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Publications:  Dr Jeffrey Davies

DAVIES JK, Brennan L, Wingard J et al.(2018). Infusion of alloanergized donor lymphocytes after CD34-selected haploidentical myeloablative hematopoietic stem cell transplantation. Clinical Cancer Research
10.1158/1078-0432.CCR-18-0449
https://qmro.qmul.ac.uk/handle/123456789/39404
Araf S, Wang J, Korfi K et al.(2018). Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma. Leukemia vol. 32, (5) 1258-1263.
10.1038/s41375-018-0043-y
https://qmro.qmul.ac.uk/handle/123456789/36269
DAVIES JK, Hassan S, Sarker S et al.(2017). Durable graft-versus-leukaemia effects without donor lymphocyte infusions- results of a Phase II study of sequential T-replete allogeneic transplantation for high-risk acute myeloid leukaemia and myelodysplasia. British Journal of Haematology
10.1111/bjh.14980
https://qmro.qmul.ac.uk/handle/123456789/25815
Kotsiou E, Okosun J, Besley C et al.(2016). TNFRSF14 aberrations in follicular lymphoma increase clinically significant allogeneic T-cell responses. Blood vol. 128, (1) 72-81.
10.1182/blood-2015-10-679191
https://qmro.qmul.ac.uk/handle/123456789/12275
Kotsiou E, Gribben JG, Davies JK(2016). Allospecific Tregs expanded after anergization remain suppressive in inflammatory conditions but lack expression of gut-homing molecules. Molecular therapy : the journal of the American Society of Gene Therapy vol. 24, (6) 1126-1134.
10.1038/mt.2016.64
https://qmro.qmul.ac.uk/handle/123456789/25657
Hassan S, Davies J, Smith M et al. (2015). DURABLE REMISSIONS AFTER SEQUENTIAL TRANSPLANTATION USING T-REPLETE NON-MYELOABLATIVE CONDITIONING FOR RELAPSED/REFRACTORY ACUTE MYELOID LEUKAEMIA AND MYELODYSPLASIA. HAEMATOLOGICA. vol. 100, 278-278.
Kotsiou E, Guinan E, Gribben J et al. (2015). Phenotypic and functional stability of regulatory T cells expanded after alloanergization with costimulatory molecule blockade. BONE MARROW TRANSPLANTATION. vol. 50, S373-S373.
Besley CM, Kotsiou E, Petty R et al. (2014). Lenalidomide Enhances Human Alloresponses By Increasing Proliferation of Effector Memory CD8 T Cells with Enhanced Polyfunctional Effector Capacity and a Unique Gene Expression Profile. BLOOD. vol. 124,
https://qmro.qmul.ac.uk/handle/123456789/7521
Kotsiou E, Okosun J, Clear AJ et al. (2014). TNFRSF14 aberrations in Follicular Lymphoma B Cells Result in Increased Alloresponses in Vitro and in Vivo. BLOOD. vol. 124,
Besley C, Kotsiou E, Petty R et al. (2014). Lenalidomide potentiates human T cell alloresponses by selectively increasing proliferation of alloreactive CD8+cells which exhibit a novel gene expression profile - implications for IMiD therapy after allogeneic haematopoietic stem cell transplant. BRITISH JOURNAL OF HAEMATOLOGY. vol. 165, 16-17.
https://qmro.qmul.ac.uk/handle/123456789/9504
Besley C, Kotsiou E, Petty R et al. (2014). LENALIDOMIDE POTENTIATES HUMAN T CELL ALLORESPONSES BY SELECTIVELY INCREASING PROLIFERATION OF ALLOREACTIVE CD8+CELLS WHICH EXHIBIT A NOVEL GENE EXPRESSION PROFILE - IMPLICATIONS FOR IMID THERAPY AFTER ALLOGENEIC HAEMATOPOIETIC CELL TRANSPLANT. BONE MARROW TRANSPLANTATION. vol. 49, S310-S311.
Barbon CM, Davies JK, Voskertchian A et al.(2014). Alloanergization of human T cells results in expansion of alloantigen-specific CD8(+) CD28(-) suppressor cells. Am J Transplant vol. 14, (2) 305-318.
10.1111/ajt.12575
Kotsiou E, Gribben J, Davies J (2013). Phenotypic and functional characterisation of alloantigen-specific regulatory T cells expanded after in vitro anergisation with co-stimulatory molecule blockade. IMMUNOLOGY. vol. 140, 22-22.
Miraki-Moud F, Anjos-Afonso F, Hodby KA et al.(2013). Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation. Proc Natl Acad Sci U S A vol. 110, (33) 13576-13581.
10.1073/pnas.1301891110
Davies JK, Taussig D, Oakervee H et al.(2013). Long-term survival with low toxicity after allogeneic transplantation for acute myeloid leukaemia and myelodysplasia using non-myeloablative conditioning without T cell depletion. Br J Haematol vol. 162, (4) 525-529.
