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Publications:  Dr Mark Baker

Bode DC, Stanyon HF, Hirani T, Baker MD, Nield J, Viles JH(2018). Serum Albumin's Protective Inhibition of Amyloid-β Fibre Formation Is Suppressed by Cholesterol, Fatty Acids and Warfarin. J Mol Biol
10.1016/j.jmb.2018.01.008
BAKER D(2017). Big conductance calcium-activated potassium channel openers control spasticity without sedation. British Journal of Pharmcology
10.1111/bph.13889
BAKER MD, Kanagaratnam M, Pendleton C, Souza DA, Pettit J, Howells J(2017). Diuretic sensitive electroneutral Na+ movement and temperature effects on central axons. The Journal of Physiology
10.1113/JP273963
BAKER MD(2016). Ion Channel Formation by Amyloid-β42 Oligomers but not Amyloid-β40 in Cellular Membranes. Journal of Biological Chemistry
10.1074/jbc.M116.762526
Park SB, Baker MD(2016). Too fast: rare neuropathic pain state associated with easy activation of NaV1.9. J Neurol Neurosurg Psychiatry
10.1136/jnnp-2016-314417
Hockley JRF, Tranter MM, McGuire C, Bondouki G, Cibert-Goton V, Thaha MA, Blackshaw L, Michael GJ et al.(2016). P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors. Journal of Neuroscience vol. 36, (8) Article 26911685, 2364-2376.
10.1523/jneurosci.3369-15.2016
Coates TA, Woolnough O, Masters JM, Asadova G, Chandrakumar C, Baker MD(2015). Acute temperature sensitivity in optic nerve axons explained by an electrogenic membrane potential. Pflugers Arch vol. 467, (11) 2337-2349.
10.1007/s00424-015-1696-2
Bulmer D, Hockley J, Mcguire C, Cibert-Goton V, Tranter M, Knowles C, Baker M, Mcmurray S et al.(2015). Differential roles of voltage-gated sodium channels on visceral afferent excitability to mechanical and inflammatory mediators. NEUROGASTROENTEROLOGY AND MOTILITY vol. 27, 110-110.
Hockley JRF, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN et al.(2014). Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli. Pain vol. 155, (10) 1962-1975.
10.1016/j.pain.2014.06.015
Hockley JRF, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN et al.(2014). Multiple roles for Na<inf>V</inf>1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli. Pain vol. 155, (10) 1962-1975.
10.1016/j.pain.2014.06.015
Hadavi S, Baker MD, Dobson R(2014). Sustained-release fampridine in Multiple Sclerosis. Mult Scler Relat Disord vol. 3, (1) 17-21.
10.1016/j.msard.2013.06.003
Baker MD(2013). Potential therapeutic mechanism of K(+) channel block for MS. Mult Scler Relat Disord vol. 2, (4) 270-280.
10.1016/j.msard.2013.01.005
Bubb KJ, Wen H, Panayiotou CM, Finsterbusch M, Khan FJ, Chan MV, Priestley JV, Baker MD et al.(2013). Activation of neuronal transient receptor potential vanilloid 1 channel underlies 20-hydroxyeicosatetraenoic acid-induced vasoactivity: role for protein kinase A. Hypertension vol. 62, (2) 426-433.
10.1161/HYPERTENSIONAHA.111.00942
Hockley JR, Cibert-Goton V, Boundouki G, Wood J, Knowles CH, Baker MD, Winchester W, Bulmer DC (2013). Mechanotransduction in Mouse Visceral Afferent Fibres Is Modulated by Nav1.9. GASTROENTEROLOGY. vol. 144, S935-S935.
Lidster K, Jackson SJ, Ahmed Z, Munro P, Coffey P, Giovannoni G, Baker MD, Baker D(2013). Neuroprotection in a novel mouse model of multiple sclerosis. PLoS One vol. 8, (11)
10.1371/journal.pone.0079188
Eijkelkamp N, Linley JE, Baker MD, Minett MS, Cregg R, Werdehausen R, Rugiero F, Wood JN(2012). Neurological perspectives on voltage-gated sodium channels. Brain vol. 135, (Pt 9) 2585-2612.
10.1093/brain/aws225
Hockley J, Mcguire C, Boundouki G, Knowles C, Baker M, Winchester W, Bulmer D(2012). P2Y mediated activation of mouse and human sensory nerves: Critical role for Nav1.9. NEUROGASTROENTEROLOGY AND MOTILITY vol. 24, 17-18.
