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Publications:  Prof John Marshall

Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB et al.(2019). The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy. J Pathol
10.1002/path.5320
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58426
Anderson RL, Balasas T, Callaghan J, Coombes RC, Evans J, Hall JA, Kinrade S, Jones D et al.(2019). A framework for the development of effective anti-metastatic agents. Nat Rev Clin Oncol vol. 16, (3) 185-204.
10.1038/s41571-018-0134-8
HUANG D, PATEL K, Perez-Garrido S, MARSHALL J, PALMA M(2019). DNA Origami Nanoarrays for Multivalent Investigations of Cancer Cell Spreading with Nanoscale Spatial Resolution and Single- Molecule Control. ACS Nano
10.1021/acsnano.8b08010
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54850
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker A-M, Kapitonova E, Bakhouche BA, Tanner Y et al.(2018). PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer. Cell Rep vol. 22, (9) 2469-2481.
10.1016/j.celrep.2018.02.028
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56422
Man YKS, Davies JA, Coughlan L, Pantelidou C, Blázquez-Moreno A, Marshall JF, Parker AL, Halldén G(2018). The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells. Mol Cancer Ther vol. 17, (2) 575-587.
10.1158/1535-7163.MCT-17-0671
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56038
Marshall JF(2018). Targeting CDH17 in Cancer: When Blocking the Ligand Beats Blocking the Receptor?. Clin Cancer Res vol. 24, (2) 253-255.
10.1158/1078-0432.CCR-17-2823
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56040
Pinnington SJL, Marshall JF, Wheeler AP(2018). Correlative 3D Structured Illumination Microscopy and Single-Molecule Localization Microscopy for Imaging Cancer Invasion. Methods Mol Biol vol. 1764, 253-265.
10.1007/978-1-4939-7759-8_15
Caley M, Martins V, Moore K, Lashari M, Marshall J, O'Toole EA (2017). Tumour associated macrophage recruitment in SCC. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 137, S250-S250.
10.1016/j.jid.2017.07.531
Hayward M, Allen MD, Gomm JJ, Haywood L, Marshall JF, Jones LJ (2017). Myoepithelial Cell Phenotype in DCIS Progression: Functional Significance of Integrin alpha v beta 6 and Fibronectin. JOURNAL OF PATHOLOGY. vol. 243, S16-S16.
Raab-Westphal S, Marshall JF, Goodman SL(2017). Integrins as Therapeutic Targets: Successes and Cancers. Cancers (Basel) vol. 9, (9)
10.3390/cancers9090110
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34005
Hung K-Y, Harris PWR, Desai A, Marshall JF, Brimble MA(2017). Structure-activity relationship study of the tumour-targeting peptide A20FMDV2 via modification of Lys16, Leu13, and N- and/or C-terminal functionality. Eur J Med Chem vol. 136, 154-164.
10.1016/j.ejmech.2017.05.008
Tod J, Hanley CJ, Morgan MR, Rucka M, Mellows T, Lopez M-A, Kiely P, Moutasim KA et al.(2017). Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch. J Pathol vol. 243, (1) 37-50.
10.1002/path.4923
https://qmro.qmul.ac.uk/xmlui/handle/123456789/33525
Hodgins NO, Al-Jamal WT, Wang JT-W, Klippstein R, Costa PM, Sosabowski JK, Marshall JF, Maher J et al.(2017). Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy. J Control Release vol. 256, 141-152.
10.1016/j.jconrel.2017.04.025
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22659
Sarper M, Allen MD, Gomm J, Haywood L, Decock J, Thirkettle S, Ustaoglu A, Sarker S-J et al.(2017). Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function. Breast Cancer Res vol. 19, (1)
10.1186/s13058-017-0822-9
Rudran B, Desai A, Luzarraga M, Hodivala-Dilke K, Foster J, Sosabowski J, Marshall J (2017). Development of non-invasive imaging of integrin alpha-v-beta-6 (alpha v beta 6)-positive lung cancers in advance of testing alpha v beta 6-targeted therapies. Lung Cancer. Conference: British Thoracic Oncology Group Conference 2017 (Dublin, Ireland) from: 25/01/2017 to: 27/01/2017, vol. 103, S4-S4.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25184
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A et al.(2017). Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells. Mol Ther vol. 25, (1) 259-273.
10.1016/j.ymthe.2016.10.012
https://qmro.qmul.ac.uk/xmlui/handle/123456789/49611
Hayward M, Allen MD, Dreger S, Marshall JF, Jones JL (2016). Investigating the Functional Significance of Aberrant alpha v beta 6 and Fibronectin Expression in Myoepithelial Cells: Role in the Progression of DCIS?. JOURNAL OF PATHOLOGY. vol. 240, 28-28.