10.1111/bjh.12402
Riches JC, Davies JK, McClanahan F et al.(2013). T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production. Blood vol. 121, (9) 1612-1621.
10.1182/blood-2012-09-457531
Kotsiou E, Davies JK(2013). New ways to separate graft-versus-host disease and graft-versus-tumour effects after allogeneic haematopoietic stem cell transplantation. Br J Haematol vol. 160, (2) 133-145.
10.1111/bjh.12115
Auer RL, MacDougall F, Oakervee HE et al.(2012). T-cell replete fludarabine/cyclophosphamide reduced intensity allogeneic stem cell transplantation for lymphoid malignancies. Br J Haematol vol. 157, (5) 580-585.
10.1111/j.1365-2141.2012.09106.x
DAVIES JK, Gribben JG(2012). Blockade of chemotaxis in graft-versus-host disease. New England Journal of Medicine vol. 367, (17)
10.1056/NEJMc1209665
DAVIES JK, Barbon CM, Voskertchian A et al.(2012). Ex vivo alloanergization with belatacept: a strategy to selectively modulate alloresponses after transplantation. Cell Transplantation vol. 21, (9) 2047-2061.
10.3727/096368912X637479
Davies J(2011). First-line therapy for CML: nilotinib comes of age. Lancet Oncol vol. 12, (9) 826-827.
10.1016/S1470-2045(11)70228-5
Davies JK(2011). Costimulatory blockade with monoclonal antibodies to induce alloanergy in donor lymphocytes. Int J Hematol vol. 93, (5) 594-601.
10.1007/s12185-011-0819-6
Davies JK, Barbon CM, Voskertchian A et al. (2011). Es Vivo Costimulatory Blockade with Belatacept Provides a Strategy To Control Alloresponses after Allogeneic Transplantation. AMERICAN JOURNAL OF TRANSPLANTATION. vol. 11, 93-93.
Davies JK, Barbon CM, Voskertchian AR et al.(2011). Induction of alloantigen-specific anergy in human peripheral blood mononuclear cells by alloantigen stimulation with co-stimulatory signal blockade. J Vis Exp (49)
10.3791/2673
https://qmro.qmul.ac.uk/handle/123456789/13571
Riches JC, Davies J, Iqbal S et al. (2011). T-cells from Patients With CLL Exhibit Phenotypic and Transcription Factor Profiles Of Exhaustion Independent of CMV Serostatus. Blood. vol. 118, 1780-1783.
DAVIES JK, Nadler LM, Guinan EC(2010). Alloanergization in Haploidentical Hematopoietic Stem Cell Transplantation. Bone Marrow Transplantation Across Major Genetic Barriers, Editors: Reisner, Y, World Scientific Publishing
Davies JK, Singh H, Huls H et al.(2010). Combining CD19 redirection and alloanergization to generate tumor-specific human T cells for allogeneic cell therapy of B-cell malignancies. Cancer Res vol. 70, (10) 3915-3924.
10.1158/0008-5472.CAN-09-3845
Davies JK, Nadler LM, Guinan EC(2009). Expansion of allospecific regulatory T cells after anergized, mismatched bone marrow transplantation. Sci Transl Med vol. 1, (1)
10.1126/scitranslmed.3000153
Davies JK, De Lima M, Cooper TJN et al. (2009). Delayed Infusion Of Alloanergized Donor Peripheral Blood Mononuclear Cells (PBMC) Augments Pathogen-Specific Immune Reconstitution After T Cell Depleted (TCD) Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) For High-Risk Acute LEUKEMIA/MDS. Biology of Blood and Marrow Transplantation. vol. 15, 139-139.
10.1016/j.bbmt.2008.12.423.
Davies JK, Singh H, Yuk D et al. (2009). TO AUGMENT A GVL EFFECT AND REDUCE GVHD: ALLOREACTIVITY OF HUMAN CD19-SPECIFIC T CELLS CAN BE REDUCED BY ALLOANERGIZATION WITHOUT REDUCTION OF TUMOR-SPECIFIC KILLING. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. vol. 15, 121-121.
10.1016/j.bbmt.2008.12.372
Davies J, Yuk D, Nadler L et al. (2008). Alloanergization of HILA-Mismatched Human Donor T Cells Results in the Generation of Allosuppressive CD4(+) T Regulatory Cells Both in Vitro and in Vivo. BLOOD. vol. 112, 83-84.
Davies J, De Lima M, Cooper L et al. (2008). Phase 1 Clinical Study of Adoptive Immunotherapy with Delayed Infusion of Alloanergized Donor T Cells to Improve Immune Reconstution after Haploidentical Stem Cell Transplantation. BLOOD. vol. 112, 422-423.
Davies JK, Yuk D, Nadler LM et al.(2008). Induction of alloanergy in human donor T cells without loss of pathogen or tumor immunity. Transplantation vol. 86, (6) 854-864.
10.1097/TP.0b013e3181861b6c
Davies JK, Gribben JG, Brennan LL et al.(2008). Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies. BLOOD vol. 112, (6) 2232-2241.
