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Publications:  Prof Maurice Elphick

Yañez-Guerra LA, DELROISSE J, Barreiro-Iglesias A et al.(2018). Discovery and functional characterisation of a luqin-type neuropeptide signalling system in a deuterostome. Scientific Reports
Kim C-H, Go H-J, Oh HY et al.(2018). Identification of a novel antimicrobial peptide from the sea star Patiria pectinifera. Developmental & Comparative Immunology
Kim C-H, Go H-J, Oh HY et al.(2018). Identification of evolutionarily conserved residues required for the bioactivity of a pedal peptide/orcokinin-type neuropeptide. Peptides
Dylus D, Czarkwiani A, BLOWES L et al.(2018). Developmental transcriptomics of the brittle star Amphiura filiformis reveals gene regulatory network rewiring in echinoderm larval skeleton evolution. Genome Biology vol. 19,
ELPHICK MR, Mirabeau O, Larhammar D(2018). Evolution of neuropeptide signalling systems. Journal of Experimental Biology
Gupta HS, Szulgit G, Elphick MR et al.(2018). Unlocking the secrets of mutable collagenous tissue. Biochemist vol. 40, (1) 8-11.
Li L, Su S, Perry CJ et al.(2018). Large-scale transcriptome changes in the process of long-term visual memory formation in the bumblebee, Bombus terrestris. Sci Rep vol. 8, (1) 534-534.
LIN M, EGERTOVA M, Zampronio C et al.(2017). Functional characterization of a second pedal peptide/orcokinin-type neuropeptide signaling system in the starfish Asterias rubens. Journal of Comparative Neurology
Suwansa-Ard S, Chaiyamoon A, Talarovicova A et al.(2017). Transcriptomic discovery and comparative analysis of neuropeptide precursors in sea cucumbers (Holothuroidea). Peptides
Li L, MaBouDi H, Egertová M et al.(2017). A possible structural correlate of learning performance on a colour discrimination task in the brain of the bumblebee. Proc Biol Sci vol. 284, (1864)
Tian S, Egertova M, Elphick MR(2017). Functional Characterization of Paralogous Gonadotropin-Releasing Hormone-Type and Corazonin-Type Neuropeptides in an Echinoderm. Frontiers in Endocrinology vol. 8, Article 259, 1-24.
Kim CH, Go HJ, Oh HY et al.(2017). Transcriptomics reveals tissue/organ-specific differences in gene expression in the starfish Patiria pectinifera. Marine Genomics
Zandawala M, Moghul I, Yanez Guerra LA et al.(2017). Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms. Open Biology vol. 7, Article 170129, 1-20.
Lin M, Egertová M, Zampronio CG et al.(2017). Pedal peptide/orcokinin-type neuropeptide signaling in a deuterostome: The anatomy and pharmacology of starfish myorelaxant peptide in Asterias rubens. Journal of Comparative Neurology
Blowes LM, Egertova M, Liu Y et al.(2017). Body wall structure in the starfish Asterias rubens. Journal of Anatomy Article JOA12646,
ELPHICK MR, Tian S, Zandawala M(2017). The evolution and nomenclature of GnRH-type and corazonin-type neuropeptide signaling systems. General and Comparative Endocrinology
Smith MK, Wang T, Suwansa-Ard S et al.(2017). The neuropeptidome of the Crown-of-Thorns Starfish, Acanthaster planci. J Proteomics
ELPHICK MR, Semmens(2017). The evolution of neuropeptide signalling: insights from echinoderms. Briefings in Functional Genomics
Mayorova TD, Tian S, Cai W et al.(2016). Localization of Neuropeptide Gene Expression in Larvae of an Echinoderm, the Starfish Asterias rubens. Front Neurosci vol. 10, 553-553.
Lin M, Mita M, Egertová M et al.(2016). Cellular localization of relaxin-like gonad-stimulating peptide expression in Asterias rubens: New insights into neurohormonal control of spawning in starfish. J Comp Neurol
Mo J, Prévost SF, Blowes LM et al.(2016). Interfibrillar stiffening of echinoderm mutable collagenous tissue demonstrated at the nanoscale. Proc Natl Acad Sci U S A
Tian S, Zandawala M, Beets I et al.(2016). Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways. Scientific Reports vol. 6, Article 28788,
Guggenhuber S, Alpar A, Chen R et al.(2016). Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus. Brain Struct Funct vol. 221, (4) 2061-2074.
