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Publications:  Dr Jeffrey Davies

Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al.(2019). Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma. Leukemia vol. 33, (6)
10.1038/s41375-019-0425-9
DAVIES JK, Brennan L, Wingard J, Cogle C, Kapoor N, Shah A, Dey B, Spitzer T et al.(2018). Infusion of alloanergized donor lymphocytes after CD34-selected haploidentical myeloablative hematopoietic stem cell transplantation. Clinical Cancer Research
10.1158/1078-0432.CCR-18-0449
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39404
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al.(2018). Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma. Leukemia vol. 32, (5) 1261-1265.
10.1038/s41375-018-0043-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36269
DAVIES JK, Hassan S, Sarker S, Besley C, Oakervee H, Smith M, Taussig D, Gribben JG et al.(2017). Durable graft-versus-leukaemia effects without donor lymphocyte infusions- results of a Phase II study of sequential T-replete allogeneic transplantation for high-risk acute myeloid leukaemia and myelodysplasia. British Journal of Haematology
10.1111/bjh.14980
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25815
Kotsiou E, Okosun J, Besley C, Iqbal S, Matthews J, Fitzgibbon J, Gribben J, DAVIES JK(2016). TNFRSF14 aberrations in follicular lymphoma increase clinically significant allogeneic T-cell responses. Blood vol. 128, (1) 72-81.
10.1182/blood-2015-10-679191
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12275
Kotsiou E, Gribben JG, Davies JK(2016). Allospecific Tregs expanded after anergization remain suppressive in inflammatory conditions but lack expression of gut-homing molecules. Molecular therapy : the journal of the American Society of Gene Therapy vol. 24, (6) 1126-1134.
10.1038/mt.2016.64
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25657
Hassan S, Davies J, Smith M, Tsitsikas D, Oakervee H, Hallam S, Taussig D, Gribben J et al. (2015). DURABLE REMISSIONS AFTER SEQUENTIAL TRANSPLANTATION USING T-REPLETE NON-MYELOABLATIVE CONDITIONING FOR RELAPSED/REFRACTORY ACUTE MYELOID LEUKAEMIA AND MYELODYSPLASIA. HAEMATOLOGICA. vol. 100, 278-278.
Kotsiou E, Guinan E, Gribben J, Davies J (2015). Phenotypic and functional stability of regulatory T cells expanded after alloanergization with costimulatory molecule blockade. BONE MARROW TRANSPLANTATION. vol. 50, S373-S373.
Besley CM, Kotsiou E, Petty R, Sangaralingum A, Le Dieu R, Gribben JG, Davies JK (2014). Lenalidomide Enhances Human Alloresponses By Increasing Proliferation of Effector Memory CD8 T Cells with Enhanced Polyfunctional Effector Capacity and a Unique Gene Expression Profile. BLOOD. vol. 124,
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7521
Kotsiou E, Okosun J, Clear AJ, Iqbal S, Fitzgibbon J, Gribben JG, Davies JK (2014). TNFRSF14 aberrations in Follicular Lymphoma B Cells Result in Increased Alloresponses in Vitro and in Vivo. BLOOD. vol. 124,
Besley C, Kotsiou E, Petty R, Sangaralingam A, LeDieu R, Gribben J, Davies J (2014). Lenalidomide potentiates human T cell alloresponses by selectively increasing proliferation of alloreactive CD8+cells which exhibit a novel gene expression profile - implications for IMiD therapy after allogeneic haematopoietic stem cell transplant. BRITISH JOURNAL OF HAEMATOLOGY. vol. 165, 16-17.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9504
Besley C, Kotsiou E, Petty R, Sangaralingam A, LeDieu R, Gribben J, Davies J (2014). LENALIDOMIDE POTENTIATES HUMAN T CELL ALLORESPONSES BY SELECTIVELY INCREASING PROLIFERATION OF ALLOREACTIVE CD8+CELLS WHICH EXHIBIT A NOVEL GENE EXPRESSION PROFILE - IMPLICATIONS FOR IMID THERAPY AFTER ALLOGENEIC HAEMATOPOIETIC CELL TRANSPLANT. BONE MARROW TRANSPLANTATION. vol. 49, S310-S311.
