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Publications:  Dr James Whiteford

Godmann L, Bollmann M, Korb-Pap A, König U, Sherwood J, Beckmann D, Mühlenberg K, Echtermeyer F et al.(2020). Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling. Ann Rheum Dis vol. 79, (4) 481-489.
10.1136/annrheumdis-2019-216847
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64382
Arokiasamy S, Balderstone MJM, De Rossi G, Whiteford JR(2020). Syndecan-3 in Inflammation and Angiogenesis. Frontiers in Immunology vol. 10,
10.3389/fimmu.2019.03031
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62712
De Rossi G, Vahatupa M, Cristante E, Liyanage SE, May U, Uusitalo-Jarvinen H, Bainbridge JW, Jarvinen TAH et al. (2019). A novel role for Syndecan-4 in neovascular eye diseases. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 100, A38-A38.
Whiteford JR, Arokiasamy S, De Rossi G(2019). Translating the matrix. British Journal of Pharmacology vol. 176, (1) 3-4.
10.1111/bph.14517
Vahatupa M, De Rossi G, Jarvinen TAH, Uusitalo-Jarvinen H, Whiteford JR (2018). Sdc4 deficiency leads to reduced VEGFA induced pathological ocular angiogenesis. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. vol. 59,
Eldridge SE, Thomas BL, Shanmuganathan K, Strachan D, Ali A, Thorup A-S, Caxaria S, Nalesso G et al. (2017). AGRIN INHIBITS CANONICAL WNT SIGNALLING THROUGH LRP4. OSTEOARTHRITIS AND CARTILAGE. vol. 25, S165-S165.
10.1016/j.joca.2017.02.281
De Rossi G, Cristante E, Bland E, Bainbridge JW, Whiteford JR (2017). A syndecan-derived peptide for the treatment of Wet age-related macular degeneration. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A15-A15.
De Rossi G, Cristante E, Vahatupa M, Liyanage SE, May U, Pellinen L, Uusitalo-Jarvinen H, Bainbridge JW et al. (2017). VEGFA-driven pathological angiogenesis requires the proteoglycan syndecan-4. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98, A14-A15.
Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD(2016). Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1. The FASEB Journal
10.1096/fj.201600530R
https://qmro.qmul.ac.uk/xmlui/handle/123456789/16583
WHITEFORD J, Ma B, Woodfin, Nourshargh(2016). Underlying chronic inflammation alters the profile and mechanisms of acute neutrophil recruitment. Journal of Pathology
10.1002/path.4776
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15915
Reglerol N, Beall R, Cabrera C, Pickworthl C, Golding M, Whiteford J, Nightingale T, Imhof B et al. (2016). JAM-C deficiency primes endothelial cells for a pro-inflammatory state. FASEB JOURNAL. vol. 30,
Eldridge SE, Petrycki E, Pitzalis C, Whiteford J, Dell'Accio F (2016). MMP3 CLEAVES AGRIN IN CARTILAGE AND REDUCES ITS CHONDROGENIC POTENCY. OSTEOARTHRITIS AND CARTILAGE. vol. 24, S379-S379.
10.1016/j.joca.2016.01.676
Hawkins KE, Joy S, Delhove JMKM, Kotiadis VN, Fernandez E, Fitzpatrick LM, Whiteford JR, King PJ et al.(2016). NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming. Cell Reports vol. 14, (8) 1883-1891.
10.1016/j.celrep.2016.02.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12358
Woodfin A, Beyrau M, Voisin M-B, Ma B, Whiteford JR, Hordijk PL, Hogg N, Nourshargh S(2016). ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia. Blood vol. 127, (7) 898-907.
10.1182/blood-2015-08-664995
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13894
Whiteford JR, De Rossi G, Woodfin A(2016). Mutually Supportive Mechanisms of Inflammation and Vascular Remodeling. vol. 326, 201-278.
10.1016/bs.ircmb.2016.05.001
https://qmro.qmul.ac.uk/xmlui/handle/123456789/37423
Madalli S, Beyrau M, Whiteford J, Duchene J, Nandhra IS, Patel NSA, Motwani MP, Gilroy DW et al.(2015). Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states. Biology of Sex Differences vol. 6, (1)
10.1186/s13293-015-0047-5
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12543
Kay E, Gomez-Garcia L, Woodfin A, Scotland RS, Whiteford JR(2015). Sexual dimorphisms in leukocyte trafficking in a mouse peritonitis model. J Leukoc Biol vol. 98, (5) 805-817.
10.1189/jlb.3A1214-601RR
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15118
Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE et al.(2015). Interleukin-6 stimulates defective angiogenesis. Cancer Research vol. 75, (15) 3098-3107.