Kim C-H, Kim EJ, Go H-J et al.(2016). Identification of a novel starfish neuropeptide that acts as a muscle relaxant. J Neurochem vol. 137, (1) 33-45.
Semmens DC, Mirabeau O, Moghul I et al.(2016). Transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution. Open Biol vol. 6, (2)
Jones CE, Zandawala M, Semmens DC et al.(2016). Identification of a neuropeptide precursor protein that gives rise to a "cocktail" of peptides that bind Cu(II) and generate metal-linked dimers. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS vol. 1860, (1) 57-66.
Jones CE, Zandawala M, Semmens DC et al.(2016). Identification of a neuropeptide precursor protein that gives rise to a "cocktail" of peptides that bind Cu(II) and generate metal-linked dimers. Biochim Biophys Acta vol. 1860, (1 Pt A) 57-66.
D'Aniello S, Delroisse J, Valero-Gracia A et al.(2015). Opsin evolution in the Ambulacraria. Marine Genomics vol. 24, 177-183.
D'Aniello S, Delroisse J, Valero-Gracia A et al.(2015). Opsin evolution in the Ambulacraria. Mar Genomics vol. 24 Pt 2, 177-183.
Smith TH, Blume LC, Straiker A et al.(2015). Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation. Mol Pharmacol vol. 87, (4) 747-765.
Semmens DC, Beets I, Rowe ML et al.(2015). Discovery of sea urchin NGFFFamide receptor unites a bilaterian neuropeptide family. Open Biol vol. 5, (4)
Christensen AB, Herman JL, Elphick MR et al.(2015). Phylogeny of Echinoderm Hemoglobins. PLoS One vol. 10, (8)
Elphick MR, Semmens DC, Blowes LM et al.(2015). Reconstructing SALMFamide Neuropeptide Precursor Evolution in the Phylum Echinodermata: Ophiuroid and Crinoid Sequence Data Provide New Insights. Front Endocrinol (Lausanne) vol. 6,
Jones CE, Otara CB, Younan ND et al.(2014). Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides S1 and S2. Biochim Biophys Acta vol. 1844, (10) 1842-1850.
Elphick MR(2014). SALMFamide salmagundi: the biology of a neuropeptide family in echinoderms. Gen Comp Endocrinol vol. 205, 23-35.
Rowe ML, Achhala S, Elphick MR(2014). Neuropeptides and polypeptide hormones in echinoderms: new insights from analysis of the transcriptome of the sea cucumber Apostichopus japonicus. Gen Comp Endocrinol vol. 197, 43-55.
Otara CB, Jones CE, Younan ND et al.(2014). Structural analysis of the starfish SALMFamide neuropeptides S1 and S2: the N-terminal region of S2 facilitates self-association. Biochim Biophys Acta vol. 1844, (2) 358-365.
Bedse G, Romano A, Cianci S et al.(2014). Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer's disease. J Alzheimers Dis vol. 40, (3) 701-712.
Elphick MR, Mirabeau O(2014). The Evolution and Variety of RFamide-Type Neuropeptides: Insights from Deuterostomian Invertebrates. Front Endocrinol (Lausanne) vol. 5,
Semmens DC, Dane RE, Pancholi MR et al.(2013). Discovery of a novel neurophysin-associated neuropeptide that triggers cardiac stomach contraction and retraction in starfish. J Exp Biol vol. 216, (Pt 21) 4047-4053.
Elphick MR(2013). From gonadotropin-inhibitory hormone to SIFamides: are echinoderm SALMFamides the "missing link" in a bilaterian family of neuropeptides that regulate reproductive processes?. Gen Comp Endocrinol vol. 193, 229-233.
ELPHICK MR, Achhala S, Martynyuk N(2013). The evolution and diversity of SALMFamide neuropeptides. PLoS One vol. 8, (3)
Elphick MR(2012). The evolution and comparative neurobiology of endocannabinoid signalling. Philos Trans R Soc Lond B Biol Sci vol. 367, (1607) 3201-3215.
Rowe ML, Elphick MR(2012). The neuropeptide transcriptome of a model echinoderm, the sea urchin Strongylocentrotus purpuratus. Gen Comp Endocrinol vol. 179, (3) 331-344.
