Menu
 
Research menu
Jump to menu

Publications:  Prof Claude Chelala

Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J et al.(2018). The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature. Nature Communications vol. 9, (1)
10.1038/s41467-018-06027-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/46163
Dayem Ullah AZ, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C(2018). SNPnexus: Assessing the functional relevance of genetic variation to facilitate the promise of precision medicine. Nucleic Acids Research vol. 46, (W1) W109-W113.
10.1093/nar/gky399
Wang J, Dayem Ullah AZ, Chelala C(2018). IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome. Nucleic acids research vol. 46, (8)
10.1093/nar/gky057
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36475
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al.(2018). Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma. Leukemia vol. 32, (5) 1258-1263.
10.1038/s41375-018-0043-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36269
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y et al.(2018). PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer. Cell Reports vol. 22, (9) 2469-2481.
10.1016/j.celrep.2018.02.028
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56422
Gadaleta E, Pirrò S, Dayem Ullah AZ, Marzec J, Chelala C(2018). BCNTB bioinformatics: The next evolutionary step in the bioinformatics of breast cancer tissue banking. Nucleic Acids Research vol. 46, (D1) D1055-D1061.
10.1093/nar/gkx913
https://qmro.qmul.ac.uk/xmlui/handle/123456789/35083
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al.(2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov
10.1158/2159-8290.CD-17-0284
https://qmro.qmul.ac.uk/xmlui/handle/123456789/30984
Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R et al.(2017). Splice variants as novel targets in pancreatic ductal adenocarcinoma. Scientific Reports vol. 7, (1)
10.1038/s41598-017-03354-z
https://qmro.qmul.ac.uk/xmlui/handle/123456789/24508
Marzec J, Dayem Ullah AZ, Pirrò S, Gadaleta E, Crnogorac-Jurcevic T, Lemoine NR, Kocher HM, Chelala C(2017). The Pancreatic Expression Database: 2018 update. Nucleic Acids Res vol. 46, (D1) D1107-D1110.
10.1093/nar/gkx955
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31471
Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al.(2017). 'Multi-omic' data analysis using O-miner. Brief Bioinform
10.1093/bib/bbx080
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36329
Tawana K, Wang J, Király PA, Kállay K, Benyó G, Zombori M, Csomor J, Al Seraihi A et al.(2017). Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree. European Journal of Human Genetics vol. 25, (8) 1020-1024.
10.1038/ejhg.2017.80
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36112
Harwood C, Proby C, Wang J, Nagano A, Alexandrov L, Purdie K, Chelala C, Inman G et al. (2017). Chronic azathioprine treatment is causal in cutaneous squamous cell carcinoma development and is associated with a novel mutational signature. BRITISH JOURNAL OF DERMATOLOGY. vol. 177, 9-10.
Thomson J, Wang A, Nagano A, Chelala C, Purdie K, Har C, Proby C, Inman G et al. (2017). Understanding actinic keratosis and squamous cell carcinoma in the era of whole-exome and -genome sequencing. BRITISH JOURNAL OF DERMATOLOGY. vol. 177, 15-16.
Besley C, Kotsiou E, Petty R, Sangaralingam A, Chelala C, Ghazaly E, LeDieu R, Gribben J et al. (2017). ALLORESPONSES OF HUMAN T-CELLS FROM ADULT PERIPHERAL BLOOD AND UMBILICAL CORD BLOOD ARE DIFFERENTIALLY IMPACTED BY LENALIDOMIDE - IMPLICATIONS FOR AHSCT. HAEMATOLOGICA. vol. 102, 638-638.
Ironside A, Hawkesford K, Gomm J, Haywood L, Goulding I, Wang J, Lamaziere A, Poirot M et al. (2017). Molecular mediators of mammographic density. CANCER RESEARCH. vol. 77,
10.1158/1538-7445.SABCS16-P4-15-04
Morrissey B, Blyth K, Carter P, Chelala C, Jones L, Holen I, Speirs V(2017). The Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal Research. PLoS Biol vol. 15, (1) e2000719-e2000719.
