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Publications:  Prof Mark Caulfield

van Setten J, Verweij N, Mbarek H et al.(2019). Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits. Eur J Hum Genet
10.1038/s41431-018-0295-z
Erzurumluoglu AM, Liu M, Jackson VE et al.(2019). Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Mol Psychiatry
10.1038/s41380-018-0313-0
Giri A, Hellwege JN, Keaton JM et al.(2019). Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nat Genet vol. 51, (1) 51-62.
10.1038/s41588-018-0303-9
Evangelou E, Warren HR, Mosen-Ansorena D et al.(2018). Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet vol. 50, (12) 1755-1755.
10.1038/s41588-018-0297-3
Allix-Beguec C, Arandjelovic I, Bi L et al.(2018). Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing. NEW ENGLAND JOURNAL OF MEDICINE vol. 379, (15) 1403-1415.
10.1056/NEJMoa1800474
Robbe P, Popitsch N, Knight SJL et al.(2018). Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project. Genet Med vol. 20, (10) 1196-1205.
10.1038/gim.2017.241
Collier DJ, Juhasz A, Agabiti-Rosei E et al.(2018). Efficacy and safety of azilsartan medoxomil/chlortalidone fixed-dose combination in hypertensive patients uncontrolled on azilsartan medoxomil alone: A randomized trial. J Clin Hypertens (Greenwich) vol. 20, (10) 1473-1484.
10.1111/jch.13376
https://qmro.qmul.ac.uk/handle/123456789/51445
Evangelou E, Warren HR, Mosen-Ansorena D et al.(2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet vol. 50, (10) 1412-1425.
10.1038/s41588-018-0205-x
https://qmro.qmul.ac.uk/handle/123456789/47343
Ng FL, Warren HR, Caulfield MJ(2018). Hypertension genomics and cardiovascular prevention. Ann Transl Med vol. 6, (15) 291-291.
10.21037/atm.2018.06.34
https://qmro.qmul.ac.uk/handle/123456789/49368
Whitworth J, Smith PS, Martin JE et al.(2018). Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes. American Journal of Human Genetics vol. 103, (1) 3-18.
10.1016/j.ajhg.2018.04.013
https://qmro.qmul.ac.uk/handle/123456789/47785
Feitosa MF, Kraja AT, Chasman DI et al.(2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS One vol. 13, (6) e0198166-e0198166.
10.1371/journal.pone.0198166
https://qmro.qmul.ac.uk/handle/123456789/41963
Williams B, MacDonald TM, Morant SV et al.(2018). Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. Lancet Diabetes Endocrinol vol. 6, (6) 464-475.
10.1016/S2213-8587(18)30071-8
https://qmro.qmul.ac.uk/handle/123456789/47823
Turnbull C, Scott RH, Thomas E et al.(2018). The 100 000 Genomes Project: bringing whole genome sequencing to the NHS. BMJ vol. 361,
10.1136/bmj.k1687
Sung YJ, Winkler TW, de Las Fuentes L et al.(2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet vol. 102, (3) 375-400.
10.1016/j.ajhg.2018.01.015
https://qmro.qmul.ac.uk/handle/123456789/35963
Pazoki R, Dehghan A, Evangelou E et al.(2018). Genetic Predisposition to High Blood Pressure and Lifestyle Factors: Associations With Midlife Blood Pressure Levels and Cardiovascular Events. Circulation vol. 137, (7) 653-661.
10.1161/CIRCULATIONAHA.117.030898
McCarthy NS, Vangjeli C, Surendran P et al.(2018). Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Atherosclerosis vol. 269, 42-49.
10.1016/j.atherosclerosis.2017.12.013
https://qmro.qmul.ac.uk/handle/123456789/32223
Farmery JHR, Smith ML, NIHR BioResource - Rare Diseases et al.(2018). Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data. Sci Rep vol. 8, (1)
10.1038/s41598-017-14403-y
Munroe PB, Jahangir SNS, Caulfield MJ(2018). Genetics and genomics of systemic hypertension. Cardiovascular Genetics and Genomics: Principles and Clinical Practice,
https://qmro.qmul.ac.uk/handle/123456789/45283
Turcot V, Lu Y, Highland HM et al.(2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet vol. 50, (1) 26-41.
10.1038/s41588-017-0011-x
https://qmro.qmul.ac.uk/handle/123456789/34563
Ren M, Ng FL, Warren HR et al.(2018). The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle. Hum Mol Genet vol. 27, (1) 199-210.
10.1093/hmg/ddx375
https://qmro.qmul.ac.uk/handle/123456789/30823
Liu DJ, Peloso GM, Yu H et al.(2017). Exome-wide association study of plasma lipids in >300,000 individuals. Nat Genet vol. 49, (12) 1758-1766.
10.1038/ng.3977
https://qmro.qmul.ac.uk/handle/123456789/28624
MacDonald TM, Williams B, Webb DJ et al.(2017). Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial. J Am Heart Assoc vol. 6, (11)
10.1161/JAHA.117.006986
https://qmro.qmul.ac.uk/handle/123456789/34993
Kraja AT, Cook JP, Warren HR et al.(2017). New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Circ Cardiovasc Genet vol. 10, (5)
10.1161/CIRCGENETICS.117.001778
Warren HR, Evangelou E, Cabrera CP et al.(2017). Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet vol. 49, (10) 1558-1558.
10.1038/ng1017-1558a
https://qmro.qmul.ac.uk/handle/123456789/50805
Wain LV, Vaez A, Jansen R et al.(2017). Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension
10.1161/HYPERTENSIONAHA.117.09438
https://qmro.qmul.ac.uk/handle/123456789/26603
Dale CE, Fatemifar G, Palmer TM et al.(2017). Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis. Circulation vol. 135, (24) 2373-2388.
10.1161/CIRCULATIONAHA.116.026560
https://qmro.qmul.ac.uk/handle/123456789/24949
Song C, Burgess S, Eicher JD et al.(2017). Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease. Journal of the American Heart Association vol. 6, (6)
10.1161/JAHA.116.004918
https://qmro.qmul.ac.uk/handle/123456789/25717
Sabatine MS, Giugliano RP, Keech AC et al.(2017). Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med vol. 376, (18) 1713-1722.
10.1056/NEJMoa1615664
MUNROE PB, Caulfield M, Stirrups K et al.(2017). Discovery of novel heart rate-associated loci using the exome chip. Human Molecular Genetics
10.1093/hmg/ddx113
https://qmro.qmul.ac.uk/handle/123456789/22369
Taylor RL, Arno G, Poulter JA et al.(2017). Association of Steroid 5α-Reductase Type 3 Congenital Disorder of Glycosylation With Early-Onset Retinal Dystrophy. JAMA Ophthalmol vol. 135, (4) 339-347.
10.1001/jamaophthalmol.2017.0046
Warren HR, Evangelou E, Cabrera CP et al.(2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet vol. 49, (3) 403-415.
10.1038/ng.3768
https://qmro.qmul.ac.uk/handle/123456789/19169
Marouli E, Graff M, Medina-Gomez C et al.(2017). Rare and low-frequency coding variants alter human adult height. Nature vol. 542, (7640) 186-190.
10.1038/nature21039
https://qmro.qmul.ac.uk/handle/123456789/23049
Ng FL, Boedtkjer E, Witkowska K et al.(2017). Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension. Hum Mol Genet
10.1093/hmg/ddx015
https://qmro.qmul.ac.uk/handle/123456789/22624
Carss KJ, Arno G, Erwood M et al.(2017). Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease. Am J Hum Genet vol. 100, (1) 75-90.
10.1016/j.ajhg.2016.12.003
https://qmro.qmul.ac.uk/handle/123456789/19450
Liang F, Caulfield MJ(2017). Status and future of genomics in blood pressure. European Heart Journal vol. 38, (14) 1011-1013.
10.1093/eurheartj/ehx088
https://qmro.qmul.ac.uk/handle/123456789/28693
Noordam R, Sitlani CM, Avery CL et al.(2016). A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. J Med Genet
10.1136/jmedgenet-2016-104112
https://qmro.qmul.ac.uk/handle/123456789/19162
Rathod KS, Jones DA, Van-Eijl TJA et al.(2016). Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study. BMJ Open vol. 6, (12)
10.1136/bmjopen-2016-012728
https://qmro.qmul.ac.uk/handle/123456789/18455
Evangelou E, Warren H, Cabrera C et al. (2016). UK Biobank GWAS Identifies over 100 Novel Variants Associated with Blood Pressure. vol. 40, is. 7, pp. 613-613.
Ng FL, Boedtkjer E, Ye S et al. (2016). Blood pressure-associated polymorphisms in SLC4A7 (sodium/bicarbonate co-transporter NBCn1) are linked to gene expression and intracellular pH (pHi) regulation. vol. 30, is. 10, pp. 636-636.
MUNROE PB(2016). Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension. Nature Genetics
10.1038/ng.3654
https://qmro.qmul.ac.uk/handle/123456789/13707
MUNROE PB(2016). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics
10.1038/ng.3667
https://qmro.qmul.ac.uk/handle/123456789/15563
Postmus I, Warren HR, Trompet S et al.(2016). Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. Journal of Medical Genetics
10.1136/jmedgenet-2016-103966
https://qmro.qmul.ac.uk/handle/123456789/15127
Ren M, Ng F, Witkowska K et al. (2016). [OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II. England , vol. 34 Suppl 2, Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,
10.1097/01.hjh.0000491573.57396.0f
https://qmro.qmul.ac.uk/handle/123456789/42746
Zhang R, Witkowska K, Afonso Guerra-Assunção J et al.(2016). A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity. Hum Mol Genet vol. 25, (18) 4117-4126.
