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Publications:  Prof Maurice Elphick

Mo J, Prévost SF, Blowes LM et al. (2016) . Interfibrillar stiffening of echinoderm mutable collagenous tissue demonstrated at the nanoscale.Proc Natl Acad Sci U S A
Tian S, Zandawala M, Beets I et al. (2016) . Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways.Scientific Reports vol. 6, Article 28788,
Guggenhuber S, Alpar A, Chen R et al. (2016) . Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus.Brain Struct Funct vol. 221, (4) 2061-2074.
Kim CH, Kim EJ, Go HJ et al. (2016) . Identification of a novel starfish neuropeptide that acts as a muscle relaxant.J Neurochem vol. 137, (1) 33-45.
Semmens DC, Mirabeau O, Moghul I et al. (2016) . Transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution.Open Biol vol. 6, (2)
Jones CE, Zandawala M, Semmens DC et al. (2016) . Identification of a neuropeptide precursor protein that gives rise to a "cocktail" of peptides that bind Cu(II) and generate metal-linked dimers.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS vol. 1860, (1) 57-66.
Jones CE, Zandawala M, Semmens DC et al. (2016) . Identification of a neuropeptide precursor protein that gives rise to a "cocktail" of peptides that bind Cu(II) and generate metal-linked dimers.Biochim Biophys Acta vol. 1860, (1 Pt A) 57-66.
D'Aniello S, Delroisse J, Valero-Gracia A et al. (2015) . Opsin evolution in the Ambulacraria.Marine Genomics vol. 24, 177-183.
D'Aniello S, Delroisse J, Valero-Gracia A et al. (2015) . Opsin evolution in the Ambulacraria.Mar Genomics vol. 24 Pt 2, 177-183.
Smith TH, Blume LC, Straiker A et al. (2015) . Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.Mol Pharmacol vol. 87, (4) 747-765.
Semmens DC, Beets I, Rowe ML et al. (2015) . Discovery of sea urchin NGFFFamide receptor unites a bilaterian neuropeptide family.Open Biol vol. 5, (4)
Christensen AB, Herman JL, Elphick MR et al. (2015) . Phylogeny of Echinoderm Hemoglobins.PLoS One vol. 10, (8)
Elphick MR, Semmens DC, Blowes LM et al. (2015) . Reconstructing SALMFamide Neuropeptide Precursor Evolution in the Phylum Echinodermata: Ophiuroid and Crinoid Sequence Data Provide New Insights.Front Endocrinol (Lausanne) vol. 6,
Jones CE, Otara CB, Younan ND et al. (2014) . Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides S1 and S2.Biochim Biophys Acta vol. 1844, (10) 1842-1850.
Elphick MR (2014) . SALMFamide salmagundi: the biology of a neuropeptide family in echinoderms.Gen Comp Endocrinol vol. 205, 23-35.
Rowe ML, Achhala S, Elphick MR (2014) . Neuropeptides and polypeptide hormones in echinoderms: new insights from analysis of the transcriptome of the sea cucumber Apostichopus japonicus.Gen Comp Endocrinol vol. 197, 43-55.
Otara CB, Jones CE, Younan ND et al. (2014) . Structural analysis of the starfish SALMFamide neuropeptides S1 and S2: the N-terminal region of S2 facilitates self-association.Biochim Biophys Acta vol. 1844, (2) 358-365.
Bedse G, Romano A, Cianci S et al. (2014) . Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer's disease.J Alzheimers Dis vol. 40, (3) 701-712.
Elphick MR (2014) . SALMFamide salmagundi: The biology of a neuropeptide family in echinoderms.General and Comparative Endocrinology
Elphick MR, Mirabeau O (2014) . The Evolution and Variety of RFamide-Type Neuropeptides: Insights from Deuterostomian Invertebrates.Front Endocrinol (Lausanne) vol. 5,
Semmens DC, Dane RE, Pancholi MR et al. (2013) . Discovery of a novel neurophysin-associated neuropeptide that triggers cardiac stomach contraction and retraction in starfish.J Exp Biol vol. 216, (Pt 21) 4047-4053.
Elphick MR (2013) . From gonadotropin-inhibitory hormone to SIFamides: are echinoderm SALMFamides the "missing link" in a bilaterian family of neuropeptides that regulate reproductive processes?.Gen Comp Endocrinol vol. 193, 229-233.