10.1158/0008-5472.CAN-15-1227
Rauzi F, Kirkby N, Edin M, Zeldin D, Whiteford J, Mitchell J, Warner T (2015). 15(S)-HETE is a pro-angiogenic factor produced by platelets through COX-1. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. vol. 13, 225-225.
Ma B, Whiteford JR, Nourshargh S, Woodfin A(2015). Angiogenesis associated macrophages support elevated acute inflammatory responses. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 45, 48-48.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11498
De Rossi G, Whiteford JR(2014). Syndecans in angiogenesis and endothelial cell biology. Biochemical Society Transactions vol. 42, (6) 1643-1646.
10.1042/BST20140232
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6640
Kay E, Scotland RS, Whiteford JR (2014). Sex-differences in classical monocyte recruitment during inflammation. CYTOKINE. vol. 70, 50-50.
10.1016/j.cyto.2014.07.102
De Rossi G, Evans AR, Kay E, Woodfin A, McKay TR, Nourshargh S, Whiteford JR(2014). Shed syndecan-2 inhibits angiogenesis. J Cell Sci vol. 127, (Pt 21) 4788-4799.
10.1242/jcs.153015
https://qmro.qmul.ac.uk/xmlui/handle/123456789/11427
De Rossi G, Nourshargh S, Whiteford JR(2014). Shed syndecan-2 is a regulator of angiogenesis. ANGIOGENESIS vol. 17, (3) 756-756.
De Rossi G, Nourshargh S, Whiteford JR(2014). Syndecan-4 is required for VEGF-induced angiogenesis. ANGIOGENESIS vol. 17, (3) 715-715.
Kay E, Nourshargh S, Scotland RS, Whiteford JR(2014). Sex-differences in classical monocyte recruitment during inflammation. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 44, 14-15.
Evans AR, De Rossi G, Woodfin A, Kay E, Leese AJ, Nourshargh S, Whiteford JR(2014). The role of syndecan-4 in inflammation. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 44, 23-23.
Kay E, Scotland RS, Whiteford JR(2014). Toll-like receptors: Role in inflammation and therapeutic potential. Biofactors vol. 40, (3) 284-294.
10.1002/biof.1156
Halai K, Whiteford J, Ma B, Nourshargh S, Woodfin A(2014). ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo. J Cell Sci vol. 127, (Pt 3) 620-629.
10.1242/jcs.137463
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13895
Leinster DA, Colom B, Whiteford JR, Ennis DP, Lockley M, McNeish IA, Aurrand-Lions M, Chavakis T et al.(2013). Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer. FASEB J vol. 27, (10) 4244-4253.
10.1096/fj.13-230441
De Rossi G, Whiteford JR(2013). Novel insight into the biological functions of syndecan ectodomain core proteins. Biofactors vol. 39, (4) 374-382.
10.1002/biof.1104
De Rossi G, Scotland R, Whiteford J(2013). Critical Factors in Measuring Angiogenesis Using the Aortic Ring Model. J Genet Syndr Gene Ther vol. 4, (5)
10.4172/2157-7412.1000147
De Rossi G, Nourshargh S, Whiteford JR (2013). Syndecan extracellular core proteins have anti-angiogenic properties. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 94, A44-A45.
De Rossi G, Whiteford JR(2013). A novel role for syndecan-3 in angiogenesis. F1000Res vol. 2,
10.12688/f1000research.2-270.v1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14730
WHITEFORD J, Xian X, Couchman JR(2012). Syndecans as receptors for pericellular molecules. Extracellular Matrix: Pathobiology and Signaling, Editors: Karamanos, N, Walter de Gruyter
Proebstl D, Voisin MB, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S(2012). Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med vol. 209, (6) 1219-1234.
10.1084/jem.20111622
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14750
Whiteford JR, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S, Couchman JR(2011). Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148. Molecular Biology of the Cell vol. 22, (19) 3609-3624.
10.1091/mbc.E11-02-0099
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14751
Schaefer L, Evan L, Whiteford J, Dyer D, Rowan D (2011). Cell signalling in inflammation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 92, A6-A7.
Whiteford JR, Xian X, Couchman JR (2011). Syndecan-2 core protein directly interacts with the protein tyrosine phosphatase CD148/PTPRJ to promote integrin-mediated adhesion. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 92, A13-A14.
Whiteford JR, Xian X, Couchman JR (2010). Cell adhesion to the adhesion regulatory domains of syndecan-2 and-4 require the protein tyrosine receptor CD148/PTPRJ. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 91, A26-A26.