10.1093/hmg/ddw236
https://qmro.qmul.ac.uk/handle/123456789/15051
Kanoni S, Masca NGD, Stirrups KE et al.(2016). Analysis with the exome array identifies multiple new independent variants in lipid loci. Human Molecular Genetics vol. 25, (18) ddw227-ddw227.
10.1093/hmg/ddw227
https://qmro.qmul.ac.uk/handle/123456789/14812
Yang W, Ng FL, Chan K et al.(2016). Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction. PLoS Genetics vol. 12, (7) e1006127-e1006127.
10.1371/journal.pgen.1006127
https://qmro.qmul.ac.uk/handle/123456789/13881
Burchell AE, Chan K, Ratcliffe LEK et al.(2016). Controversies Surrounding Renal Denervation: Lessons Learned From Real-World Experience in Two United Kingdom Centers. J Clin Hypertens (Greenwich) vol. 18, (6) 585-592.
10.1111/jch.12789
Sharp ASP, Davies JE, Lobo MD et al.(2016). Renal artery sympathetic denervation: observations from the UK experience. Clin Res Cardiol vol. 105, (6) 544-552.
10.1007/s00392-015-0959-4
Lessard S, Manning AK, Low-Kam C et al.(2016). Testing the role of predicted gene knockouts in human anthropometric trait variation. Hum Mol Genet vol. 25, (10) 2082-2092.
10.1093/hmg/ddw055
https://qmro.qmul.ac.uk/handle/123456789/12772
Bodea CA, Neale BM, Ripke S et al.(2016). A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies. American Journal of Human Genetics vol. 98, (5) 857-868.
10.1016/j.ajhg.2016.02.025
Leusink M, Maitland-van der Zee AH, Ding B et al.(2016). A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering. Pharmacogenomics vol. 17, (6) 583-591.
10.2217/pgs.16.8
https://qmro.qmul.ac.uk/handle/123456789/12771
Diver LA, MacKenzie SM, Fraser R et al.(2016). Common Polymorphisms at the CYP17A1 Locus Associate With Steroid Phenotype: Support for Blood Pressure Genome-Wide Association Study Signals at This Locus. Hypertension vol. 67, (4) 724-732.
10.1161/hypertensionaha.115.06925
Brown MJ, Williams B, Morant SV et al.(2016). Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial. Lancet Diabetes Endocrinol vol. 4, (2) 136-147.
10.1016/S2213-8587(15)00377-0
https://qmro.qmul.ac.uk/handle/123456789/19183
Pattaro C, Teumer A, Gorski M et al.(2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun vol. 7,
10.1038/ncomms10023
https://qmro.qmul.ac.uk/handle/123456789/12758
Williams B, MacDonald TM, Morant S et al.(2015). Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet vol. 386, (10008) 2059-2068.
10.1016/S0140-6736(15)00257-3
https://qmro.qmul.ac.uk/handle/123456789/19182
Doyle JJ, Doyle AJ, Wilson NK et al.(2015). A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. ELIFE vol. 4, Article ARTN e08648,
10.7554/eLife.08648
Doyle JJ, Doyle AJ, Wilson NK et al.(2015). A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. Elife vol. 4,
10.7554/eLife.08648
Ren M, Ng FL, Witkowska K et al. (2015). Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II. vol. 29, is. 10, pp. 624-624.
Zhang R, Witkowska K, Ng FL et al.(2015). Hypertension related variant of SLC39A8 gene influences cadmium uptake and cell toxicity. JOURNAL OF HUMAN HYPERTENSION vol. 29, (10) 645-645.
Wain LV, Shrine N, Miller S et al.(2015). Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respir Med vol. 3, (10) 769-781.
10.1016/S2213-2600(15)00283-0
Warren H, Sever P, Poulter N et al.(2015). Pharmacogenetic GWAS meta-analysis of response to antihypertensive drugs. JOURNAL OF HUMAN HYPERTENSION vol. 29, (10) 627-627.
Poulter NR, Prabhakaran D, Caulfield M(2015). Hypertension. Lancet vol. 386, (9995) 801-812.
10.1016/S0140-6736(14)61468-9
Treibel TA, Zemrak F, Sado DM et al.(2015). Extracellular volume quantification in isolated hypertension - changes at the detectable limits?. J Cardiovasc Magn Reson vol. 17,
10.1186/s12968-015-0176-3
https://qmro.qmul.ac.uk/handle/123456789/9687
Brown MJ, Williams B, MacDonald TM et al.(2015). Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): protocol for a randomised double-blind trial in patients with essential hypertension. BMJ Open vol. 5, (8)
10.1136/bmjopen-2015-008086
https://qmro.qmul.ac.uk/handle/123456789/19184
MacDonald TM, Williams B, Caulfield M et al.(2015). Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial. BMJ Open vol. 5, (8)
10.1136/bmjopen-2015-007645
Williams B, MacDonald TM, Caulfield M et al.(2015). Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension. BMJ Open vol. 5, (8)
10.1136/bmjopen-2015-008951
Joshi PK, Esko T, Mattsson H et al.(2015). Directional dominance on stature and cognition in diverse human populations. Nature vol. 523, (7561) 459-462.
10.1038/nature14618
https://qmro.qmul.ac.uk/handle/123456789/12751
Mega JL, Stitziel NO, Smith JG et al.(2015). Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials. Lancet vol. 385, (9984) 2264-2271.
10.1016/S0140-6736(14)61730-X
Khanji M, Balawon A, Boubertakh R et al. (2015). LB01.07: ELEVATED BLOOD PRESSURE WITHOUT HYPERTROPHY RAISES LEFT VENTRICULAR EJECTION FRACTION. J Hypertens. vol. 33 Suppl 1,
10.1097/01.hjh.0000467469.28955.ad
https://qmro.qmul.ac.uk/handle/123456789/11460
Zhang R, Witkowska K, Ng F et al.(2015). LB03.08: HYPERTENSION RELATED VARIANT OF SOLUTE CARRIER FAMILY 39 MEMBER 8 GENE INFLUENCES CADMIUM UPTAKE AND CELL TOXICITY. J Hypertens vol. 33 Suppl 1,
10.1097/01.hjh.0000467698.82617.d6
https://qmro.qmul.ac.uk/handle/123456789/7974
Yousaf N, Low WY, Onipinla A et al.(2015). Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF-R1) and regulation by cytokines. Clin Exp Immunol vol. 180, (2) 289-304.
10.1111/cei.12575
Padmanabhan S, Caulfield M, Dominiczak AF(2015). Genetic and molecular aspects of hypertension. Circ Res vol. 116, (6) 937-959.
10.1161/CIRCRESAHA.116.303647
https://qmro.qmul.ac.uk/handle/123456789/8742
Huan T, Esko T, Peters MJ et al.(2015). A meta-analysis of gene expression signatures of blood pressure and hypertension. PLoS Genet vol. 11, (3)
10.1371/journal.pgen.1005035
Cabrera CP, Ng FL, Warren HR et al.(2015). Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics. Wiley Interdiscip Rev Syst Biol Med vol. 7, (2) 73-90.
10.1002/wsbm.1290
Kapil V, Khambata RS, Robertson A et al.(2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study. Hypertension vol. 65, (2) 320-327.
10.1161/HYPERTENSIONAHA.114.04675
https://qmro.qmul.ac.uk/handle/123456789/6639
Locke AE, Kahali B, Berndt SI et al.(2015). Genetic studies of body mass index yield new insights for obesity biology. Nature vol. 518, (7538) 197-206.
10.1038/nature14177
https://qmro.qmul.ac.uk/handle/123456789/6989
Shungin D, Winkler TW, Croteau-Chonka DC et al.(2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature vol. 518, (7538) 187-196.
10.1038/nature14132
https://qmro.qmul.ac.uk/handle/123456789/7200
Kapil V, Khambata RS, Robertson A et al.(2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension vol. 65, (2) 320-327.
10.1161/HYPERTENSIONAHA.114.04675
Rautanen A, Mills TC, Gordon AC et al.(2015). Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med vol. 3, (1) 53-60.
10.1016/S2213-2600(14)70290-5
Lobo MD, de Belder MA, Cleveland T et al.(2015). Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension. Heart vol. 101, (1) 10-16.
10.1136/heartjnl-2014-307029
https://qmro.qmul.ac.uk/handle/123456789/6575
Huffman JE, Albrecht E, Teumer A et al.(2015). Modulation of genetic associations with serum urate levels by body-mass-index in humans. PLoS One vol. 10, (3)
10.1371/journal.pone.0119752
https://qmro.qmul.ac.uk/handle/123456789/7347
Warren H, Sever P, Poulter N et al. (2015). Pharmacogenetic Meta-Analysis of Response to Antihypertensive Drugs within ASCOT. HUMAN HEREDITY. vol. 79, 49-49.
https://qmro.qmul.ac.uk/handle/123456789/7585
Wood AR, Esko T, Yang J et al.(2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics vol. 46, (11) 1173-1186.
