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Publications:  Prof Kenneth Linton

Adamska A, Domenichini A, Capone E, Damiani V, Akkaya BG, Linton KJ, Di Sebastiano P, Chen X et al.(2019). Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer. J Exp Clin Cancer Res vol. 38, (1)
10.1186/s13046-019-1308-7
Adamska A, Ferro R, Lattanzio R, Capone E, Domenichini A, Damiani V, Chiorino G, Akkaya BG et al.(2019). ABCC3 is a novel target for the treatment of pancreatic cancer. Advances in Biological Regulation vol. 73, Article 100634, 100634-100634.
10.1016/j.jbior.2019.04.004
Kawecki C, Bocquet O, Schmelzer CEH, Heinz A, Ihling C, Wahart A, Romier B, Bennasroune A et al.(2019). Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex. Cellular and molecular life sciences : CMLS vol. 76, (4) 791-807.
10.1007/s00018-018-2978-6
Rahman MM, Hazan A, Selway JL, Herath DS, Harwood CA, Pirzado MS, Atkar R, Kelsell DP et al.(2018). A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors. Cancer research vol. 78, (10) 2577-2588.
10.1158/0008-5472.can-17-2897
Andress EJ, Nicolaou M, McGeoghan F, Linton KJ(2017). ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population. Cell Mol Life Sci
10.1007/s00018-017-2472-6
Linton KJ(2015). Lipid flopping in the liver. Biochemical Society Transactions vol. 43, (5) 1003-1010.
10.1042/bst20150132
Akkaya BG, Zolnerciks JK, Ritchie TK, Bauer B, Hartz AMS, Sullivan JA, Linton KJ(2015). The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1. Molecular membrane biology vol. 32, (2) 39-45.
10.3109/09687688.2015.1023378
Sanders D, Zampronio CG, Nettleship JE, Owens RJ, Owen C, Linton KJ(2014). Characterisation of the scavenger receptor CD36. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE vol. 92, (6) 587-587.
Zolnerciks JK, Akkaya BG, Snippe M, Chiba P, Seelig A, Linton KJ(2014). The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle. FASEB J vol. 28, (10) 4335-4346.
10.1096/fj.13-245639
Blaydon DC, Lind LK, Plagnol V, Linton KJ, Smith FJD, Wilson NJ, McLean WHI, Munro CS et al.(2013). Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma. Am J Hum Genet vol. 93, (2) 330-335.
10.1016/j.ajhg.2013.06.008
Blaydon DC, Lind L, Plagnol V, Linton KJ, South AP, Leigh IM, O'Toole EA, Lundstrom A et al. (2013). Aquaporin 5 (AQP5), a water channel protein, is mutated in autosomal dominant diffuse non-epidermolytic palmoplantar keratoderma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S139-S139.
Andress EJ, Nicolaou M, Romero MR, Naik S, Dixon PH, Williamson C, Linton KJ(2013). A molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4. Hepatology
10.1002/hep.26970
Falasca M, Linton KJ(2012). Investigational ABC transporter inhibitors. Expert Opin Investig Drugs vol. 21, (5) 657-666.
10.1517/13543784.2012.679339
Nicolaou M, Andress EJ, Zolnerciks JK, Dixon PH, Williamson C, Linton KJ(2012). Canalicular ABC transporters and liver disease. J Pathol vol. 226, (2) 300-315.
10.1002/path.3019
Groen A, Romero MR, Kunne C, Hoosdally SJ, Dixon PH, Wooding C, Williamson C, Seppen J et al.(2011). Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity. Gastroenterology vol. 141, (5)
10.1053/j.gastro.2011.07.042
Zolnerciks JK, Andress EJ, Nicolaou M, Linton KJ(2011). Structure of ABC transporters. Essays Biochem vol. 50, (1) 43-61.
10.1042/bse0500043
Linton KJ, Zolnerciks JK, Schmitt L(2011). General Introduction, Structure and Likely Mechanism of Action of ABC Transport Proteins. The ABC Transporters of Human Physiology and Disease: Genetics and Biochemistry of ATP Binding Cassette Transporters, Editors: Linton, KJ, Holland, IB, World Scientific Publishing
Linton KJ, Holland IB(2011). Preface.
Linton KJ, Holland IB(2011). The ABC transporters of human physiology and disease: Genetics and biochemistry of atp binding cassette transporters.
Hoosdally SJ, Andress EJ, Wooding C, Martin CA, Linton KJ(2009). The Human Scavenger Receptor CD36 GLYCOSYLATION STATUS AND ITS ROLE IN TRAFFICKING AND FUNCTION. J BIOL CHEM vol. 284, (24) 16277-16288.
10.1074/jbc.M109.007849
Dixon PH, van Mil SWC, Chambers J, Strautnieks S, Thompson RJ, Lammert F, Kubitz R, Keitel V et al.(2009). Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy. GUT vol. 58, (4) 537-544.
