, Tian G, Cao H, Jiang T, Kim SY et al.(2013). Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. DIABETOLOGIA vol. 56, (2) 298-310.
10.1007/s00125-012-2756-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14570
Cooper JD, Simmonds MJ, Walker NM, Burren O, Brand OJ, Guo H, Wallace C, Stevens H et al.(2012). Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics vol. 21, (23) 5202-5208.
10.1093/hmg/dds357
Callejo D, Cuervo J, Rebollo P, Diaz H, Hitman G, Hussain A(2012). SYSTEMATIC REVIEW OF EARLY LIFE DETERMINANTS OF METABOLIC SYNDROME AND DIABETES MELLITUS IN BANGLADESH, INDIA AND PAKISTAN. VALUE IN HEALTH vol. 15, (7) A496-A496.
10.1016/j.jval.2012.08.1660
Deedwania PC, Demicco DA, Breazna A, Wun CC, Pedersen T, Colhoun HM, Neil A, Hitman G (2012). The effect of visit-to-visit variability in blood pressure on stroke and coronary events in 5213 patients with diabetes: pooled analyses of TNT, IDEAL, and CARDS trials. EUROPEAN HEART JOURNAL. vol. 33, 359-359.
Deedwania PC, Demicco DA, Breazna A, Wun CC, Pedersen T, Colhoun HM, Neil A, Hitman G (2012). The effect of visit-to-visit variability in blood pressure on stroke and coronary events in the TNT, IDEAL and CARDS trials. EUROPEAN HEART JOURNAL. vol. 33, 657-657.
Mihaylova B, Emberson J, Blackwell L, Keech A, Simes J, Barnes EH, Voysey M, Gray A et al.(2012). The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: Meta-analysis of individual data from 27 randomised trials. The Lancet vol. 380, (9841) 581-590.
10.1016/S0140-6736(12)60367-5
van Leeuwen N, Nijpels G, Becker ML, Deshmukh H, Zhou K, Stricker BHC, Uitterlinden AG, Hofman A et al.(2012). A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts. DIABETOLOGIA vol. 55, (7) 1971-1977.
10.1007/s00125-012-2537-x
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14551
Holt RIG, Hitman GA, Young BS, Alberti KGMM(2012). The publication of Diabetes UK position statements and care recommendations; a virtual issue. Diabet Med
10.1111/j.1464-5491.2012.03696.x
Deshmukh HA, Colhoun HM, Johnson T, McKeigue PM, Betteridge DJ, Durrington PN, Fuller JH, Livingstone S et al.(2012). Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). JOURNAL OF LIPID RESEARCH vol. 53, (5) 1000-1011.
10.1194/jlr.P021113
Boekholdt SM, Arsenault BJ, Mora S, Pedersen TR, LaRosa JC, Nestel PJ, Simes RJ, Durrington P et al.(2012). Association of LDL Cholesterol, Non-HDL Cholesterol, and Apolipoprotein B Levels With Risk of Cardiovascular Events Among Patients Treated With Statins A Meta-analysis. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION vol. 307, (12) 1302-1309.
10.1001/jama.2012.366
Finer S, Khan KS, Hitman GA, Griffiths C, Martineau A, Meads C(2012). Inadequate vitamin D status in pregnancy: evidence for supplementation. Acta Obstet Gynecol Scand vol. 91, (2) 159-163.
10.1111/j.1600-0412.2011.01305.x
Colhoun HM, Betteridge DJ, Durrington P, Hitman G, Neil A, Livingstone S, Charlton-Menys V, Bao WH et al.(2011). Total Soluble and Endogenous Secretory Receptor for Advanced Glycation End Products as Predictive Biomarkers of Coronary Heart Disease Risk in Patients With Type 2 Diabetes An Analysis From the CARDS Trial. DIABETES vol. 60, (9) 2379-2385.
10.2337/db11-0291
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14897
Hitman GA, Finer S(2011). Obesity and Type 2 diabetes; achieving weight loss. Diabet Med vol. 28, (6)
10.1111/j.1464-5491.2011.03319.x
Edghill EL, Khamis A, Weedon MN, Walker M, Hitman GA, McCarthy MI, Owen KR, Ellard S et al.(2011). Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes. Diabet Med vol. 28, (6) 681-684.
10.1111/j.1464-5491.2011.03269.x
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14892
Holt RIG, Young BS, Hitman GA, Alberti KGMM(2011). The publication of Diabetes UK position statements and care recommendations. Diabet Med vol. 28, (5)
10.1111/j.1464-5491.2011.03247.x
Nedjai B, Hitman GA, Church LD, Minden K, Whiteford ML, McKee S, Stjernberg S, Pettersson T et al.(2011). Differential cytokine secretion results from p65 and c-Rel NF-κB subunit signaling in peripheral blood mononuclear cells of TNF receptor-associated periodic syndrome patients. Cell Immunol vol. 268, (2) 55-59.
10.1016/j.cellimm.2011.02.007
Nedjai B, Hitman GA, Quillinan N, Coughlan RJ, Church L, McDermott MF, Turner MD (2011). THE ANTI-TNF DRUG, INFLIXIMAB, HAS A PROINFLAMMATORY ACTION IN PATIENTS WITH TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PERIODIC SYNDROME (TRAPS). ADVANCES IN TNF FAMILY RESEARCH. Editors: Wallach, D, Kovalenko, A, Feldman, M, vol. 691, 708-708.
Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C et al.(2010). Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. NAT GENET vol. 42, (7) 579-U155.
10.1038/ng.609
Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C et al.(2010). Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. NATURE vol. 464, (7289) 713-U86.
10.1038/nature08979
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14895
Finer S, Holland M, Rakyan V, Hitman G (2010). A model of intrauterine hyperglycaemia provides evidence for fetal programming of glucose tolerance and a platform for epigenomic studies in mouse and human. Longitudinal and Life Course Studies: international journal. Conference: The 5th Conference on Epidemiology and Longitudonal Studies in Europe (Paphos, Cyprus) from: 13/10/2010 to: 15/10/2010, vol. 1,
Bell CG, Finer S, Lindgren CM, Wilson GA, Rakyan VK, Teschendoff AE, Akan P, Stupka E et al.(2010). Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus. PLOS One
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https://qmro.qmul.ac.uk/xmlui/handle/123456789/14550
Nedjai B, Quillinan N, Coughlan RJ, Church L, McDermott MF, Hitman GA, Turner MD(2010). Lessons from anti-TNF biologics: infliximab failure in a TRAPS family with the T50M mutation in TNFRSF1A. Advances in Tnf Family Research; Proceedings from the 12th International TNF Conference, 2009., Editors: Wallach, D, Kovalenko, A, Feldmann, M, vol. 691, Springer (New York),
Charlton-Menys V, Colhoun HM, Betteridge DJ, Soedamah-Muthu S, Hitman G, Neil HA, Livingstone S, Bao WH et al. (2009). C-reactive Protein and Amyloid A as Predictors of Cardiovascular Events in Type 2 Diabetes in CARDS. CIRCULATION. vol. 120, S398-S398.
Betteridge DJ, Colhoun HM, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, Bao WH, DeMicco DA et al. (2009). Change in Lp-PLA2 With Risk Change on Statin Therapy in the Collaborative Atorvastatin Diabetes Study (CARDS). CIRCULATION. vol. 120, S420-S420.
Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HAW, Livingstone SJ, Charlton-Menys V, DeMicco DA et al.(2009). Effects of Atorvastatin on Kidney Outcomes and Cardiovascular Disease in Patients With Diabetes: An Analysis From the Collaborative Atorvastatin Diabetes Study (CARDS). AM J KIDNEY DIS vol. 54, (5) 810-819.
10.1053/j.ajkd.2009.03.022
Colhoun HM, Betteridge DJ, Durrington PN, Hitman G, Neil HAW, Charlton-Menys V, Bao W, DeMicco D et al. (2009). Circulating neopterin and monocyte chemoattractant protein-1 are responsive to statin therapy but are poor predictors of cardiovascular events in type 2 diabetes in CARDS. DIABETOLOGIA. vol. 52, S481-S481.
Sinclair C, O'Toole EA, Paige D, El Bashir H, Robinson J, Dobson R, Lench N, Stevens HP et al.(2009). Filaggrin mutations are associated with ichthyosis vulgaris in the Bangladeshi population. Br J Dermatol vol. 160, (5) 1113-1115.
10.1111/j.1365-2133.2009.09050.x
Chowdhury TA, Boucher BJ, Hitman GA(2009). Vitamin D and type 2 diabetes. Is there a link?. Primary Care Diabetes vol. 3, (2) 115-116.
10.1016/j.pcd.2009.03.004
Chowdhury TA, Hitman GA(2009). Commentary NICE guidance for identification and treatment of familial hypercholesterolaemia: Commentary 2. Heart vol. 95, (7) 589-591.
10.1136/hrt.2008.150888
Chowdhury TA, Hitman GA(2009). NICE guidance for identification and treatment of familial hypercholesterolaemia: Commentary 1. HEART vol. 95, (7) 587-589.
10.1136/hrt.2008.162917
Charlton-Menys V, Betteridge DJ, Colhoun H, Fuller J, France M, Hitman GA, Livingstone SJ, Neil HAW et al.(2009). Apolipoproteins, cardiovascular risk and statin response in type 2 diabetes: the Collaborative Atorvastatin Diabetes Study (CARDS) (vol 52, pg 218, 2009). DIABETOLOGIA vol. 52, (3) 556-556.
10.1007/s00125-008-1235-1
Charlton-Menys V, Betteridge DJ, Colhoun H, Fuller J, France M, Hitman GA, Livingstone SJ, Neil HAW et al.(2009). Targets of statin therapy: LDL cholesterol, non-HDL cholesterol, and apolipoprotein B in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS). Clin Chem vol. 55, (3) 473-480.
10.1373/clinchem.2008.111401
Timpson NJ, Lindgren CM, Weedon MN, Randall J, Ouwehand WH, Strachan DP, Rayner NW, Walker M et al.(2009). Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes vol. 58, (2) 505-510.
10.2337/db08-0906
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14900
Charlton-Menys V, Betteridge DJ, Colhoun H, Fuller J, France M, Hitman GA, Livingstone SJ, Neil HAW et al.(2009). Apolipoproteins, cardiovascular risk and statin response in type 2 diabetes: the Collaborative Atorvastatin Diabetes Study (CARDS). Diabetologia vol. 52, (2) 218-225.
10.1007/s00125-008-1176-8
Nedjai B, Hitman GA, Quillinan N, Coughlan RJ, Church L, McDermott MF, Turner MD(2009). Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum vol. 60, (2) 619-625.
10.1002/art.24294
Churchman SM, Church LD, Savic S, Coulthard LR, Hayward B, Nedjai B, Turner MD, Mathews RJ et al.(2008). A novel TNFRSF1A splice mutation associated with increased nuclear factor kappaB (NF-kappaB) transcription factor activation in patients with tumour necrosis factor receptor associated periodic syndrome (TRAPS). Ann Rheum Dis vol. 67, (11) 1589-1595.
10.1136/ard.2007.078667
Barroso I, Luan JA, Wheeler E, Whittaker P, Wasson J, Zeggini E, Weedon MN, Hunt S et al.(2008). Population-Specific Risk of Type 2 Diabetes Conferred by HAT4A P2 Promoter Variants A Lesson for Replication Studies. DIABETES vol. 57, (11) 3161-3165.
10.2337/db08-0719
Hitman GA, Hawa MI, Leslie RDG, Ola T, Wun CC, DeMicco D, Betteridge DJ, Durrington PN et al.(2008). The clinical implications of GAD antibody positivity in older patients with established non-insulin requiring diabetes. DIABETOLOGIA vol. 51, S230-S231.
Newman CB, Szarek M, Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HAW, Demicco DA et al.(2008). The safety and tolerability of atorvastatin 10 mg in the Collaborative Atorvastatin Diabetes Study (CARDS). Diab Vasc Dis Res vol. 5, (3) 177-183.
10.3132/dvdr.2008.029
Turner MD, Nedjai B, Hitman GA, McDermott M(2008). Cell surface expression of TNFRI in tumor necrosis factor receptor-associated periodic syndrome: comment on the article by Nedjai et al - Reply. ARTHRITIS RHEUM vol. 58, (7) 2214-2215.
10.1002/art.23547
Chowdhury TA, Hitman GA(2008). Diabetes care for south Asian patients: a special case. Lancet vol. 371, (9626) 1728-1730.
10.1016/S0140-6736(08)60738-2
Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PIW, Abecasis GR et al.(2008). Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet vol. 40, (5) 638-645.
10.1038/ng.120
Nedjai B, Hitman G, Yousaf N, Chernajovsky Y, Stjernberg-Salmela S, Pettersson T, Ranki A, Hawkins P et al.(2008). Abnormal TNFR1 cell surface expression and NF-kappaB activation in TNFR1-Associated Periodic Fever Syndrome (TRAPS). CLIN EXP RHEUMATOL vol. 26, (2) 182-182.
Nedjai B, Hitman GA, Yousaf N, Chernajovsky Y, Stjernberg-Salmela S, Pettersson T, Ranki A, Hawkins PN et al.(2008). Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum vol. 58, (1) 273-283.
10.1002/art.23123
Mohsin F, Hitman G, Leslie R, Hawa M, Biswas K, Zabeen B, Nahar N, Azad K(2008). Clinical Profile and Autoantibody Status in Younger Onset Diabetes in Bangladesh. HORM RES vol. 70, 14-14.
Hitman GA, Colhoun H, Newman C, Szarek M, Betteridge DJ, Durrington PN, Fuller J, Livingstone S et al.(2007). Stroke prediction and stroke prevention with atorvastatin in the Collaborative Atorvastatin Diabetes Study (CARDS). Diabet Med vol. 24, (12) 1313-1321.
10.1111/j.1464-5491.2007.02268.x
Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium (TASC), Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A et al.(2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet vol. 39, (11) 1329-1337.
10.1038/ng.2007.17
Chowdhury TA, Hitman GA(2007). Type 2 diabetes in people of South Asian origin: Potential strategies for prevention. British Journal of Diabetes and Vascular Disease vol. 7, (6) 279-282.
10.1177/14746514070070060401
Hassan Z, Faruque MO, Biswas KB, Islam R, Azad K, Khan AKA, Ali L, Hitman GA (2007). Common variants of pancreatic beta cell related transcription factor genes are not associated with young onset diabetic subjects of Bangladesh. DIABETOLOGIA. vol. 50, S169-S169.