10.1038/ng.3097
Wood AR, Esko T, Yang J et al.(2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet vol. 46, (11) 1173-1186.
10.1038/ng.3097
https://qmro.qmul.ac.uk/handle/123456789/6379
Postmus I, Trompet S, Deshmukh HA et al.(2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nature Communications vol. 5, Article 5068,
10.1038/ncomms6068
https://qmro.qmul.ac.uk/handle/123456789/6802
Saxena M, Jain A, Mathur A et al. (2014). Early reduction in blood pressure and heart rate variability following multielectrode radio-frequency renal denervation in medicines intolerant patients. JOURNAL OF HUMAN HYPERTENSION. vol. 28, 647-647.
Burchell A, Chan K, Ratcliffe L et al. (2014). Highly variable response to renal denervation for resistant hypertension - real world experience from 2 UK centres. JOURNAL OF HUMAN HYPERTENSION. vol. 28, 645-646.
Postmus I, Trompet S, Warren HR et al. (2014). Pharmacogenetic GWAS meta-analysis of LDL cholesterol response to statins. JOURNAL OF HUMAN HYPERTENSION. vol. 28, 624-624.
Moyes AJ, Khambata RS, Villar I et al.(2014). Endothelial C-type natriuretic peptide maintains vascular homeostasis. J Clin Invest vol. 124, (9) 4039-4051.
10.1172/JCI74281
https://qmro.qmul.ac.uk/handle/123456789/6288
Postmus I, Trompet S, Deshmukh HA et al.(2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nature Communications vol. 5, Article 5068,
10.1038/ncomms6068
https://qmro.qmul.ac.uk/handle/123456789/6802
Arking DE, Pulit SL, Crotti L et al.(2014). Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet vol. 46, (8) 826-836.
10.1038/ng.3014
https://qmro.qmul.ac.uk/handle/123456789/13708
Ganesh SK, Chasman DI, Larson MG et al.(2014). Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. American Journal of Human Genetics vol. 95, (1) 49-65.
10.1016/j.ajhg.2014.06.002
Ganesh SK, Chasman DI, Larson MG et al.(2014). Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. Am J Hum Genet vol. 95, (1) 49-65.
10.1016/j.ajhg.2014.06.002
Hoggart CJ, Venturini G, Mangino M et al.(2014). Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. PLoS Genet vol. 10, (7)
10.1371/journal.pgen.1004508
Rapsomaniki E, Timmis A, George J et al.(2014). Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people. Lancet vol. 383, (9932) 1899-1911.
10.1016/S0140-6736(14)60685-1
Tragante V, Barnes MR, Ganesh SK et al.(2014). Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet vol. 94, (3) 349-360.
10.1016/j.ajhg.2013.12.016
https://qmro.qmul.ac.uk/handle/123456789/7839
Mahajan A, Go MJ, Zhang W et al.(2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. NATURE GENETICS vol. 46, (3) 234-+.
10.1038/ng.2897
Caulfield M(2014). Home Blood Pressure Monitoring: New Evidence for an Expanded Role. PLOS MEDICINE vol. 11, (1) Article ARTN e1001592,
10.1371/journal.pmed.1001592
https://qmro.qmul.ac.uk/handle/123456789/19178
Dobson RJB, Munroe PB, Caulfield MJ et al.(2014). Protein interaction networks associated with cardiovascular disease and cancer: exploring the effect of bias on shared network properties. INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS vol. 9, (4) 339-357.
10.1504/IJDMB.2014.062150
Thorgeirsson TE, Gudbjartsson DF, Sulem P et al.(2013). A common biological basis of obesity and nicotine addiction. Transl Psychiatry vol. 3,
10.1038/tp.2013.81
Yadav S, Cotlarciuc I, Munroe PB et al.(2013). Genome-wide analysis of blood pressure variability and ischemic stroke. Stroke vol. 44, (10) 2703-2709.
10.1161/STROKEAHA.113.002186
Robinson PJ, Ng FL, Lobo MD et al.(2013). Phaeochromocytoma-paraganglioma syndrome presenting as a para-renal mass: A case report. JOURNAL OF HUMAN HYPERTENSION vol. 27, (10) 654-655.
Huang C, Ng F, Kapil V et al.(2013). Prognostic significance of short term blood pressure variability in a tertiary referral centre population. JOURNAL OF HUMAN HYPERTENSION vol. 27, (10) 651-651.
Shah T, Engmann J, Dale C et al.(2013). Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. PLoS ONE vol. 8, (8)
10.1371/journal.pone.0071345
https://qmro.qmul.ac.uk/handle/123456789/6801
Hu YJ, Berndt SI, Gustafsson S et al.(2013). Meta-analysis of gene-level associations for rare variants based on single-variant statistics. American Journal of Human Genetics vol. 93, (2) 236-248.
10.1016/j.ajhg.2013.06.011
Ganesh SK, Tragante V, Guo W et al.(2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics vol. 22, (16) 3394-3395.
10.1093/hmg/ddt177
Mancia G, Fagard R, Narkiewicz K et al.(2013). 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J vol. 34, (28) 2159-2219.
10.1093/eurheartj/eht151
Randall JC, Winkler TW, Kutalik Z et al.(2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genetics vol. 9, (6)
10.1371/journal.pgen.1003500
https://qmro.qmul.ac.uk/handle/123456789/19179
Munroe PB, Barnes MR, Caulfield MJ(2013). Advances in blood pressure genomics. Circ Res vol. 112, (10) 1365-1379.
10.1161/CIRCRESAHA.112.300387
Pu X, Xiao Q, Kiechl S et al. (2013). ADAMTS7 CLEAVAGE AND VASCULAR SMOOTH MUSCLE CELL MIGRATION IS AFFECTED BY A CORONARY ARTERY DISEASE ASSOCIATED VARIANT. HEART. vol. 99, A5-U20.
10.1136/heartjnl-2013-304019.270
Ghosh SM, Kapil V, Fuentes-Calvo I et al.(2013). Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential. Hypertension vol. 61, (5) 1091-1102.
10.1161/HYPERTENSIONAHA.111.00933
Berndt SI, Gustafsson S, Maegi R et al.(2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. NATURE GENETICS vol. 45, (5) 501-U69.
10.1038/ng.2606
Ganesh SK, Tragante V, Guo W et al.(2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array. HUMAN MOLECULAR GENETICS vol. 22, (8) 1663-1678.
10.1093/hmg/dds555
Ehret GB, Caulfield MJ(2013). Genes for blood pressure: an opportunity to understand hypertension. EUROPEAN HEART JOURNAL vol. 34, (13) 951-961.
10.1093/eurheartj/ehs455
Pu X, Xiao Q, Kiechl S et al.(2013). ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. American Journal of Human Genetics vol. 92, (3) 366-374.
10.1016/j.ajhg.2013.01.012
Pu X, Xiao Q, Kiechl S et al.(2013). ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. Am J Hum Genet vol. 92, (3) 366-374.
10.1016/j.ajhg.2013.01.012
Vimaleswaran KS, Berry DJ, Lu C et al.(2013). Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts. PLoS Medicine vol. 10, (2)
10.1371/journal.pmed.1001383
Köttgen A, Albrecht E, Teumer A et al.(2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics vol. 45, (2) 145-154.
10.1038/ng.2500
Alvarez-Madrazo S, MacKenzie SM, Davies E et al.(2013). Common Polymorphisms in the CYP11B1 and CYP11B2 Genes: Evidence for a Digenic Influence on Hypertension. HYPERTENSION vol. 61, (1) 232-+.
10.1161/HYPERTENSIONAHA.112.200741
Guo Y, Lanktree MB, Taylor KC et al.(2013). Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Hum Mol Genet vol. 22, (1) 184-201.
10.1093/hmg/dds396
Huertas-Vazquez A, Nelson CP, Guo X et al.(2013). Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease. PLoS One vol. 8, (4)
10.1371/journal.pone.0059905
Postmus I, Trompet S, Warren H et al. (2013). Pharmacogenetic GWAS Meta-Analysis of LDL Cholesterol Response to Statins. HUMAN HEREDITY. vol. 76, 101-101.
Maller JB, McVean G, Byrnes J et al.(2012). Bayesian refinement of association signals for 14 loci in 3 common diseases. NATURE GENETICS vol. 44, (12) 1294-1301.
10.1038/ng.2435
Eyre S, Bowes J, Diogo D et al.(2012). High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet vol. 44, (12) 1336-1340.
10.1038/ng.2462
Cooper JD, Simmonds MJ, Walker NM et al.(2012). Seven newly identified loci for autoimmune thyroid disease. Hum Mol Genet vol. 21, (23) 5202-5208.
10.1093/hmg/dds357
Asselbergs FW, Guo Y, van Iperen EPA et al.(2012). Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. AMERICAN JOURNAL OF HUMAN GENETICS vol. 91, (5) 823-838.
10.1016/j.ajhg.2012.08.032
Jostins L, Ripke S, Weersma RK et al.(2012). Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature vol. 491, (7422) 119-124.
10.1038/nature11582
Doyle AJ, Doyle JJ, Bessling SL et al.(2012). Mutations in the TGF-beta repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm. NATURE GENETICS vol. 44, (11) 1249-1254.