Caley M, Martins V, Moore K, Lashari M, Kahari V, Nissinen L, Donaldson M, Marshall J et al. (2016). Loss of Laminin alpha 3 drives SCC invasion via ROCK signalling. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 136, S241-S241.
10.1016/j.jid.2016.06.494
Heuser S, Hufbauer M, Steiger J, Marshall J, Sterner-Kock A, Mauch C, Zigrino P, Akgül B(2016). The fibronectin/α3β1 integrin axis serves as molecular basis for keratinocyte invasion induced by βHPV. Oncogene vol. 35, (34) 4529-4539.
10.1038/onc.2015.512
Khan Z, Marshall JF(2016). The role of integrins in TGFβ activation in the tumour stroma. Cell and Tissue Research vol. 365, (3) 657-673.
10.1007/s00441-016-2474-y
Caley M, Martins V, Moore K, Lashari M, Donaldson M, Marshall JF, O'Toole EA (2016). ROCK and Rac1 signalling in squamous cell carcinoma with loss of laminin 332. BRITISH JOURNAL OF DERMATOLOGY. vol. 174, E51-E51.
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic R, Violette S, Ghaem-Maghami S, Vallath S et al. (2016). Chimeric antigen receptor T-cells targeting the alpha v beta 6 integrin demonstrate potent antitumor activity in multiple solid tumors. CANCER IMMUNOLOGY RESEARCH. vol. 4,
10.1158/2326-6074.CRICIMTEATIAACR15-B129
Pantelidou C, Man YKS, Coughlan L, Marshall J, Kocher H, Hallden G(2016). Oncolytic adenoviral mutants deleted in the anti-apoptotic E1B19K gene sensitize pancreatic cancer cells to drug-induced DNA damage. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 38, S58-S58.
Slack RJ, Hafeji M, Rogers R, Ludbrook SB, Marshall JF, Flint DJ, Pyne S, Denyer JC(2016). Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2. Pharmacology vol. 97, (3-4) 114-125.
10.1159/000443180
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M et al.(2015). Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC. J Natl Cancer Inst vol. 108, (1)
10.1093/jnci/djv293
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29087
Paillas S, Desai A, Quetier I, Marshall J, Pouget J, Sosabowski J (2015). Targeted Radionuclide Therapy using high-LET particle emitter-labeled vectors against alpha-v-beta6-expressing cancers. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. vol. 42, S201-S201.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/10035
Martins V, Caley M, Moore K, Szentpetery Z, Marsh S, Murrell DF, Kaehaeri V, McGrath J et al. (2015). Skin type VII collagen acts as a tumour suppressor by regulating TGF beta and angiogenesis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 135, S28-S28.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/10961
Caley M, Martins V, Marsh S, Moore K, Lashari M, Donaldson MJ, Marshall J, O'toole E (2015). Squamous Cell Carcinoma progression and Laminin 332. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 135, S23-S23.
Reader CS, Vallath S, Morton J, Steele C, Kocher HM, Keyse SM, Sansom O, Marshall JF (2015). Cell lines generated from PDAC transgenic mice reveal integrin alpha v beta 6 modifies the invasive phenotype of pancreatic cancer. CANCER RESEARCH. vol. 75,
10.1158/1538-7445.PANCA2014-B87
Rudran B, Marshall JF (2015). The integrin alpha v beta 6: a new target for therapy in non-small cell Lung cancer. LUNG CANCER. vol. 87, S3-S3.
10.1016/S0169-5002(15)50007-X
https://qmro.qmul.ac.uk/xmlui/handle/123456789/9506
Allen MD, Marshall JF, Jones JL(2014). αvβ6 Expression in myoepithelial cells: a novel marker for predicting DCIS progression with therapeutic potential. Cancer Res vol. 74, (21) 5942-5947.
10.1158/0008-5472.CAN-14-1841
Caley M, Martins V, Moore K, Marshall J, O'toole E (2014). Diverse roles for laminin 332 subunits in squamous cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 134, S19-S19.
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al.(2014). Therapeutic targeting of integrin αvβ6 in breast cancer. J Natl Cancer Inst vol. 106, (8)
10.1093/jnci/dju169
https://qmro.qmul.ac.uk/xmlui/handle/123456789/8829
Elosegui-Artola A, Bazellières E, Allen MD, Andreu I, Oria R, Sunyer R, Gomm JJ, Marshall JF et al.(2014). Rigidity sensing and adaptation through regulation of integrin types. Nat Mater vol. 13, (6) 631-637.
