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Publications:  Dr Moheyeldin Elshikh

El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ et al.(2019). Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis. Journal of Autoimmunity
10.1016/j.jaut.2019.06.008
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58983
Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM et al.(2018). Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production. Annals of the Rheumatic Diseases vol. 77, (12) 1773-1781.
10.1136/annrheumdis-2018-213418
https://qmro.qmul.ac.uk/xmlui/handle/123456789/44263
Altamimi A-MS, Alafeefy AM, Balode A, Vozny I, Pustenko A, Shikh MEE, Alasmary FAS, Abdel-Gawad SA et al.(2017). Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A. Journal of Enzyme Inhibition and Medicinal Chemistry vol. 33, Article 1, 147-150.
10.1080/14756366.2017.1404593
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32141
Lownik JC, Luker AJ, Damle SR, Cooley LF, El Sayed R, Hutloff A, Pitzalis C, Martin RK et al.(2017). ADAM10-mediated ICOS ligand shedding on b cells is necessary for proper T Cell ICOS regulation and T follicular helper responses. Journal of Immunology vol. 199, (7) 2305-2315.
10.4049/jimmunol.1700833
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25831
El Shikh MEM, El Sayed R, Pitzalis C(2017). Isolation and Characterization of Mouse and Human Follicular Dendritic Cells. Methods Mol Biol vol. 1623, 113-123.
10.1007/978-1-4939-7095-7_10
https://qmro.qmul.ac.uk/xmlui/handle/123456789/28692
Rivellese F, Humby F, Kelly S, Nerviani A, Mauro D, Rocher-Ros V, El Shikh ME, de Paulis A et al. (2016). SYNOVIAL MAST CELLS CORRELATE WITH LOCAL AND SYSTEMIC INFLAMMATION AND ARE FUNCTIONALLY ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS. Presented at: EULAR 2016,
https://qmro.qmul.ac.uk/xmlui/handle/123456789/51563
Cooley LF, El Shikh ME, Li W, Keim RC, Zhang Z, Strauss JF, Zhang Z, Conrad DH(2016). Impaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice. Sci Rep vol. 6, 25840-25840.
10.1038/srep25840
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19681
Llibre A, López-Macías C, Marafioti T, Mehta H, Partridge A, Kanzig C, Rivellese F, Galson JD et al.(2016). LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation. J Immunol vol. 196, (5) 2085-2094.
10.4049/jimmunol.1502462
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22123
Cooley LF, Martin RK, Zellner HB, Irani A-M, Uram-Tuculescu C, El Shikh ME, Conrad DH(2015). Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice. PLoS One vol. 10, (5) e0124331-e0124331.
10.1371/journal.pone.0124331
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22303
El Shikh MEM (2014). FOLLICULAR DENDRITIC CELLS IN IMMUNITY AND AUTOIMMUNITY. ANNALS OF THE RHEUMATIC DISEASES. vol. 73, 4-4.
10.1136/annrheumdis-2014-eular.6102
Al-Mousawi AZ, El Shikh MEM, Pitzalis C (2014). IMMUNE COMPLEX RETENTION BY SYNOVIAL FIBROBLASTS IN RHEUMATOID ARTHRITIS. RHEUMATOLOGY. vol. 53, 84-84.
Folgosa L, Zellner HB, El Shikh ME, Conrad DH(2013). Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-α shedding. J Immunol vol. 191, (12) 5951-5958.
10.4049/jimmunol.1302042
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22170
El Shikh ME, Kmieciak M, Manjili MH, Szakal AK, Pitzalis C, Tew JG(2013). Multi-therapeutic potential of autoantibodies induced by immune complexes trapped on follicular dendritic cells. Hum Vaccin Immunother vol. 9, (11) 2434-2444.
10.4161/hv.25596
El Shikh ME, Biggioggero M, El Sayed R, Kmieciak M, Manjili M, Szakal A, Meroni PL, Pitzalis C et al.(2013). REGULATION OF AUTO-ANTIBODY PRODUCTION BY AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS. ANNALS OF THE RHEUMATIC DISEASES vol. 71, 129-129.
10.1136/annrheumdis-2012-eular.1901
Folgosa L, El Shikh M, Conrad D(2013). New implications of ADAMs in TNF{alpha} related diseases: ADAM10 deficient B cells exhibit increased ADAM17 and TNF{alpha} (P4388). The Journal of Immunology vol. 190, (Meeting Abstracts 1)
SUKUMAR S, EL SHIKH MEM, TEW JG, SANCHEZ-SCHMITZ G, DRAKE DIII, MOSQUERA L, LI C, KACHURIN AM et al. (2012). Methods of evaluating an immune response to an antigen. no. 13167115,
El Shikh MEM, Biggioggero M, El Sayed RM, Kmieciak M, Manjili MH, Szakal AK, Meroni PL, Pitzalis C et al. (2012). REGULATION OF AUTO-ANTIBODY PRODUCTION BY PERSISTING AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS. ANNALS OF THE RHEUMATIC DISEASES. vol. 71, A38-A38.