Sandhu MS, Weedon MN, Fawcett KA, Wasson J, Debenham SL, Daly A, Lango H, Frayling TM et al.(2007). Common variants in WFS1 confer risk of type 2 diabetes. NAT GENET vol. 39, (8) 951-953.
10.1038/ng2067
Ramachandran A, Snehalatha C, Sivasankari S, Hitman GA, Vijay V(2007). Parental influence on the spectrum of type 2 diabetes in the offspring among Indians. J Assoc Physicians India vol. 55, 560-562.
Bell JT, Elliot K, Morris A, Groves CJ, Fiddy SE, Frayling TM, Hattersley AT, Walker M et al. (2007). Genome-wide search for multiple loci in type 2 diabetes. GENETIC EPIDEMIOLOGY. vol. 31, 462-463.
Rayner W, Groves CJ, Powell B, Hitman GA, Walker M, Elliott K, Weedon MN, Frayling TM et al. (2007). Analysis of insulin gene variants in 5663 UK subjects provides evidence of a modest effect on T2D risk. DIABETES. vol. 56, A292-A292.
Meirhaeghe A, Sandhu MS, McCarthy MI, de Groote P, Cottel D, Arveiler D, Ferrières J, Groves CJ et al.(2007). Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations. Hum Mol Genet vol. 16, (11) 1343-1350.
10.1093/hmg/ddm084
Colhoun HM, Szarek M, Demicco DA, Neil AW, Betteridge J, Hitman GA, Durrington PN, Fuller JH (2007). Atorvastatin reduces the risk of major cardiovascular events in patients with diabetes and impaired renal function in the collaborative atorvastatin diabetes study (CARDS). DIABETES. vol. 56, A139-A140.
Gueorguiev M, Wiltshire S, Garcia EA, Mein C, Lecoeur C, Kristen B, Allotey R, Hattersley AT et al.(2007). Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes. J Clin Endocrinol Metab vol. 92, (6) 2201-2204.
10.1210/jc.2006-2657
Zeggini E, Weedon MN, Lindgren CM, Lango H, Timpson NJ, Rayner NW, Elliott K, Groves CJ et al. (2007). Genome-wide association analysis in UK subjects provides evidence for a novel type 2 diabetes susceptibility gene in the CDKAL1 region of chromosome 6. DIABETES. vol. 56, A302-A302.
WALLACE C, Wellcome Trust CCC(2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature vol. 447, (7145) 661-678.
10.1038/nature05911
Lopez-Alvarenga JC, Allotey R, Ramachandran A, Snehalatha C, Cassell PG, Commuzzie AG, Hitman GA (2007). Is there an increased genetic component to metabolic syndrome and traits associated with diabetes in families from south India?. DIABETES. vol. 56, A298-A298.
Groves CJ, Zeggini E, Vaxillaire M, Meyre D, Boutin P, Hitman GA, Walker M, Hattersley AT et al. (2007). Large-scale analysis of 11 candidate genes for insulin resistance in 5602 samples from the UK and France: the BAIR human geneiics validation study. DIABETES. vol. 56, A306-A306.
Chinnery PF, Mowbray C, Patel SK, Elson JL, Sampson M, Hitman GA, McCarthy MI, Hattersley AT et al.(2007). Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls. J Med Genet vol. 44, (6)
10.1136/jmg.2007.048876
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JRB et al.(2007). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science vol. 316, (5829) 1336-1341.
10.1126/science.1142364
Weedon MN, Zeggini E, Lango H, Lindgren CM, Perry J, Timpson NJ, Rayner NW, Elliott K et al. (2007). The first UK type 2 diabetes genome-wide association study identifies a gene that contributes to type 2 diabetes risk: FTO. DIABETES. vol. 56, A93-A93.
Allotey R, Cassell PG, Lopez-Alvarenga JC, Commuzzie AG, Snehalatha C, Ramachandran A, Hitman GA (2007). Uncoupling genes UCP2 and UCP3 polymorphisms and their relation to obesity phenotypes: A family association approach. DIABETES. vol. 56, A297-A297.
Sandhu MS, Weedon MN, Fawcett KA, Wasson J, Debenham SL, Daly A, Lango H, Frayling TM et al. (2007). WFS1 is a type 2 diabetes susceptibility gene. DIABETES. vol. 56, A20-A20.
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS et al.(2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science vol. 316, (5826) 889-894.
10.1126/science.1141634
Marshall C, Hitman GA, Cassell PG, Turner MD(2007). Effect of glucolipotoxicity and rosiglitazone upon insulin secretion. Biochem Biophys Res Commun vol. 356, (3) 756-762.
10.1016/j.bbrc.2007.03.047
Raikou M, McGuire A, Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HAW, Livingstone SJ et al.(2007). Cost-effectiveness of primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes: results from the Collaborative Atorvastatin Diabetes Study (CARDS). Diabetologia vol. 50, (4) 733-740.
10.1007/s00125-006-0561-4
Owen KR, Groves CJ, Hanson RL, Knowler WC, Shuldiner AR, Elbein SC, Mitchell BD, Froguel P et al.(2007). Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. Diabetes vol. 56, (3) 879-883.
10.2337/db06-0930
Winckler W, Weedon MN, Graham RR, McCarrolll SA, Purcell S, Almgren P, Tuomi T, Gaudet D et al.(2007). Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. DIABETES vol. 56, (3) 685-693.
10.2337/db06-0202
Freathy RM, Weedon MN, McCarthy MI, Walker M, Hitman GA, Ring SM, Ben-Shlomo Y, Smith GD et al.(2007). Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight. DIABETIC MED vol. 24, 10-10.
Turner MD, Fulcher FK, Jones CV, Smith BT, Aganna E, Partridge CJ, Hitman GA, Clark A et al.(2007). Calpain facilitates actin reorganization during glucose-stimulated insulin secretion. Biochem Biophys Res Commun vol. 352, (3) 650-655.
10.1016/j.bbrc.2006.11.077
Desai M, Zeggini E, Horton VA, Owen KR, Hattersley AT, Levy JC, Walker M, Gillespie KM et al.(2007). An association analysis of the HLA gene region in latent autoimmune diabetes in adults. DIABETOLOGIA vol. 50, (1) 68-73.
10.1007/s00125-006-0513-z
Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M et al.(2006). Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk (vol 55, pg 2640, 2006). DIABETES vol. 55, (12) 3635-3635.
Neil HAW, DeMicco DA, Luo D, Betteridge DJ, Colhoun HM, Durrington PN, Livingstone SJ, Fuller JH et al.(2006). Analysis of efficacy and safety in patients aged 65-75 years at randomization: Collaborative Atorvastatin Diabetes Study (CARDS). Diabetes Care vol. 29, (11) 2378-2384.
10.2337/dc06-0872
Wiltshire S, Bell JT, Groves CJ, Dina C, Hattersley AT, Frayling TM, Walker M, Hitman GA et al.(2006). Epistasis between type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans. ANN HUM GENET vol. 70, 726-737.
10.1111/j.1469-1809.2006.00289.x
Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC et al.(2006). Erratum: The international type 2 diabetes 1q consortium: Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q (Diabetes (2006) 55 (2541-2548)). Diabetes vol. 55, (11)
10.2337/db06-er11
Weedon MN, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM(2006). No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 UK caucasians. DIABETES vol. 55, (11) 3175-3179.