10.1038/nmat3960
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6445
Moutasim KA, Mellows T, Mellone M, Lopez M-A, Tod J, Kiely PC, Sapienza K, Greco A et al.(2014). Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function. JOURNAL OF PATHOLOGY vol. 233, (2) 196-208.
10.1002/path.4342
Muhammad H, Taher T, Mullen L, Pastan I, Marshall J, Chernajovsky Y, Gould D, Mageed R (2014). Development of a novel approach for targeted delivery of siRNA to B lymphocytes with a potential application in cancer. HUMAN GENE THERAPY. vol. 25, A5-A5.
Caley M, Martins V, Moore K, Marshall J, O'Toole E (2014). Diverse roles for laminin-332 subunits in squamous cell carcinoma. BRITISH JOURNAL OF DERMATOLOGY. vol. 170, E26-E26.
Allen MD, Thomas GJ, Clark S, Dawoud MM, Vallath S, Payne SJ, Gomm JJ, Dreger SA et al.(2014). Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence. Clin Cancer Res vol. 20, (2) 344-357.
10.1158/1078-0432.CCR-13-1504
Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al.(2014). A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma. Genome Med vol. 6, (12)
10.1186/s13073-014-0105-3
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6841
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al.(2013). Integrin avb6 is a therapeutic target for high-risk breast cancer and enhances trastuzumab efficacy. CANCER RESEARCH vol. 73,
10.1158/0008-5472.SABCS13-P4-15-01
John AE, Luckett JC, Tatler AL, Awais RO, Desai A, Habgood A, Ludbrook S, Blanchard AD et al.(2013). Preclinical SPECT/CT Imaging of alpha v beta 6 Integrins for Molecular Stratification of Idiopathic Pulmonary Fibrosis. JOURNAL OF NUCLEAR MEDICINE vol. 54, (12) 2146-2152.
10.2967/jnumed.113.120592
Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J et al.(2013). Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology vol. 145, (5) 1121-1132.
10.1053/j.gastro.2013.07.025
Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K et al.(2013). Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research vol. 15, (5)
10.1186/bcr3493
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al.(2013). Therapeutic targeting of integrin alpha v beta 6 in high-risk breast cancer. MOLECULAR CANCER RESEARCH vol. 11,
10.1158/1557-3125.ADVBC-B046
Eberlein C, Kendrew J, McDaid K, Alfred A, Kang JS, Jacobs VN, Ross SJ, Rooney C et al.(2013). A human monoclonal antibody 264RAD targeting alpha v beta 6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo. ONCOGENE vol. 32, (37) 4406-4416.
10.1038/onc.2012.460
Caley MP, Martins V, Moore K, Marshall JF, O'Toole EA (2013). Diverse roles for laminin 332 subunits in squamous cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S64-S64.
Martins VL, Caley MP, Moore K, Szentpetery Z, Murrell DF, Kim MH, McGrath JA, Cerio R et al. (2013). Loss of type VII collagen in cutaneous SCC increases angiogenesis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S158-S158.
Sarper M, Allen MD, Decock J, Thirkettle S, Edwards DR, Marshall JF, Jones LJ (2013). MMP-8 Loss Contributes to Altered Myoepithelial Cell Function in DCIS. JOURNAL OF PATHOLOGY. vol. 229, S11-S11.
Ali I, Gautrot J, Caley M, Marshall JF, Wheeler A(2013). Formation and inhibition of invadopodia in oral squamous cell carcinoma. MOLECULAR BIOLOGY OF THE CELL vol. 24,
Kogelberg H, Miranda E, Burnet J, Ellison D, Tolner B, Foster J, Picón C, Thomas GJ et al.(2013). Generation and characterization of a diabody targeting the αvβ6 integrin. PLoS One vol. 8, (9)
10.1371/journal.pone.0073260
John AE, Luckett JC, Tatler AL, Awais RO, Habgood A, Ludbrook S, Blanchard A, Perkins AC et al. (2013). Pre-Clinical Imaging Of The alpha v beta 6 Integrin For Molecular Stratification Of Idiopathic Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 187,
Elosegui-Artola A, Bazellieres E, Allen MD, Andreu I, Marshall JF, Jones JL, Trepat X, Roca-Cusachs P(2013). Rigidity sensing and adaptation through regulation of integrin populations. MOLECULAR BIOLOGY OF THE CELL vol. 24,
Man YKS, DiCara D, Chan N, Vessillier S, Mather SJ, Rowe ML, Howard MJ, Marshall JF et al.(2013). Structural guided scaffold phage display libraries as a source of bio-therapeutics. PLoS One vol. 8, (8)
10.1371/journal.pone.0070452
John AE, Luckett J, Awas R, Habgood A, Ludbrook S, Blanchard A, Perkins A, Jenkins RG et al. (2012). TARGETED IN VIVO IMAGING OF THE alpha V beta 6 INTEGRIN IN MICE WITH BLEOMYCIN-INDUCED LUNG FIBROSIS. THORAX. vol. 67, A33-A33.