10.1182/blood-2008-03-143636
Haining WN, Davies J, Kanzler H et al.(2008). CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans. Clin Cancer Res vol. 14, (17) 5626-5634.
10.1158/1078-0432.CCR-08-0526
Davies J, Gribben J, Brennan L et al. (2008). ALLOANERGIZED HLA-MISMATCHED BONE MARROW TRANSPLANTATION - LOW INCIDENCE OF CLINICALLY SIGNIFICANT GVHD AND VIRAL INFECTION RESULTING IN LONG TERM DISEASE FREE SURVIVAL. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. Conference: Annual Meeting of the American-Society-for-Blood-and-Marrow-Transplantation (San Diego, CA) from: 13/02/2008 to: 17/02/2008, vol. 14, 16-17.
10.1016/j.bbmt.2007.12.046
Davies J, Yuk D, Brennan L et al. (2008). IN VIVO EXPANSION OF CD4+FOXP3+REGULATORY T CELLS MAY CONTRIBUTE TO CONTROL OF ACUTE GVHD AFTER HLA-MISMATCHED ALLOANERGIZED HSCT. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. vol. 14, 18-18.
10.1016/j.bbmt.2007.12.050
Davies J, Yuk D, Nadler L et al. (2007). Donor-derived T cells can be rendered hyporesporisive to alloantigen without loss of pathogen or tumor immune responses. BLOOD. vol. 110, 237A-237A.
Davies J, Yuk D, Brennan L et al. (2007). In vivo expansion of CD4+ FOXP3+ regulatory T cells may contribute to control of acute GvHD after HLA-mismatched alloanergized HSCT. BLOOD. vol. 110, 874A-875A.
Davies JK, Brennan LL, Nadler LM et al. (2007). Ex vivo alloantigen-specific costimulatory blockade in haploidentical bone marrow transplantation (BMT)-results of a pilot clinical study. PEDIATR BLOOD CANCER. vol. 48, 621-621.
Davies JK, Guinan EC(2007). An update on the management of severe idiopathic aplastic anaemia in children. Br J Haematol vol. 136, (4) 549-564.
10.1111/j.1365-2141.2006.06461.x
Killick SB, Cavenagh JD, Davies JK et al.(2006). Low dose antithymocyte globulin for the treatment of older patients with aplastic anaemia. LEUKEMIA RES vol. 30, (12) 1517-1520.
10.1016/j.leukres.2006.02.003
Davies JK, Gorgun G, Nadler LM et al. (2006). Effective control of mismatched alloreactivity via ex vivo alloantigen-specific co-stimulatory blockade does not significantly impact pathogen-specific immunity. BLOOD. vol. 108, 907A-907A.
Davies JK, Taussig DC, Oakervee H et al.(2006). Long-Term Follow-Up After Reduced-Intensity Conditioning Allogeneic Transplantation for Acute Myeloid Leukemia/Myelodysplastic Syndrome: Late CNS Relapses Despite Graft-Versus-Host Disease. Journal of Clinical Oncology vol. 24, 23e-25.
10.1200/JCO.2006.05.7281
Allard S, Earley J, Davies JK et al. (2006). Hospital blood transfusion services in a mass casualty situation: lessons to be learned from July 2005 London bombings. BRITISH JOURNAL OF HAEMATOLOGY. vol. 133, 2-2.
Davies JK, Cavenagh JD(2006). The importance of consistent use of denominators across patient groups in assessing responses in clinical trials. BRIT J HAEMATOL vol. 132, (6) 794-795.
10.1111/j.1365-2141.2006.05962.x
Addison EG, North J, Bakhsh I et al.(2005). Ligation of CD8alpha on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity. Immunology vol. 116, (3) 354-361.
DAVIES JK, Koh MB, Lowdell MW(2004). Antiviral immunity and T-regulatory cell function are retained after selective alloreactive T-cell depletion in both the HLA-identical and HLA-mismatched settings. Biol Blood Marrow Transplant vol. 10, (4) 259-268.
10.1016/j.bbmt.2003.12.001
Davies JK, Telfer P, Cavenagh JD et al.(2003). Autoimmune cytopenias in the 22q11.2 deletion syndrome. Clin Lab Haematol vol. 25, (3) 195-197.
10.1046/j.1365-2257.2003.00508.x
DAVIES JK, Lowdell MW(2003). New advances in acute graft-versus-host disease prophylaxis. Transfusion Medicine vol. 13, (6) 387-397.
DAVIES JK, Ahktar N, Ranasinge E(2001). A Juicy Problem. Lancet vol. 358, (9299) 2126-2126.
10.1016/S0140-6736(01)07220-8
Papaioannou S, Davies JK, Grant I et al.(2000). Folate deficiency in pregnancy presenting as acute megaloblastic crisis. Journal of Obstetrics and Gynaecology vol. 20, (2) 190-190.
Dunne CA, Davies JK(1996). Epidemiology of adult Still's disease. Annals of the Rheumatic Diseases vol. 55, (4) 272-272.
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