10.2337/db06-0410
Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC et al.(2006). The International Type 2 Diabetes 1q Consortium: Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. (vol 55, pg 2541, 2006). DIABETES vol. 55, (11) 3197-3197.
Weedon MN, McCarthy MI, Hitman G, Walker M, Groves CJ, Zeggini E, Rayner NW, Shields B et al.(2006). Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLOS MED vol. 3, (10) Article e374, 1877-1882.
10.1371/journal.pmed.0030374
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14898
Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M et al.(2006). Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes vol. 55, (9) 2640-2644.
10.2337/db06-0355
Reiling E, Dekker JM, Hansen T, Weedon MN, Nijpels G, Hitman GA, Walker M, McCarthy MI et al. (2006). Evidence that the LARS2 gene represents a novel type 2 diabetes mellitus gene. DIABETOLOGIA. vol. 49, 37-38.
Hassan Z, Hawa MI, Faruque MO, Biswas KB, Azad K, Khan AKA, Ali L, Leslie RDG et al. (2006). INSVNTR polymorphism in young onset diabetes subjects of Bangladesh. DIABETOLOGIA. vol. 49, 178-178.
Aganna E, Burrin JM, Hitman GA, Turner MD(2006). Involvement of calpain and synaptotagmin Ca2+ sensors in hormone secretion from excitable endocrine cells. J Endocrinol vol. 190, (3) R1-R7.
10.1677/joe.1.06737
Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M et al. (2006). Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes. DIABETOLOGIA. vol. 49, 14-14.
Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC et al.(2006). Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. Diabetes vol. 55, (9) 2541-2548.
10.2337/db06-0088
Gloyn AL, Mackay DJG, Weedon MN, McCarthy MI, Walker M, Hitman G, Knight BA, Owen KR et al.(2006). Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes - A comparative genomic and tagging single nucleotide polymorphism approach. DIABETES vol. 55, (8) 2272-2276.
10.2337/db06-0216
Castleden HAJ, Shields B, Bingley PJ, Williams AJK, Sampson M, Walker M, Gibson JM, McCarthy MI et al.(2006). GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes. Diabet Med vol. 23, (8) 834-838.
10.1111/j.1464-5491.2006.01915.x
Singh R, Pearson E, Avery PJ, McCarthy MI, Levy JC, Hitman GA, Sampson M, Walker M et al.(2006). Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes. Diabetologia vol. 49, (8) 1876-1880.
10.1007/s00125-006-0285-5
Sze C, Gould D, Hitman G, Chowdhury TA(2006). Relapsing and remitting insulin requiring diabetes: type 1 or type 2?. J R Soc Med vol. 99, (8) 415-416.
10.1258/jrsm.99.8.415
Ogunkolade WB, Boucher BJ, Bustin SA, Burrin JM, Noonan K, Mannan N, Hitman GA(2006). Vitamin D metabolism in peripheral blood mononuclear cells is influenced by chewing "betel nut" (Areca catechu) and vitamin D status. J Clin Endocrinol Metab vol. 91, (7) 2612-2617.
10.1210/jc.2005-2750
Freathy RM, Weedon MN, Melzer D, Shields B, Hitman GA, Walker M, McCarthy MI, Hattersley AT et al.(2006). The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians. BMC Med Genet vol. 7,
10.1186/1471-2350-7-51
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14899
Durrington PN, Livingstone S, Charlton-Menys V, Colhoun H, Betteridge DJ, Fuller J, Hitman G, Neil HAW et al. (2006). Apolipoproteins as predictors of cardiovascular risk in the collaborative atorvastatin diabetes study (CARDS). ATHEROSCLEROSIS SUPPLEMENTS. vol. 7, 37-37.
10.1016/S1567-5688(06)80113-3
Patel S, Minton JAL, Weedon MN, Frayling TM, Ricketts C, Hitman GA, McCarthy MI, Hattersley AT et al.(2006). Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population. Diabetologia vol. 49, (6) 1209-1213.
10.1007/s00125-006-0227-2
Newman C, Szarek M, Demicco D, Hitman GA, Colhoun HM, Betteridge DJ, Durrington PN, Neil HA et al. (2006). Safety of atorvastatin in the collaborative AtoRvastatin diabetes study (CARDS). DIABETES. vol. 55, A522-A522.
Groves CJ, Zeggini E, Walker M, Hitman GA, Levy JC, O'Rahilly S, Hattersley AT, McCarthy MI et al.(2006). Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate. Diabetes vol. 55, (6) 1884-1889.
10.2337/db05-1674
Desai M, Zeggini E, Horton VA, Owen KR, Hattersley AT, Levy JC, Hitman GA, Walker M et al.(2006). The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults. Diabetes vol. 55, (6) 1890-1894.
10.2337/db06-0089
Freathy RM, Weedon MN, Shields B, Hitman GA, Walker M, McCarthy MI, Hattersley AT, Frayling TM(2006). Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population. JOP vol. 7, (3) 295-302.
Gordon AC, Waheed U, Hansen TK, Hitman GA, Garrard CS, Turner MW, Klein NJ, Brett SJ et al.(2006). Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock vol. 25, (1) 88-93.
10.1097/01.shk.0000186928.57109.8d
Zeggini E, Rayner W, Morris AP, Hattersley AT, Walker M, Hitman GA, Deloukas P, Cardon LR et al.(2005). An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets. Nat Genet vol. 37, (12) 1320-1322.
10.1038/ng1670
Zeggini E, Parkinson JRC, Halford S, Owen KR, Walker M, Hitman GA, Levy JC, Sampson MJ et al.(2005). Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples. Diabet Med vol. 22, (12) 1696-1700.
10.1111/j.1464-5491.2005.01717.x
Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HAW, Livingstone SJ, Thomason MJ, Fuller JH et al.(2005). Rapid emergence of effect of atorvastatin on cardiovascular outcomes in the Collaborative Atorvastatin Diabetes Study (CARDS). Diabetologia vol. 48, (12) 2482-2485.
10.1007/s00125-005-0029-y
Chinnery PF, Elliott HR, Patel S, Lambert C, Keers SM, Durham SE, McCarthy MI, Hitman GA et al.(2005). Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes. Lancet vol. 366, (9497) 1650-1651.
10.1016/S0140-6736(05)67492-2
Turner MD, Cassell PG, Hitman GA(2005). Calpain-10: from genome search to function. Diabetes Metab Res Rev vol. 21, (6) 505-514.
10.1002/dmrr.578
Singh R, Pearson E, Avery PJ, McCarthy MI, Levy JC, Hitman GA, Sampson M, Walker M et al. (2005). Reduced beta cell function in offspring of mothers with young onset type 2 diabetes. PEDIATRIC RESEARCH. vol. 58, 1030-1031.
DeMicco D, Luo D, Betteridge DJ, Colhoun HM, Durrington PN, Hitman GA, Neil HA, Livingstone SJ et al. (2005). Effect of atorvastatin in patients 65 years of age with type 2 diabetes: Subgroup analysis from the collaborative atorvastatin diabetes study (CARDS). CIRCULATION. vol. 112, U907-U907.
Newman C, Szarek M, Hitman GA, Colhoun HM, Betteridge DJ, Durrington PN, Neil HA, Livingstone SJ et al. (2005). Effect of atorvastatin on stroke in the collaborative atorvastatin diabetes study (CARDS): Factors predictive of the risk of stroke. CIRCULATION. vol. 112, U667-U667.