Boundouki G, Hockley J, Mcguire C, Knowles C, Aziz Q, Baker M, Bulmer D(2012). The role of Nav1.9 in the activation of visceral afferent fibres by human inflammatory supernatants. NEUROGASTROENTEROLOGY AND MOTILITY vol. 24, 41-41.
Pristera A, Baker MD, Okuse K(2012). Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability. PLOS ONE vol. 7, (8) Article ARTN e40079,
10.1371/journal.pone.0040079
Wen H, Östman J, Bubb KJ, Panayiotou C, Priestley JV, Baker MD, Ahluwalia A(2012). 20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel. J Biol Chem vol. 287, (17) 13868-13876.
10.1074/jbc.M111.334896
Baker MD, Waxman SG(2012). Sodium channel slow inactivation and adaptation in C-fibres. JOURNAL OF PHYSIOLOGY-LONDON vol. 590, (7) 1513-1514.
10.1113/jphysiol.2011.224436
Baker MD, Chen Y-C, Shah SU, Okuse K(2011). In vitro and intrathecal siRNA mediated K(V)1.1 knock-down in primary sensory neurons. Mol Cell Neurosci vol. 48, (3) 258-265.
10.1016/j.mcn.2011.08.007
Lidster K, Jackson S, Coffey P, Baker M, Garthwaite J, Selwood D, Giovannoni G, Baker D(2011). Neuroprotection in a novel optic neuritis model. MULTIPLE SCLEROSIS JOURNAL vol. 17, S435-S435.
Peiris M, Bulmer DC, Baker MD, Boundouki G, Sinha S, Hobson A, Lee K, Aziz Q et al.(2011). Human visceral afferent recordings: preliminary report. Gut vol. 60, (2) 204-208.
10.1136/gut.2010.221820
Boundouki G, Peiris M, Baker MD, Bulmer DC, Aziz Q, Hobson A, Sinha S, Lee K et al.(2010). A novel in vitro model of visceral pain using the human appendix. BRITISH JOURNAL OF SURGERY vol. 97, 31-32.
Zhao J, Lee M-C, Momin A, Cendan C-M, Shepherd ST, Baker MD, Asante C, Bee L et al.(2010). Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds. J Neurosci vol. 30, (32) 10860-10871.
10.1523/JNEUROSCI.1980-10.2010
Baker MD, Wen H(2010). Tethered-toxin debut gets cold reception. J Physiol vol. 588, (Pt 10)
10.1113/jphysiol.2010.190736
Snape A, Pittaway JF, Baker MD(2010). Excitability parameters and sensitivity to anemone toxin ATX-II in rat small diameter primary sensory neurones discriminated by Griffonia simplicifolia isolectin IB4. J Physiol vol. 588, (Pt 1) 125-137.
10.1113/jphysiol.2009.181107
Shao D, Baker MD, Abrahamsen B, Rugiero F, Malik-Hall M, Poon WYL, Cheah KSE, Yao KM et al.(2009). A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel Na(V)1.8. MOL CELL NEUROSCI vol. 42, (3) 219-225.
10.1016/j.mcn.2009.07.003
Baker MD(2009). Action potential initiation in unmyelinated afferents comes in from the cold. J Physiol vol. 587, (Pt 6)
10.1113/jphysiol.2009.170571
Ostman JAR, Nassar MA, Wood JN, Baker MD(2008). GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9. J Physiol vol. 586, (4) 1077-1087.
10.1113/jphysiol.2007.147942
Fertleman CR, Baker MD, Parker KA, Moffatt S, Elmslie FV, Abrahamsen B, Ostman J, Klugbauer N et al.(2006). SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron vol. 52, (5) 767-774.
10.1016/j.neuron.2006.10.006
Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mouldt J, Drinkwater R, Baker MD et al.(2006). mu O-conotoxin MrVIB selectively blocks Na(v)1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. P NATL ACAD SCI USA vol. 103, (45) 17030-17035.
10.1073/pnas.0601819103
Nassar MA, Baker MD, Levato A, Ingram R, Mallucci G, McMahon SB, Wood JN(2006). Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice. Mol Pain vol. 2,
10.1186/1744-8069-2-33
Foulkes T, Nassar MA, Lane T, Matthews EA, Baker MD, Gerke V, Okuse K, Dickenson AH et al.(2006). Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior. J Neurosci vol. 26, (41) 10499-10507.
10.1523/JNEUROSCI.1997-06.2006
Baker MD(2005). Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na+ current in rat and mouse sensory neurones. J Physiol vol. 567, (Pt 3) 851-867.
