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Publications:  Prof Mark Caulfield

Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al.(2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nat Genet vol. 51, (3) 452-469.
10.1038/s41588-018-0334-2
van Setten J, Verweij N, Mbarek H, Niemeijer MN, Trompet S, Arking DE, Brody JA, Gandin I et al.(2019). Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits. Eur J Hum Genet
10.1038/s41431-018-0295-z
Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C et al.(2019). Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Mol Psychiatry
10.1038/s41380-018-0313-0
Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP et al.(2019). Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nat Genet vol. 51, (1) 51-62.
10.1038/s41588-018-0303-9
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al.(2018). Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet vol. 50, (12) 1755-1755.
10.1038/s41588-018-0297-3
CRyPTIC Consortium and the 100,000 Genomes Project, Allix-Béguec C, Arandjelovic I, Bi L, Beckert P, Bonnet M, Bradley P, Cabibbe AM et al.(2018). Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing. N Engl J Med vol. 379, (15) 1403-1415.
10.1056/NEJMoa1800474
Robbe P, Popitsch N, Knight SJL, Antoniou P, Becq J, He M, Kanapin A, Samsonova A et al.(2018). Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project. Genet Med vol. 20, (10) 1196-1205.
10.1038/gim.2017.241
Collier DJ, Juhasz A, Agabiti-Rosei E, Lloyd E, Hisada M, Zhao L, Kupfer S, Caulfield MJ(2018). Efficacy and safety of azilsartan medoxomil/chlortalidone fixed-dose combination in hypertensive patients uncontrolled on azilsartan medoxomil alone: A randomized trial. J Clin Hypertens (Greenwich) vol. 20, (10) 1473-1484.
10.1111/jch.13376
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al.(2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet vol. 50, (10) 1412-1425.
10.1038/s41588-018-0205-x
Ng FL, Warren HR, Caulfield MJ(2018). Hypertension genomics and cardiovascular prevention. Ann Transl Med vol. 6, (15) 291-291.
10.21037/atm.2018.06.34
Whitworth J, Smith PS, Martin JE, West H, Luchetti A, Rodger F, Clark G, Carss K et al.(2018). Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes. American Journal of Human Genetics vol. 103, (1) 3-18.
10.1016/j.ajhg.2018.04.013
Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N et al.(2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS One vol. 13, (6) e0198166-e0198166.
10.1371/journal.pone.0198166
Williams B, MacDonald TM, Morant SV, Webb DJ, Sever P, McInnes GT, Ford I, Cruickshank JK et al.(2018). Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. Lancet Diabetes Endocrinol vol. 6, (6) 464-475.
10.1016/S2213-8587(18)30071-8
Turnbull C, Scott RH, Thomas E, Jones L, Murugaesu N, Pretty FB, Halai D, Baple E et al.(2018). The 100 000 Genomes Project: bringing whole genome sequencing to the NHS. BMJ vol. 361,
10.1136/bmj.k1687
Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I et al.(2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet vol. 102, (3) 375-400.
10.1016/j.ajhg.2018.01.015
Pazoki R, Dehghan A, Evangelou E, Warren H, Gao H, Caulfield M, Elliott P, Tzoulaki I(2018). Genetic Predisposition to High Blood Pressure and Lifestyle Factors: Associations With Midlife Blood Pressure Levels and Cardiovascular Events. Circulation vol. 137, (7) 653-661.
10.1161/CIRCULATIONAHA.117.030898
McCarthy NS, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, Sever P, Thom S et al.(2018). Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Atherosclerosis vol. 269, 42-49.
10.1016/j.atherosclerosis.2017.12.013
Farmery JHR, Smith ML, NIHR BioResource - Rare Diseases, Lynch AG(2018). Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data. Sci Rep vol. 8, (1)
10.1038/s41598-017-14403-y
Munroe PB, Jahangir SNS, Caulfield MJ(2018). Genetics and genomics of systemic hypertension. Cardiovascular Genetics and Genomics: Principles and Clinical Practice,
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al.(2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet vol. 50, (1) 26-41.