Schneider M, Elphick MR(2012). Neuropharmacology of cannabinoids. Encyclopedia of Addictive Behaviours, Editors: Miller, PM, Academic Press
Elphick MR(2012). The protein precursors of peptides that affect the mechanics of connective tissue and/or muscle in the echinoderm Apostichopus japonicus. PLoS One vol. 7, (8)
Stauffer B, Wallis KT, Wilson SP et al.(2011). CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity. NEUROSCI LETT vol. 503, (3) 224-228.
Pertwee RG, Howlett AC, Abood ME et al.(2010). International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2. PHARMACOL REV vol. 62, (4) 588-631.
Elphick MR(2010). NG peptides: a novel family of neurophysin-associated neuropeptides. Gene vol. 458, (1-2) 20-26.
Rowe ML, Elphick MR(2010). Discovery of a second SALMFamide gene in the sea urchin Strongylocentrotus purpuratus reveals that L-type and F-type SALMFamide neuropeptides coexist in an echinoderm species. MAR GENOM vol. 3, (2) 91-97.
Blair RE, Deshpande LS, Sombati S et al.(2009). Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy. NEUROPHARMACOLOGY vol. 57, (3) 208-218.
Guasti L, Richardson D, Jhaveri M et al.(2009). Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain. Mol Pain vol. 5,
Chan LF, Webb TR, Chung T-T et al.(2009). MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc Natl Acad Sci U S A vol. 106, (15) 6146-6151.
Hardt TA, Elphick M, Lewis DL et al.(2009). Cannabinoid Receptor Interacting Protein (CRIP1a) attenuates CB1 signalling. FASEB JOURNAL vol. 23,
Elphick MR, Rowe ML(2009). NGFFFamide and echinotocin: structurally unrelated myoactive neuropeptides derived from neurophysin-containing precursors in sea urchins. J Exp Biol vol. 212, (Pt 8) 1067-1077.
Lever IJ, Robinson M, Cibelli M et al.(2009). Localization of the Endocannabinoid-Degrading Enzyme Fatty Acid Amide Hydrolase in Rat Dorsal Root Ganglion Cells and Its Regulation after Peripheral Nerve Injury. J NEUROSCI vol. 29, (12) 3766-3780.
Cooray SN, Almiro Do Vale I, Leung K-Y et al.(2008). The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line. Endocrinology vol. 149, (4) 1935-1941.
Egertová M, Simon GM, Cravatt BF et al.(2008). Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules. J Comp Neurol vol. 506, (4) 604-615.
Niehaus JL, Liu Y, Wallis KT et al.(2007). CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Mol Pharmacol vol. 72, (6) 1557-1566.
Elphick MR(2007). BfCBR: A cannabinoid receptor ortholog in the cephalochordate Branchiostoma floridae (Amphioxus). GENE vol. 399, (1) 65-71.
Yun SS, Thorndyke MC, Elphick MR(2007). Identification of novel SALMFamide neuropeptides in the starfish Marthasterias glacialis. COMP BIOCHEM PHYS A vol. 147, (2) 536-542.
Egertova M, Elphick MR(2007). Localization of CiCBR in the invertebrate chordate Ciona intestinalis: Evidence of an ancient role for cannabinoid receptors as axonal regulators of neuronal signalling. J COMP NEUROL vol. 502, (4) 660-672.
Ott SR, Aonuma H, Newland PL et al.(2007). Nitric oxide synthase in crayfish walking leg ganglia: Segmental differences in chemo-tactile centers argue against a generic role in sensory integration. J COMP NEUROL vol. 501, (3) 381-399.
Ott SR, Philippides A, Elphick MR et al.(2007). Enhanced fidelity of diffusive nitric oxide signalling by the spatial segregation of source and target neurones in the memory centre of an insect brain. Eur J Neurosci vol. 25, (1) 181-190.
Burke RD, Angerer LM, Elphick MR et al.(2006). A genomic view of the sea urchin nervous system. DEV BIOL vol. 300, (1) 434-460.
Sodergren E, Weinstock GM, Davidson EH et al.(2006). Research article - The genome of the sea urchin Strongylocentrotus purpuratus. SCIENCE vol. 314, (5801) 941-952.
Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM et al.(2006). The genome of the sea urchin Strongylocentrotus purpuratus. Science vol. 314, (5801) 941-952.
Monory K, Massa F, Egertova M et al.(2006). The endocannabinoid system controls key epileptogenic circuits in the hippocampus. NEURON vol. 51, (4) 455-466.
Elphick MR, Thorndyke MC(2005). Molecular characterisation of SALMFamide neuropeptides in sea urchins. J Exp Biol vol. 208, (Pt 22) 4273-4282.
