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Publications:  Dr Ewan Main

Millership C, Phillips JJ, Main ERG (2016) . Ising Model Reprogramming of a Repeat Protein's Equilibrium Unfolding Pathway.Journal of Molecular Biology vol. 428, (9 Pt A) 1804-1817.
Perez-Riba A, Main ER, Itzhaki LS (2016) . The Effect of Loop Insertions on the Folding of Tandem-Repeat Proteins. BIOPHYSICAL JOURNAL. vol. 110, 181A-181A.
Rowling PJE, Sivertsson EM, Perez-Riba A et al. (2015) . Dissecting and reprogramming the folding and assembly of tandem-repeat proteins.Biochem Soc Trans vol. 43, (5) 881-888.
Main ERG, Phillips JJ, Millership C (2013) . Repeat protein engineering: creating functional nanostructures/biomaterials from modular building blocks.Biochem Soc Trans vol. 41, (5) 1152-1158.
Singh SK, Boyle AL, Main ERG (2013) . LcrH, a class II chaperone from the type three secretion system, has a highly flexible native structure.J Biol Chem vol. 288, (6) 4048-4055.
Phillips JJ, Millership C, Main ERG (2012) . Fibrous nanostructures from the self-assembly of designed repeat protein modules.Angew Chem Int Ed Engl vol. 51, (52) 13132-13135.
Phillips JJ, Javadi Y, Millership C et al. (2012) . Modulation of the multistate folding of designed TPR proteins through intrinsic and extrinsic factors.Protein Sci vol. 21, (3) 327-338.
Mahendrarajah K, Dalby PA, Wilkinson B et al. (2011) . A high-throughput fluorescence chemical denaturation assay as a general screen for protein-ligand binding.Anal Biochem vol. 411, (1) 155-157.
Boyd LK, Mercer B, Thompson D et al. (2010) . Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60.PLoS One vol. 5, (9)
Gaudet M, Remtulla N, Jackson SE et al. (2010) . Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale.PROTEIN SCI vol. 19, (8) 1544-1554.
Javadi Y, Main ERG (2009) . Exploring the folding energy landscape of a series of designed consensus tetratricopeptide repeat proteins.P NATL ACAD SCI USA vol. 106, (41) 17383-17388.
Main ERG, Lowe AR, Mochrie SGJ et al. (2005) . A recurring theme in protein engineering: the design, stability and folding of repeat proteins.CURR OPIN STRUC BIOL vol. 15, (4) 464-471.
Kajander T, Cortajarena AL, Main ERG et al. (2005) . A new folding paradigm for repeat proteins.J AM CHEM SOC vol. 127, (29) 10188-10190.
Main ERG, Stott K, Jackson SE et al. (2005) . Local and long-range stability in tandemly arrayed tetratricopeptide repeats.P NATL ACAD SCI USA vol. 102, (16) 5721-5726.
Maxwell KL, Wildes D, Zarrine-Afsar A et al. (2005) . Protein folding: Defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins.PROTEIN SCI vol. 14, (3) 602-616.
Main ERG, Jackson SE, Regan L (2003) . The folding and design of repeat proteins: reaching a consensus.CURR OPIN STRUC BIOL vol. 13, (4) 482-489.
Main ERG, Xiong Y, Cocco MJ et al. (2003) . Design of stable alpha-helical arrays from an idealized TPR motif.STRUCTURE vol. 11, (5) 497-508.
Main ERG, Fulton KF, Daggett V et al. (2001) . A comparison of experimental and computational methods for mapping the interactions present in the transition state for folding of FKBP12.J BIOL PHYS vol. 27, (2) 99-117.
Main ERG, Jackson SE (1999) . Does trifluoroethanol affect folding pathways and can it be used as a probe of structure in transition states?.NAT STRUCT BIOL vol. 6, (9) 831-835.
Main ERG, Fulton KF, Jackson SE (1999) . Folding pathway of FKBP12 and characterisation of the transition state.J MOL BIOL vol. 291, (2) 429-444.
Fulton KF, Main ERG, Daggett V et al. (1999) . Mapping the interactions present in the transition state for unfolding/folding of FKBP12.J MOL BIOL vol. 291, (2) 445-461.
Main ERG, Fulton KF, Jackson SE (1998) . Context-dependent nature of destabilizing mutations on the stability of FKBP12.BIOCHEMISTRY-US vol. 37, (17) 6145-6153.
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