ELPHICK MR, Achhala S, Martynyuk N (2013) . The evolution and diversity of SALMFamide neuropeptides.PLoS One vol. 8, (3)
Elphick MR (2012) . The evolution and comparative neurobiology of endocannabinoid signalling.Philos Trans R Soc Lond B Biol Sci vol. 367, (1607) 3201-3215.
Rowe ML, Elphick MR (2012) . The neuropeptide transcriptome of a model echinoderm, the sea urchin Strongylocentrotus purpuratus.Gen Comp Endocrinol vol. 179, (3) 331-344.
Schneider M, Elphick MR (2012) . Neuropharmacology of cannabinoids.Encyclopedia of Addictive Behaviours, Editors: Miller, PM, Academic Press
Elphick MR (2012) . The protein precursors of peptides that affect the mechanics of connective tissue and/or muscle in the echinoderm Apostichopus japonicus.PLoS One vol. 7, (8)
Stauffer B, Wallis KT, Wilson SP et al. (2011) . CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity.NEUROSCI LETT vol. 503, (3) 224-228.
Pertwee RG, Howlett AC, Abood ME et al. (2010) . International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2.PHARMACOL REV vol. 62, (4) 588-631.
Elphick MR (2010) . NG peptides: a novel family of neurophysin-associated neuropeptides.Gene vol. 458, (1-2) 20-26.
Rowe ML, Elphick MR (2010) . Discovery of a second SALMFamide gene in the sea urchin Strongylocentrotus purpuratus reveals that L-type and F-type SALMFamide neuropeptides coexist in an echinoderm species.MAR GENOM vol. 3, (2) 91-97.
Blair RE, Deshpande LS, Sombati S et al. (2009) . Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy.NEUROPHARMACOLOGY vol. 57, (3) 208-218.
Guasti L, Richardson D, Jhaveri M et al. (2009) . Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain.Mol Pain vol. 5,
Chan LF, Webb TR, Chung TT et al. (2009) . MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.Proc Natl Acad Sci U S A vol. 106, (15) 6146-6151.
Hardt TA, Elphick M, Lewis DL et al. (2009) . Cannabinoid Receptor Interacting Protein (CRIP1a) attenuates CB1 signalling.FASEB JOURNAL vol. 23,
Elphick MR, Rowe ML (2009) . NGFFFamide and echinotocin: structurally unrelated myoactive neuropeptides derived from neurophysin-containing precursors in sea urchins.J Exp Biol vol. 212, (Pt 8) 1067-1077.
Lever IJ, Robinson M, Cibelli M et al. (2009) . Localization of the Endocannabinoid-Degrading Enzyme Fatty Acid Amide Hydrolase in Rat Dorsal Root Ganglion Cells and Its Regulation after Peripheral Nerve Injury.J NEUROSCI vol. 29, (12) 3766-3780.
Cooray SN, Almiro Do Vale I, Leung KY et al. (2008) . The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line.Endocrinology vol. 149, (4) 1935-1941.
Egertová M, Simon GM, Cravatt BF et al. (2008) . Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules.J Comp Neurol vol. 506, (4) 604-615.
Niehaus JL, Liu Y, Wallis KT et al. (2007) . CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a.Mol Pharmacol vol. 72, (6) 1557-1566.
Elphick MR (2007) . BfCBR: A cannabinoid receptor ortholog in the cephalochordate Branchiostoma floridae (Amphioxus).GENE vol. 399, (1) 65-71.
Yun SS, Thorndyke MC, Elphick MR (2007) . Identification of novel SALMFamide neuropeptides in the starfish Marthasterias glacialis.COMP BIOCHEM PHYS A vol. 147, (2) 536-542.
Egertova M, Elphick MR (2007) . Localization of CiCBR in the invertebrate chordate Ciona intestinalis: Evidence of an ancient role for cannabinoid receptors as axonal regulators of neuronal signalling.J COMP NEUROL vol. 502, (4) 660-672.
Ott SR, Aonuma H, Newland PL et al. (2007) . Nitric oxide synthase in crayfish walking leg ganglia: Segmental differences in chemo-tactile centers argue against a generic role in sensory integration.J COMP NEUROL vol. 501, (3) 381-399.