Elphick MR(2005). Neuropeptide structure and function in echinoderms. COMP BIOCHEM PHYS A vol. 141, (3) S160-S161.
Otara CB, Jones CE, Melarange R et al.(2005). Tertiary structure and activity of SALMFamide neuropeptides. COMP BIOCHEM PHYS A vol. 141, (3) S161-S161.
Kurylas AE, Ott SR, Schachtner J et al.(2005). Localization of nitric oxide synthase in the central complex and surrounding midbrain neuropils of the locust Schistocerca gregaria. J. Comp. Neurol vol. 484, (2) 206-223.
Elphick MR, Egertová M(2005). The phylogenetic distribution and evolutionary origins of endocannabinoid signalling. Handb Exp Pharmacol (168) 283-297.
Egertová M, Michael GJ, Cravatt BF et al.(2004). Fatty acid amide hydrolase in brain ventricular epithelium: mutually exclusive patterns of expression in mouse and rat. J Chem Neuroanat vol. 28, (3) 171-181.
Ott SR, Delago A, Elphick MR(2004). An evolutionarily conserved mechanism for sensitization of soluble guanylyl cyclase reveals extensive nitric oxide-mediated upregulation of cyclic GMP in insect brain. Eur J Neurosci vol. 20, (5) 1231-1244.
Ott SR, Elphick MR(2003). New techniques for whole-mount NADPH-diaphorase histochemistry demonstrated in insect ganglia. J Histochem Cytochem vol. 51, (4) 523-532.
Melarange R, Elphick MR(2003). Comparative analysis of nitric oxide and SALMFamide neuropeptides as general muscle relaxants in starfish. J EXP BIOL vol. 206, (5) 893-899.
Elphick MR, Satou Y, Satoh N(2003). The invertebrate ancestry of endocannabinoid signalling: an orthologue of vertebrate cannabinoid receptors in the urochordate Ciona intestinalis. GENE vol. 302, (1-2) 95-101.
Egertova M, Cravatt BF, Elphick MR(2003). Comparative analysis of fatty acid amide hydrolase and CB1 cannabinoid receptor expression in the mouse brain: Evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. NEUROSCIENCE vol. 119, (2) 481-496.
Bridges D, Rice ASC, Egertova M et al. (2003). Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry. NEUROSCIENCE. vol. 119, 803-812.
Ott SR, Elphick MR(2002). Nitric oxide synthase histochemistry in insect nervous systems: Methanol/formalin fixation reveals the neuroarchitecture of formaldehyde-sensitive NADPH diaphorase in the cockroach Periplaneta americana. J Comp Neurol vol. 448, (2) 165-185.
Elphick MR(2002). Evolution of cannabinoid receptors in vertebrates: Identification of a CB2 gene in the puffer fish Fugu rubripes. BIOL BULL vol. 202, (2) 104-107.
Elphick MR, Melarange R(2001). Neural control of muscle relaxation in echinoderms. Journal of Experimental Biology vol. 204, (5) 875-885.
Ott SR, Burrows M, Elphick MR (2001). The neuroanatomy of nitric oxide-cyclic GMP signaling in the locust: Functional implications for sensory systems. AMERICAN ZOOLOGIST. vol. 41, 321-331.
Elphick MR, Egertová M(2001). The neurobiology and evolution of cannabinoid signalling. Philos Trans R Soc Lond B Biol Sci vol. 356, (1407) 381-408.
Elphick MR, Melarange R(2001). Neural control of muscle relaxation in echinoderms. J Exp Biol vol. 204, (Pt 5) 875-885.
Ott SR, Jones IW, Burrows M et al.(2000). Sensory afferents and motor neurons as targets for nitric oxide in the locust. J Comp Neurol vol. 422, (4) 521-532.
Egertová M, Elphick MR(2000). Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB. J Comp Neurol vol. 422, (2) 159-171.
Egertová M, Elphick MR(2000). Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB<inf>1</inf>. Journal of Comparative Neurology vol. 422, (2) 159-171.
Farquhar-Smith WP, Egertová M, Bradbury EJ et al.(2000). Cannabinoid CB(1) receptor expression in rat spinal cord. Mol Cell Neurosci vol. 15, (6) 510-521.
Egertová M, Cravatt BF, Elphick MR(2000). Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide. Neurosci Lett vol. 282, (1-2) 13-16.