Barbon CM, Davies JK, Voskertchian A, Kelner RH, Brennan LL, Nadler LM, Guinan EC(2014). Alloanergization of human T cells results in expansion of alloantigen-specific CD8(+) CD28(-) suppressor cells. Am J Transplant vol. 14, (2) 305-318.
10.1111/ajt.12575
Kotsiou E, Gribben J, Davies J (2013). Phenotypic and functional characterisation of alloantigen-specific regulatory T cells expanded after in vitro anergisation with co-stimulatory molecule blockade. IMMUNOLOGY. vol. 140, 22-22.
Miraki-Moud F, Anjos-Afonso F, Hodby KA, Griessinger E, Rosignoli G, Lillington D, Jia L, Davies JK et al.(2013). Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation. Proc Natl Acad Sci U S A vol. 110, (33) 13576-13581.
10.1073/pnas.1301891110
Davies JK, Taussig D, Oakervee H, Smith M, Agrawal S, Cavenagh JD, Gribben JG(2013). Long-term survival with low toxicity after allogeneic transplantation for acute myeloid leukaemia and myelodysplasia using non-myeloablative conditioning without T cell depletion. Br J Haematol vol. 162, (4) 525-529.
10.1111/bjh.12402
Riches JC, Davies JK, McClanahan F, Fatah R, Iqbal S, Agrawal S, Ramsay AG, Gribben JG(2013). T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production. Blood vol. 121, (9) 1612-1621.
10.1182/blood-2012-09-457531
Kotsiou E, Davies JK(2013). New ways to separate graft-versus-host disease and graft-versus-tumour effects after allogeneic haematopoietic stem cell transplantation. Br J Haematol vol. 160, (2) 133-145.
10.1111/bjh.12115
Auer RL, MacDougall F, Oakervee HE, Taussig D, Davies JK, Syndercombe-Court D, Agrawal S, Cavenagh JD et al.(2012). T-cell replete fludarabine/cyclophosphamide reduced intensity allogeneic stem cell transplantation for lymphoid malignancies. Br J Haematol vol. 157, (5) 580-585.
10.1111/j.1365-2141.2012.09106.x
DAVIES JK, Gribben JG(2012). Blockade of chemotaxis in graft-versus-host disease. New England Journal of Medicine vol. 367, (17)
10.1056/NEJMc1209665
DAVIES JK, Barbon CM, Voskertchian A, Nadler LM, Guinan EC(2012). Ex vivo alloanergization with belatacept: a strategy to selectively modulate alloresponses after transplantation. Cell Transplantation vol. 21, (9) 2047-2061.
10.3727/096368912X637479
Davies J(2011). First-line therapy for CML: nilotinib comes of age. Lancet Oncol vol. 12, (9) 826-827.
10.1016/S1470-2045(11)70228-5
Davies JK(2011). Costimulatory blockade with monoclonal antibodies to induce alloanergy in donor lymphocytes. Int J Hematol vol. 93, (5) 594-601.
10.1007/s12185-011-0819-6
Davies JK, Barbon CM, Voskertchian A, Nadler LM, Guinan EC (2011). Es Vivo Costimulatory Blockade with Belatacept Provides a Strategy To Control Alloresponses after Allogeneic Transplantation. AMERICAN JOURNAL OF TRANSPLANTATION. vol. 11, 93-93.
Davies JK, Barbon CM, Voskertchian AR, Nadler LM, Guinan EC(2011). Induction of alloantigen-specific anergy in human peripheral blood mononuclear cells by alloantigen stimulation with co-stimulatory signal blockade. J Vis Exp (49)
10.3791/2673
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13571
Riches JC, Davies J, Iqbal S, Fatah R, Agrawal S, Ramsay AG, Gribben JG (2011). T-cells from Patients With CLL Exhibit Phenotypic and Transcription Factor Profiles Of Exhaustion Independent of CMV Serostatus. Blood. vol. 118, 1780-1783.