10.1038/ng.2421
Choi H, Plenge RM, Koettgen A et al. (2012). Genetic Variants of Serum Uric Acid and Gout: An Analysis of > 170,000 Individuals. ARTHRITIS AND RHEUMATISM. vol. 64, S696-S697.
Surendran P, Vangjeli C, McCarthy N et al.(2012). Genome-wide association analysis identifies the MTHFR-CLCN6-NPPA-NPPB gene cluster as an important influence on BNP levels-implications for the use of BNP levels in the diagnosis and therapeutic monitoring of heart failure-an ASCOT sub study. JOURNAL OF HUMAN HYPERTENSION vol. 26, (10) 620-620.
Saxena M, Collier D, Caulfield M et al.(2012). Patients with resistant hypertension warrant a trial of salt restriction before and after renal denervation (RD). JOURNAL OF HUMAN HYPERTENSION vol. 26, (10) 619-619.
Chan K, Ng FL, Saxena M et al.(2012). Renal denervation in resistant hypertension-a prospective case series. JOURNAL OF HUMAN HYPERTENSION vol. 26, (10) 631-631.
Motterle A, Pu X, Wood H et al.(2012). Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells. Hum Mol Genet vol. 21, (18) 4021-4029.
10.1093/hmg/dds224
Scott RA, Lagou V, Welch RP et al.(2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics vol. 44, (9) 991-1005.
10.1038/ng.2385
Islam M, Jafar TH, Wood AR et al.(2012). Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis. DIABETOLOGIA vol. 55, (8) 2193-2204.
10.1007/s00125-012-2560-y
Lanktree MB, Guo Y, Murtaza M et al.(2012). Erratum: Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height ((The American Journal of Human Genetics (2010) 88 (6-18)). American Journal of Human Genetics vol. 90, (6) 1116-1117.
10.1016/j.ajhg.2012.05.017
Islam M, Jafar T, Wood A et al. (2012). Genetic risk scores are associated with diabetes related traits in South Asians and provide tools for Mendelian randomization studies. CIRCULATION. vol. 125, E680-E680.
Louis-Dit-Picard H, Barc J, Trujillano D et al.(2012). Erratum: KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron (Nature Genetics (2012) 44 (458-462)). Nature Genetics vol. 44, (5)
10.1038/ng0512-609
Deshmukh HA, Colhoun HM, Johnson T et al.(2012). Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). JOURNAL OF LIPID RESEARCH vol. 53, (5) 1000-1011.
10.1194/jlr.P021113
Saxena R, Elbers CC, Guo Y et al.(2012). Erratum: Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci (American Journal of Human Genetics (2012) 90 (410-425)). American Journal of Human Genetics vol. 90, (4)
10.1016/j.ajhg.2012.03.001
Louis-Dit-Picard H, Barc J, Trujillano D et al.(2012). KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. NATURE GENETICS vol. 44, (4) 456-+.
10.1038/ng.2218
Saxena R, Elbers CC, Guo Y et al.(2012). Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci. AMERICAN JOURNAL OF HUMAN GENETICS vol. 90, (3) 410-425.
10.1016/j.ajhg.2011.12.022
Caulfield M (2012). Genetics of Blood Pressure. JOURNAL OF PATHOLOGY. vol. 226, S2-S2.
Angelakopoulou A, Shah T, Sofat R et al.(2012). Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Eur Heart J vol. 33, (3) 393-407.
10.1093/eurheartj/ehr225
Salvi E, Kutalik Z, Glorioso N et al.(2012). Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension vol. 59, (2) 248-255.
10.1161/HYPERTENSIONAHA.111.181990
Motterle A, Xiao Q, Kiechl S et al.(2012). Influence of matrix metalloproteinase-12 on fibrinogen level. Atherosclerosis vol. 220, (2) 351-354.
10.1016/j.atherosclerosis.2011.11.003
McManus RJ, Caulfield M, Williams B(2012). NICE hypertension guideline 2011: evidence based evolution. BRITISH MEDICAL JOURNAL vol. 344, Article ARTN e181,
10.1136/bmj.e181
Scott RA, Lagou V, Welch RP et al.(2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics
10.1038/ng.2385
Dastani Z, Hivert M-F, Timpson N et al.(2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet vol. 8, (3)
10.1371/journal.pgen.1002607
Johnson T, Gaunt TR, Newhouse SJ et al.(2011). Blood pressure loci identified with a gene-centric array. Am J Hum Genet vol. 89, (6) 688-700.
10.1016/j.ajhg.2011.10.013
Bown MJ, Jones GT, Harrison SC et al.(2011). Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. American Journal of Human Genetics vol. 89, (5) 619-627.
10.1016/j.ajhg.2011.10.002
Heid IM, Jackson AU, Randall JC et al.(2011). Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (Nature Genetics (2010) 42 (949-960)). Nature Genetics vol. 43, (11)
10.1038/ng1111-1164a
Chambers JC, Zhang WH, Sehmi J et al.(2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. NAT GENET vol. 43, (11) 1131-U129.
10.1038/ng.970
Williams B, Krause T, Lovibond K et al.(2011). Authors' reply to Harding and colleagues, Taylor, Cruickshank, and El Turabi and Payne. BMJ (Online) vol. 343, (7827)
10.1136/bmj.d6506
Wain LV, Verwoert GC, O'Reilly PF et al.(2011). A large genome-wide association study of pulse pressure and mean arterial pressure reveals seven novel blood pressure LOCI. J HUM HYPERTENS vol. 25, (10) 647-647.
Lovibond K, Jowett S, Barton P et al.(2011). Cost-effectiveness of options for the diagnosis of high blood pressure in primary care: a modelling study. LANCET vol. 378, (9798) 1219-1230.
10.1016/S0140-6736(11)61184-7
Michell AR, Bodey AR, Caulfield M(2011). Evolution, essential hypertension and the high arterial pressures in certain athletic breeds of dogs (vol 188, pg 125, 2011). VET J vol. 190, (1) 184-184.
10.1016/j.tvjl.2011.08.015
Wain LV, Verwoert GC, O'Reilly PF et al.(2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. NAT GENET vol. 43, (10) 1005-U122.
10.1038/ng.922
https://qmro.qmul.ac.uk/handle/123456789/19185
Kooner JS, Saleheen D, Sim X et al.(2011). Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. NAT GENET vol. 43, (10) 984-U94.
10.1038/ng.921
McCarthy N, Vangjeli C, Surendran P et al.(2011). PPARGC1 beta is a genetic determinant of the cardiovascular risk factor, Thromboxane A2-an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) sub-study. J HUM HYPERTENS vol. 25, (10) 625-625.
Patel S, Ng FL, Uddin I et al.(2011). Plasma renin activity in the South Asian population-an intermediate group. J HUM HYPERTENS vol. 25, (10) 631-631.
Patel S, Ng FL, Uddin I et al.(2011). Salt intake in hypertensive patients with at or above-target blood pressures. J HUM HYPERTENS vol. 25, (10) 632-632.
Ehret G, Munroe PB, Rice K et al.(2011). Sixteen novel loci influence blood pressure and cardiovascular risk. J HUM HYPERTENS vol. 25, (10) 635-636.
International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB et al.(2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature vol. 478, (7367) 103-109.
10.1038/nature10405
https://qmro.qmul.ac.uk/handle/123456789/13815
Krause T, Lovibond K, Caulfield M et al.(2011). GUIDELINES Management of hypertension: summary of NICE guidance. BRIT MED J vol. 343, Article d4891,
10.1136/bmj.d4891
Putku M, Kepp K, Org E et al.(2011). Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans. Hum Mutat vol. 32, (7) 806-814.
10.1002/humu.21508
Fox ER, Young JH, Li YL et al.(2011). Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. HUM MOL GENET vol. 20, (11) 2273-2284.
10.1093/hmg/ddr092
Fox ER, Young JH, Li Y et al.(2011). Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet vol. 20, (11) 2273-2284.
10.1093/hmg/ddr092
Johnson AD, Newton-Cheh C, Chasman DI et al.(2011). Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Hypertension vol. 57, (5) 903-910.
10.1161/HYPERTENSIONAHA.110.158667
Michell AR, Bodey AR, Caulfield M(2011). Evolution, essential hypertension and the high arterial pressures in certain athletic breeds of dogs. VET J vol. 188, (2) 125-127.
10.1016/j.tvjl.2011.03.011
Peden JF, Hopewell JC, Saleheen D et al.(2011). A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. NAT GENET vol. 43, (4) 339-U89.
10.1038/ng.782
Speliotes EK, Yerges-Armstrong LM, Wu J et al.(2011). Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet vol. 7, (3)
10.1371/journal.pgen.1001324
Collier DJ, Poulter NR, Dahlöf B et al.(2011). Impact of amlodipine-based therapy among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA). J Hypertens vol. 29, (3) 583-591.
10.1097/HJH.0b013e328342c845
Collier DJ, Poulter NR, Dahlöf B et al.(2011). Impact of atorvastatin among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid-Lowering Arm. J Hypertens vol. 29, (3) 592-599.
10.1097/HJH.0b013e328342c8f7
Lanktree MB, Guo YR, Murtaza M et al.(2011). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. AM J HUM GENET vol. 88, (1) 6-18.