Zeggini E, Groves CJ, Parkinson JRC, Halford S, Owen KR, Frayling TM, Walker M, Hitman GA et al.(2005). Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes. Diabetologia vol. 48, (10) 2013-2017.
10.1007/s00125-005-1902-4
Yousaf N, Gould DJ, Aganna E, Hammond L, Mirakian RM, Turner MD, Hitman GA, McDermott MF et al.(2005). Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-kappaB activation. Arthritis Rheum vol. 52, (9) 2906-2916.
10.1002/art.21268
Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM(2005). A large-scale association analysis of common variation of the HNF1 alpha gene with type 2 diabetes in the UK Caucasian population. DIABETES vol. 54, (8) 2487-2491.
10.2337/diabetes.54.8.2487
Newman DJ, Mattock MB, Dawnay ABS, Kerry S, McGuire A, Yaqoob M, Hitman GA, Hawke C(2005). Systematic review on urine albumin testing for early detection of diabetic complications. HEALTH TECHNOL ASSES vol. 9, (30) 1-+.
10.3310/hta9300
Newman DJ, Mattock MB, Dawnay AB, Kerry S, McGuire A, Yaqoob M, Hitman GA, Hawke C(2005). Systematic review on urine albumin testing for early detection of diabetic complications. Health technology assessment (Winchester, England) vol. 9, (30)
Boucher BJ, Timms PM, Hitman GA(2005). Association between fasting glucose and C-reactive protein in middle-aged subjects. Diabet Med vol. 22, (4) 508-509.
10.1111/j.1464-5491.2005.1436a.x
Raikou M, McGuire A, Colhoun H, Betteridge J, Durrington P, Hitman G, Neil A, Livingstone S et al. (2005). Cost-effectiveness of atorvastatin (10mg) in patients with type 2 diabetes without coronary heart disease: CARDS trial analysis and extrapolation. DIABETOLOGIA. vol. 48, A331-A331.
Hitman GA, Newman C, Szarek M, Colhoun H, Betteridge J, Durrington P, Neil A, Livingstone S et al. (2005). Effect of atorvastatin on stroke in patients with type 2 diabetes: factors predicting the risk of stroke in the Collaborative Atorvastatin Diabetes Study (CARDS). DIABETOLOGIA. vol. 48, A47-A48.
Marshall C, Hitman GA, Partridge CJ, Clark A, Ma H, Shearer TR, Turner MD(2005). Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic beta-cells. Mol Endocrinol vol. 19, (1) 213-224.
10.1210/me.2004-0064
Maeda S, Tsukada S, Kanazawa A, Sekine A, Tsunoda T, Koya D, Maegawa H, Kashiwagi A et al.(2005). Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. J Hum Genet vol. 50, (6) 283-292.
10.1007/s10038-005-0253-9
Hassan Z, Hawa MI, Faruque MO, Ali L, Azad K, Leslie RDG, Khan AKA, Hitman GA (2005). Prevalence of type 1 diabetes in a Bangladeshi population based on the presence of GAD and IA2 antibody. DIABETOLOGIA. vol. 48, A55-A55.
Singh R, Pearson ER, Avery PJ, McCarthy MI, Levy JC, Hitman GA, Sampson M, Walker M et al. (2005). Programming results in reduced beta-cell function in offspring of mothers with young-onset type 2 diabetes. DIABETES. vol. 54, A81-A81.
Desai M, Zeggini E, Owen KR, Holman RR, Levy JC, Hattersley AT, Hitman GA, Walker M et al. (2005). Susceptibility for latent autoimmune diabetes in adults (LADA) is determined by variation at the 1DDM2 (insulin-gene) locus in white Caucasian patients from UK repositories. DIABETOLOGIA. vol. 48, A86-A86.
Newman DJ, Mattock MB, Dawnay ABS, Kerry S, McGuire A, Yaqoob M, Hitman GA, Hawke C(2005). Systematic review on urine albumin testing for early detection of diabetic complications. Health Technology Assessment vol. 9, (30)
10.3310/hta9300
Neil HAW, Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Livingstone SJ, Thomason MJ, Fuller JH (2005). The effect of atorvastatin on renal outcomes in patients with type 2 diabetes: Data from the collaborative atorvastatin diabetes study (CARDS). DIABETES. vol. 54, A124-A124.
Liew CF, Groves CJ, Wiltshire S, Zeggini E, Frayling TM, Owen KR, Walker M, Hitman GA et al.(2004). Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. Diabetologia vol. 47, (12) 2168-2175.
10.1007/s00125-004-1575-4
Zeggini E, Parkinson J, Halford S, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC et al.(2004). Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset. Diabetes vol. 53, (12) 3319-3322.
10.2337/diabetes.53.12.3319
Gordon AC, Lagan AL, Aganna E, Cheung L, Peters CJ, McDermott MF, Millo JL, Welsh KI et al.(2004). TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. Genes Immun vol. 5, (8) 631-640.
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Allotey RA, Mohan V, McDermott MF, Deepa R, Premalatha G, Hassan Z, Cassell PG, North BV et al.(2004). The EIF2AK3 gene region and type I diabetes in subjects from South India. Genes Immun vol. 5, (8) 648-652.
10.1038/sj.gene.6364139
Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Love-Gregory LD, Permutt MA et al.(2004). Common variants of the hepatocyte nuclear factor-4 alpha P2 promoter are associated with type 2 diabetes in the UK population. DIABETES vol. 53, (11) 3002-3006.
10.2337/diabetes.53.11.3002
Hitman GA, Sudagani J (2004). Searching for genes in diabetes and the metabolic syndrome. Int J Clin Pract Suppl. 3-8.
10.1111/j.1368-504x.2004.00374.x
Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HAW, Livingstone SJ, Thomason MJ, Mackness MI et al.(2004). Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet vol. 364, (9435) 685-696.
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(2004). 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia vol. 47, (Suppl 1) A1-A464.
10.1007/BF03375463
Thomason MJ, Colhoun HM, Livingstone SJ, Mackness MI, Betteridge DJ, Durrington PN, Hitman GA, Neil HAW et al.(2004). Baseline characteristics in the Collaborative AtoRvastatin Diabetes Study (CARDS) in patients with Type 2 diabetes. Diabet Med vol. 21, (8) 901-905.
10.1111/j.1464-5491.2004.01401.x
Zeggini E, Parkinson J, Groves CJ, Frayling TM, Hitman GA, Walker M, Sampson M, Levy JC et al. (2004). Large-scale association studies of candidate genes and their interactions in Type 2 diabetes. DIABETOLOGIA. vol. 47, A141-A141.
Jackson AE, Cassell PG, North BV, Vijayaraghavan S, Gelding SV, Ramachandran A, Snehalatha C, Hitman GA(2004). Polymorphic variations in the neurogenic differentiation-1, neurogenin-3, and hepatocyte nuclear factor-1alpha genes contribute to glucose intolerance in a South Indian population. Diabetes vol. 53, (8) 2122-2125.
10.2337/diabetes.53.8.2122
Boucher BJ, Hitman GA(2004). The vitamin D receptor gene variant and physical activity predicts fasting blood glucose levels in healthy young men. Diabet Med vol. 21, (7)
10.1111/j.1464-5491.2004.1217a.x
Aganna E, Hawkins PN, Ozen S, Pettersson T, Bybee A, McKee SA, Lachmann HJ, Karenko L et al.(2004). Allelic variants in genes associated with hereditary periodic fever syndromes as susceptibility factors for reactive systemic AA amyloidosis. Genes Immun vol. 5, (4) 289-293.