DAVIES JK, Nadler LM, Guinan EC(2010). Alloanergization in Haploidentical Hematopoietic Stem Cell Transplantation. Bone Marrow Transplantation Across Major Genetic Barriers, Editors: Reisner, Y, World Scientific Publishing
Davies JK, Singh H, Huls H, Yuk D, Lee DA, Kebriaei P, Champlin RE, Nadler LM et al.(2010). Combining CD19 redirection and alloanergization to generate tumor-specific human T cells for allogeneic cell therapy of B-cell malignancies. Cancer Res vol. 70, (10) 3915-3924.
10.1158/0008-5472.CAN-09-3845
Davies JK, Nadler LM, Guinan EC(2009). Expansion of allospecific regulatory T cells after anergized, mismatched bone marrow transplantation. Sci Transl Med vol. 1, (1)
10.1126/scitranslmed.3000153
Davies JK, De Lima M, Cooper TJN, Spitzer T, Kapoor N, Yuk D, Brennan LL, Thall P et al. (2009). Delayed Infusion Of Alloanergized Donor Peripheral Blood Mononuclear Cells (PBMC) Augments Pathogen-Specific Immune Reconstitution After T Cell Depleted (TCD) Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) For High-Risk Acute LEUKEMIA/MDS. Biology of Blood and Marrow Transplantation. vol. 15, 139-139.
10.1016/j.bbmt.2008.12.423.
Davies JK, Singh H, Yuk D, Champlin RE, Nadler LM, Guinan EC, Cooper LJN (2009). TO AUGMENT A GVL EFFECT AND REDUCE GVHD: ALLOREACTIVITY OF HUMAN CD19-SPECIFIC T CELLS CAN BE REDUCED BY ALLOANERGIZATION WITHOUT REDUCTION OF TUMOR-SPECIFIC KILLING. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. vol. 15, 121-121.
10.1016/j.bbmt.2008.12.372
Davies J, Yuk D, Nadler L, Guinan E (2008). Alloanergization of HILA-Mismatched Human Donor T Cells Results in the Generation of Allosuppressive CD4(+) T Regulatory Cells Both in Vitro and in Vivo. BLOOD. vol. 112, 83-84.
Davies J, De Lima M, Cooper L, Spitzer T, Kapoor N, Brennan L, Thall P, McMannis J et al. (2008). Phase 1 Clinical Study of Adoptive Immunotherapy with Delayed Infusion of Alloanergized Donor T Cells to Improve Immune Reconstution after Haploidentical Stem Cell Transplantation. BLOOD. vol. 112, 422-423.
Davies JK, Yuk D, Nadler LM, Guinan EC(2008). Induction of alloanergy in human donor T cells without loss of pathogen or tumor immunity. Transplantation vol. 86, (6) 854-864.
10.1097/TP.0b013e3181861b6c
Davies JK, Gribben JG, Brennan LL, Yuk DG, Nadler LM, Guinan EC(2008). Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies. BLOOD vol. 112, (6) 2232-2241.
10.1182/blood-2008-03-143636
Haining WN, Davies J, Kanzler H, Drury L, Brenn T, Evans J, Angelosanto J, Rivoli S et al.(2008). CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans. Clin Cancer Res vol. 14, (17) 5626-5634.
10.1158/1078-0432.CCR-08-0526
Davies J, Gribben J, Brennan L, Nadler L, Guinan E (2008). ALLOANERGIZED HLA-MISMATCHED BONE MARROW TRANSPLANTATION - LOW INCIDENCE OF CLINICALLY SIGNIFICANT GVHD AND VIRAL INFECTION RESULTING IN LONG TERM DISEASE FREE SURVIVAL. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. Conference: Annual Meeting of the American-Society-for-Blood-and-Marrow-Transplantation (San Diego, CA) from: 13/02/2008 to: 17/02/2008, vol. 14, 16-17.
10.1016/j.bbmt.2007.12.046
Davies J, Yuk D, Brennan L, Nadler L, Guinan E (2008). IN VIVO EXPANSION OF CD4+FOXP3+REGULATORY T CELLS MAY CONTRIBUTE TO CONTROL OF ACUTE GVHD AFTER HLA-MISMATCHED ALLOANERGIZED HSCT. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. vol. 14, 18-18.