10.1371/journal.pbio.2000719
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31472
Moniz LS, Surinova S, Ghazaly E, Velasco LG, Haider S, Rodríguez-Prados JC, Berenjeno IM, Chelala C et al.(2017). Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate. Scientific Reports vol. 7,
10.1038/srep39985
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36598
Besley C, Kotsiou E, Petty R, Ajanthah S, Chelala C, Ghazaly E, Le Dieu R, Davies J et al. (2016). Alloresponses of Human T-Cells from Adult Peripheral Blood and Umbilical Cord Blood Are Differentially Impacted By Lenalidomide. BLOOD. vol. 128,
10.1182/blood.V128.22.5714.5714
Makoukji J, Makhoul NJ, Khalil M, El-Sitt S, Aldin ES, Jabbour M, Boulos F, Gadaleta E et al.(2016). Gene expression profiling of breast cancer in Lebanese women. Scientific Reports vol. 6, 36639-36639.
10.1038/srep36639
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31468
Ghayad SE, Rammal G, Ghamloush F, Basma H, Nasr R, Diab-Assaf M, Chelala C, Saab R(2016). Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts. Scientific Reports vol. 6, Article 37088,
10.1038/srep37088
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31466
Proby CM, Inman G, Wang JA, Nagano A, Purdie KJ, Gulati A, Lambert S, Mladkova N et al. (2016). Characterisation of the molecular landscape of cutaneous squamous cell carcinoma and Identification of a novel mutational signature associated with chronic azathioprine exposure. BRITISH JOURNAL OF DERMATOLOGY. vol. 175, 58-59.
Speirs V, Morrisey B, Holen I, Blyth K, Carter P, Chelala C, Jones L(2016). SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals. Journal of Pathology vol. 240, (1) 120-120.
10.1002/path.4755
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31474
Mao X, Luo F, Boyd LK, Zhou B, Zhang Y, Stankiewicz E, Marzec J, Vasiljevic N et al.(2016). NKAIN2 functions as a novel tumor suppressor in prostate cancer. Oncotarget
10.18632/oncotarget.11690
https://qmro.qmul.ac.uk/xmlui/handle/123456789/16191
Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D et al.(2016). Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature Communications vol. 7, 12493-12493.
10.1038/ncomms12493
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31383
Jones JL, Gomm J, Haywood L, Morgan A, Goulding I, Allen M, Chelala C, Gadelata E (2016). Breast Cancer Now Cell Culture Programme: a bespoke resource for the research community. Breast Cancer Research and Treatment. Conference: UK Breast Cancer Research Symposium 2016 from: 22/07/2016 to: 23/07/2016, vol. 159, 196-196.
10.1007/s10549-016-3898-5
Balarajah V, Ambily A, Dayem Ullah AZ, Imrali A, Dowe T, Al-Sarireh B, Abu Hilal M, Davidson BR et al.(2016). Pancreatic cancer tissue banks: where are we heading?. Future Oncol vol. 12, (23) 2661-2663.
10.2217/fon-2016-0243
Locke M, Ghazaly E, Freitas MO, Mitsinga M, Lattanzio L, Lo Nigro C, Nagano A, Wang J et al.(2016). Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1. Cell Reports vol. 16, (6) 1604-1613.
10.1016/j.celrep.2016.06.097
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15049
Proby C, Inman G, Wang J, Nagano A, Purdie K, Mladkova N, Lambert S, Gulati A et al. (2016). Characterisation of the molecular landscape of cutaneous squamous cell carcinoma. MELANOMA RESEARCH. vol. 26, E69-E69.
Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Libertini S, Ridgway R, Mchugh A et al. (2016). Frequent loss of function mutations in TGF beta R1 and TGF beta R2 implicate hair follicle bulge stem cells as a cell of origin of cutaneous squamous cell carcinoma. MELANOMA RESEARCH. vol. 26, E63-E64.