10.1038/sj.gene.6364070
Groves CJ, Wiltshire S, Walker M, Hitman GA, O'Rahilly S, Hattersley AT, Levy JC, McCarthy MI (2004). Fine mapping of linkage signals identified in the primary genome scan of 573 UK Type 2 diabetes families. DIABETES. vol. 53, A273-A273.
McCarthy MI, Parkinson J, Groves CJ, Frayling TM, Hitman GA, Walker M, Weedon MN, Wiltshire S et al. (2004). Large-scale association studies of candidate genes in insulin action: Confirmation of type 2 diabetes susceptibility effects at PPARG and evidence for association at TNF/LTA locus. DIABETES. vol. 53, A276-A277.
Owen KR, Evans JC, Frayling TM, Hattersley AT, McCarthy MI, Walker M, Hitman GA(2004). Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes. Diabetologia vol. 47, (5) 957-958.
10.1007/s00125-004-1397-4
Aganna E, Davidson JE, Cleary G, Sills JA, Bybee A, Drewe E, Hitman GA, Woo P et al.(2004). HETEROGENEITY AMONGST PATIENTS WITH CHRONIC INFANTILE NEUROLOGICAL CUTANEOUS AND ARTICULAR (CINCA) SYNDROME. RHEUMATOLOGY vol. 43, 21-21.
Mills GW, Avery PJ, McCarthy MI, Hattersley AT, Levy JC, Hitman GA, Sampson M, Walker M(2004). Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes. Diabetologia vol. 47, (4) 732-738.
10.1007/s00125-004-1338-2
Wiltshire S, Frayling TM, Groves CJ, Levy JC, Hitman GA, Sampson M, Walker M, Menzel S et al.(2004). Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24. Diabetes vol. 53, (3) 855-860.
10.2337/diabetes.53.3.855
Weedon MN, Schwarz PEH, Horikawa Y, Iwasaki N, Illig T, Holle R, Rathmann W, Selisko T et al.(2003). Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. AM J HUM GENET vol. 73, (5) 1208-1212.
10.1086/379285
Aganna E, Hawkins PN, Lachmann HJ, Bybee A, Karenko L, Pettersson T, Ranki A, Hitman GA et al. (2003). The spectrum and frequency of MEFV, TNFRSF1A, and NALP3/CIAS1/PYPAF1 mutations in patients with AA amyloidosis associated with systemic inflammation. AMERICAN JOURNAL OF HUMAN GENETICS. vol. 73, 508-508.
Snehalatha C, Ramachandran A, Satyavani K, Sivasankari S, Nanditha R, Vijay V, Hitman GA(2003). Evaluation of the beta cell response by C-peptide measurement in parents of children with type I diabetes. J Assoc Physicians India vol. 51, 927-928.
Aganna E, Hammond L, Hawkins PN, Aldea A, McKee SA, van Amstel HKP, Mischung C, Kusuhara K et al.(2003). Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes. Arthritis Rheum vol. 48, (9) 2632-2644.
10.1002/art.11215
North BV, Curtis D, Cassell PG, Hitman GA, Sham PC(2003). Assessing optimal neural network architecture for identifying disease-associated multi-marker genotypes using a permutation test, and application to calpain 10 polymorphisms associated with diabetes. Ann Hum Genet vol. 67, (Pt 4) 348-356.
10.1046/j.1469-1809.2003.00030.x
Frayling TM, Wiltshire S, Hitman GA, Walker M, Levy JC, Sampson M, Groves CJ, Menzel S et al.(2003). Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11. Diabetes vol. 52, (7) 1857-1863.
10.2337/diabetes.52.7.1857
Murphy HC, Regan G, Bogdarina IG, Clark AJL, Iles RA, Cohen RD, Hitman GA, Berry CL et al.(2003). Fetal programming of perivenous glucose uptake reveals a regulatory mechanism governing hepatic glucose output during refeeding. Diabetes vol. 52, (6) 1326-1332.
10.2337/diabetes.52.6.1326
Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC et al.(2003). Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility. Diabetes vol. 52, (5) 1300-1305.
10.2337/diabetes.52.5.1300
Barnett AH, Grant PJ, Hitman GA, Mather H, Pawa M, Robertson L, Trelfa A, Indo-Asian Trial Investigators(2003). Rosiglitazone in Type 2 diabetes mellitus: an evaluation in British Indo-Asian patients. Diabet Med vol. 20, (5) 387-393.
10.1046/j.1464-5491.2003.00925.x
Barakat K, Kennon S, Mathur A, Hitman GA, Aganna E, Shanmugam N, Price CP, Mills PG et al. (2003). The influence of vitamin D deficiency and vitamin D receptor polymorphisms on prognosis following non ST elevation acute coronary syndromes. HEART. vol. 89, A9-A9.
Barakat K, Kennon S, Mathur A, Hitman GA, Aganna E, Brull D, Price CP, Mills PG et al. (2003). The interleukin 6-174 G > C promoter polymorphism is associated with a poor prognosis following admission with non ST elevation acute coronary syndromes. HEART. vol. 89, A8-A8.
Peters CJ, Aganna E, Nanjee MN, Cheung L, Gordon AC, Piper RD, Hitman G, Miller NE et al. (2003). Relationship of paraoxonase 1 R/Q polymorphism to outcome from severe sepsis and septic shock. BRITISH JOURNAL OF ANAESTHESIA. vol. 90, 539P-539P.
Soedamah-Muthu SS, Colhoun HM, Thomason MJ, Betteridge DJ, Durrington PN, Hitman GA, Fuller JH, Julier K et al.(2003). The effect of atorvastatin on serum lipids, lipoproteins and NMR spectroscopy defined lipoprotein subclasses in type 2 diabetic patients with ischaemic heart disease. Atherosclerosis vol. 167, (2) 243-255.
10.1016/s0021-9150(02)00428-8
Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC et al.(2003). Large-scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. DIABETES vol. 52, (2) 568-572.
10.2337/diabetes.52.2.568
Timms PM, Mannan N, Hitman GA, Noonan K, Mills PG, Syndercombe-Court D, Aganna E, Price CP et al.(2002). Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders?. QJM vol. 95, (12) 787-796.
10.1093/qjmed/95.12.787
Hassan Z, Mohan V, Ali L, Allotey R, Barakat K, Faruque MO, Deepa R, McDermott MF et al.(2002). SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent. Am J Hum Genet vol. 71, (4) 964-968.
10.1086/342731
Aganna E, Martinon F, Hawkins PN, Ross JB, Swan DC, Booth DR, Lachmann HJ, Bybee A et al.(2002). Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum vol. 46, (9) 2445-2452.
10.1002/art.10509
Gordon AC, Cheung L, Aganna E, Peters CJ, McDermott MF, Hitman GA, Piper RD, Hinds CJ (2002). Lack of association between the-308 TNF promoter polymorphism & outcome from sepsis & septic shock. INTENSIVE CARE MEDICINE. vol. 28, S99-S99.
Gordon AC, Aganna E, Cheung L, Peters CJ, Piper RD, Mirakian RM, McDermott MF, Hitman GA et al. (2002). Polymorphisms of the TNFRSF1B gene: Relationship to outcome from severe sepsis and septic shock. INTENSIVE CARE MEDICINE. vol. 28, S99-S99.