10.1016/j.ajhg.2010.11.007
Chapman N, Chang CL, Caulfield M et al.(2011). ETHNIC VARIATIONS IN LIPID-LOWERING IN RESPONSE TO A STATIN (EVIREST): A SUBSTUDY OF THE ANGLO-SCANDINAVIAN CARDIAC OUTCOMES TRIAL (ASCOT). ETHNIC DIS vol. 21, (2) 150-157.
Esler MD, Krum H, Sobotka PA et al.(2010). Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. LANCET vol. 376, (9756) 1903-1909.
10.1016/S0140-6736(10)62039-9
Sotoodehnia N, Isaacs A, de Bakker PIW et al.(2010). Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. NAT GENET vol. 42, (12) 1068-U62.
10.1038/ng.716
https://qmro.qmul.ac.uk/handle/123456789/19344
Speliotes EK, Willer CJ, Berndt SI et al.(2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet vol. 42, (11) 937-948.
10.1038/ng.686
Tabara Y, Kohara K, Kita Y et al.(2010). Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project. Hypertension vol. 56, (5) 973-980.
10.1161/HYPERTENSIONAHA.110.153429
Heid IM, Jackson AU, Randall JC et al.(2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet vol. 42, (11) 949-960.
10.1038/ng.685
Padmanabhan S, Melander O, Johnson T et al.(2010). Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet vol. 6, (10)
10.1371/journal.pgen.1001177
https://qmro.qmul.ac.uk/handle/123456789/19180
Allen HL, Estrada K, Lettre G et al.(2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. NATURE vol. 467, (7317) 832-838.
10.1038/nature09410
Johnson T, Shaw-Hawkins S, Howard P et al.(2010). A novel gene locus for blood pressure variability identified by genomewide association scanning in the Anglo-Scandinavian Cardiac Outcome Trial. J HUM HYPERTENS vol. 24, (10) 694-694.
Hastie CE, Padmanabhan S, Melander O et al.(2010). Genome wide association study of blood pressure extremes identifies variant in uromodulin gene associated with hypertension. J HUM HYPERTENS vol. 24, (10) 687-687.
Collier DJ, Robson J, Scott R et al.(2010). HiLo: a health services intervention study: methods and interim results on the first 2000 patients at 1 year. J HUM HYPERTENS vol. 24, (10) 708-709.
Gupta AK, Poulter NR, Dobson J et al.(2010). Ethnic Differences in Blood Pressure Response to First and Second-Line Antihypertensive Therapies in Patients Randomized in the ASCOT Trial. AM J HYPERTENS vol. 23, (9) 1023-1030.
10.1038/ajh.2010.105
Teslovich TM, Musunuru K, Smith AV et al.(2010). Biological, clinical and population relevance of 95 loci for blood lipids. NATURE vol. 466, (7307) 707-713.
10.1038/nature09270
Dolan E, Caulfield M, Thom S et al. (2010). AMBULATORY ARTERIAL STIFFNESS INDEX PREDICTS CARDIOVASCULAR MORBIDITY AND MORTALITY IN TREATED HYPERTENSIVE PATIENTS - AN ANGLO - SCANDINAVIAN CARDIAC OUTCOME TRIAL SUB-STUDY. JOURNAL OF HYPERTENSION. vol. 28, E13-E14.
Padmanabhan S, Melander O, Johnson T et al. (2010). GENOME WIDE ASSOCIATION STUDY OF BLOOD PRESSURE EXTREMES IDENTIFIES VARIANT IN UMOD ASSOCIATED WITH HYPERTENSION. JOURNAL OF HYPERTENSION. vol. 28, E237-E237.
Alvarez-Madrazo S, Padmanabhan S, Friel E et al. (2010). Validation of Association of Hypertension at the CYP11B1/B2 Locus in Caucasians. ENDOCRINE REVIEWS. vol. 31,
Mancia G, Laurent S, Agabiti-Rosei E et al.(2010). European guidelines on the management of hypertension: The European Society of Hypertension position statement (2009). Nadcisnienie Tetnicze vol. 14, (1) 1-47.
Chambers JC, Zhang WH, Lord GM et al.(2010). Genetic loci influencing kidney function and chronic kidney disease. NAT GENET vol. 42, (5) 373-375.
10.1038/ng.566
Liu JZ, Tozzi F, Waterworth DM et al.(2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. NAT GENET vol. 42, (5) 436-U75.
10.1038/ng.572
Lindgren CM, Heid IM, Randall JC et al.(2010). Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. PLOS GENET vol. 6, (4) Article e1000508,
10.1371/journal.pgen.1000508
Craddock N, Hurles ME, Cardin N et al.(2010). Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. NATURE vol. 464, (7289) 713-U86.
10.1038/nature08979
https://qmro.qmul.ac.uk/handle/123456789/14895
van der Harst P, Bakker SJL, de Boer RA et al.(2010). Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. HUM MOL GENET vol. 19, (2) 387-395.
10.1093/hmg/ddp489
Munroe PB, Johnson T, Caulfield MJ(2009). The genetic architecture of blood pressure variation. Current Cardiovascular Risk Reports vol. 3, (6) 418-425.
10.1007/s12170-009-0062-3
Talmud PJ, Drenos F, Shah S et al.(2009). Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip. AM J HUM GENET vol. 85, (5) 628-642.
10.1016/j.ajhg.2009.10.014
Mancia G, Laurent S, Agabiti-Rosei E et al.(2009). Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J HYPERTENS vol. 27, (11) 2121-2158.
10.1097/HJH.0b013e328333146d
Vidyarthi M, Balakumar Y, Perry I et al.(2009). Hypokalaemic hypertension due to a rare cause. J HUM HYPERTENS vol. 23, (10) 698-698.
Dobson RJB, Munroe PB, Caulfield MJ et al.(2009). Global sequence properties for superfamily prediction: a machine learning approach. J Integr Bioinform vol. 6, (1)
10.2390/biecoll-jib-2009-109
Caulfield M(2009). Atheromatous vascular disease and ischaemic stroke in the UK. J DENT vol. 37, (8) S579-S581.
10.1016/j.jdent.2009.05.018
Caulfield M(2009). PREDICTION OF ANTIHYPERTENSIVE RESPONSE - GENOTYPE. BASIC CLIN PHARMACOL vol. 105, 11-11.
Nolte IM, Wallace C, Newhouse SJ et al.(2009). Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS One vol. 4, (7)
10.1371/journal.pone.0006138
Sõber S, Org E, Kepp K et al.(2009). Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. PLoS One vol. 4, (6)
10.1371/journal.pone.0006034
https://qmro.qmul.ac.uk/handle/123456789/12218
Org E, Eyheramendy S, Juhanson P et al.(2009). Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. HUM MOL GENET vol. 18, (12) 2288-2296.
10.1093/hmg/ddp135
Caulfield MJ, Bochud M, Global BP Gen (2009). EIGHT BLOOD PRESSURE LOCI IDENTIFIED BY A GENOME-WIDE ASSOCIATION STUDY OF 34,433 PEOPLE OF EUROPEAN ANCESTRY. JOURNAL OF HYPERTENSION. vol. 27, S167-S167.
Lindgren CM, Heid IM, Randall JC et al.(2009). Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. PLOS GENET vol. 5, (6) Article e1000508,
10.1371/journal.pgen.1000508
https://qmro.qmul.ac.uk/handle/123456789/19181
Newton-Cheh C, Johnson T, Gateva V et al.(2009). Genome-wide association study identifies eight loci associated with blood pressure. NAT GENET vol. 41, (6) 666-676.
10.1038/ng.361
Kolz M, Johnson T, Sanna S et al.(2009). Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. PLOS GENET vol. 5, (6) Article e1000504,
10.1371/journal.pgen.1000504
https://qmro.qmul.ac.uk/handle/123456789/19172
Newhouse S, Farrall M, Wallace C et al.(2009). Polymorphisms in the WNK1 Gene Are Associated with Blood Pressure Variation and Urinary Potassium Excretion. PLOS ONE vol. 4, (4) Article e5003,
10.1371/journal.pone.0005003
https://qmro.qmul.ac.uk/handle/123456789/12217
Dolan E, Stanton AV, Thom S et al.(2009). Ambulatory blood pressure monitoring predicts cardiovascular events in treated hypertensive patients - an Anglo-Scandinavian cardiac outcomes trial substudy. J HYPERTENS vol. 27, (4) 876-885.
10.1097/HJH.0b013e328322cd62
Collier DJ, Stride TJ, He S et al. (2009). Impact of Lifestyle Changes During Five Years of Drug Treatment in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. vol. 53, A215-A215.
Mancia G, Laurent S, Agabiti-Rosei E et al.(2009). Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. BLOOD PRESSURE vol. 18, (6) 308-347.
10.3109/08037050903450468
Willer CJ, Speliotes EK, Loos RJF et al.(2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. NAT GENET vol. 41, (1) 25-34.
10.1038/ng.287
Ostergren J, Poulter NR, Sever PS et al.(2008). The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes. J HYPERTENS vol. 26, (11) 2103-2111.
10.1097/HJH.0b013e328310e0d9
Samani NJ, Braund PS, Erdmann J et al.(2008). The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. J MOL MED-JMM vol. 86, (11) 1233-1241.