10.1136/thoraxjnl-2012-202678.072
Awais RO, Mather SJ, John AE, Luckett JCA, Habgood A, Jenkins GR, Marshall JF, Perkins AC (2012). NanoSPECT/CT imaging of pulmonary alpha v beta 6 with [In-111]A20FMDV2 as a surrogate marker for monitoring lung fibrosis. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. vol. 39, S215-S215.
Martins V, Caley M, Moore K, Murrell DF, McGrath JA, Chen M, Marshall JF, O'Toole EA (2012). Loss of keratinocyte type VII collagen in SCC increases TGF-beta signalling and angiogenesis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 132, S45-S45.
Dreger SA, Payne SJ, Dawoud M, Robinson SD, Marshall JF, Hodivala-Dilke KM, Allen MD, Jones JL (2012). Up-regulation of alpha v beta 6 integrin and fibronectin EDA in myoepithelial cells contribute to the angiogenic switch in pre-invasive breast cancer. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 93, A24-A24.
Ahmed KO, Allen M, Gomm J, Marshall J, Jones JL (2012). MYOEPITHELIAL CONTROL OF THE INFLAMMATORY MICROENVIRONMENT PROMOTES TRANSITION OF DCIS TO INVASIVE DISEASE. ANNALS OF ONCOLOGY. vol. 23, 19-19.
Martins V, Caley M, Moore K, Chen M, Marshall J, O'Toole E (2012). Loss of type VII collagen in squamous cell carcinoma increases angiogenesis in vitro and in vivo. BRITISH JOURNAL OF DERMATOLOGY. vol. 166, e25-e26.
Lines KE, Chelala C, Dmitrovic B, Wijesuriya N, Kocher HM, Marshall JF, Crnogorac-Jurcevic T(2012). S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells. Am J Pathol vol. 180, (4) 1485-1494.
10.1016/j.ajpath.2011.12.031
Sarper M, Allen M, Decock J, Marshall JF, Edwards DR, Jones JL (2012). Loss of MMP-8 Expression Contributes to Altered Myoepithelial Cell Function in DCIS. JOURNAL OF PATHOLOGY. vol. 226, S13-S13.
Wagstaff JL, Rowe ML, Hsieh S-J, DiCara D, Marshall JF, Williamson RA, Howard MJ(2012). NMR relaxation and structural elucidation of peptides in the presence and absence of trifluoroethanol illuminates the critical molecular nature of integrin alpha v beta 6 ligand specificity. RSC ADVANCES vol. 2, (29) 11019-11028.
10.1039/c2ra21655h
Moore KM, Hart IR, Jones LJ, Marshall JF(2011). Integrin avb6 Mediates HER2-Driven Invasion in Breast Cancer. CANCER RESEARCH vol. 71,
10.1158/0008-5472.SABCS11-P2-01-05
Martins VL, Moore K, Chen M, Marshall J, O'Toole EA (2011). Loss of type VII collagen in SCC leads to increased invasion and TGF-beta signalling in vivo. BRITISH JOURNAL OF DERMATOLOGY. vol. 164, 910-910.
Martins V, Moore K, Chen M, Marshall J, O'Toole EA (2011). Loss of type VII collagen in squamous cell carcinoma leads to increased invasion and TGF-beta signalling in vivo. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 131, S33-S33.
Morgan MR, Jazayeri M, Ramsay AG, Thomas GJ, Boulanger MJ, Hart IR, Marshall JF(2011). Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion. Oncogene vol. 30, (12) 1422-1435.
10.1038/onc.2010.535
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al.(2011). Stromal features are predictive of disease mortality in oral cancer patients. J Pathol vol. 223, (4) 470-481.
10.1002/path.2830
Moutasim KA, Jenei V, Sapienza K, Marsh D, Weinreb PH, Violette SM, Lewis MP, Marshall JF et al.(2011). Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. J Pathol vol. 223, (3) 366-377.
10.1002/path.2786
Marshall J(2011). Transwell(®) invasion assays. Methods Mol Biol vol. 769, 97-110.
10.1007/978-1-61779-207-6_8
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al.(2010). Stromal features are predictive of disease mortality in oral cancer patients. J Pathol
10.1002/path.2830
Moutasim KA, Jenei V, Sapienza K, Marsh D, Weinreb PH, Violette SM, Lewis MP, Marshall JF et al.(2010). Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. J Pathol
10.1002/path.2786
Moutasim KA, Jenei V, Sapienza K, Marsh D, Marshall J, Fortune F, Tilakaratne WM, Hart IR et al.(2010). Alkaloid-dependent upregulation of AlphavBeta6 integrin promotes oral submucous fibrosis. ORAL DIS vol. 16, (6) 528-528.