Inman G, Proby CM, Wang JA, Nagano A, Alexandrov L, Purdie K, Rose A, Weir L et al. (2016). Identification of a novel mutational signature in cutaneous SCC associated with chronic azathioprine exposure. MELANOMA RESEARCH. vol. 26, E114-E115.
Morrissey B, Holen I, Chelala C, Carter P, Jones L, Blyth K, Speirs V(2016). Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research. NPJ Breast Cancer vol. 2, 16020-16020.
10.1038/npjbcancer.2016.20
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34164
Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J et al.(2016). Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia. Leukemia
10.1038/leu.2016.134
GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al.(2016). Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma. Cancer Research
10.1158/0008-5472.CAN-16-0481
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12978
Araf S, Wang J, Pangault C, Kotsiou E, Hoxha E, Iqbal S, Davies J, Johnson P et al. (2016). GENOMIC PROFILING REVEALS SPATIAL HETEROGENEITY IN FOLLICULAR LYMPHOMA: IMPLICATIONS FOR PRECISION MEDICINE. HAEMATOLOGICA. vol. 101, 270-270.
Rose-Zerilli MJJ, Gibson J, Wang J, Tapper W, Davis Z, Parker H, Larrayoz M, McCarthy H et al.(2016). Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease. Leukemia vol. 30, (6) 1301-1310.
10.1038/leu.2016.10
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al.(2016). Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma (vol 48, pg 183, 2016). NATURE GENETICS vol. 48, (6) 700-700.
10.1038/ng0616-700b
Rio-Machin A, Cardoso S, Tawana K, Wang J, Chelala C, Plagnol V, Wallis Y, Ryan G et al. (2016). WHOLE EXOME SEQUENCING REVEALS NOVEL CANDIDATE GENES IN FAMILIAL MDS/AML. HAEMATOLOGICA. vol. 101, 205-206.
Morrissey B, Blyth K, Carter P, Chelala C, Jones L, Holen I, Speirs V(2016). SEARCHBreast: A new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers. Breast Cancer Research vol. 18, (1)
10.1186/s13058-016-0716-2
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36339
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Seraihi AFA et al.(2016). Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nat Genet vol. 48, (6) 700-700.
10.1038/ng0616-700b
Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Coates P, Sapkota G, Purdie K et al. (2016). Inactivation of transforming growth factor-beta receptors in human cutaneous squamous cell carcinoma and murine hair follicle stem cells drives tumorigenesis. BRITISH JOURNAL OF DERMATOLOGY. vol. 174, E51-E52.
Proby C, Inman G, Nagano A, Purdie K, Mladkova N, Alexandrov L, Stratton M, Watt S et al. (2016). The molecular landscape of cutaneous squamous cell carcinoma. BRITISH JOURNAL OF DERMATOLOGY. vol. 174, E50-E51.
Marzec J, Mao X, Li M, Wang M, Feng N, Gou X, Wang G, Sun Z et al.(2016). A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population. Oncotarget vol. 7, (16) 21393-21403.
10.18632/oncotarget.7250
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23707
Blyth K, Carter P, Morrissey B, Chelala C, Jones L, Holen I, Speirs V(2016). SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs. Breast Cancer Research and Treatment vol. 156, (3) 447-452.
10.1007/s10549-016-3785-0
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al.(2016). Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nature Genetics vol. 48, (2) 183-188.
10.1038/ng.3473
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. (2015). Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nature Genetics.
10.1038/ng.3473
Morrissey B, Blyth K, Carter P, Chelala C, Holen I, Jones L, Speirs V(2015). SEARCHBreast workshop proceedings: 3D modelling of breast cancer. ATLA Alternatives to Laboratory Animals vol. 43, (6) 367-375.
10.1177/026119291504300604
Tawana K, Wang J, Renneville A, Bödör C, Hills R, Loveday C, Savic A, Van Delft FW et al.(2015). Disease evolution and outcomes in familial AML with germline CEBPA mutations. Blood vol. 126, (10) 1214-1223.