10.1136/gut.2008.159541
Byrne JA, Strautnieks SS, Ihrke G, Pagani F, Kinsely AS, Linton KJ, Mieli-Vergani G, Thompson RJ(2009). Missense Mutations and Single Nucleotide Polymorphisms in ABCB11 Impair Bile Salt Export Pump Processing and Function or Disrupt Pre-Messenger RNA Splicing. HEPATOLOGY vol. 49, (2) 553-567.
10.1002/hep.22683
Zolnerciks JK, Wooding C, Linton KJ(2007). Evidence for a Sav1866-like architecture for the human multidrug transporter P-glycoprotein. FASEB J vol. 21, (14) 3937-3948.
10.1096/fj.07-8610com
Martin CA, Longman E, Wooding C, Hoosdally SJ, Ali S, Aitman TJ, Gutmann DAP, Freemont PS et al.(2007). Cd36, a class B scavenger receptor, functions as a monomer to bind acetylated and oxidized low-density lipoproteins. PROTEIN SCI vol. 16, (11) 2531-2541.
10.1110/ps.073007207
Linton KJ(2007). Structure and function of ABC transporters. PHYSIOLOGY vol. 22, 122-130.
10.1152/physiol.00046.2006
Linton KJ, Higgins CF(2007). Structure and function of ABC transporters: the ATP switch provides flexible control. PFLUG ARCH EUR J PHY vol. 453, (5) 555-567.
10.1007/s00424-006-0126-x
Byrne JA, Strautnieks SS, Ihrke G, Knisley AS, Jankowska I, Pawlowska J, Linton KJ, Higgins CF et al. (2005). Investigation of MRNA splicing associated with the common BSEP mutations: An important disease mechanism for D482. HEPATOLOGY. vol. 42, 518A-519A.
Lepretre F, Linton KJ, Lacquemant C, Vatin V, Samson C, Dina C, Chikri M, Ali S et al.(2004). Genetic study of the CD36 gene In a French diabetic population. DIABETES METAB vol. 30, (5) 459-463.
10.1016/S1262-3636(07)70143-X
Higgins CF, Linton KJ(2004). The ATP switch model for ABC transporters. NAT STRUCT MOL BIOL vol. 11, (10) 918-926.
10.1038/nsmb836
Rothnie A, Storm J, Campbell J, Linton KJ, Kerr ID, Callaghan R(2004). The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein. J BIOL CHEM vol. 279, (33) 34913-34921.
10.1074/jbc.M405336200
Lepretre F, Vasseur F, Vaxillaire M, Scherer PE, Ali S, Linton KJ, Aitman T, Froguel P(2004). A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes. Hum Mutat vol. 24, 104-110.
10.1002/humu.9256
Kerr ID, Berridge G, Linton KJ, Higgins CF, Callaghan R(2003). Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein. EUR BIOPHYS J BIOPHY vol. 32, (7) 644-654.
10.1007/s00249-003-0327-6
Jodoin J, Demeule M, Fenart L, Cecchelli R, Farmer S, Linton KJ, Higgins CF, Beliveau R(2003). P-glycoprotein in blood-brain barrier endothelial cells: interaction and oligomerization with caveolins. J NEUROCHEM vol. 87, (4) 1010-1023.
10.1046/j.1471-4159.2003.02081.x
Stenham DR, Campbell JD, Sansom MSP, Higgins CF, Kerr ID, Linton KJ(2003). An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulphide cross-linking and homology modeling. FASEB J vol. 17, (13) 2287-+.
10.1096/fj.03-0107fje
Gabriel MP, Storm J, Rothnie A, Taylor AM, Linton KJ, Kerr ID, Callaghan R(2003). Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508. BIOCHEMISTRY-US vol. 42, (25) 7780-7789.
10.1021/bi0341049
Mullenbach R, Linton KJ, Wiltshire S, Weerasekera N, Chambers J, Elias E, Higgins CF, Johnston DG et al.(2003). ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy. J MED GENET vol. 40, (5) Article e70,
10.1136/jmg.40.5.e70
Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ (2003). Characterisation of substrate specificity and identification of inhibitors of the human bile salt export pump, BSEP. GUT. vol. 52,
Mullenbach R, Linton KJ, Wiltshire S, Elias E, McCarthy MI, Williamson C (2003). ABCB4 sequence variation in women with intrahepatic cholestasis of pregnancy. JOURNAL OF HEPATOLOGY. vol. 38, 213-213.
10.1016/S0168-8278(03)80114-9
Byrne JA, Strautnieks SS, Higgins CF, Linton KJ, Thompson RJ (2003). Function of BSEP. BILE ACIDS: FROM GENOMICS TO DISEASE AND THERAPY. Editors: Paumgartner, G, Keppler, D, Leuschner, U, Stiehl, A et al., vol. 129, 99-103.
Byrne JA, Strautniks SS, Higgins CF, Linton KJ, Thompson RJ(2003). Function of BSEP. Editors: Paumgartner, G, Springer
Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ(2002). The human bile salt export pump: Characterization of substrate specificity and identification of inhibitors. GASTROENTEROLOGY vol. 123, (5) 1649-1658.