Saha A, Ellison D, Thomas GJ, Vallath S, Mather SJ, Hart IR, Marshall JF(2010). High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin alphavbeta6. J Pathol vol. 222, (1) 52-63.
10.1002/path.2745
Froeling FEM, Marshall JF, Kocher HM(2010). Pancreatic cancer organotypic cultures. J Biotechnol vol. 148, (1) 16-23.
10.1016/j.jbiotec.2010.01.008
Sampaio ALF, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF, Perretti M(2010). Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis. J Leukoc Biol vol. 87, (5) 877-884.
10.1189/jlb.1009670
Alexopoulou AN, Leao M, Caballero OL, Da Silva L, Reid L, Lakhani SR, Simpson AJ, Marshall JF et al.(2010). Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines. Breast Cancer Res vol. 12, (4)
10.1186/bcr2610
Wagstaff JL, Vallath S, Marshall JF, Williamson RA, Howard MJ(2010). Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin alpha v beta 6 protein-peptide interactions. CHEM COMMUN vol. 46, (40) 7533-7535.
10.1039/c0cc01846e
Payne SJL, Allen M, Dreger S, Marshall J, Hodiavala-Dilke K, Hart I, Jones L (2009). Myoepithelial Cells in DCIS Exhibit an Altered Phenotype and Promote Angiogenesis. CANCER RESEARCH. vol. 69, 642S-643S.
Robinson SD, Reynolds LE, Kostourou V, Reynolds AR, da Silva RG, Tavora B, Baker M, Marshall JF et al.(2009). Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis. J Biol Chem vol. 284, (49) 33966-33981.
10.1074/jbc.M109.030700
Gagnon MKJ, Hausner SH, Marik J, Abbey CK, Marshall JF, Sutcliffe JL(2009). High-throughput in vivo screening of targeted molecular imaging agents. P NATL ACAD SCI USA vol. 106, (42) 17904-17909.
10.1073/pnas.0906925106
Hausner SH, Abbey CK, Bold RJ, Gagnon MK, Marik J, Marshall JF, Stanecki CE, Sutcliffe JL(2009). Targeted In vivo Imaging of Integrin alpha(v)beta(6) with an Improved Radiotracer and Its Relevance in a Pancreatic Tumor Model. CANCER RES vol. 69, (14) 5843-5850.
10.1158/0008-5472.CAN-08-4410
Coughlan L, Vallath S, Saha A, Flak M, McNeish IA, Vassaux G, Marshall JF, Hart IR et al.(2009). In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery. J Virol vol. 83, (13) 6416-6428.
10.1128/JVI.00445-09
Coughlan L, Vallath S, Saha A, McNeish IA, Vassaux G, Marshall JF, Hart IR, Thomas GJ (2009). An Ad5 Vector Retargeted to alpha v beta 6 Displays Improved Tumour Transduction Combined with Reduced Liver Uptake Following Systemic Delivery. MOLECULAR THERAPY. vol. 17, S323-S323.
Sampaio ALF, Leoni G, Marshall JF, Perretti M (2009). A role for alpha 5 beta 1 integrin in leukocyte accumulation in acute peritonitis. EUR J CLIN INVEST. vol. 39, 22-23.
Hausner SH, Kukis DL, Gagnon MKJ, Stanecki CE, Ferdani R, Marshall JF, Anderson CJ, Sutcliffe JL(2009). Evaluation of [Cu-64]Cu-DOTA and [Cu-64]Cu-CB-TE2A Chelates for Targeted Positron Emission Tomography with an alpha(v)beta(6)-Specific Peptide. MOL IMAGING vol. 8, (2) 111-121.
10.2310/7290.2009.00015
Kogelberg H, Tolner B, Thomas GJ, Di Cara D, Minogue S, Ramesh B, Sodha S, Marsh D et al.(2008). Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus. J Mol Biol vol. 382, (2) 385-401.
10.1016/j.jmb.2008.07.013
Coughlan L, McNeish I, Vassaux G, Marshall J, Hart IR, Thomas G (2008). Transductional retargeting of adenovirus-5 to alphavbeta6 integrin. HUMAN GENE THERAPY. vol. 19, 1102-1102.
Lees DM, Hart IR, Marshall JF(2008). Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues. J Mol Biol vol. 379, (4) 645-655.
10.1016/j.jmb.2008.04.020
Roy S, Marshall JF, Speight PM, Whawell SA (2008). Role of alpha 9 beta 1 integrin in the regulation of epithelial cell behaviour. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 89, A8-A9.