10.1182/blood-2015-05-647172
Speirs V, Blyth K, Carter P, Chelala C, Holen I, Jones L, Morrissey B(2015). Animal research: Share surplus animal tissue. Nature vol. 522, (7555) 156-156.
10.1038/522156c
Makoukji J, Raad M, Genadry K, El-Sitt S, Makhoul NJ, Aldin ES, Nohra E, Jabbour M et al.(2015). Association between CLN3 (neuronal ceroid lipofuscinosis, CLN3 type) gene expression and clinical characteristics of breast cancer patients. Frontiers in Oncology vol. 5, (OCT)
10.3389/fonc.2015.00215
Cutts RJ, Guerra-Assunção JA, Gadaleta E, Dayem Ullah AZ, Chelala C(2015). BCCTBbp: the Breast Cancer Campaign Tissue Bank bioinformatics portal. Nucleic Acids Res vol. 43, (Database issue) D831-D836.
10.1093/nar/gku984
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36107
Debernardi S, Massat NJ, Radon TP, Sangaralingam A, Banissi A, Ennis DP, Dowe T, Chelala C et al.(2015). Noninvasive urinary miRNA biomarkers for early detection of pancreatic adenocarcinoma. American Journal of Cancer Research vol. 5, (11) 3455-3466.
Guillermet-Guibert J, Smith LB, Halet G, Whitehead MA, Pearce W, Rebourcet D, León K, Crépieux P et al.(2015). Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells. PLoS Genetics vol. 11, (7)
10.1371/journal.pgen.1005304
Smedley D, Haider S, Durinck S, Pandini L, Provero P, Allen J, Arnaiz O, Awedh MH et al.(2015). The BioMart community portal: An innovative alternative to large, centralized data repositories. Nucleic Acids Research vol. 43, (W1) W589-W598.
10.1093/nar/gkv350
Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al.(2014). A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma. Genome Medicine vol. 6, (12)
10.1186/s13073-014-0105-3
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6841
Cutts R, Jithesh PV, Delage B, Luong P, Thomas G, Chelala C, Szlosarek PW (2014). Gene expression analysis of argininosuccinate synthetase loss and the effects of pegylated arginine deiminase in malignant pleural mesothelioma. CANCER RESEARCH. vol. 74,
10.1158/1538-7445.AM2014-1431
Ren G, Zhang Y, Mao X, Liu X, Mercer E, Marzec J, Ding D, Jiao Y et al.(2014). Transcription-mediated chimeric RNAs in prostate cancer: time to revisit old hypothesis?. OMICS vol. 18, (10) 615-624.
10.1089/omi.2014.0042
Wong P-P, Yeoh CC, Ahmad AS, Chelala C, Gillett C, Speirs V, Jones JL, Hurst HC(2014). Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer. Oncogene vol. 33, (37) 4579-4588.
10.1038/onc.2014.45
https://qmro.qmul.ac.uk/xmlui/handle/123456789/8519
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al.(2014). Therapeutic targeting of integrin αvβ6 in breast cancer. J Natl Cancer Inst vol. 106, (8)
10.1093/jnci/dju169
https://qmro.qmul.ac.uk/xmlui/handle/123456789/8829
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevi¿ N, Chaplin T et al.(2014). Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol vol. 232, (5) 566-577.
10.1002/path.4327
Speirs V, Chelala C, Coates R, Jones JL, Matharoo-Ball B, Quinlan P (2014). The Breast Cancer Campaign Tissue Bank: Generating new biomaterials to accelerate breast cancer research. EUROPEAN JOURNAL OF CANCER. vol. 50, S200-S200.
Okosun J, Bödör C, Wang J, Araf S, Yang CY, Pan C, Boller S, Cittaro D et al.(2014). Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nature Genetics vol. 46, (2) 176-181.
