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Publications:  Dr Jurgen Groet

Gough G, O'Brien NL, Alic I, Goh PA, Yeap YJ, Groet J, Nizetic D, Murray A(2020). Modeling Down syndrome in cells: From stem cells to organoids. Progress in Brain Research, vol. 251,
Strydom A, Heslegrave A, Startin CM, Mok KY, Hardy J, Groet J, Nizetic D, Zetterberg H et al.(2018). Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome. Alzheimer's Research and Therapy vol. 10, (1)
10.1186/s13195-018-0367-x
https://qmro.qmul.ac.uk/xmlui/handle/123456789/45363
Buss L, Fisher E, Hardy J, Nizetic D, Groet J, Pulford L, Strydom A(2016). Intracerebral haemorrhage in Down syndrome: protected or predisposed?. F1000Res vol. 876,
10.12688/f1000research.7819.1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63730
Karmiloff-Smith A, Al-Janabi T, D'Souza H, Groet J, Massand E, Mok K, Startin C, Fisher E et al.(2016). The importance of understanding individual differences in Down syndrome. F1000Research vol. 5,
10.12688/f1000research.7506.1
Goh P, Murray A, Rovelet-Lecrux A, Wallon D, Karmiloff-Smith A, Hardy J, Strydom A, Groet J et al.(2015). MODELLING NEURAL PATHOLOGY AND DEMENTIA IN DOWN SYNDROME USING INDUCED PLURIPOTENT STEM CELLS. JOURNAL OF INTELLECTUAL DISABILITY RESEARCH vol. 59, (9) 790-790.
Murray A, Letourneau A, Canzonetta C, Stathaki E, Gimelli S, Sloan-Bena F, Abrehart R, Goh P et al.(2015). Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration. STEM CELLS vol. 33, (6) 2077-2084.
10.1002/stem.1968
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15766
Nikolaev SI, Garieri M, Santoni F, Falconnet E, Ribaux P, Guipponi M, Murray A, Groet J et al.(2014). Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations. Nat Commun vol. 5,
10.1038/ncomms5654
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7642
Nikolaev SI, Santoni F, Vannier A, Falconnet E, Giarin E, Basso G, Hoischen A, Veltman JA et al.(2013). Exome sequencing identifies putative drivers of progression of transient myeloproliferative disorder to AMKL in infants with Down syndrome. Blood vol. 122, (4) 554-561.
10.1182/blood-2013-03-491936
Nižeti¿ D, Groet J(2012). Tumorigenesis in Down's syndrome: big lessons from a small chromosome. Nat Rev Cancer vol. 12, (10) 721-732.
10.1038/nrc3355
Canzonetta C, Hoischen A, Giarin E, Basso G, Veltman JA, Nacheva E, Nizetic D, Groet J(2012). Amplified segment in the 'Down syndrome critical region' on HSA21 shared between Down syndrome and euploid AML-M0 excludes RUNX1, ERG and ETS2. Br J Haematol vol. 157, (2) 197-200.
10.1111/j.1365-2141.2011.08985.x
De Vita S, Canzonetta C, Mulligan C, Delom F, Groet J, Baldo C, Vanes L, Dagna-Bricarelli F et al.(2010). Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome. Oncogene vol. 29, (46) 6102-6114.
10.1038/onc.2010.351
Delom F, Burt E, Hoischen A, Veltman J, Groet J, Cotter FE, Nizetic D(2009). Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix. Proteome Sci vol. 7,
10.1186/1477-5956-7-31
Wang Y, Mulligan C, Denyer G, Delom F, Dagna-Bricarelli F, Tybulewicz VLJ, Fisher EMC, Griffiths WJ et al.(2009). Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome. Mol Cell Proteomics vol. 8, (4) 585-595.
10.1074/mcp.M800256-MCP200
De Vita S, Devoy A, Groet J, Kruslin B, Kuzmic-Prusac I, Nizetic D(2008). Megakaryocyte hyperproliferation without GATA1 mutation in foetal liver of a case of Down syndrome with hydrops foetalis. BRIT J HAEMATOL vol. 143, (2) 300-303.
10.1111/j.1365-2141.2008.07332.x
Canzonetta C, Mulligan C, Deutsch S, Ruf S, O'Doherty A, Lyle R, Borel C, Lin-Marq N et al.(2008). DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. AM J HUM GENET vol. 83, (3) 388-400.
10.1016/j.ajhg.2008.08.012
Mensah A, Mulligan C, Linehan J, Ruf S, O'Doherty A, Grygalewicz B, Shipley J, GROET J et al.(2007). An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model. BMC Dev Biol vol. 7,
10.1186/1471-213X-7-131
De Vita S, Mulligan C, McElwaine S, Dagna-Bricarelli F, Spinelli M, Basso G, Nizetic D, GROET J(2007). Loss-of-function JAK3 mutations in TMD and AMKL of Down Syndrome. Br J Haematol. vol. 137, 337-341.
10.1111/j.1365-2141.2007.06574.x
GROET J, Mulligan C, Spinelli M, Serra A, McElwaine S, Cotter F, Dagna Bricarelli F, Saglio G et al.(2005). Independent clones at separable stages of differentiation, bearing different GATA1 mutations, in the same TMD patient with Down syndrome. Blood vol. 106, 1887-1888.
10.1182/blood-2005-03-1071
McElwaine S, Mulligan C, Groet J, Spinelli M, Rinaldi A, Denyer G, Mensah A, Cavani S et al.(2004). Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic leukaemia (M7) in Down's syndrome, revealing PRAME as a specific discriminating marker. Br J Haematol vol. 125, (6) 729-742.
10.1111/j.1365-2141.2004.04982.x
Groet J, McElwaine S, Spinelli M, Rinaldi A, Burtscher I, Mulligan C, Mensah A, Cavani S et al.(2003). Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder. Lancet vol. 361, (9369) 1617-1620.
10.1016/S0140-6736(03)13266-7
Groet J, Ives JH, Jones TA, Chen L, Danton M, Flomen RH, Sheer D, Hrascan R et al.(2001). Allelic loss in the gene-poor band 21q11 -> q21 in squamous non-small cell lung carcinoma: cloning of a novel ubiquitin specific protease from the minimal deleted region. CYTOGENET CELL GENET vol. 92, (1-2) 16-16.
Groet J, Chen L, Blechschmidt K, Rosenthal A, Yaspo ML, Nizetic D(2001). Structural and functional analysis of a novel human gene (and its mouse homologue), coding for a potential nuclear sam protein, identified within the gene-poor region 21q11, which is associated with abnormal myelopoiesis in Down syndrome. CYTOGENET CELL GENET vol. 92, (1-2) 16-16.
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