Melarange R, Potton DJ, Thorndyke MC et al.(1999). SALMFamide neuropeptides cause relaxation and eversion of the cardiac stomach in starfish. Proceedings of the Royal Society B: Biological Sciences vol. 266, (1430) 1785-1789.
Jones IW, Elphick MR(1999). Dark-dependent soluble guanylyl cyclase activity in locust photoreceptor cells. Proceedings of the Royal Society B: Biological Sciences vol. 266, (1417) 413-419.
Egertová M, Giang DK, Cravatt BF et al.(1998). A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. Proc Biol Sci vol. 265, (1410) 2081-2085.
Elphick MR, Jones IW(1998). Localization of soluble guanylyl cyclase alpha-subunit in identified insect neurons. Brain Res vol. 800, (1) 174-179.
Elphick MR(1998). An invertebrate G-protein coupled receptor is a chimeric cannabinoid/melanocortin receptor. Brain Res vol. 780, (1) 170-173.
Elphick MR, Melarange R(1998). Nitric oxide function in an echinoderm. Biological Bulletin vol. 194, (3) 260-266.
Elphick MR, Schleiffer R(1997). Comparative physiology of the L-arginine-nitric oxide pathway: An overview of a symposium at the 4th International Congress of Comparative Physiology and Biochemistry, 1995. Comparative Biochemistry and Physiology - A Physiology vol. 118, (4) 921-923.
Elphick MR(1997). Localization of nitric oxide synthase using NADPH diaphorase histochemistry. Methods Mol Biol vol. 72, 153-158.
Elphick MR, Williams L, O'Shea M(1996). New features of the locust optic lobe: Evidence of a role for nitric oxide in insect vision. Journal of Experimental Biology vol. 199, (11) 2395-2407.
Elphick M, Williams L, Shea M(1996). New features of the locust optic lobe: evidence of a role for nitric oxide in insect vision. J Exp Biol vol. 199, (Pt 11) 2395-2407.
Elphick MR, Newman SJ, Thorndyke MC(1995). Distribution and action of SALMFamide neuropeptides in the starfish Asterias rubens. J Exp Biol vol. 198, (Pt 12) 2519-2525.
Elphick MR, Newman SJ, Thorndyke MC(1995). Distribution and action of SLAMFamide neuropeptides in the starfish Asterias rubens. Journal of Experimental Biology vol. 198, (12) 2519-2525.
Elphick MR, Kemenes G, Staras K et al.(1995). Behavioral role for nitric oxide in chemosensory activation of feeding in a mollusc. J Neurosci vol. 15, (11) 7653-7664.
Newman SJ, Elphick MR, Thorndyke MC(1995). Tissue distribution of the SALMFamide neuropeptides S1 and S2 in the starfish Asterias rubens using novel monoclonal and polyclonal antibodies. I. Nervous and locomotory systems. Proc Biol Sci vol. 261, (1360) 139-145.
Elphick M, Rayne R, Riveros-Moreno V et al.(1995). Nitric oxide synthesis in locust olfactory interneurones. J Exp Biol vol. 198, (Pt 3) 821-829.
Newman SJ, Elphick MR, Thorndyke MC(1995). Tissue distribution of the SALMFamide neuropeptides S1 and S2 in the starfish Asterias rubens using novel monoclonal and polyclonal antibodies. II. Digestive system. Proceedings of the Royal Society B: Biological Sciences vol. 261, (1361) 187-192.
Green IC, Cunningham JM, Delaney CA et al.(1994). Effects of cytokines and nitric oxide donors on insulin secretion, cyclic GMP and DNA damage: relation to nitric oxide production. Biochem Soc Trans vol. 22, (1) 30-37.
Elphick MR, Green IC, O'Shea M(1993). Nitric oxide synthesis and action in an invertebrate brain. Brain Res vol. 619, (1-2) 344-346.
Elphick MR, Reeve JR, Burke RD et al.(1991). Isolation of the neuropeptide SALMFamide-1 from starfish using a new antiserum. Peptides vol. 12, (3) 455-459.
Elphick MR, Price DA, Lee TD et al.(1991). The SALMFamides: a new family of neuropeptides isolated from an echinoderm. Proc Biol Sci vol. 243, (1307) 121-127.
Andrews EB, Elphick MR, Thorndyke MC(1991). Pharmacologically active constituents of the accessory salivary and hypobranchial glands of Nucella lapillus. Journal of Molluscan Studies vol. 57, (1) 136-138.
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