10.1038/ng.2856
Okosun J, Bödör C, Wang J, Araf S, Yang C-Y, Pan C, Boller S, Cittaro D et al.(2014). Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nat Genet vol. 46, (2) 176-181.
10.1038/ng.2856
Allen MD, Luong P, Hudson C, Leyton J, Delage B, Ghazaly E, Cutts R, Yuan M et al.(2014). Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging. Cancer Res vol. 74, (3) 896-907.
10.1158/0008-5472.CAN-13-1702
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6977
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevíc N, Chaplin T et al.(2014). Erratum:Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol (2014); 232: 566-577)). Journal of Pathology vol. 234, (1)
10.1002/path.4396
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Marzec J, Vasiljevic N, Chaplin T, Foster JM et al.(2014). Identification of ZDHHC14 as a novel human tumour suppressor: gene. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 34, S90-S90.
Mao X, Marzec J, Li M, Zhang Z, Feng N, Gou X, Sun Z, Xu J et al.(2014). Population differences in the genetic risk of prostate cancer and predisposition loci in the Chinese population. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 34, S89-S89.
Dayem Ullah AZ, Cutts RJ, Ghetia M, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR, Chelala C(2014). The pancreatic expression database: recent extensions and updates. Nucleic Acids Res vol. 42, (Database issue) D944-D949.
10.1093/nar/gkt959
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18503
Speirs V, Good R, Hanby A, Matharoo-Ball B, Thomson B, Ellis I, Quinlan P, Lyons D et al.(2013). Early experience of patient donation and researcher use of tissues donated to a national breast cancer tissue bank. CANCER RESEARCH vol. 73,
10.1158/0008-5472.SABCS13-P4-19-02
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al.(2013). Integrin avb6 is a therapeutic target for high-risk breast cancer and enhances trastuzumab efficacy. CANCER RESEARCH vol. 73,
10.1158/0008-5472.SABCS13-P4-15-01
Tawana K, Renneville A, Wang J, Georgiades P, Thomas X, Mialou V, Savic A, Van Delft FW et al. (2013). Familial AML With Germline CEBPA Mutations: Extended Clinical Outcomes and Analysis Of Secondary Mutations Using Whole Exome Sequencing. BLOOD. vol. 122,
10.1182/blood.V122.21.740.740
Popov N, Maniati E, Marzec J, Okosun J, Scott R, Kranz A, Stewart F, Chelala C et al. (2013). Investigating The Role Of MLL2 (Mll4) In B Cell Development. BLOOD. vol. 122,
10.1182/blood.V122.21.343.343
Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J et al.(2013). Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology vol. 145, (5) 1121-1132.
10.1053/j.gastro.2013.07.025
Bödör C, Grossmann V, Popov N, Okosun J, O'Riain C, Tan K, Marzec J, Araf S et al.(2013). EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood vol. 122, (18) 3165-3168.
10.1182/blood-2013-04-496893
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al.(2013). Therapeutic targeting of integrin alpha v beta 6 in high-risk breast cancer. MOLECULAR CANCER RESEARCH vol. 11,
10.1158/1557-3125.ADVBC-B046
Gadaleta E, Cutts RJ, Sangaralingam A, Lemoine NR, Chelala C(2013). An Integrated Systems Approach to the Study of Pancreatic Cancer. Systems Biology in Cancer Research and Drug Discovery,
Dayem Ullah AZ, Lemoine NR, Chelala C(2013). A practical guide for the functional annotation of genetic variations using SNPnexus. Brief Bioinform vol. 14, (4) 437-447.
10.1093/bib/bbt004
Kadaba R, Birke H, Wang J, Hooper S, Andl CD, Di Maggio F, Soylu E, Ghallab M et al.(2013). Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes. J Pathol vol. 230, (1) 107-117.
10.1002/path.4172
Milne R, La Vecchia C, Van Steen K, Hahn S, Buchholz M, Costello E, Esposito I, Hoheisel JD et al.(2013). EU pancreas: An integrated european platform for pancreas cancer research - From basic science to clinical and public health interventions for a rare disease. Public Health Genomics vol. 16, (6) 305-312.