Allotey RA, Mohan V, McDermott MF, Deepa R, Premalatha G, Hassan Z, Cassell PG, North BV et al. (2002). Association between E1F2AK3 gene region and Type 1 diabetes in Southern Indian subjects. DIABETOLOGIA. vol. 45, A111-A111.
Groves CJ, Wiltshire S, Menzel S, Bennett A, Hattersley AT, Frayling TM, Walker M, Levy JC et al. (2002). Linkage studies of the Type 2 diabetes susceptibility locus on chromosome 1q: Combined analysis of 1200 UK and French affected sibpairs. DIABETOLOGIA. vol. 45, A55-A56.
Cassell PG, Ramachandran A, Snehalatha C, Kopelman PG, Hitman GA (2002). Marked differences in the frequency of protein tyrosine phosphatase 1b gene variants between White-European and South Indian subjects. DIABETOLOGIA. vol. 45, A121-A121.
Hassan Z, Mohan V, Ali L, Allotey R, Faruque O, McDermott MF, Khan AKA, Hitman GA (2002). SPINK1 is a major gene for fibrocalculous diabetes in subjects from the southern Indian sub-continent. DIABETOLOGIA. vol. 45, A121-A121.
McCarthy MI, Stead JDH, Huxtable SJ, Haddad L, Jeffreys AJ, Cassell P, Snehalatha C, Ramachandran A et al. (2002). Variation at the+3580 MspI locus modulates insulin VNTR-minisatellite encoded susceptibility to Type 2 diabetes. DIABETOLOGIA. vol. 45, A132-A133.
Ogunkolade B-W, Boucher BJ, Prahl JM, Bustin SA, Burrin JM, Noonan K, North BV, Mannan N et al.(2002). Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Diabetes vol. 51, (7) 2294-2300.
10.2337/diabetes.51.7.2294
Andersen G, Hansen T, Gharani N, Frayling TM, Owen KR, Sampson M, Ellard S, Walker M et al.(2002). A common Gly482Ser polymorphism of PGC-1 is associated with type 2 diabetes mellitus in two European populations. DIABETES vol. 51, A49-A50.
Allotey RA, Mohan V, Mcdermott MF, Deepa R, Premalatha G, Cassell P, North B, Mein C et al.(2002). Demonstration of association between the EIF2AK3 gene and type 1 diabetes in southern Indian subjects. DIABETES vol. 51, A38-A38.
Groves CJ, Wiltshire S, Menzel S, Walker M, Hitman GA, Hattersley AT, Levy JC, O'Rahilly S et al.(2002). Evidence for interaction between type 2 diabetes susceptibility loci on chromosomes 10q and 1q from analysis of 687 UK families. DIABETES vol. 51, A51-A51.
Jackson AE, Cassell PG, North BV, Gelding SV, Vijayaraghavan S, Ramachandran A, Snehalatha C, Hitman GA(2002). NeuroD1/BETA2 and neurogenin-3 polymorphisms are associated with glucose impairment in a South Indian population. DIABETES vol. 51, A265-A266.
Mccarthy MI, Wiltshire S, Hattersley AT, Walker M, Hitman GA, O'Rahilly S, Levy JC, Menzel S et al.(2002). The type 2 diabetes susceptibility region on chromosome 1q: Studies in UK and French nuclear families. DIABETES vol. 51, A50-A51.
Ogunkolade BW, Boucher BJ, Fairclough PD, Hitman GA, Dorudi S, Jenkins PJ, Bustin SA(2002). Expression of 25-hydroxyvitamin D-1-alpha-hydroxylase mRNA in individuals with colorectal cancer. Lancet vol. 359, (9320) 1831-1832.
10.1016/s0140-6736(02)08680-4
Cassell PG, Jackson AE, North BV, Evans JC, Syndercombe-Court D, Phillips C, Ramachandran A, Snehalatha C et al.(2002). Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians. Diabetes vol. 51, (5) 1622-1628.
10.2337/diabetes.51.5.1622
Kennon S, Barakat K, Hitman GA, Price CP, Mills PG, Ranjadayalan K, Cooper J, Clark H et al.(2002). Angiotensin converting enzyme inhibition is associated with reduced troponin release in non-ST-elevation acute coronary syndromes. (vol 38, pg 724, 2002). J AM COLL CARDIOL vol. 39, (8) 1407-1407.
Colhoun HM, Thomason MJ, Mackness MI, Maton SM, Betteridge DJ, Durrington PN, Hitman GA, Neil HAW et al.(2002). Design of the Collaborative AtoRvastatin Diabetes Study (CARDS) in patients with type 2 diabetes. Diabet Med vol. 19, (3) 201-211.
10.1046/j.1464-5491.2002.00643.x
Wiltshire S, Frayling TM, Hattersley AT, Hitman GA, Walker M, Levy JC, O'Rahilly S, Groves CJ et al.(2002). Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes. Am J Hum Genet vol. 70, (2) 543-546.
10.1086/338760
Chowdhury ZM, McDermott MF, Davey S, Hassan Z, Sinnott PJ, Hemmatpour SK, Sherwin S, Ali L et al.(2002). Genetic susceptibility to fibrocalculous pancreatic diabetes in Bangladeshi subjects: a family study. Genes Immun vol. 3, (1) 5-8.
10.1038/sj.gene.6363814
Aganna E, Zeharia A, Hitman GA, Basel-Vanagaite L, Allotey RA, Booth DR, Hawkins PN, Thacker C et al.(2002). An Israeli Arab patient with a de novo TNFRSF1A mutation causing tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum vol. 46, (1) 245-249.
10.1002/1529-0131(200201)46:1<245::AID-ART10038>3.0.CO;2-6
Penfornis A, Tuomilehto-Wolf E, Faustman DL, Hitman GA, DiMe (Childhood Diabetes in Finland) Study Group(2002). Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes. Hum Immunol vol. 63, (1) 61-70.
10.1016/s0198-8859(01)00365-2
Taylor KW, Cassell PG, Hitman GA(2001). Familial diabetes with insulin dependency in later life involving all six members of one generation of a family. Practical Diabetes International vol. 18, (8) 283-286.
10.1002/pdi.258
Barakat K, Kennon S, Hitman GA, Aganna E, Price CP, Mills PG, Ranjadayalan K, North B et al.(2001). Interaction between smoking and the glycoprotein IIIa P1(A2) polymorphism in non-ST-elevation acute coronary syndromes. J Am Coll Cardiol vol. 38, (6) 1639-1643.
10.1016/s0735-1097(01)01610-2
Wiltshire S, Hattersley AT, Hitman GA, Walker M, Levy JC, Sampson M, O'Rahilly S, Frayling TM et al.(2001). A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet vol. 69, (3) 553-569.
10.1086/323249
Kennon S, Barakat K, Hitman GA, Price CP, Mills PG, Ranjadayalan K, Cooper J, Clark H et al.(2001). Angiotensin-converting enzyme inhibition is associated with reduced troponin release in non-ST-elevation acute coronary syndromes. J Am Coll Cardiol vol. 38, (3) 724-728.
10.1016/s0735-1097(01)01426-7
Barakat K, Hitman GA(2001). Genetic susceptibility to macrovascular complications of type 2 diabetes mellitus. Best Pract Res Clin Endocrinol Metab vol. 15, (3) 359-370.