10.1136/annrheumdis-2011-201234.15
TEW J, EL SHIKH MEM, SINGH I, MISHKIN E, DRAKE DIII, SONG H, WARREN W (2012). MODELS FOR VACCINE ASSESSMENT. no. 07872536.3,
El Shikh MEM, El Sayed R, Szakal AK, Tew JG, Drake III DR, Wittman V, Eatrides J, Warren WL (2012). Rapid generation of T cell-independent antibody responses to T cell-dependent antigens. no. EP20110185845,
Tew JG, El Shikh, Mohey, Edin, M., Singh I, Mishkin E, Drake D, Song H, Warren WL (2012). Models for vaccine assessment. no. EP20110165211,
Tew JG, El Shikh ME, El Sayed RM, Schenkein HA(2012). Dendritic cells, antibodies reactive with oxLDL, and inflammation. J Dent Res vol. 91, (1) 8-16.
10.1177/0022034511407338
El Shikh MEM, Pitzalis C(2012). Follicular dendritic cells in health and disease. Front Immunol vol. 3,
10.3389/fimmu.2012.00292
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22320
SUKUMAR S, EL SHIKH MEM, TEW JG, SANCHEZ-SCHMITZ G, DRAKE, III, Donald, MOSQUERA L, MISHKIN E, KACHURIN AM et al. (2011). In vitro germinal centers. no. 11642938,
El Shikh ME, El Sayed R, Kmieciak M, Manjili M, Szakal A, Pitzalis C, Tew J (2011). BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS. RHEUMATOLOGY. vol. 50, 51-51.
El Shikh ME, El Sayed RM, Kmieciak M, Manjili M, Szakal A, Pitzalis C, Tew J (2011). BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS. ANNALS OF THE RHEUMATIC DISEASES. vol. 70,
10.1136/ard.2010.148999.9
Kikuchi T, El Shikh MM, El Sayed RM, Purkall DB, Elaasser MM, Sarraf A, Barbour SE, Schenkein HA et al.(2010). Anti-phosphorylcholine-opsonized low-density lipoprotein promotes rapid production of proinflammatory cytokines by dendritic cells and natural killer cells. Journal of Periodontal Research vol. 45, (6) 720-730.
10.1111/j.1600-0765.2010.01292.x
Hanaa YA, El Shikh HH, Eglal AG, Ragab AM, Saad AA, Hashem AM, El Sayed RM, El Shikh ME(2010). Fungal Secondary Metabolites: A Promising Source of Antineoplastic Drugs. Current Cancer Therapy Reviews vol. 6, (3) 222-228.
10.2174/157339410791698223
El Shikh MEM, El Sayed RM, Sukumar S, Szakal AK, Tew JG(2010). Activation of B cells by antigens on follicular dendritic cells. Trends Immunol vol. 31, (6) 205-211.
10.1016/j.it.2010.03.002
TEW JG, EL SHIKH MEM, SINGH I, MISHKIN E, DRAKE, III, Donald, SONG H, WARREN WL (2010). Models for vaccine assessment. no. 11819335,
El Shikh ME, El Sayed R, Szakal A, Tew J(2010). Breaking B cell tolerance by multimerized self antigens on follicular dendritic cells. The Journal of Immunology vol. 184, (Meeting Abstract Supplement)
El Sayed R, El Shikh ME, Schenkein H, Tew J(2010). Dominance of macrophage derived IFN-{gamma} in atheromatous lesions. The Journal of Immunology vol. 184, (Meeting Abstract Supplement)
Gibb DR, El Shikh M, Kang D, Rowe WJ, El Sayed R, Cichy J, Yagita H, Tew JG et al.(2010). ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. The Journal of Experimental Medicine vol. 207, (3) 623-635.
10.1084/jem.20091990
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23787
El Shikh ME, Sayed RM, Tew JG, Burton GF(2010). Follicular Dendritic Cells (B Lymphocyte Stimulating). Encyclopedia of Life Sciences, 32 Volume Set, Editors: Ltd, JWS, Wiley
Wu Y, El Shikh MEM, El Sayed RM, Best AM, Szakal AK, Tew JG(2009). IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation. Int Immunol vol. 21, (6) 745-756.
