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Publications:  Prof Leo Dunkel

Howard S, de Roux N, Leger J, Carel J-C, Dunkel L(2019). Puberty and its disorders. Brook's Clinical Pediatric Endocrinology, Editors: Dattani, M, Brook, C, John Wiley & Sons
Mancini A, Howard SR, Cabrera CP, Barnes MR, David A, Wehkalampi K, Heger S, Lomniczi A et al.(2019). EAP1 regulation of GnRH promoter activity is important for human pubertal timing. Human Molecular Genetics vol. 28, (8) 1357-1368.
10.1093/hmg/ddy451
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55065
Howard SR, Dunkel L(2019). Delayed Puberty – Phenotypic Diversity, Molecular Genetic Mechanisms and Recent Discoveries. Endocrine Reviews
10.1210/er.2018-00248
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59136
Howard S, Dunkel L(2019). Genetics of Delayed Puberty. Contemporary Endocrinology,
Varimo T, Toiviainen-Salo S, Raivio T, Kerttula L, Dunkel L, Hero M(2019). Letrozole monotherapy in pre- And early-pubertal boys does not increase adult height. Frontiers in Endocrinology vol. 10, (APR)
10.3389/fendo.2019.00201
https://qmro.qmul.ac.uk/xmlui/handle/123456789/57821
Kuiri-Hänninen T, Koskenniemi J, Dunkel L, Toppari J, Sankilampi U(2019). Postnatal Testicular Activity in Healthy Boys and Boys With Cryptorchidism. Front Endocrinol (Lausanne) vol. 10,
10.3389/fendo.2019.00489
Howard SR, Oleari R, Poliandri A, Chantzara V, Fantin A, Ruiz-Babot G, Metherell LA, Cabrera CP et al.(2018). HS6ST1 Insufficiency Causes Self-Limited Delayed Puberty in Contrast with Other GnRH Deficiency Genes. Journal of Clinical Endocrinology and Metabolism vol. 103, (9) 3420-3429.
10.1210/jc.2018-00646
https://qmro.qmul.ac.uk/xmlui/handle/123456789/42223
Kuiri-Hänninen T, Dunkel L, Sankilampi U(2018). Sexual dimorphism in postnatal gonadotrophin levels in infancy reflects diverse maturation of the ovarian and testicular hormone synthesis. Clinical Endocrinology vol. 89, (1) 85-92.
10.1111/cen.13716
Howard S, Dunkel L(2018). ‘Management of Hypogonadism From Birth to Adolescence’ for Best Practice and Research Clinical Endocrinology and Metabolism. Best Practice & Research Clinical Endocrinology & Metabolism
10.1016/j.beem.2018.05.011
https://qmro.qmul.ac.uk/xmlui/handle/123456789/40963
Cassatella D, Howard SR, Acierno JS, Xu C, Papadakis GE, Santoni FA, Dwyer AA, Santini S et al.(2018). Congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty have distinct genetic architectures. European Journal of Endocrinology vol. 178, (4) 377-388.
10.1530/EJE-17-0568
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36683
DUNKEL L, Saari A, Virta LJ, Sankilampi U(2018). Inhaled corticosteroids in infants and toddlers attenuate linear growth. Journal of Allergy and Clinical Immunology
10.1016/j.jaci.2018.02.009
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36476
Howard SR, Guasti L, Poliandri A, David A, Cabrera CP, Barnes MR, Wehkalampi K, O'Rahilly S et al.(2018). Contributions of function-Altering variants in genes implicated in pubertal timing and body mass for self-limited delayed puberty. Journal of Clinical Endocrinology and Metabolism vol. 103, (2) 649-659.
10.1210/jc.2017-02147
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32184
Howard S, Dunkel L(2018). Delayed puberty and hypogonadism; female. Encyclopedia of Endocrine Diseases,
Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR et al.(2017). Ajmaline blocks I<inf>Na</inf> and I<inf>Kr</inf> without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters. Stem Cell Research vol. 25, 233-244.
10.1016/j.scr.2017.11.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29483
Dunkel L, Howard S(2017). The Genetic Basis of Delayed Puberty. Neuroendocrinology vol. 106, (3) 283-291.
10.1159/000481569
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31203
Katugampola H, King PJ, Chatterjee S, Meso M, Duncan AJ, Achermann JC, Guasti L, Ghataore L et al.(2017). Kisspeptin is a novel regulator of human fetal adrenocortical development and function – a finding with important implications for the human feto-placental unit. The Journal of Clinical Endocrinology & Metabolism
10.1210/jc.2017-00763
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25680
Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T et al.(2017). Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells. Molecular and Cellular Endocrinology vol. 447, 12-22.
10.1016/j.mce.2017.02.030
Quinton R, Mamoojee Y, Jayasena CN, Young J, Howard S, Dunkel L, Cheetham T, Smith N et al.(2017). Society for Endocrinology UK guidance on the evaluation of suspected disorders of sexual development: emphasizing the opportunity to predict adolescent pubertal failure through a neonatal diagnosis of absent minipuberty. Clin Endocrinol (Oxf) vol. 86, (2) 305-306.