10.1053/beem.2001.0151
Barakat K, Kennon S, Hitman GA, Aganna E, Price C, Mills PG, Ranjadayalan K, North B et al.(2001). Interaction between smoking, and the glycoprotein IIIa P1A2 polymorphism in non-ST-segment elevation acute coronary syndromes. EUR HEART J vol. 22, 150-150.
Evans JC, Frayling TM, Cassell PG, Saker PJ, Hitman GA, Walker M, Levy JC, O'Rahilly S et al.(2001). Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. Am J Hum Genet vol. 69, (3) 544-552.
10.1086/323315
Jackson AE, Cassell PG, Ramachandran A, Snehalatha C, Hitman GA(2001). A Beta2/NeuroD1 polymorphism as a determinant of susceptibility to Type 2 Diabetes in a South Indian population. DIABETOLOGIA vol. 44, A90-A90.
Allotey R, Premalatha G, Mohan V, Wood DF, Ramachandran A, Snehalatha C, Hitman GA(2001). A novel association between the Wolcott-Rallison gene and type I diabetes in South Indians. DIABETOLOGIA vol. 44, A82-A82.
McCarthy MI, Hattersley AT, Walker M, Hitman GA, Levy JC, O'Rahilly S, Lathrop GM, Simecek N et al.(2001). Linkage analysis in the Diabetes (UK) Warren 2 sibpair repository supports localisation of a type 2 diabetes susceptibility gene to chromosome 1q21-24. DIABETOLOGIA vol. 44, A37-A37.
Hitman GA, Ogunkolade BW, Prahl JM, Bustin S, Burrin J, Noonan K, North BV, Mannan N et al.(2001). Vitamin D receptor mRNA and VDR protein levels in relation to vitamin D status and to VDR genotype. DIABETOLOGIA vol. 44, A98-A98.
Cassell PG, Jackson AE, Evans JC, Ramachandran A, Snehalatha C, Hitman GA(2001). A haplotype combination of the calpain10 gene polymorphisms is a determinant of abnormal glucose tolerance in south Indians. DIABETES vol. 50, A28-A28.
McCarthy MI, Hattersley AT, Walker M, Hitman GA, Levy JC, O'Rahilly S, Frayling TM, Bennett A et al.(2001). Genome scan linkage data from a large European family collection supports localisation of a type 2 diabetes susceptibility gene to chromosome 1q21-23. DIABETES vol. 50, A27-A27.
Frayling TM, Wiltshire S, Walker M, Hitman GA, Levy JC, O'Rahilly S, Lathrop M, Menzel SM et al.(2001). Genome wide linkage analyses in subsets of young onset type 2 diabetes families from the diabetes (UK) warren 2 sibpair repository reveal loci on chromosomes 1, 5, 8, 10 and 22. DIABETES vol. 50, A28-A28.
Metcalfe KA, Hitman GA, Rowe RE, Hawa M, Huang X, Stewart T, Leslie RD(2001). Concordance for type 1 diabetes in identical twins is affected by insulin genotype. Diabetes Care vol. 24, (5) 838-842.
10.2337/diacare.24.5.838
Aganna E, Aksentijevich I, Hitman GA, Kastner DL, Hoepelman AI, Posma FD, Zweers EJ, McDermott MF(2001). Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a Dutch family: evidence for a TNFRSF1A mutation with reduced penetrance. Eur J Hum Genet vol. 9, (1) 63-66.
10.1038/sj.ejhg.5200573
Hassan Z, Mohan V, McDermott MF, Ali L, Ogunkolade WB, Aganna E, Cassell PG, Deepa R et al.(2000). Pancreatitis in fibrocalculous pancreatic diabetes mellitus is not associated with common mutations in the trypsinogen gene. DIABETES-METAB RES vol. 16, (6) 454-457.
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Ogunkolade WB, Ramachandran A, McDermott MF, Kumarajeewa TR, Curtis D, Snehalatha C, Mohan V, Cassell PG et al.(2000). Family association studies of markers on chromosome 2q and Type 1 diabetes in subjects from South India. Diabetes/Metabolism Research and Reviews vol. 16, (4) 276-280.
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Huxtable SJ, Saker PJ, Haddad L, Walker M, Frayling TM, Levy JC, Hitman GA, O'Rahilly S et al.(2000). Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles. Diabetes vol. 49, (1) 126-130.
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Cassell PG, Neverova M, Janmohamed S, Uwakwe N, Qureshi A, McCarthy MI, Saker PJ, Albon L et al.(1999). An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes. Diabetologia vol. 42, (6) 688-692.
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McDermott MF, McDermott EM, Quane KA, Jones LC, Ogunkolade BW, Curtis D, Waldron-Lynch F, Phelan M et al.(1998). Exclusion of the familial Mediterranean fever locus as a susceptibility region for autosomal dominant familial Hibernian fever. Journal of Medical Genetics vol. 35, (5) 432-434.
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Mohan V, Deepa R, Bhatia E, Singh AK, Hitman GA, Zimmet PZ, MacKay IR(1998). Antibodies to pancreatic islet cell antigens in diabetes seen in Southern India with particular reference to fibrocalculous pancreatic diabetes. Diabetic Medicine vol. 15, (2) 156-159.
10.1002/(SICI)1096-9136(199802)15:2<156::AID-DIA533>3.0.CO;2-E
McDermott MF, Ramachandran A, Ogunkolade BW, Aganna E, Curtis D, Boucher BJ, Snehalatha C, Hitman GA(1997). Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians. Diabetologia vol. 40, (8) 971-975.
10.1007/s001250050776
Jolly BC, Jones A, Dacre JE, Elzubeir M, Kopelman P, Hitman G(1996). Relationships between students' clinical experiences in introductory clinical courses and their performances on an objective structured clinical examination (OSCE). Academic Medicine vol. 71, (8) 909-916.
10.1097/00001888-199608000-00021
SACHS JA, WHICHELOW CE, HITMAN GA, NIVEN M, THODE H, MEAGER A(1990). The Effect of HLA and Insulin‐Dependent Diabetes Mellitus on the Secretion Levels of Tumour Necrosis Factors Alpha and Beta and Gamma Interferon. Scandinavian Journal of Immunology vol. 32, (6) 703-708.
10.1111/j.1365-3083.1990.tb03213.x
Fernandez N, Hitman GA, Festenstein H, Garde L, Labeta M, Walker-Smith JA, Sachs JA(1988). Novel HLA class II-associated structural patterns in coeliac disease and type I diabetes. Clinical and Experimental Immunology vol. 72, (3) 362-366.
Ferns GAA, Hitman GA, Trembath R, Williams L, Tarn A, Gale EA, Galton DJ(1986). DNA polymorphic haplotypes on the short arm of chromosome 11 and the inheritance of type I diabetes mellitus. Journal of Medical Genetics vol. 23, (3) 210-216.
10.1136/jmg.23.3.210
Jowett NI, Williams LG, Hitman GA, Galton DJ(1984). Diabetic hypertriglyceridaemia and related 5' flanking polymorphism of the human insulin gene. British Medical Journal vol. 288, (6411) 96-99.
10.1136/bmj.288.6411.96
Hitman GA, Jowett NI, Williams LG, Humphries S, Winter RM, Galton DJ(1984). Polymorphisms in the 5'-flanking region of the insulin gene and non-insulin-dependent diabetes. Clinical Science vol. 66, (4) 383-388.
10.1042/cs0660383
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