Ott SR, Philippides A, Elphick MR et al. (2007) . Enhanced fidelity of diffusive nitric oxide signalling by the spatial segregation of source and target neurones in the memory centre of an insect brain.Eur J Neurosci vol. 25, (1) 181-190.
Burke RD, Angerer LM, Elphick MR et al. (2006) . A genomic view of the sea urchin nervous system.DEV BIOL vol. 300, (1) 434-460.
Sodergren E, Weinstock GM, Davidson EH et al. (2006) . Research article - The genome of the sea urchin Strongylocentrotus purpuratus.SCIENCE vol. 314, (5801) 941-952.
Monory K, Massa F, Egertova M et al. (2006) . The endocannabinoid system controls key epileptogenic circuits in the hippocampus.NEURON vol. 51, (4) 455-466.
Elphick MR, Thorndyke MC (2005) . Molecular characterisation of SALMFamide neuropeptides in sea urchins.J Exp Biol vol. 208, (Pt 22) 4273-4282.
Elphick MR (2005) . Neuropeptide structure and function in echinoderms.COMP BIOCHEM PHYS A vol. 141, (3) S160-S161.
Otara CB, Jones CE, Melarange R et al. (2005) . Tertiary structure and activity of SALMFamide neuropeptides.COMP BIOCHEM PHYS A vol. 141, (3) S161-S161.
Kurylas AE, Ott SR, Schachtner J et al. (2005) . Localization of nitric oxide synthase in the central complex and surrounding midbrain neuropils of the locust Schistocerca gregaria.J. Comp. Neurol vol. 484, (2) 206-223.
Elphick MR, Egertová M (2005) . The phylogenetic distribution and evolutionary origins of endocannabinoid signalling.Handb Exp Pharmacol (168) 283-297.
Egertová M, Michael GJ, Cravatt BF et al. (2004) . Fatty acid amide hydrolase in brain ventricular epithelium: mutually exclusive patterns of expression in mouse and rat.J Chem Neuroanat vol. 28, (3) 171-181.
Ott SR, Delago A, Elphick MR (2004) . An evolutionarily conserved mechanism for sensitization of soluble guanylyl cyclase reveals extensive nitric oxide-mediated upregulation of cyclic GMP in insect brain.Eur J Neurosci vol. 20, (5) 1231-1244.
Ott SR, Elphick MR (2003) . New techniques for whole-mount NADPH-diaphorase histochemistry demonstrated in insect ganglia.J Histochem Cytochem vol. 51, (4) 523-532.
Melarange R, Elphick MR (2003) . Comparative analysis of nitric oxide and SALMFamide neuropeptides as general muscle relaxants in starfish.J EXP BIOL vol. 206, (5) 893-899.
Elphick MR, Satou Y, Satoh N (2003) . The invertebrate ancestry of endocannabinoid signalling: an orthologue of vertebrate cannabinoid receptors in the urochordate Ciona intestinalis.GENE vol. 302, (1-2) 95-101.
Egertova M, Cravatt BF, Elphick MR (2003) . Comparative analysis of fatty acid amide hydrolase and CB1 cannabinoid receptor expression in the mouse brain: Evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling.NEUROSCIENCE vol. 119, (2) 481-496.
Bridges D, Rice ASC, Egertova M et al. (2003) . Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry. NEUROSCIENCE. vol. 119, 803-812.
Ott SR, Elphick MR (2002) . Nitric oxide synthase histochemistry in insect nervous systems: Methanol/formalin fixation reveals the neuroarchitecture of formaldehyde-sensitive NADPH diaphorase in the cockroach Periplaneta americana.J Comp Neurol vol. 448, (2) 165-185.
Elphick MR (2002) . Evolution of cannabinoid receptors in vertebrates: Identification of a CB2 gene in the puffer fish Fugu rubripes.BIOL BULL vol. 202, (2) 104-107.
Ott SR, Burrows M, Elphick MR (2001) . The neuroanatomy of nitric oxide-cyclic GMP signaling in the locust: Functional implications for sensory systems. AMERICAN ZOOLOGIST. vol. 41, 321-331.
Elphick MR, Egertová M (2001) . The neurobiology and evolution of cannabinoid signalling.Philos Trans R Soc Lond B Biol Sci vol. 356, (1407) 381-408.
Elphick MR, Melarange R (2001) . Neural control of muscle relaxation in echinoderms.J Exp Biol vol. 204, (Pt 5) 875-885.
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