10.1159/000355937
Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR et al.(2013). S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells. Clin Exp Metastasis vol. 30, (3) 251-264.
10.1007/s10585-012-9532-y
Crnogorac-Jurcevic T, Chelala C, Barry S, Harada T, Bhakta V, Lattimore S, Jurcevic S, Bronner M et al.(2013). Molecular analysis of precursor lesions in familial pancreatic cancer. PLoS One vol. 8, (1)
10.1371/journal.pone.0054830
https://qmro.qmul.ac.uk/xmlui/handle/123456789/4930
Okosun J, Boedoer C, Wang J, Araf S, Marzec J, Iqbal S, Matthews J, Calaminici M et al. (2012). Whole Genome Sequencing in Sequential Biopsies Reveals the Genetic Evolution of Follicular Lymphoma to Transformed Follicular Lymphoma. BLOOD. vol. 120,
10.1182/blood.V120.21.145.145
Cutts RJ, Dayem Ullah AZ, Sangaralingam A, Gadaleta E, Lemoine NR, Chelala C(2012). O-miner: an integrative platform for automated analysis and mining of -omics data. Nucleic Acids Res vol. 40, (Web Server issue) W560-W568.
10.1093/nar/gks432
Dayem Ullah AZ, Lemoine NR, Chelala C(2012). SNPnexus: a web server for functional annotation of novel and publicly known genetic variants (2012 update). Nucleic Acids Res vol. 40, (Web Server issue) W65-W70.
10.1093/nar/gks364
Lines KE, Chelala C, Dmitrovic B, Wijesuriya N, Kocher HM, Marshall JF, Crnogorac-Jurcevic T(2012). S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells. Am J Pathol vol. 180, (4) 1485-1494.
10.1016/j.ajpath.2011.12.031
Gadaleta E, Cutts RJ, Kelly GP, Crnogorac-Jurcevic T, Kocher HM, Lemoine NR, Chelala C(2011). A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws. Nucleic Acids Res vol. 39, (18) 7900-7907.
10.1093/nar/gkr533
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18659
Froeling FEM, Feig C, Chelala C, Dobson R, Mein CE, Tuveson DA, Clevers H, Hart IR et al.(2011). Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression. Gastroenterology vol. 141, (4) 1486-1497.14.
10.1053/j.gastro.2011.06.047
Froeling F, Chelala C, Clevers H, Hart I, Kocher H (2011). Retinoic Acid-Induced Stellate Cell Quiescence Results in Sfrp4 Secretion Which Abrogates Wnt-beta-Catenin Signalling Pathway Modulating Human Pancreatic Tumour Cell Behaviour. GASTROENTEROLOGY. vol. 140, S156-S157.
Lines KE, Audi N, Chelala C, Wijesuriya N, Kocher H, Hurst H, Crnogorac-Jurcevic T(2011). Role of S100PBP in pancreatic adenocarcinoma. CANCER RESEARCH vol. 71,
10.1158/1538-7445.AM2011-1537
Allen MD, Vaziri R, Green M, Chelala C, Brentnall AR, Dreger S, Vallath S, Nitch-Smith H et al.(2011). Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion. J Pathol vol. 223, (5) 646-658.
10.1002/path.2833
Guberman JM, Ai J, Arnaiz O, Baran J, Blake A, Baldock R, Chelala C, Croft D et al.(2011). BioMart Central Portal: an open database network for the biological community. Database (Oxford) vol. 2011,
10.1093/database/bar041
Gadaleta E, Lemoine NR, Chelala C(2011). Online resources of cancer data: barriers, benefits and lessons. Brief Bioinform vol. 12, (1) 52-63.
10.1093/bib/bbq010
Cutts RJ, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR, Chelala C(2011). The Pancreatic Expression database: 2011 update. Nucleic Acids Res vol. 39, (Database issue) D1023-D1028.