10.1093/intimm/dxp041
TEW JG, EL SHIKH, Mohey, Edin, M., SINGH I, MISHKIN E, DRAKE D, SONG H, WARREN WL (2009). MODELS FOR VACCINE ASSESSMENT. no. EP20070872536 200706,
Gibb DR, El Shikh M, Kang D, El Sayed R, Crawford H, Tew JG, Conrad DH(2009). ADAM10 regulates B cell development and immunoglobulin production. The Journal of Immunology vol. 182, (1_MeetingAbstracts)
El Shikh MEM, El Sayed RM, Szakal AK, Tew JG(2009). T-independent antibody responses to T-dependent antigens: a novel follicular dendritic cell-dependent activity. J Immunol vol. 182, (6) 3482-3491.
10.4049/jimmunol.0802317
Abu Seadah AA, El Shikh ME(2008). RAPD typing of Aspergillus chevalieri, Aspergillus nidulans, Aspergillus tetrazonus (quadrilineatus) and their teleomorphs using 5'-d[AACGCGCAAC]-3' and 5'-d[CCCGTCAGCA]-3' primers. Mol Biol Rep vol. 35, (2) 89-95.
10.1007/s11033-007-9057-7
Shikh MEE, Sayed RE, Szakal AK, Tew JG(2008). Conversion of T-dependent (TD) antigens to T-independent (TI) antigens: A novel follicular dendritic cell (FDC)-dependent activity. The FASEB Journal vol. 22, (2_MeetingAbstracts)
John DV, Crisa L, Cauvi G, El Shikh ME, Tew JG, Torbett BE(2008). Primary human immune response to dendritic cell inoculation in humanized mice. The FASEB Journal vol. 22, (2_MeetingAbstracts)
Sukumar S, El Shikh ME, Tew JG, Szakal AK(2008). Ultrastructural study of highly enriched follicular dendritic cells reveals their morphology and the periodicity of immune complex binding. Cell Tissue Res vol. 332, (1) 89-99.
10.1007/s00441-007-0566-4
Tew JG, El Shikh MEM, Singh I, Mishkin E, Drake D, Song H, Warren WL (2008). Models for vaccine assessment. no. US 11/819,335,
Wu YZ, Sukumar S, El Shikh ME, Best AM, Szakal AK, Tew JG(2008). Immune complex-bearing follicular dendritic cells deliver a late antigenic signal that promotes somatic hypermutation. J IMMUNOL vol. 180, (1) 281-290.
10.4049/jimmunol.180.1.281
El Shikh MEM, El Sayed RM, Wu Y, Szakal AK, Tew JG(2007). TLR4 on follicular dendritic cells: an activation pathway that promotes accessory activity. J Immunol vol. 179, (7) 4444-4450.
10.4049/jimmunol.179.7.4444
Sukumar S, El Shikh MEM, Warren WL, Fahlenkamp H, Tew JG, Sanchez-Schmitz G, Drake D, Mosquera L et al. (2007). In Vitro germinal centers. no. US 11/642,938,
El Shikh ME, El Sayed RM, Tew JG, Szakal AK(2007). Follicular dendritic cells stimulated by collagen type I develop dendrites and networks in vitro. Cell Tissue Res vol. 329, (1) 81-89.
10.1007/s00441-007-0394-6
Shikh MEME, Sayed RME, Wu Y, Szakal AK, Tew JG(2007). Induction of human primary antibody responses in vitro by ovalbumin (OVA) or anthrax (rPA) on dendritic cells (DCs) and follicular dendritic cells (FDCs) in temporally controlled germinal center reactions (GCRs). The Journal of Immunology vol. 178, (MeetingAbstracts)
El Shikh ME, El Sayed R, Szakal AK, Tew JG(2006). Follicular dendritic cell (FDC)-FcgammaRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development. Eur J Immunol vol. 36, (10) 2715-2724.
10.1002/eji.200636122
Szakal AK, El Shikh ME, Elsayed R, Tew JG (2006). Influence of collagen on follicular dendritic cells to develop dendrites and reticula in vitro. JOURNAL OF IMMUNOLOGY. vol. 176, S213-S213.
El Shikh ME, Elsayed R, Szakal AK, Tew JG (2006). Interaction of immune complexes with Fc gamma RIIB on follicular dendritic cells upregulates Fc gamma RIIB expression as well as VCAM-1, ICAM-1 and CD320. JOURNAL OF IMMUNOLOGY. vol. 176, S75-S75.
El Shikh ME, Wu YZ, Elsayed R, Szakal AK, Tew JG (2006). Interaction of poly(I : C) and LPS with toll receptors upregulates CR1/2, Fc gamma RIIB and VCAM-1 expression on follicular dendritic cells via NF-kappa B. JOURNAL OF IMMUNOLOGY. vol. 176, S96-S96.
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