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Publications:  Dr John Connelly

Ghetti M, Topouzi H, Theocharidis G, Papa V, Williams G, Bondioli E, Cenacchi G, Connelly JT et al.(2018). Subpopulations of dermal skin fibroblasts secrete distinct extracellular matrix: implications for using skin substitutes in the clinic. Br J Dermatol vol. 179, (2) 381-393.
10.1111/bjd.16255
Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP, Connelly JT(2018). Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling. J Cell Sci vol. 131, (10)
10.1242/jcs.215780
Kanapathy M, Hachach-Haram N, Bystrzonowski N, Connelly JT, O'Toole EA, Becker DL, Mosahebi A, Richards T(2017). Epidermal grafting for wound healing: a review on the harvesting systems, the ultrastructure of the graft and the mechanism of wound healing. Int Wound J vol. 14, (1) 16-23.
10.1111/iwj.12686
GAUTROT JEE, Di Cio S, Boggild T, Connelly J, Sutherland DS(2016). Differential Integrin Expression Regulates Cell Sensing of the Matrix Nanoscale Geometry. Acta Biomaterialia
10.1016/j.actbio.2016.11.069
Sharili AS, Kenny FN, Vartiainen MK, Connelly JT(2016). Nuclear actin modulates cell motility via transcriptional regulation of adhesive and cytoskeletal genes. Sci Rep vol. 6, 33893-33893.
10.1038/srep33893
Kao AP, Connelly JT, Barber AH(2016). 3D nanomechanical evaluations of dermal structures in skin. Journal of the mechanical behavior of biomedical materials vol. 57, 14-23.
10.1016/j.jmbbm.2015.11.017
Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM, Connelly JT(2016). Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. J Invest Dermatol vol. 136, (1) 74-83.
10.1038/JID.2015.352
Almeida FV, Walko G, McMillan JR, McGrath JA, Wiche G, Barber AH, Connelly JT(2015). The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes. J Cell Sci vol. 128, (24) 4475-4486.
10.1242/jcs.173435
Dalbay MT, Thorpe SD, Connelly JT, Chapple JP, Knight MM(2015). Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation. Stem Cells vol. 33, (6) 1952-1961.
10.1002/stem.1975
Kenny FN, Connelly JT(2015). Integrin-mediated adhesion and mechano-sensing in cutaneous wound healing. Cell Tissue Res vol. 360, (3) 571-582.
10.1007/s00441-014-2064-9
Costa P, Gautrot JE, Connelly JT(2014). Directing cell migration using micropatterned and dynamically adhesive polymer brushes. Acta Biomater vol. 10, (6) 2415-2422.
10.1016/j.actbio.2014.01.029
Sharili AS, Connelly JT(2014). Nucleocytoplasmic shuttling: a common theme in mechanotransduction. Biochem Soc Trans vol. 42, (3) 645-649.
10.1042/BST20130286
McMurray RJ, Wann AKT, Thompson CL, Connelly JT, Knight MM(2013). Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells. Sci Rep vol. 3,
10.1038/srep03545
Tan DW, Jensen KB, Trotter MW, Connelly JT, Broad S, Watt FM(2013). Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells. Development vol. 140, (7) 1433-1444.
10.1242/dev.087551
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM, Wheeler AP(2013). Super-resolution imaging strategies for cell biologists using a spinning disk microscope. PLoS One vol. 8, (10)
10.1371/journal.pone.0074604
Costa P, Almeida FVM, Connelly JT(2012). Biophysical signals controlling cell fate decisions: how do stem cells really feel?. Int J Biochem Cell Biol vol. 44, (12) 2233-2237.
10.1016/j.biocel.2012.09.003
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H et al.(2012). Extracellular-matrix tethering regulates stem-cell fate. Nat Mater vol. 11, (7) 642-649.
10.1038/nmat3339
Driskell RR, Juneja VR, Connelly JT, Kretzschmar K, Tan DW-M, Watt FM(2012). Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo. J Invest Dermatol vol. 132, (4) 1084-1093.
10.1038/jid.2011.428
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H et al.(2012). Erratum: Extracellular-matrix tethering regulates stem-cell fate (Nature Materials (2012) 11 (642-649)). Nature Materials vol. 11, (8)
10.1038/nmat3387
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H et al.(2012). Extracellular-matrix tethering regulates stem-cell fate. Nature Materials vol. 11, (7) 642-649.
10.1038/nmat3339
Connelly JT(2012). Terminal differentiation of human epidermal stem cells on micro-patterned substrates. Methods Mol Biol vol. 916, 15-22.
10.1007/978-1-61779-980-8_2
Connelly JT, Petrie TA, García AJ, Levenston ME(2011). Fibronectin- and collagen-mimetic ligands regulate bone marrow stromal cell chondrogenesis in three-dimensional hydrogels. Eur Cell Mater vol. 22, 168-176.
10.22203/eCM.v022a13
Connelly JT, Mishra A, Gautrot JE, Watt FM(2011). Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. PLoS One vol. 6, (11)
10.1371/journal.pone.0027259
Connelly JT, Gautrot JE, Trappmann B, Tan DW-M, Donati G, Huck WTS, Watt FM(2010). Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol vol. 12, (7) 711-718.
10.1038/ncb2074
Connelly JT, Vanderploeg EJ, Mouw JK, Wilson CG, Levenston ME(2010). Tensile loading modulates bone marrow stromal cell differentiation and the development of engineered fibrocartilage constructs. Tissue Eng Part A vol. 16, (6) 1913-1923.
10.1089/ten.TEA.2009.0561
Connelly JT, García AJ, Levenston ME(2008). Interactions between integrin ligand density and cytoskeletal integrity regulate BMSC chondrogenesis. J Cell Physiol vol. 217, (1) 145-154.
10.1002/jcp.21484
Connelly JT, Wilson CG, Levenston ME(2008). Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs. Osteoarthritis Cartilage vol. 16, (9) 1092-1100.
10.1016/j.joca.2008.01.004
Mouw JK, Connelly JT, Wilson CG, Michael KE, Levenston ME(2007). Dynamic compression regulates the expression and synthesis of chondrocyte-specific matrix molecules in bone marrow stromal cells. Stem Cells vol. 25, (3) 655-663.
10.1634/stemcells.2006-0435
Connelly JT, García AJ, Levenston ME(2007). Inhibition of in vitro chondrogenesis in RGD-modified three-dimensional alginate gels. Biomaterials vol. 28, (6) 1071-1083.
10.1016/j.biomaterials.2006.10.006
Connelly JT, Vanderploeg EJ, Levenston ME(2004). The influence of cyclic tension amplitude on chondrocyte matrix synthesis: experimental and finite element analyses. Biorheology vol. 41, (3-4) 377-387.
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