Gopal S, Bober A, Whiteford JR, Multhaupt H, Yoneda A, Couchman JR(2010). Heparan sulfate chain valency controls syndecan-4 function in cell adhesion. Journal of Biological Chemistry vol. 285, 14247-14258.
10.1074/jbc.M109.056945
Multhaupt HAB, Yoneda A, Whiteford JR, Oh E-S, Lee W, Couchman JR(2009). Syndecan signaling: when, where and why?. J Physiol Pharmacol vol. 60 Suppl 4, 31-38.
Okina E, Manon-Jensen T, Whiteford JR, Couchman JR(2009). Syndecan proteoglycan contributions to cytoskeletal organization and contractility. Scand J Med Sci Sports vol. 19, (4) 479-489.
10.1111/j.1600-0838.2009.00941.x
Whiteford JR, Ko S, Lee W, Couchman JR(2008). Structural and cell adhesion properties of zebrafish syndecan-4 are shared with higher vertebrates. J Biol Chem vol. 283, (43) 29322-29330.
10.1074/jbc.M803505200
Lacroix H, Whiteford JR, Spanu PD(2008). Localization of Cladosporium fulvum hydrophobins reveals a role for HCf-6 in adhesion. FEMS Microbiol Lett vol. 286, (1) 136-144.
10.1111/j.1574-6968.2008.01227.x
Whiteford J, Couchman J (2008). Integrin mediated cell adhesion to the syndecan-4 ectodomain requires N-glycosylation and phosphatases. FASEB JOURNAL. vol. 22,
Alexopoulou AN, Couchman JR, Whiteford JR(2008). The CMV early enhancer/chicken beta actin (CAG) promoter can be used to drive transgene expression during the differentiation of murine embryonic stem cells into vascular progenitors. BMC Cell Biology vol. 9, (2)
10.1186/1471-2121-9-2
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14770
Whiteford JR, Behrends V, Kirby H, Kusche-Gullberg M, Muramatsu T, Couchman JR(2007). Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways. Exp Cell Res vol. 313, (18) 3902-3913.
10.1016/j.yexcr.2007.08.002
Whiteford JR, Couchman JR(2006). A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain. J Biol Chem vol. 281, (43) 32156-32163.
10.1074/jbc.M605553200
Koo BK, Han I, Mortier E, Zimmermann P, Whiteford JR, Couchman JR, Oh ES, Lee W (2006). Structural basis of cell adhesion signalling of syndecan-4 proteoglycan as a cell surface receptor. FEBS JOURNAL. vol. 273, 90-90.
Koo B-K, Jung YS, Shin J, Han I, Mortier E, Zimmermann P, Whiteford JR, Couchman JR et al.(2006). Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling. J Mol Biol vol. 355, (4) 651-663.
10.1016/j.jmb.2005.09.087
Whiteford JR, Lacroix H, Talbot NJ, Spanu PD(2004). Stage-specific cellular localisation of two hydrophobins during plant infection by the pathogenic fungus Cladosporium fulvum. Fungal Genet Biol vol. 41, (6) 624-634.
10.1016/j.fgb.2004.02.005
Johnson H, Whiteford JR, Eckert SE, Spanu PD(2003). Production and secretion of Aspergillus nidulans catalase B in filamentous fungi driven by the promoter and signal peptide of the Cladosporium fulvum hydrophobin gene hcf-1. Curr Genet vol. 44, (3) 155-163.
10.1007/s00294-003-0421-4
Whiteford JR, Spanu PD(2002). Hydrophobins and the interactions between fungi and plants. Mol Plant Pathol vol. 3, (5) 391-400.
10.1046/j.1364-3703.2002.00129.x
Whiteford JR, Spanu PD(2001). The hydrophobin HCf-1 of Cladosporium fulvum is required for efficient water-mediated dispersal of conidia. Fungal Genet Biol vol. 32, (3) 159-168.
10.1006/fgbi.2001.1263
Whiteford JR, Wilson C, Tiwana H, Ebringer A(2000). Genetic diversity in Proteus mirabilis isolates found in the urinary tract of rheumatoid arthritis patients. J INFECTION vol. 41, (3) 245-248.
10.1053/jinf.2000.0740
Whiteford JR, Wood DA, Thurston CF(2000). Characterisation of xylanases produced in liquid and compost cultures of the cultivated mushroom Agaricus bisporus. MYCOLOGICAL RESEARCH vol. 104, 810-819.
10.1017/S0953756299001914
Whiteford JR, Thurston CF(2000). The molecular genetics of cultivated mushrooms. Adv Microb Physiol vol. 42, 1-23.
10.1016/s0065-2911(00)42001-1
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