10.1038/s41588-017-0011-x
Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R et al.(2018). The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle. Hum Mol Genet vol. 27, (1) 199-210.
10.1093/hmg/ddx375
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al.(2017). Exome-wide association study of plasma lipids in >300,000 individuals. Nat Genet vol. 49, (12) 1758-1766.
10.1038/ng.3977
MacDonald TM, Williams B, Webb DJ, Morant S, Caulfield M, Cruickshank JK, Ford I, Sever P et al.(2017). Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial. J Am Heart Assoc vol. 6, (11)
10.1161/JAHA.117.006986
Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N et al.(2017). New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Circ Cardiovasc Genet vol. 10, (5)
10.1161/CIRCGENETICS.117.001778
Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al.(2017). Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet vol. 49, (10) 1558-1558.
10.1038/ng1017-1558a
Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP et al.(2017). Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension
10.1161/HYPERTENSIONAHA.117.09438
Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T et al.(2017). Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis. Circulation vol. 135, (24) 2373-2388.
10.1161/CIRCULATIONAHA.116.026560
Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD, Huang J, Sabater-Lleal M, Asselbergs FW et al.(2017). Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease. Journal of the American Heart Association vol. 6, (6)
10.1161/JAHA.116.004918
Sabatine MS, Giugliano RP, Keech AC, Honarpour N, Wiviott SD, Murphy SA, Kuder JF, Wang H et al.(2017). Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med vol. 376, (18) 1713-1722.
10.1056/NEJMoa1615664
MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H, Cabrera CP(2017). Discovery of novel heart rate-associated loci using the exome chip. Human Molecular Genetics
10.1093/hmg/ddx113
Taylor RL, Arno G, Poulter JA, Khan KN, Morarji J, Hull S, Pontikos N, Rueda Martin A et al.(2017). Association of Steroid 5α-Reductase Type 3 Congenital Disorder of Glycosylation With Early-Onset Retinal Dystrophy. JAMA Ophthalmol vol. 135, (4) 339-347.
10.1001/jamaophthalmol.2017.0046
Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al.(2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet vol. 49, (3) 403-415.
10.1038/ng.3768
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y et al.(2017). Rare and low-frequency coding variants alter human adult height. Nature vol. 542, (7640) 186-190.
10.1038/nature21039
Ng FL, Boedtkjer E, Witkowska K, Ren M, Zhang R, Tucker A, Aalkjær C, Caulfield MJ et al.(2017). Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension. Hum Mol Genet
10.1093/hmg/ddx015
Carss KJ, Arno G, Erwood M, Stephens J, Sanchis-Juan A, Hull S, Megy K, Grozeva D et al.(2017). Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease. Am J Hum Genet vol. 100, (1) 75-90.
10.1016/j.ajhg.2016.12.003
Liang F, Caulfield MJ(2017). Status and future of genomics in blood pressure. European Heart Journal vol. 38, (14) 1011-1013.
10.1093/eurheartj/ehx088
Noordam R, Sitlani CM, Avery CL, Stewart JD, Gogarten SM, Wiggins KL, Trompet S, Warren HR et al.(2016). A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. J Med Genet
10.1136/jmedgenet-2016-104112
Rathod KS, Jones DA, Van-Eijl TJA, Tsang H, Warren H, Hamshere SM, Kapil V, Jain AK et al.(2016). Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study. BMJ Open vol. 6, (12)
10.1136/bmjopen-2016-012728
Evangelou E, Warren H, Cabrera C, Gao H, Tzoulaki I, Barnes M, Caulfield M, Elliott P et al. (2016). UK Biobank GWAS Identifies over 100 Novel Variants Associated with Blood Pressure. vol. 40, is. 7, pp. 613-613.