10.1113/jphysiol.2005.089771
Stirling LC, Forlani G, Baker MD, Wood JN, Matthews EA, Dickenson AH, Nassar MA(2005). Nociceptor-specific gene deletion using heterozygous Na(v)1.8-Cre recombinase mice. PAIN vol. 113, (1-2) 27-36.
10.1016/j.pain.2004.08.015
Wood JN, Boorman JP, Okuse K, Baker MD(2004). Voltage-gated sodium channels and pain pathways. J Neurobiol vol. 61, (1) 55-71.
10.1002/neu.20094
Nassar MA, Stirling LC, Forlani G, Baker MD, Matthews EA, Dickenson AH, Wood JN(2004). Nociceptor-specific gene deletion reveals a major role for Na(v)1.7 (PN1) in acute and inflammatory pain. P NATL ACAD SCI USA vol. 101, (34) 12706-12711.
10.1073/pnas.0404915101
Wood JN, Baker MD, Okuse K, Stirling LC, Nassar M(2004). Voltage-gated sodium channels and pain pathways. FUNDAMENTAL & CLINICAL PHARMACOLOGY vol. 18, 16-16.
Wood JN, Abrahamsen B, Baker MD, Boorman JD, Donier E, Drew LJ, Nassar MA, Okuse K et al.(2004). Ion channel activities implicated in pathological pain. Novartis Found Symp vol. 261, 32-40.
Wood JN, Abrahamsen B, Baker MD, Boorman JD, Donier E, Drew L, Nassar MA, Okuse K et al. (2004). Mechanisms of hyperalgesia: Regulation of nociceptor activation and excitability. HYPERALGESIA: MOLECULAR MECHANISMS AND CLINICAL IMPLICATIONS. Editors: Brune, K, Handwerker, HO, vol. 30, 19-26.
Baker MD, Chandra SY, Ding YN, Waxman SG, Wood JN(2003). GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones. J PHYSIOL-LONDON vol. 548, (2) 373-382.
10.1113/jphysiol.2003.039131
Malik-Hall M, Poon WYL, Baker MD, Wood JN, Okuse K(2003). Sensory neuron proteins interact with the intracellular domains of sodium channel Na(v)1.8. MOL BRAIN RES vol. 110, (2) 298-304.
10.1016/s0169-328x(02)00661-7
Kiernan MC, Baker MD, Bostock H(2003). Characteristics of late Na+ current in adult rat small sensory neurons. NEUROSCIENCE vol. 119, (3) 653-660.
10.1016/S0306-4522(03)00194-5
Baker MD, Chandra SY, Wood JN (2002). Up-regulation of Na+ current attributed to Na(v)1.9 (NaN) changes firing properties of small diameter sensory neurones. JOURNAL OF PHYSIOLOGY-LONDON. vol. 544, 74P-74P.
Okuse K, Malik-Hall M, Baker MD, Poon W-YL, Kong H, Chao MV, Wood JN(2002). Annexin II light chain regulates sensory neuron-specific sodium channel expression. Nature vol. 417, (6889) 653-656.
10.1038/nature00781
Baker MD(2002). Electrophysiology of mammalian Schwann cells. PROG BIOPHYS MOL BIO vol. 78, (2-3) 83-103.
10.1016/S0079-6107(02)00007-X
Wood JN, Akopian AN, Baker M, Ding Y, Geoghegan F, Nassar M, Malik-Hall M, Okuse K et al.(2002). Sodium channels in primary sensory neurons: relationship to pain states. SODIUM CHANNELS AND NEURONAL HYPEREXCITABILITY vol. 241, 159-172.
Wood JN, Baker M(2001). Voltage-gated sodium channels. Curr Opin Pharmacol vol. 1, (1) 17-21.
10.1016/s1471-4892(01)00007-8
Baker MD, Wood JN(2001). Involvement of Na+ channels in pain pathways. Trends Pharmacol Sci vol. 22, (1) 27-31.
10.1016/s0165-6147(00)01585-6
BAKER MD, Wood JN(2001). Voltage-gated sodium channels. Current Opinion in Pharmacology vol. 21, 1-17.
BAKER D. Big conductance calcium-activated potassium channel openers control spasticity without sedation. British Journal of Pharmacology
10.1111/bph.13889
BAKER MD, Kanagaratnam M, Pendleton C, Souza DA, Pettit J, Howells J. Diuretic sensitive electroneutral Na+ movement and temperature effects on central axons. The Journal of Physiology
10.1113/JP273963
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