Marsh D, Dickinson S, Neill GW, Marshall JF, Hart IR, Thomas GJ(2008). alpha v beta 6 integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation. CANCER RES vol. 68, (9) 3295-3303.
10.1158/0008-5472.CAN-08-0174
Dicara D, Burman A, Clark S, Berryman S, Howard MJ, Hart IR, Marshall JF, Jackson T(2008). Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness. J Virol vol. 82, (3) 1537-1546.
10.1128/JVI.01480-07
Allen M, Mulligan K, Clark S, Hart I, Marshall JF, Jones JL (2008). De novo expression of alpha(v)beta(6) integrin by myoepithelial cells in ductal carcinoma in situ may be an important marker of disease progression. BREAST CANCER RESEARCH. vol. 10, S16-S16.
10.1186/bcr1912
Jones JL, Thomas GJ, Duffy SW, Gabe R, Ellis I, Green A, Saha A, Mulligan KT et al. (2007). Expression of alphavbeta6 supersedes Her2 and triple-negative/basal classification of breast cancer and defines novel subgroups with poor survival: implications for breast cancer classification and treatment. BREAST CANCER RESEARCH AND TREATMENT. vol. 106, S11-S11.
Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E(2007). Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol vol. 9, (12) 1392-1400.
10.1038/ncb1658
Ramsay AG, Marshall JF, Hart IR(2007). Integrin trafficking and its role in cancer metastasis. Cancer Metastasis Rev vol. 26, (3-4) 567-578.
10.1007/s10555-007-9078-7
Clark SE, Marshall JE, Hart IR, Carpenter R, Jones JL (2007). Molecular profiling of DCIS: identification of distinct subgroups of potential prognostic importance. BREAST CANCER RESEARCH AND TREATMENT. vol. 106, S221-S221.
Hausner SH, DiCara D, Marik J, Marshall JF, Sutcliffe JL(2007). Use of a peptide derived from foot-and-mouth disease virus for the Noninvasive Imaging of human cancer: Generation and evaluation of 4-[F-18]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin alpha(v)beta(6) expression with positron emission tomography. CANCER RES vol. 67, (16) 7833-7840.
10.1158/0008-5472.CAN-07-1026
Ramsay AG, Keppler MD, Jazayeri M, Thomas GJ, Parsons M, Violette S, Weinreb P, Hart IR et al.(2007). HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6. Cancer Res vol. 67, (11) 5275-5284.
10.1158/0008-5472.CAN-07-0318
DiCara D, Rapisarda C, Sutcliffe JL, Violette SM, Weinreb PH, Hart IR, Howard MJ, Marshall JF(2007). Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands. J Biol Chem vol. 282, (13) 9657-9665.
10.1074/jbc.M610461200
Nystrom ML, McCulloch D, Weinreb PH, Violette SM, Speight PM, Marshall JF, Hart IR, Thomas GJ(2006). Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion. Cancer Res vol. 66, (22) 10833-10842.
10.1158/0008-5472.CAN-06-1640
Hart I, Dicara D, Marshall JF(2006). Targeting the invasion-association integrin alphavbeta6 as an anti-carcinoma strategy. EJC SUPPL vol. 4, (12) 82-82.
10.1016/S1359-6349(06)70260-9
Thomas GJ, Nyström ML, Marshall JF(2006). Alphavbeta6 integrin in wound healing and cancer of the oral cavity. J Oral Pathol Med vol. 35, (1) 1-10.
10.1111/j.1600-0714.2005.00374.x
Allen M, Mulligan K, Clark S, Hart I, Marshall JF, Jones JL (2006). Functional analysis of normal and DCIS modified breast myoepithelial cells. BREAST CANCER RESEARCH. vol. 8, S9-S9.
10.1186/bcr1569
Salama I, Mihaimeed F, Marshall J, Jazayeri M, Thomas G, Duffy S, Jones LJ (2006). S100A7 and the basal phenotype in breast cancer. BREAST CANCER RESEARCH AND TREATMENT. vol. 100, S159-S159.
Hooper S, Marshall JF, Sahai E(2006). Tumor cell migration in three dimensions. Methods Enzymol vol. 406, 625-643.
10.1016/S0076-6879(06)06049-6
Ylipalosaari M, Thomas GJ, Nystrom M, Salhimi S, Marshall JF, Huotari V, Tervahartiala T, Sorsa T et al.(2005). alpha v beta 6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells. EXP CELL RES vol. 309, (2) 273-283.