Ng FL, Boedtkjer E, Ye S, Caulfield M (2016). Blood pressure-associated polymorphisms in SLC4A7 (sodium/bicarbonate co-transporter NBCn1) are linked to gene expression and intracellular pH (pHi) regulation. vol. 30, is. 10, pp. 636-636.
MUNROE PB(2016). Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension. Nature Genetics
10.1038/ng.3654
MUNROE PB(2016). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics
10.1038/ng.3667
Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE et al.(2016). Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. Journal of Medical Genetics
10.1136/jmedgenet-2016-103966
Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. (2016). [OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II. England , vol. 34 Suppl 2, Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,
10.1097/01.hjh.0000491573.57396.0f
Zhang R, Witkowska K, Afonso Guerra-Assunção J, Ren M, Ng FL, Mauro C, Tucker AT, Caulfield MJ et al.(2016). A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity. Hum Mol Genet vol. 25, (18) 4117-4126.
10.1093/hmg/ddw236
Kanoni S, Masca NGD, Stirrups KE, Varga TV, Warren HR, Scott RA, Southam L, Zhang W et al.(2016). Analysis with the exome array identifies multiple new independent variants in lipid loci. Human Molecular Genetics vol. 25, (18) ddw227-ddw227.
10.1093/hmg/ddw227
Yang W, Ng FL, Chan K, Pu X, Poston RN, Ren M, An W, Zhang R et al.(2016). Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction. PLoS Genetics vol. 12, (7) e1006127-e1006127.
10.1371/journal.pgen.1006127
Burchell AE, Chan K, Ratcliffe LEK, Hart EC, Saxena M, Collier DJ, Jain AK, Mathur A et al.(2016). Controversies Surrounding Renal Denervation: Lessons Learned From Real-World Experience in Two United Kingdom Centers. J Clin Hypertens (Greenwich) vol. 18, (6) 585-592.
10.1111/jch.12789
Sharp ASP, Davies JE, Lobo MD, Bent CL, Mark PB, Burchell AE, Thackray SD, Martin U et al.(2016). Renal artery sympathetic denervation: observations from the UK experience. Clin Res Cardiol vol. 105, (6) 544-552.
10.1007/s00392-015-0959-4
Lessard S, Manning AK, Low-Kam C, Auer PL, Giri A, Graff M, Schurmann C, Yaghootkar H et al.(2016). Testing the role of predicted gene knockouts in human anthropometric trait variation. Hum Mol Genet vol. 25, (10) 2082-2092.
10.1093/hmg/ddw055
Bodea CA, Neale BM, Ripke S, Daly MJ, Devlin B, Roeder K(2016). A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies. American Journal of Human Genetics vol. 98, (5) 857-868.
10.1016/j.ajhg.2016.02.025
Leusink M, Maitland-van der Zee AH, Ding B, Drenos F, van Iperen EP, Warren HR, Caulfield MJ, Cupples LA et al.(2016). A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering. Pharmacogenomics vol. 17, (6) 583-591.
10.2217/pgs.16.8
Diver LA, MacKenzie SM, Fraser R, McManus F, Freel EM, Alvarez-Madrazo S, McClure JD, Friel EC et al.(2016). Common Polymorphisms at the CYP17A1 Locus Associate With Steroid Phenotype: Support for Blood Pressure Genome-Wide Association Study Signals at This Locus. Hypertension vol. 67, (4) 724-732.
10.1161/hypertensionaha.115.06925
Brown MJ, Williams B, Morant SV, Webb DJ, Caulfield MJ, Cruickshank JK, Ford I, McInnes G et al.(2016). Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial. Lancet Diabetes Endocrinol vol. 4, (2) 136-147.
10.1016/S2213-8587(15)00377-0
Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A et al.(2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun vol. 7,
10.1038/ncomms10023
Williams B, MacDonald TM, Morant S, Webb DJ, Sever P, McInnes G, Ford I, Cruickshank JK et al.(2015). Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet vol. 386, (10008) 2059-2068.