10.1007/s00109-008-0387-2
Keating BJ, Tischfield S, Murray SS et al.(2008). Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies. PLOS ONE vol. 3, (10) Article e3583,
10.1371/journal.pone.0003583
https://qmro.qmul.ac.uk/handle/123456789/19174
Gupta AK, Poulter NR, Eldridge S et al.(2008). Ethnic differences in blood pressure response to atenolol and amlodipine monotherapy and to add on diuretic and ACE inhibitor dual therapy in hypertensive patients from UK in ASCOT-BPLA. J HUM HYPERTENS vol. 22, (10) 726-727.
Huq SM, Oldapo MNJ, Wang Y et al. (2008). High glucose and low lactate: a metabolic signature of hypertension in human serum?. HYPERTENSION. vol. 52, 758-759.
Caulfield MJ, Munroe PB, O'Neill D et al.(2008). SLC2A9 Is a High-Capacity Urate Transporter in Humans. PLOS MED vol. 5, (10) Article E197, 1509-1523.
10.1371/journal.pmed.0050197
https://qmro.qmul.ac.uk/handle/123456789/12221
Brown MJ, Newhouse S, Wallace C et al. (2008). Systematic analysis of 123 candidate genes reveals two novel genes for hypertension. HYPERTENSION. vol. 52, 764-765.
Hoti M, Newhouse S, Clayton D et al. (2008). WNK1 - functional analyses of variants associated with blood pressure and essential hypertension. J HUM HYPERTENS. vol. 22, 722-722.
Hoti M, Newhouse S, Clayton D et al. (2008). WNK1-functional analyses of variants associated with blood pressure and essential hypertension. HYPERTENSION. vol. 52, 764-764.
Delles C, Padmanabhan S, Lee WK et al.(2008). Glutathione S-transferase variants and hypertension. J HYPERTENS vol. 26, (7) 1343-1352.
10.1097/HJH.0b013e3282fe1d67
Tobin MD, Tomaszewski M, Braund PS et al.(2008). Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population. HYPERTENSION vol. 51, (6) 1658-1664.
10.1161/HYPERTENSIONAHA.108.112664
Tomaszewski M, Tobin MD, Braund PS et al. (2008). Common variants in the gene underlying type 2 Bartter syndrome are associated with blood pressure in the general population - The results of the genetic scan in the GRAPHIC (genetic regulation of arterial pressure of humans in the community) study. JOURNAL OF HYPERTENSION. vol. 26, S12-S12.
Loos RJF, Lindgren CM, Li SX et al.(2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. NAT GENET vol. 40, (6) 768-775.
10.1038/ng.140
Doblado M, Munroe PB, O'Neill D et al. (2008). Functional studies identify a glucose transporter SLC2A9 as a novel urate transporter. DIABETES. vol. 57, A356-A356.
Weedon MN, Lango H, Lindgren CM et al.(2008). Genome-wide association analysis identifies 20 loci that influence adult height. NAT GENET vol. 40, (5) 575-583.
10.1038/ng.121
Sever PS, Poulter NR, Dahlof B et al.(2008). The Anglo-Scandinavian Cardiac Outcomes Trial lipid lowering arm: extended observations 2 years after trial closure. EUR HEART J vol. 29, (4) 499-508.
10.1093/eurheartj/ehm583
Johnston L, Ester W, Koelega AH et al.(2008). Analysis of GDF5-UQCC polymorphism with height in NESTEGG SGA and ISS subjects. HORM RES vol. 70, 90-90.
Dobson RJB, Munroe PB, Mein CA et al. (2008). Combining protein-protein interaction (PPI) network and sequence attributes for predicting hypertension related proteins. BIOINFORMATICS RESEARCH AND DEVELOPMENT, PROCEEDINGS. Editors: Elloumi, M, Kung, J, Linial, M, Murphy, RF et al., vol. 13, 377-391.
Wallace C, Newhouse SJ, Braund P et al.(2008). Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipiclemia. AM J HUM GENET vol. 82, (1) 139-149.
10.1016/j.ajhg.2007.11.001
Nejentsev S, Howson JMM, Walker NM et al.(2007). Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature vol. 450, (7171) 887-892.
10.1038/nature06406
Burke B, Gungadoo J, Marçano ACB et al.(2007). Monogenic Forms of Human Hypertension. Comprehensive Hypertension,
Freel EM, Ingram M, Friel EC et al.(2007). Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. CLIN ENDOCRINOL vol. 67, (6) 832-838.
10.1111/j.1365-2265.2007.02971.x
Thomson W, Barton A, Ke X et al.(2007). Rheumatoid arthritis association at 6q23. Nat Genet vol. 39, (12) 1431-1433.
10.1038/ng.2007.32
Wallace C, Newhouse SJ, Braund P et al. (2007). Discovery of novel genes for serum urate and low-density lipoprotein cholesterol - Two biomarkers of cardiovascular disease. CIRCULATION RESEARCH. vol. 101, 1208-1208.
Newhouse SJ, Wallace C, Hoti M et al. (2007). Novel associations of the Wnk1 gene with risk for essential hypertension and electrolyte homeostasis. CIRCULATION RESEARCH. vol. 101, 1208-1208.
Barter PJ, Caulfield M, Eriksson M et al.(2007). Effects of torcetrapib in patients at high risk for coronary events. NEW ENGL J MED vol. 357, (21) 2109-2122.
10.1056/NEJMoa0706628
Newport M, Sirugo G, Lyons E et al.(2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. NAT GENET vol. 39, (11) 1329-1337.
10.1038/ng.2007.17
HITMAN GA, Todd JA, Samani NJ et al.(2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet vol. 39, 129-1337.
10.1038/ng.2007.17
Wallace C, Dobson RJ, Munroe PB et al.(2007). Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates. Genome Res vol. 17, (11) 1596-1602.
10.1101/gr.5996407
Padmanabhan S, Davies E, MacKenzie SM et al.(2007). Association of the CYP11B1 and CYP11B2 gene polymorphisms with hypertension in the British Genetics of Hypertension case-control study. J HUM HYPERTENS vol. 21, (10) 837-837.
Newhouse S, Wallace C, Hoti M et al. (2007). Association of the WNK1 gene with essential hypertension, blood pressure variability and serum and urine electrolytes. J HUM HYPERTENS. vol. 21, 831-831.
Collier DJ, Davies LC, Bernardi L et al.(2007). Baroreceptor function changes with differing blood pressure treatment during the anglo-scandinavian cardiac outcomes trial: principal results from the cardiac autonomic reflex assessment trial (CARAT). J HUM HYPERTENS vol. 21, (10) 846-847.
Padmanabhan S, Menni C, Delles C et al. (2007). Urinary albumin excretion in hypertensive siblings in the British Genetics of Hypertension study. J HUM HYPERTENS. vol. 21, 843-843.
Marcano ACB, Burke B, Gungadoo J et al.(2007). Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension. J MED GENET vol. 44, (9) Article 603,
10.1136/jmg.2007.049718
Burton PR, Clayton DG, Cardon LR et al.(2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. NATURE vol. 447, (7145) 661-678.
10.1038/nature05911
Collier D, Davies L, Bernardi L et al. (2007). Baroreceptor function changes with differing blood pressure treatment during the Anglo-Scandinavian Cardiac Outcomes Trial: Principal results from the Cardiac Autonomic Reflex Assessment Trial (CARAT). JOURNAL OF HYPERTENSION. vol. 25, S292-S292.
Collier D, Arunachalam G, Johnston A et al. (2007). Continuing reduction of microalbuminuria and proteinuria during follow-up for the Anglo-Scandinavian Cardiac Outcomes Trial dominance of duration and blood pressure over other effects. JOURNAL OF HYPERTENSION. vol. 25, S150-S150.
Zeggini E, Weedon MN, Lindgren CM et al.(2007). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science vol. 316, (5829) 1336-1341.
10.1126/science.1142364
Brown M, Boon N, Brooks N et al.(2007). Medical training in the UK: sleepwalking to disaster. Lancet vol. 369, (9574) 1673-1675.
10.1016/S0140-6736(07)60754-5
Genetics of Pre-eclampsia (GOPEC) consortium(2007). Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study. J Hypertens vol. 25, (4) 849-854.
10.1097/HJH.0b013e32803fb634
Brown M, Boon N, Brooks N et al.(2007). Modernising Medical Careers, Medical Training Application Service, and the Postgraduate Medical Education and Training Board: time for the emperors to don their clothes. LANCET vol. 369, (9566) 967-968.
10.1016/S0140-6736(07)60459-0
Sever P, Dahlöf B, Poulter N et al.(2007). Erratum: Potential synergy between lipid-lowering and blood-pressure- lowering in the Anglo-Scandinavian Cardiac Outcomes Trial (European Heart Journal (2006) 27 (2982-2988)). European Heart Journal vol. 28, (1)
10.1093/eurheartj/ehl453
Barr M, MacKenzie SM, Friel EC et al.(2007). Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. HYPERTENSION vol. 49, (1) 113-119.
10.1161/01.HYP.0000249904.93940.7a
Sever P, Dahlöf B, Poulter N et al.(2006). Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial. Eur Heart J vol. 27, (24) 2982-2988.
10.1093/eurheartj/ehl403
Collier DJ, Caulfield MJ, Poulter NR et al. (2006). Did older or younger patients benefit more from amlodipine based vs atenolol based therapy in ASCOT-BPLA?. CIRCULATION. vol. 114, 896-896.