10.1016/j.bbmt.2007.12.050
Davies J, Yuk D, Nadler L, Guinan E (2007). Donor-derived T cells can be rendered hyporesporisive to alloantigen without loss of pathogen or tumor immune responses. BLOOD. vol. 110, 237A-237A.
Davies J, Yuk D, Brennan L, Nadler L, Guinan E (2007). In vivo expansion of CD4+ FOXP3+ regulatory T cells may contribute to control of acute GvHD after HLA-mismatched alloanergized HSCT. BLOOD. vol. 110, 874A-875A.
Davies JK, Brennan LL, Nadler LM, Guinan EC (2007). Ex vivo alloantigen-specific costimulatory blockade in haploidentical bone marrow transplantation (BMT)-results of a pilot clinical study. PEDIATR BLOOD CANCER. vol. 48, 621-621.
Davies JK, Guinan EC(2007). An update on the management of severe idiopathic aplastic anaemia in children. Br J Haematol vol. 136, (4) 549-564.
10.1111/j.1365-2141.2006.06461.x
Killick SB, Cavenagh JD, Davies JK, Marsh JCW(2006). Low dose antithymocyte globulin for the treatment of older patients with aplastic anaemia. LEUKEMIA RES vol. 30, (12) 1517-1520.
10.1016/j.leukres.2006.02.003
Davies JK, Gorgun G, Nadler LM, Guinan EC (2006). Effective control of mismatched alloreactivity via ex vivo alloantigen-specific co-stimulatory blockade does not significantly impact pathogen-specific immunity. BLOOD. vol. 108, 907A-907A.
Davies JK, Taussig DC, Oakervee H, Davies AJ, AGRAWAL SG, Gribben JG, Lister TA, Cavenagh JD(2006). Long-Term Follow-Up After Reduced-Intensity Conditioning Allogeneic Transplantation for Acute Myeloid Leukemia/Myelodysplastic Syndrome: Late CNS Relapses Despite Graft-Versus-Host Disease. Journal of Clinical Oncology vol. 24, 23e-25.
10.1200/JCO.2006.05.7281
Allard S, Earley J, Davies JK, Cantwell C, Fulkes V (2006). Hospital blood transfusion services in a mass casualty situation: lessons to be learned from July 2005 London bombings. BRITISH JOURNAL OF HAEMATOLOGY. vol. 133, 2-2.
Davies JK, Cavenagh JD(2006). The importance of consistent use of denominators across patient groups in assessing responses in clinical trials. BRIT J HAEMATOL vol. 132, (6) 794-795.
10.1111/j.1365-2141.2006.05962.x
Addison EG, North J, Bakhsh I, Marden CM, Haq S, Al-Sarraj S, Malayeri R, Wickremasinghe SE et al.(2005). Ligation of CD8alpha on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity. Immunology vol. 116, (3) 354-361.
DAVIES JK, Koh MB, Lowdell MW(2004). Antiviral immunity and T-regulatory cell function are retained after selective alloreactive T-cell depletion in both the HLA-identical and HLA-mismatched settings. Biol Blood Marrow Transplant vol. 10, (4) 259-268.
10.1016/j.bbmt.2003.12.001
Davies JK, Telfer P, Cavenagh JD, Foot N, Neat M(2003). Autoimmune cytopenias in the 22q11.2 deletion syndrome. Clin Lab Haematol vol. 25, (3) 195-197.
10.1046/j.1365-2257.2003.00508.x
DAVIES JK, Lowdell MW(2003). New advances in acute graft-versus-host disease prophylaxis. Transfusion Medicine vol. 13, (6) 387-397.
DAVIES JK, Ahktar N, Ranasinge E(2001). A Juicy Problem. Lancet vol. 358, (9299) 2126-2126.
10.1016/S0140-6736(01)07220-8
Papaioannou S, Davies JK, Grant I, Osei E(2000). Folate deficiency in pregnancy presenting as acute megaloblastic crisis. Journal of Obstetrics and Gynaecology vol. 20, (2) 190-190.
Dunne CA, Davies JK(1996). Epidemiology of adult Still's disease. Annals of the Rheumatic Diseases vol. 55, (4) 272-272.
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