10.1016/S0140-6736(15)00257-3
Doyle JJ, Doyle AJ, Wilson NK, Habashi JP, Bedja D, Whitworth RE, Lindsay ME, Schoenhoff F et al.(2015). A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. ELIFE vol. 4, Article ARTN e08648,
10.7554/eLife.08648
Doyle JJ, Doyle AJ, Wilson NK, Habashi JP, Bedja D, Whitworth RE, Lindsay ME, Schoenhoff F et al.(2015). A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. Elife vol. 4,
10.7554/eLife.08648
Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. (2015). Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II. vol. 29, is. 10, pp. 624-624.
Zhang R, Witkowska K, Ng FL, Caulfield M, Ye S(2015). Hypertension related variant of SLC39A8 gene influences cadmium uptake and cell toxicity. JOURNAL OF HUMAN HYPERTENSION vol. 29, (10) 645-645.
Wain LV, Shrine N, Miller S, Jackson VE, Ntalla I, Soler Artigas M, Billington CK, Kheirallah AK et al.(2015). Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respir Med vol. 3, (10) 769-781.
10.1016/S2213-2600(15)00283-0
Warren H, Sever P, Poulter N, Stanton A, Caulfield M, Munroe P(2015). Pharmacogenetic GWAS meta-analysis of response to antihypertensive drugs. JOURNAL OF HUMAN HYPERTENSION vol. 29, (10) 627-627.
Poulter NR, Prabhakaran D, Caulfield M(2015). Hypertension. Lancet vol. 386, (9995) 801-812.
10.1016/S0140-6736(14)61468-9
Treibel TA, Zemrak F, Sado DM, Banypersad SM, White SK, Maestrini V, Barison A, Patel V et al.(2015). Extracellular volume quantification in isolated hypertension - changes at the detectable limits?. J Cardiovasc Magn Reson vol. 17,
10.1186/s12968-015-0176-3
Brown MJ, Williams B, MacDonald TM, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ et al.(2015). Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): protocol for a randomised double-blind trial in patients with essential hypertension. BMJ Open vol. 5, (8)
10.1136/bmjopen-2015-008086
MacDonald TM, Williams B, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ, Mackenzie IS et al.(2015). Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial. BMJ Open vol. 5, (8)
10.1136/bmjopen-2015-007645
Williams B, MacDonald TM, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ, Salsbury J et al.(2015). Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension. BMJ Open vol. 5, (8)
10.1136/bmjopen-2015-008951
Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C et al.(2015). Directional dominance on stature and cognition in diverse human populations. Nature vol. 523, (7561) 459-462.
10.1038/nature14618
Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield M, Devlin JJ, Nordio F, Hyde C et al.(2015). Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials. Lancet vol. 385, (9984) 2264-2271.
10.1016/S0140-6736(14)61730-X
Khanji M, Balawon A, Boubertakh R, Zemrak F, Collier D, Caulfield MJ, Petersen SE (2015). LB01.07: ELEVATED BLOOD PRESSURE WITHOUT HYPERTROPHY RAISES LEFT VENTRICULAR EJECTION FRACTION. J Hypertens. vol. 33 Suppl 1,
10.1097/01.hjh.0000467469.28955.ad
Zhang R, Witkowska K, Ng F, Caulfield MJ, Ye S(2015). LB03.08: HYPERTENSION RELATED VARIANT OF SOLUTE CARRIER FAMILY 39 MEMBER 8 GENE INFLUENCES CADMIUM UPTAKE AND CELL TOXICITY. J Hypertens vol. 33 Suppl 1,
10.1097/01.hjh.0000467698.82617.d6
Yousaf N, Low WY, Onipinla A, Mein C, Caulfield M, Munroe PB, Chernajovsky Y(2015). Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF-R1) and regulation by cytokines. Clin Exp Immunol vol. 180, (2) 289-304.