Delles C, Braga-Marcano AC, Munroe PB et al. (2006). Association between variants of the human GSTM gene family and hypertension. HYPERTENSION. vol. 48, E27-E27.
Padmanabhan S, Hastie CE, Wallace C et al. (2006). Familial atherosclerotic disease and hypertension localised to chromosome 7p in the British genetics of hypertension study. HYPERTENSION. vol. 48, E98-E98.
Ostergren J, Sever P, Poulter N et al. (2006). The Anglo-Scandinavian Cardiac Outcomes Trial: Blood pressure-lowering limb (ASCOT-BPLA): effects in patients with type 2 diabetes. DIABETOLOGIA. vol. 49, 136-137.
Wallace C, Xue M-Z, Newhouse SJ et al.(2006). Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension. Am J Hum Genet vol. 79, (2) 323-331.
10.1086/506370
Munroe PB, Wallace C, Xue M-Z et al.(2006). Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study. Hypertension vol. 48, (1) 105-111.
10.1161/01.HYP.0000228324.74255.f1
Padmanabhan S, Wallace C, McBride MW et al. (2006). Genomewide linkage analysis for loci affecting electrocardiographic LV mass. JOURNAL OF HYPERTENSION. vol. 24, S330-S330.
Delles C, Marcano ACB, Munroe PB et al. (2006). Variants of the human mu type glutathione-s-transferase (GSTM) gene family are associated with hypertension. JOURNAL OF HYPERTENSION. vol. 24, S13-S13.
Dobson RJ, Munroe PB, Caulfield MJ et al.(2006). Predicting deleterious nsSNPs: an analysis of sequence and structural attributes. BMC Bioinformatics vol. 7,
10.1186/1471-2105-7-217
https://qmro.qmul.ac.uk/handle/123456789/19176
Bell JT, Wallace C, Dobson R et al.(2006). Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension. HUM MOL GENET vol. 15, (8) 1365-1374.
10.1093/hmg/ddl058
Padmanabhan S, Wallace C, Munroe PB et al. (2006). Chromosome 2p shows significant linkage to antihypertensive response in the British Genetics of Hypertension Study. Hypertension. vol. 47, 603-608.
10.1161/01.HYP.0000197947.62601.9d
Padmanabhan S, Wallace C, Munroe PB et al. (2006). Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study. HYPERTENSION. vol. 47, 603-608.
10.1161/01.HYP.0000197947.62601.9d
Binder A, Garcia E, Wallace C et al.(2006). Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study. J HYPERTENS vol. 24, (3) 471-477.
10.1097/01.hjh.0000209983.28735.33
Tobin MD, Raleigh SM, Newhouse S et al.(2005). Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. CIRCULATION vol. 112, (22) 3423-3429.
10.1161/CIRCULATIONHA.105.555474
Padmanabhan S, Wallace C, Munroe PB et al. (2005). Chromosome 2p shows genome wide significant linkage to of anti-hypertensive medication response in the British genetics of hypertension (BRIGHT) study. HYPERTENSION. vol. 46, 886-886.
Wallace C, Xue MZ, Dobson R et al. (2005). Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish genetics of Hypertension (BRIGHT) study. HYPERTENSION. vol. 46, 877-877.
Padmanabhan S, Munroe PB, Brown M et al. (2005). Chromosome 2p shows genome wide significant linkage to anti-hypertensive medication response in the British genetics hypertension (BRIGHT) study. HYPERTENSION. vol. 46, 886-886.
Munroe PB, Wallace C, Mein C et al. (2005). Enhanced support for linkage to chromosome 5q13.1 and hypertension in the British Genetics of Hypertension (BRIGHT) study. HYPERTENSION. vol. 46, 892-892.
Wallace C, Xue MZ, Dobson R et al. (2005). Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish Genetics of HyperTension (BRIGHT) study. HYPERTENSION. vol. 46, 877-877.
Xue MZ, Wallace C, Dobson R et al. (2005). Variants and haplotypes of the angiotensinogen gene are associated with hypertension in the Caerphilly Prospective Study. HYPERTENSION. vol. 46, 904-904.
Dahlof B, Sever PS, Poulter NR et al.(2005). Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. LANCET vol. 366, (9489) 895-906.
10.1016/S0140-6736(05)67185-1
Poulter NR, Wedel H, Dahlof B et al.(2005). Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA). LANCET vol. 366, (9489) 907-913.
10.1016/S0140-6736(05)67186-3
GOPEC Consortium(2005). Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study. Am J Hum Genet vol. 77, (1) 127-131.
10.1086/431245
Newhouse SJ, Wallace C, Dobson R et al.(2005). Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Hum Mol Genet vol. 14, (13) 1805-1814.
10.1093/hmg/ddi187
Marcano ACB, Onipinla AK, Caulfield MJ et al.(2005). Recent advances in the identification of genes for human hypertension. Expert Rev Cardiovasc Ther vol. 3, (4) 733-741.
10.1586/14779072.3.4.733
Sever PS, Poulter NR, Dahlof B et al.(2005). Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA). DIABETES CARE vol. 28, (5) 1151-1157.
10.2337/diacare.28.5.1151
Newhouse SJ, Huq SM, Arunachalam G et al.(2005). Genetics of hypertension. Hypertension: Principles and Practice,
Mein CA, Caulfield MJ, Munroe PB(2005). Selection of candidate genes in hypertension. vol. 108,
Munroe PB, Dobson R, Pembroke J et al. (2004). The MRC BRIGHT study: Demographic and biochemical characteristics of the sibling-pair resource. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. vol. 58, 688-688.
Lee YW, Oh VMS, Garcia E et al.(2004). Haplotypes of the beta 2-adrenegic receptor gene are associated with essential hypertension in a Singaporean Chinese population. J HYPERTENS vol. 22, (11) 2111-2116.
10.1097/00004872-200411000-00012
Newhouse S, Dobson R, Wallace C et al. (2004). No association of the WNK1 gene with essential hypertension in the MRC BRIGHT study. JOURNAL OF HYPERTENSION. vol. 22, S212-S212.
10.1097/00004872-200406002-00740
Mein CA, Caulfield MJ, Dobson RJ et al.(2004). Genetics of essential hypertension. Human Molecular Genetics vol. 13, (REV. ISS. 1)
Mein CA, Caulfield MJ, Dobson RJ et al.(2004). Genetics of essential hypertension. Hum Mol Genet vol. 13 Spec No 1, R169-R175.
10.1093/hmg/ddh078
Sever PS, Dahlof B, Poulter NR et al. (2004). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial - Lipid lowering arm (ASCOT-LLA): A multicentre randomised controlled trial. DRUGS. vol. 64, 43-60.
10.2165/00003495-200464002-00005
Newhouse SJ, Garcia E, Caulfield M et al. (2003). Haplotype structure of the WNK1 gene and association studies in hypertensive populations. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. vol. 56, 245-245.
Kübler W, Ssever P, Dahlöf B et al.(2003). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesteroal concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial - Lipid Lowering Arm (ASCOL-LLA): A multicentre randomised controlled trial. Zeitschrift fur Kardiologie vol. 92, (7)
10.1007/s00392-003-0967-7
Wilson S, Johnston A, Robson J et al.(2003). Comparison of methods to identify individuals at increased risk of coronary disease from the general population. BMJ vol. 326, (7404)
10.1136/bmj.326.7404.1436
Caulfield M, Munroe P, Pembroke J et al.(2003). Genome-wide mapping of human loci for essential hypertension. Lancet vol. 361, (9375) 2118-2123.
10.1016/S0140-6736(03)13722-1
Sever PS, Dahlof B, Poulter NR et al.(2003). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. LANCET vol. 361, (9364) 1149-1158.
10.1016/S0140-6736(03)12948-0
Wilson S, Johnston A, Collier DJ et al. (2003). Feasibility of enrolling patients to hypertension outcome trials based on an assessment of their cardiovascular risk. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. vol. 55, 425-426.
Wilson S, Johnston A, Robson J et al.(2003). Predicting coronary risk in the general population--is it necessary to measure high-density lipoprotein cholesterol?. J Cardiovasc Risk vol. 10, (2) 137-141.
10.1097/01.hjr.0000060844.48106.ff
Knight J, Munroe PB, Pembroke JC et al.(2003). Human chromosome 17 in essential hypertension. Ann Hum Genet vol. 67, (Pt 2) 193-206.
10.1046/j.1469-1809.2003.t01-1-00002.x
Garcia EA, Newhouse S, Caulfield MJ et al.(2003). Genes and hypertension. Curr Pharm Des vol. 9, (21) 1679-1689.
10.2174/1381612033454513
Garcia EA, Aristizabal D, McEwen J et al. (2002). Guanine nucleotide binding 3 (GNB3) haplotype analysis in the Venecia-Colombia Latin-American blood pressure study. AMERICAN JOURNAL OF HUMAN GENETICS. vol. 71, 366-366.
Wilson S, Johnston A, Robson J et al. (2002). Should we measure high density lipoprotein cholesterol in people with hypertension?. JOURNAL OF HYPERTENSION. vol. 20, S150-S150.
Caulfield M, Pembroke J, Dominiczak A et al. (2002). The MRC British Genetics of Hypertension Study - Genome-wide screen results. JOURNAL OF HYPERTENSION. vol. 20, S7-S7.