10.1053/gast.2002.36591
Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ (2002). In vitro characterisation of the human bile salt export pump, BSEP. HEPATOLOGY. vol. 36, 218A-218A.
Higgins CF, Linton KJ(2002). ABC transporters: An introduction and overview. ABC Proteins, Editors: Holland, IB, Cole, SPC, Kuchler, K, Higgins, CF et al., Academic Press
Linton KJ, Higgins CF(2002). P-glycoprotein misfolds in Escherichia coli: evidence against alternating-topology models of the transport cycle. MOL MEMBR BIOL vol. 19, (1) 51-58.
10.1080/09687680110103622
Linton KJ, Rosenberg M, Kerr ID, Higgins CF(2002). Structure of ABC transporters. ABC Proteins, Editors: Holland, IB, Cole, SPC, Kuchler, K, Higgins, CF et al., Academic Press
Taylor AM, Storm J, Soceneantu L, Linton KJ, Gabriel M, Martin C, Woodhouse J, Blott E et al.(2001). Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein. BRIT J PHARMACOL vol. 134, (8) 1609-1618.
10.1038/sj.bjp.0704400
Rosenberg MF, Velarde G, Ford RC, Martin C, Berridge G, Kerr ID, Callaghan R, Schmidlin A et al.(2001). Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle. EMBO J vol. 20, (20) 5615-5625.
10.1093/emboj/20.20.5615
Higgins CF, Linton KJ(2001). Structural biology - The xyz of ABC transporters. SCIENCE vol. 293, (5536) 1782-1784.
10.1126/science.1065588
Higgins CF, Linton KJ(2001). The xyz of ABC transporters. Science vol. 293, (5536) 1782-1784.
10.1126/science.1065588
Higgins CF, Callaghan R, Linton K, Ford R, Rosenberg M (2001). Structure and function of the multidrug resistance P-glycoprotein. JOURNAL OF PHYSIOLOGY-LONDON. vol. 535, 2S-2S.
Dixon PH, Weerasekera N, Linton KJ, Donaldson O, Chambers J, Egginton E, Weaver J, Nelson-Piercy C et al.(2000). Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. HUM MOL GENET vol. 9, (8) 1209-1217.
10.1093/hmg/9.8.1209
Blott EJ, Higgins CF, Linton KJ(1999). Cysteine-scanning mutagenesis provides no evidence for the extracellular accessibility of the nucleotide-binding domains of the multidrug resistance transporter P-glycoprotein. EMBO J vol. 18, (23) 6800-6808.
10.1093/emboj/18.23.6800
Higgins CF, Weylandt KH, Nastrucci C, Sardini A, Linton K, Diaz M, Valverde MA(1999). Cell swelling-activated chloride channels and their regulation by P-glycoprotein. Chloride Channels, Editors: Kozlowski, R, Isis Press
Linton KJ, Higgins CF(1998). The Escherichia coli ATP-binding cassette (ABC) proteins. MOL MICROBIOL vol. 28, (1) 5-13.
10.1046/j.1365-2958.1998.00764.x
Lewis HD, Floriano B, Linton KJ, White J, Bibb MJ, Hunter IS, Leadlay PF (1997). Evidence for a novel mechanism of resistance to the polyether polyketide tetronasin. FASEB J. vol. 11, A1032-A1032.
Higgins CF, Callaghan R, Linton KJ, Rosenberg MF, Ford RC(1997). Structure of the multidrug resistance P-glycoprotein. SEMIN CANCER BIOL vol. 8, (3) 135-142.
10.1006/scbi.1997.0067
LINTON KJ, JARVIS BW, HUTCHINSON CR(1995). CLONING OF THE GENES ENCODING THYMIDINE DIPHOSPHOGLUCOSE 4,6-DEHYDRATASE AND THYMIDINE DIPHOSPHO-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE FROM THE ERYTHROMYCIN-PRODUCING SACCHAROPOLYSPORA-ERYTHRAEA. GENE vol. 153, (1) 33-40.
10.1016/0378-1119(94)00809-7
LINTON KJ, THAMCHAIPENET A, HUNTER IS (1994). The impact of molecular genetics on understanding antibiotic biosynthesis: Design of new drugs. PREHRAMBENO-TEHNOLOSKA I BIOTEHNOLOSKA REVIJA. vol. 32, 61-65.
LINTON KJ, COOPER HN, HUNTER IS, LEADLAY PF(1994). AN ABC-TRANSPORTER FROM STREPTOMYCES-LONGISPOROFLAVUS CONFERS RESISTANCE TO THE POLYETHER-IONOPHORE ANTIBIOTIC TETRONASIN. MOL MICROBIOL vol. 11, (4) 777-785.
10.1111/j.1365-2958.1994.tb00355.x
LINTON KJ, HUNTER IS(1988). CLONING OF DNA-SEQUENCES FROM STREPTOMYCES-LONGISPOROFLAVUS WHICH CONFER INCREASED RESISTANCE TO THE IONOPHORE ANTIBIOTIC TETRONASIN IN STREPTOMYCES-LIVIDANS. HEREDITY vol. 61, 304-305.
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