10.1111/cei.12575
Padmanabhan S, Caulfield M, Dominiczak AF(2015). Genetic and molecular aspects of hypertension. Circ Res vol. 116, (6) 937-959.
10.1161/CIRCRESAHA.116.303647
Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C, Chen BH, Liu C et al.(2015). A meta-analysis of gene expression signatures of blood pressure and hypertension. PLoS Genet vol. 11, (3)
10.1371/journal.pgen.1005035
Cabrera CP, Ng FL, Warren HR, Barnes MR, Munroe PB, Caulfield MJ(2015). Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics. Wiley Interdiscip Rev Syst Biol Med vol. 7, (2) 73-90.
10.1002/wsbm.1290
Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A(2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study. Hypertension vol. 65, (2) 320-327.
10.1161/HYPERTENSIONAHA.114.04675
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S et al.(2015). Genetic studies of body mass index yield new insights for obesity biology. Nature vol. 518, (7538) 197-206.
10.1038/nature14177
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH et al.(2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature vol. 518, (7538) 187-196.
10.1038/nature14132
Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A(2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension vol. 65, (2) 320-327.
10.1161/HYPERTENSIONAHA.114.04675
Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche J-D, Parks T et al.(2015). Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med vol. 3, (1) 53-60.
10.1016/S2213-2600(14)70290-5
Lobo MD, de Belder MA, Cleveland T, Collier D, Dasgupta I, Deanfield J, Kapil V, Knight C et al.(2015). Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension. Heart vol. 101, (1) 10-16.
10.1136/heartjnl-2014-307029
Huffman JE, Albrecht E, Teumer A, Mangino M, Kapur K, Johnson T, Kutalik Z, Pirastu N et al.(2015). Modulation of genetic associations with serum urate levels by body-mass-index in humans. PLoS One vol. 10, (3)
10.1371/journal.pone.0119752
Warren H, Sever P, Poulter N, Stantont A, Caulfield M, Munroe P (2015). Pharmacogenetic Meta-Analysis of Response to Antihypertensive Drugs within ASCOT. HUMAN HEREDITY. vol. 79, 49-49.
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al.(2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics vol. 46, (11) 1173-1186.
10.1038/ng.3097
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al.(2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet vol. 46, (11) 1173-1186.
10.1038/ng.3097
Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K et al.(2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nature Communications vol. 5, Article 5068,
10.1038/ncomms6068
Saxena M, Jain A, Mathur A, Knight C, Caulfield M, Collier D, Lobo M (2014). Early reduction in blood pressure and heart rate variability following multielectrode radio-frequency renal denervation in medicines intolerant patients. JOURNAL OF HUMAN HYPERTENSION. vol. 28, 647-647.
Burchell A, Chan K, Ratcliffe L, Hart E, Saxena M, Collier D, Jain A, Mathur A et al. (2014). Highly variable response to renal denervation for resistant hypertension - real world experience from 2 UK centres. JOURNAL OF HUMAN HYPERTENSION. vol. 28, 645-646.
Postmus I, Trompet S, Warren HR, Jukema JW, Caulfield MJ, Consortium GIST (2014). Pharmacogenetic GWAS meta-analysis of LDL cholesterol response to statins. JOURNAL OF HUMAN HYPERTENSION. vol. 28, 624-624.
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ et al.(2014). Endothelial C-type natriuretic peptide maintains vascular homeostasis. J Clin Invest vol. 124, (9) 4039-4051.
10.1172/JCI74281
Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K et al.(2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nature Communications vol. 5, Article 5068,
10.1038/ncomms6068
Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ et al.(2014). Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet vol. 46, (8) 826-836.
10.1038/ng.3014
Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Xiangjun GU, Smith AV et al.(2014). Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. American Journal of Human Genetics vol. 95, (1) 49-65.
10.1016/j.ajhg.2014.06.002
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