Chapman JN, Kirby P, Caulfield MC et al.(2001). Cardiovascular risk factors in a cohort of 30 000 high-risk men and women in the UK: Cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Journal of Human Hypertension vol. 15, (SUPPL. 1)
10.1038/sj.jhh.1001078
Metherell LA, Akker SA, Munroe PB et al.(2001). Pseudoexon activation as a novel mechanism for disease resulting in atypical growth-hormone insensitivity. Am J Hum Genet vol. 69, (3) 641-646.
10.1086/323266
O'Brien E, McInnes GT, Stanton A et al.(2001). Ambulatory blood pressure monitoring and 24-h blood pressure control as predictors of outcome in treated hypertensive patients. J HUM HYPERTENS vol. 15, S47-S51.
10.1038/sj.jhh.1001076
Sever PS, Dahlof B, Poulter NR et al.(2001). Anglo-Scandinavian Cardiac Outcomes Trial: a brief history, rationale and outline protocol. J HUM HYPERTENS vol. 15, S11-S12.
10.1038/sj.jhh.1001212
Collier DJ, Bernardi L, Angell-James JE et al.(2001). Baroreflex sensitivity and heart rate variability as predictors of cardiovascular outcome in hypertensive patients with multiple risk factors for coronary disease. J Hum Hypertens vol. 15 Suppl 1, S57-S60.
10.1038/sj.jhh.1001077
Chapman JN, Kirby P, Caulfield MC et al.(2001). Cardiovascular risk factors in a cohort of 30,000 high-risk men and women in the UK: cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). J HUM HYPERTENS vol. 15, S23-S26.
10.1038/sj.jhh.1001078
Kirby PL, Caulfield MC, Collier DJ et al.(2001). Differential response to amlodipine and atenolol mono-therapy for hypertension by ethnic group. J Hum Hypertens vol. 15 Suppl 1, S61-S64.
10.1038/sj.jhh.1001080
Poulter NR, Caulfield M, Feder G(2001). Ethnic variations in response to a statin (EVIREST). J HUM HYPERTENS vol. 15, S87-S89.
10.1038/sj.jhh.1001213
Wilson S, Collier D, Johnston A et al.(2001). Evaluation of cardiovascular risk equations using the ASCOT cohort. J Hum Hypertens vol. 15 Suppl 1, S31-S33.
10.1038/sj.jhh.1001084
White PC, Agarwal AK, Li AR et al.(2001). Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase to hypertension in Black people. CLIN ENDOCRINOL vol. 55, (2) 249-252.
10.1046/j.1365-2265.2001.01314.x
Sever PS, Dahlof B, Poulter NR et al.(2001). Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian cardiac outcomes trial. J HYPERTENS vol. 19, (6) 1139-1147.
10.1097/00004872-200106000-00020
Sever PS, Dahlöf B, Poulter NR et al.(2001). Anglo-Scandinavian cardiac outcomes trial: A brief history, rationale and outline protocol. Journal of Human Hypertension vol. 15, (SUPPL. 1)
10.1038/sj.jhh.1001212
Caulfield MJ(2001). Genes for common diseases. BRIT J CLIN PHARMACO vol. 51, (1) 1-3.
10.1046/j.1365-2125.2001.01343.x
Munroe PB, Caulfield MJ(2000). Genetics of hypertension. Curr Opin Genet Dev vol. 10, (3) 325-329.
10.1016/S0959-437X(00)00081-2
Knight J, Gardner GT, Clark AJ et al. (2000). Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans. J Hum Hypertens. vol. 14, 385-387.
10.1038/sj.jhh.1001025
Munroe PB, Knight J, Caulfield MJ(2000). 1990-2000: progress in determining high blood pressure genes. Ann Acad Med Singapore vol. 29, (3) 357-363.
Caulfield M, Papp J, Pembroke J et al. (2000). A new tool for checks of data precision within the MRC British genetics of hypertension study. J HYPERTENS. vol. 18, S180-S180.
Munroe P, Sandhu M, Jadhav D et al.(2000). No association of the epithelial sodium channel beta-subunit T594M variant with essential hypertension in an African Caribbean population. J HYPERTENS vol. 18, S178-S178.
Munroe PB, Strautnieks SS, Farrall M et al.(1998). Absence of linkage of the epithelial sodium channel to hypertension in black Caribbeans. Am J Hypertens vol. 11, (8 Pt 1) 942-945.
10.1016/S0895-7061(98)00092-2
O'Byrne S, Caulfield M(1998). Genetics of hypertension. Therapeutic implications. Drugs vol. 56, (2) 203-214.
10.2165/00003495-199856020-00004
Caulfield M, Cafferkey M(1998). Gene therapy: The possibilities and the problems. International Journal of Pharmaceutical Medicine vol. 12, (1) 5-7.
Brand E, Chatelain N, Keavney B et al.(1998). Evaluation of the angiotensinogen locus in human essential hypertension: a European study. Hypertension vol. 31, (3) 725-729.
10.1161/01.HYP.31.3.725
Kotanko P, Binder A, Tasker J et al.(1997). Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor. Hypertension vol. 30, (4) 773-776.
10.1161/01.HYP.30.4.773
Caulfield M, Bouloux PM, Munroe P (1997). Progress in determining the genes for hypertension, insulin resistance, and dyslipidemia. Ann N Y Acad Sci. vol. 827, 110-117.
10.1111/j.1749-6632.1997.tb51826.x
Daniel HI, Munroe PB, Kamdar SM et al.(1997). The atrial natriuretic peptide gene and essential hypertension in African-Caribbeans from St Vincent and the Grenadines. J Hum Hypertens vol. 11, (2) 113-117.
10.1038/sj.jhh.1000389
Caulfield M, Lavender P, Newell-Price J et al. (1996). Angiotensinogen in human essential hypertension. Hypertension. vol. 28, 1123-1125.
10.1161/01.HYP.28.6.1123
Caulfield M, Newell-Price J(1995). The angiotensin converting enzyme gene in cardiovascular disease. Br Heart J vol. 74, (3) 207-208.
10.1136/hrt.74.3.207
Munroe PB, Daniel HI, Farrall M et al. (1995). Absence of genetic linkage between polymorphisms of the insulin receptor gene and essential hypertension. J Hum Hypertens. vol. 9, 669-670.
Caulfield M, Lavender P, Newell-Price J et al.(1995). Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans. J Clin Invest vol. 96, (2) 687-692.
10.1172/JCI118111
Mattu RK, Needham EW, Galton DJ et al.(1995). A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study. Circulation vol. 91, (2) 270-274.
10.1161/01.CIR.91.2.270
Brown MJ, Clayton D(1994). Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med vol. 331, (16) 1096-1097.
10.1056/NEJM199410203311615
Kamdar S, Daniel H, Fogarty P et al. (1994). ACE insertion/deletion (I/D) polymorphism in Vincentian African Caribbeans with essential hypertension. J Hum Hypertens. vol. 8,
Munroe PB, Johnston A, Duke VM et al. (1994). Investigation of lipoprotein lipase (LPL) as a candidate gene for dyslipidaemic hypertension. J Hum Hypertens. vol. 8, 613-614.
Daniel HI, Munroe PB, Lawson M et al. (1994). Investigation of the renin gene as a putative locus for essential hypertension (EH) in Vincentian African Caribbeans. J Hum Hypertens. vol. 8, 609-610.
Caulfield M, Lavender P, Farrall M et al.(1994). Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med vol. 330, (23) 1629-1633.
10.1056/NEJM199406093302301
Munroe PB, Caulfield M, Daniel H et al. (1993). Analysis of the insulin receptor RsaI polymorphism in essential hypertension. British Journal of Clinical Pharmacology. vol. 35,
Raveendran R, Heybroek W, Caulfield M et al.(1992). Indomethacin and protein binding of methotrexate. Hum Exp Toxicol vol. 11, (4) 291-293.
10.1177/096032719201100411
Raveendran R, Heybroek WM, Caulfield M et al.(1992). Protein binding of indomethacin, methotrexate and morphine in patients with cancer. Int J Clin Pharmacol Res vol. 12, (3) 117-122.
Caulfield MJ, Dilkes MG, Iles RK et al.(1990). Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests. Lancet vol. 335, (8699)
10.1016/0140-6736(90)92761-6
Heybroek WM, Caulfield M, Johnston A et al.(1990). Automatic on-line extraction coupled with electrochemical detection as an improved method for the HPLC co-analysis of codeine and morphine in plasma and gastric juice. J Pharm Biomed Anal vol. 8, (8-12) 1021-1027.
10.1016/0731-7085(90)80163-J
Saleh S, Caulfield M, Lledo P et al. (1990). Debrisoquine-type genetic polymorphism differences in medifloxamine pharmacokinetics. European Journal of Pharmacology. vol. 183,
10.1016/0014-2999(90)93953-N
Jenkins BJ, Caulfield MJ, Fowler CG et al.(1988). Reappraisal of the role of radical radiotherapy and salvage cystectomy in the treatment of invasive (T2/T3) bladder cancer. Br J Urol vol. 62, (4) 343-346.
10.1111/j.1464-410X.1988.tb04362.x
Blandy JP, Jenkins BJ, Fowler CG et al.(1988). Radical radiotherapy and salvage cystectomy for T2/3 cancer of the bladder. Prog Clin Biol Res vol. 260, 447-451.
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