10.1093/nar/gkq937
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18435
Cutts RJ, Gadaleta E, Lemoine NR, Chelala C(2011). Using BioMart as a framework to manage and query pancreatic cancer data. Database (Oxford) vol. 2011,
10.1093/database/bar024
Flak MB, Connell CM, Chelala C, Archibald K, Salako MA, Pirlo KJ, Lockley M, Wheatley SP et al.(2010). p21 Promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker. Mol Cancer vol. 9,
10.1186/1476-4598-9-175
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13470
An Q, Jones L, Tapper W, Chelala C, Iravani M, MacKay A, Hammond V, Durcan L et al. (2010). A novel tumour-based test to identify breast cancer due to BRCA1 and BRCA2 mutations. BREAST CANCER RESEARCH. vol. 12, S10-S10.
10.1186/bcr2528
Eccles DM, An Q, Jones L, Tapper W, Chelala C, Iravani M, Mckay A, Hammond V et al. (2009). A Novel Tumour-Based Test To Identify Breast Cancer Due to BRCA1 and BRCA2 Mutations. CANCER RESEARCH. vol. 69, 775S-775S.
Dawoud MM, Jones D, Hodivala-Dilke K, Dreger S, Chelala C, Asaad NY, Jones L (2009). Microenvironmental Changes in DCIS: Myoepithelial Cells Change from Tumour Suppressor to Tumour Promoter. CANCER RESEARCH. vol. 69, 760S-760S.
Barry S, Chelala C, Sunamura M, Bhakta V, Lemoine NR, Jurcevic T(2009). Search for Novel molecular targets in pancreatic cancer by comparative analysis of primary and metastatic disease. CLIN EXP METASTAS vol. 26, (7) 856-856.
Wang Y, Gangeswaran R, Zhao X, Wang P, Tysome J, Bhakta V, Yuan M, Chikkanna-Gowda CP et al.(2009). CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells. J Clin Invest vol. 119, (6) 1604-1615.
10.1172/JCI37905
Flak MB, Connell CM, Hill RM, Hallden G, Chelala C, McNeish IA (2009). Critical Role for p21 and p27 in Efficacy of Oncolytic Adenovirus dl922-947 in Ovarian Cancer. MOLECULAR THERAPY. vol. 17, S100-S100.
Chelala C, Khan A, Lemoine NR(2009). SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms. Bioinformatics vol. 25, (5) 655-661.
10.1093/bioinformatics/btn653
Chelala C, Lemoine NR, Hahn SA, Crnogorac-Jurcevic T(2009). A web-based platform for mining pancreatic expression datasets. Pancreatology vol. 9, (4) 340-343.
10.1159/000212082
Harada T, Chelala C, Crnogorac-Jurcevic T, Lemoine NR(2009). Genome-wide analysis of pancreatic cancer using microarray-based techniques. Pancreatology vol. 9, (1-2) 13-24.
10.1159/000178871
Yuan M, Tomlinson V, Lara R, Holliday D, Chelala C, Harada T, Gangeswaran R, Manson-Bishop C et al.(2008). Yes-associated protein (YAP) functions as a tumor suppressor in breast. Cell Death Differ vol. 15, (11) 1752-1759.
10.1038/cdd.2008.108
Flak MB, Connell CM, Hill RM, Hallden G, Chelala C, McNeish IA (2008). Host cell factors in ovarian cancer influencing efficacy of oncolytic adenovirus dl922-947. HUMAN GENE THERAPY. vol. 19, 1083-1083.
Gupta M, Raghavan M, Gale RE, Chelala C, Allen C, Molloy G, Chaplin T, Linch DC et al.(2008). Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia. Genes Chromosomes Cancer vol. 47, (9) 729-739.
10.1002/gcc.20573
Raghavan M, Smith L-L, Lillington DM, Chaplin T, Kakkas I, Molloy G, Chelala C, Cazier J-B et al.(2008). Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia. Blood vol. 112, (3) 814-821.