10.1016/j.yexcr.2005.06.008
Vyas J, Ahmed W, Jayazeri M, Marshall JF, Proby CM, Storey A, O'Toole EA (2005). Mechanisms of migration and invasion of squamous cell carcinoma in an in vitro model of squamous cell carcinogenesis. BRITISH JOURNAL OF DERMATOLOGY. vol. 152, 843-843.
Vyas JJ, Ahmed W, Jayazeri M, Baksh N, Marshall JF, Proby CM, Storey A, O'Toole EA (2005). Migration and invasion mechanisms in an in vitro model of squamous cell carcinogenesis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 124, A22-A22.
Nyström ML, Thomas GJ, Stone M, Mackenzie IC, Hart IR, Marshall JF(2005). Development of a quantitative method to analyse tumour cell invasion in organotypic culture. J Pathol vol. 205, (4) 468-475.
10.1002/path.1716
Scott KA, Arnott CH, Robinson SC, Moore RJ, Thompson RG, Marshall JF, Balkwill FR(2004). TNF-alpha regulates epithelial expression of MMP-9 and integrin alphavbeta6 during tumour promotion. A role for TNF-alpha in keratinocyte migration?. Oncogene vol. 23, (41) 6954-6966.
10.1038/sj.onc.1207915
Nystrom M, Stone M, Thomas GJ, Mackenzie I, Hart IR, Marshall JF (2004). A quantitative method for measuring three-dimensional invasion in vitro using organotypic cultures. BRITISH JOURNAL OF CANCER. vol. 91, S58-S58.
Lygoe KA, Norman JT, Marshall JF, Lewis MP(2004). alpha v integrins play an important role in myofibroblast differentiation. WOUND REPAIR REGEN vol. 12, (4) 461-470.
10.1111/j.1067-1927.2004.12402.x
Morgan MR, Thomas GJ, Russell A, Hart IR, Marshall JF(2004). The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9. J Biol Chem vol. 279, (25) 26533-26539.
10.1074/jbc.M401736200
Huntley SP, Davies M, Matthews JB, Thomas G, Marshall J, Robinson CM, Eveson JW, Paterson IC et al.(2004). Attenuated type II TGF-B receptor signalling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination. INT J CANCER vol. 110, (2) 170-176.
10.1002/ijc.20111
HART IR, Joshi D, Marshall JF, Russel A, Thomas GJ, Morgan MR(2004). The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote MMP-2 or MMP-9-mediated tumour cell invasion. J. Biol. Chem vol. 279, 26533-26539.
10.1074/jbc.M401736200
Dalvi N, Thomas GJ, Marshall JF, Morgan M, Bass R, Ellis V, Speight PM, Whawell SA(2004). Modulation of the urokinase-type plasminogen activator receptor by the beta 6 integrin subunit. BIOCHEM BIOPH RES CO vol. 317, (1) 92-99.
10.1016/j.bbrc.2004.02.178
Zhu G, Gilchrist R, Borley N, Chng HW, Morgan M, Marshall JF, Camplejohn RS, Muir GH et al.(2004). Reduction of TSG101 protein has a negative impact on tumor cell growth. INT J CANCER vol. 109, (4) 541-547.
10.1002/ijc.20014
Lewis MP, Lygoe KA, Nystrom ML, Anderson WP, Speight PM, Marshall JF, Thomas GJ(2004). Tumour-derived TGF-beta 1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells. BRIT J CANCER vol. 90, (4) 822-832.
10.1038/sj.bjc.6601611
Bukhary SM, Assmann V, Marshall JF, Speight PM, Thomas GJ (2003). Restoration of e-cadherin function alters morphology of oral squamous carcinoma cells. JOURNAL OF DENTAL RESEARCH. vol. 82, 485-485.
Thomas GJ, Hart IR, Marshall JF, Speight PM (2003). av beta 6 integrin interaction with the tgf-beta 1 latency-associated peptide (lap). JOURNAL OF DENTAL RESEARCH. vol. 82, 485-485.
Morgan MR, Thomas GJ, Marshall JF (2003). b6-integrin cytoplasmic tail: novel intracellular target for inhibiting oral scc invasion. JOURNAL OF DENTAL RESEARCH. vol. 82, 472-472.
Wan H, Stone MG, Simpson C, Reynolds LE, Marshall JF, Hart IR, Hodivala-Dilke KM, Eady RAJ(2003). Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes. J CELL SCI vol. 116, (20) 4239-4248.
10.1242/jcs.00701
Drayton S, Rowe J, Jones R, Vatcheva R, Cuthbert-Heavens D, Marshall J, Fried M, Peters G(2003). Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes. Cancer Cell vol. 4, (4) 301-310.
10.1016/S1535-6108(03)00242-3
South AP, Wan H, Stone MG, Dopping-Hepenstal PJC, Purkis PE, Marshall JF, Leigh IM, Eady RAJ et al.(2003). Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability. J CELL SCI vol. 116, (16) 3303-3314.
10.1242/jcs.00636
Zhu G, Reynolds L, Crnogorac-Jurcevic T, Gillett CE, Dublin EA, Marshall JF, Barnes D, D'Arrigo C et al.(2003). Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer. Oncogene vol. 22, (24) 3742-3748.
10.1038/sj.onc.1206428
Morgan MR, Thomas GJ, Marshall JF(2003). beta 6-integrin cytoplasmic tail: Novel intracellular target for inhibiting oral SCC invasion. J DENT RES vol. 82, B327-B327.
Hampton R, Walker M, Marshall J, Juhl H(2002). Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells. ONCOGENE vol. 21, (51) 7817-7823.
10.1038/sj.onc.1205906
Thomas GJ, Hart IR, Speight PM, Marshall JF(2002). Binding of TGF-beta 1 latency-associated peptide (LAP) to alpha v beta 6 integrin modulates behaviour of squamous carcinoma cells. BRIT J CANCER vol. 87, (8) 859-867.
10.1038/sj.bjc.6600545
Sutcliffe-Goulden JL, O'Doherty MJ, Marsden PK, Hart IR, Marshall JF, Bansal SS(2002). Rapid solid phase synthesis and biodistribution of F-18-labelled linear peptides. EUR J NUCL MED MOL I vol. 29, (6) 754-759.
10.1007/s00259-001-0756-3
Morgan MR, Thomas GJ, Russell A, Speight PM, Hart IR, Marshall JF(2002). The ss 6 integrin subunit C-terminal 11 amino acids are sufficient to promote invasion by squamous cell carcinoma (SCC) cells. BRIT J CANCER vol. 86, S120-S120.
Sutcliffe-Goulden JL, Marshall JF, O'Doherty MJ, Bansal S(2002). Solid phase synthesis of F-18-labelled cyclic peptides. J NUCL MED vol. 43, (5) 365P-365P.
Cassidy J, Twelves C, Van Cutsem E, Hoff P, Bajetta E, Boyer M, Bugat R, Burger U et al.(2002). First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. ANN ONCOL vol. 13, (4) 566-575.
10.1093/annonc/mdf089
Davison E, Kirby I, Whitehouse J, Hart I, Marshall JF, Santis G(2001). Adenovirus type 5 uptake by lung adenocarcinoma cells in culture correlates with Ad(5) fibre binding is mediated by alpha(v)beta(1) integrin and can be modulated by changes in beta(1) integrin function. J GENE MED vol. 3, (6) 550-559.
10.1002/jgm.223
Thomas GJ, Lewis MP, Whawell SA, Russell A, Sheppard D, Hart IR, Speight PM, Marshall JF(2001). Expression of the alpha v beta 6 integrin promotes migration and invasion in squamous carcinoma cells. J INVEST DERMATOL vol. 117, (1) 67-73.
10.1046/j.0022-202x.2001.01379.x
Gilchrist R, Stafford H, Duddy PM, Marshall JF, Camplejohn RS, Hart IR(2001). Mechanisms of adhesion-dependence in mouse melanocyte-derived cell lines. BRIT J CANCER vol. 85, 82-82.
Morgan MR, Thomas GJ, Speight PM, Hart IR, Marshall JF(2001). The terminal 11a.a. cytoplasmic tail of the beta 6 integrin subunit is essential for the promotion of alpha V beta 6-dependent invasion. BRIT J CANCER vol. 85, 22-22.
Thomas GJ, Lewis MP, Hart IR, Marshall JF, Speight PM(2001). alpha V beta 6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9. INT J CANCER vol. 92, (5) 641-650.
10.1002/1097-0215(20010601)92:5<641::AID-IJC1243>3.0.CO;2-P
Thomas GJ, Poomsawat S, Lewis MP, Hart IR, Speight PM, Marshall JF(2001). alpha v beta 6 integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes. J INVEST DERMATOL vol. 116, (6) 898-904.
10.1046/j.1523-1747.2001.01352.x
Thomas GJ, Poomsawat S, Lewis MP, Marshall JF, Speight PM(2001). alpha v beta 6-dependent upregulation of MMP-9 promotes keratinocyte migration. J DENT RES vol. 80, (4) 1155-1155.
Hapke S, Gawaz M, Dehne K, Kohler J, Marshall JF, Graeff H, Schmitt M, Reuning U et al.(2001). beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter. MOL CELL BIOL vol. 21, (6) 2118-2132.
10.1128/MCB.21.6.2118-2132.2001
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54303
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