10.1182/blood-2008-01-132431
Harada T, Chelala C, Bhakta V, Chaplin T, Caulee K, Baril P, Young BD, Lemoine NR(2008). Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays. Oncogene vol. 27, (13) 1951-1960.
10.1038/sj.onc.1210832
Chelala C, Hahn SA, Whiteman HJ, Barry S, Hariharan D, Radon TP, Lemoine NR, Crnogorac-Jurcevic T(2007). Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets. BMC Genomics vol. 8,
10.1186/1471-2164-8-439
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18860
Gupta M, Raghavan M, Gale RE, Chelala C, Allen C, Molloy G, Chaplin T, Linch DC et al. (2007). A genome-wide map of acquired uniparental disomy in acute myeloid leukemia. BLOOD. vol. 110, 302A-302A.
10.1182/blood.V110.11.996.996
Mahon PC, Baril P, Bhakta V, Chelala C, Caulee K, Harada T, Lemoine NR(2007). S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer. Cancer Res vol. 67, (14) 6786-6795.
10.1158/0008-5472.CAN-07-0440
Raghavan M, Smith LL, Chaplin T, Lillington D, Molloy G, Kakkas I, Chelala C, Cazier JB et al. (2007). Frequent relapse of acute myeloid leukaemia by mitotic recombination. BRITISH JOURNAL OF HAEMATOLOGY. vol. 137, 25-25.
Chelala C, Duchatelet S, Joffret M-L, Bergholdt R, Dubois-Laforgue D, Ghandil P, Pociot F, Caillat-Zucman S et al.(2007). PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits. Diabetes vol. 56, (2) 522-526.
10.2337/db06-0942
Harada T, Baril P, Gangeswaran R, Kelly G, Chelala C, Bhakta V, Caulee K, Mahon PC et al.(2007). Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation. Br J Cancer vol. 96, (2) 373-382.
10.1038/sj.bjc.6603563
Senée V, Chelala C, Duchatelet S, Feng D, Blanc H, Cossec J-C, Charon C, Nicolino M et al.(2006). Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. Nat Genet vol. 38, (6) 682-687.
10.1038/ng1802
Ghandil P, Chelala C, Dubois-Laforgue D, Senee V, Caillat-Zucman S, Kockum I, Luthman H, Nerup J et al.(2005). Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes. MOL GENET METAB vol. 86, (3) 379-383.
10.1016/j.ymgme.2005.07.029
Chelala C, Auffray C(2005). Sex-linked recombination variation and distribution of disease-related genes. Gene vol. 346, 29-39.
10.1016/j.gene.2004.10.019
Imanishi T, Itoh T, Suzuki Y, O'Donovan C, Fukuchi S, Koyanagi KO, Barrero RA, Tamura T et al.(2004). Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol vol. 2, (6)
10.1371/journal.pbio.0020162
Chelala C, Debignes MD, Imbeaud S, Zoorob R, Auffray C, Curis E, Benazeth S, Cox D(2002). Inconsistencies between maps of human chromosome 22 correlate with increased frequency of disease-related loci. J BIOL SYST vol. 10, (4) 303-317.
10.1142/S0218339002000743
Eveno E, Mariage-Samson R, Bortoli S, Imbeaud S, Decraene C, Pietu G, CHELALA C, Devignes MD et al.(2002). The Genexpress IMAGE Knowledge Base of the Human Genome and Transcriptomes. Analysing Gene Expression, A Handbook of Methods: Possibilities and Pitfalls, Editors: Lorkowski, S, Cullen, P, Wiley-VCH
Chelala C, Imbeaud S, Devignes MD, Zoorob R, Auffray C(2001). Refined localization of twenty-one genes in subregion p13.1 of human chromosome 1. CYTOGENET CELL GENET vol. 92, (3-4) 209-212.
10.1159/000056904
Return to top