10.1111/cen.13257
Howard S, Dunkel L(2017). Normal and delayed puberty. Contemporary Endocrinology,
Huhtaniemi I, Howard S, Dunkel L, Anderson R(2016). The Gonadal Axis: A life perspective. Hormones, Brain and Behavior, Editors: Pfaff, DW, Joels, M, Academic Press
Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P et al.(2016). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell Rep vol. 16, (4) 1026-1038.
10.1016/j.celrep.2016.06.050
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13911
Kiviranta P, Kuiri-Ha nninen T, Saari A, Lamidi M-L, Dunkel L, Sankilampi U(2016). Transient Postnatal Gonadal Activation and Growth Velocity in Infancy. Pediatrics vol. 138, (1) e20153561-e20153561.
10.1542/peds.2015-3561
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22392
Varimo T, Dunkel L, Vaaralahti K, Miettinen PJ, Hero M, Raivio T(2016). Circulating makorin ring finger protein 3 levels decline in boys before the clinical onset of puberty. European Journal of Endocrinology vol. 174, (6) 785-790.
10.1530/EJE-15-1193
Demir A, Voutilainen R, Stenman UH, Dunkel L, Albertsson-Wikland K, Norjavaara E(2016). First Morning Voided Urinary Gonadotropin Measurements as an Alternative to the GnRH Test. Hormone Research in Paediatrics vol. 85, (5) 301-308.
10.1159/000440955
Scherdel P, Dunkel L, van Dommelen P, Goulet O, Salaün JF, Brauner R, Heude B, Chalumeau M(2016). Growth monitoring as an early detection tool: A systematic review. The Lancet Diabetes and Endocrinology vol. 4, (5) 447-456.
10.1016/S2213-8587(15)00392-7
HOWARD SR, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell LA, Sternberg MJE et al.(2016). IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty. EMBO Molecular Medicine vol. 8, (6) 626-42.
10.15252/emmm.201606250
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18622
Savage MO, Backeljauw PF, Calzada R, Cianfarani S, Dunkel L, Koledova E, Wit JM, Yoo HW(2016). Early Detection, Referral, Investigation, and Diagnosis of Children with Growth Disorders. Hormone research in paediatrics
10.1159/000444525
Asadi-Azarbaijani B, Sheikhi M, Nurmio M, Tinkanen H, Juvonen V, Dunkel L, Hovatta O, Oskam IC et al.(2016). Minimal residual disease of leukemia and the quality of cryopreserved human ovarian tissue in vitro. Leukemia and Lymphoma vol. 57, (3) 700-707.
10.3109/10428194.2015.1065980
Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Sternberg M et al. (2016). Role of IGSF10 mutations in self-limited delayed puberty. LANCET. vol. 387, 14-14.
Mancini A, Howard SR, Ruiz-Babot G, Cabrera CP, Barnes MR, Guasti L, Dunkel L (2016). LGR4 and EAP1 Mutations are Implicated in the Phenotype of Self-limited Delayed Puberty. HORMONE RESEARCH IN PAEDIATRICS. vol. 86, 58-58.
Howard S, Dunkel L(2016). Sex steroid and gonadotropin treatment in male delayed puberty.
Mistry J, Ruiz-Babot G, Guasti L, Dunkel L (2016). The Mechanistic Role of Fibroblast Growth Factor 21 (FGF21) in Growth Hormone Resistance Secondary to Chronic Childhood Conditions. HORMONE RESEARCH IN PAEDIATRICS. vol. 86, 362-362.
Stalman SE, Hellinga I, Van Dommelen P, Hennekam RCM, Saari A, Sankilampi U, Dunkel L, Wit JM et al.(2015). Application of the Dutch, Finnish and British Screening Guidelines in a Cohort of Children with Growth Failure. Hormone Research in Paediatrics vol. 84, (6) 376-382.
10.1159/000440652
Raivio T, Dunkel L(2015). Letter to the Editor: Comment On The Treatment Of Adolescent Boys With Hypogonadotropic Hypogonadism By Gong C., et al. The Journal of clinical endocrinology and metabolism vol. 100, (9) L73-L74.
10.1210/jc.2015-2586
Cousminer DL, Leinonen JT, Sarin AP, Chheda H, Surakka I, Wehkalampi K, Ellonen P, Ripatti S et al.(2015). Targeted resequencing of the pericentromere of chromosome 2 linked to constitutional delay of growth and puberty. PLoS ONE vol. 10, (6)
10.1371/journal.pone.0128524
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12255
Joustra SD, Wehkalampi K, Oostdijk W, Biermasz NR, Howard S, Silander TL, Bernard DJ, Wit JM et al.(2015). IGSF1 variants in boys with familial delayed puberty. European Journal of Pediatrics vol. 174, (5) 687-692.
10.1007/s00431-014-2445-9
Storr HL, Dunkel L, Kowalczyk J, Savage MO, Metherell LA(2015). Genetic characterisation of a cohort of children clinically labelled as GH or IGF1 insensitive: diagnostic value of serum IGF1 and height at presentation. Eur J Endocrinol vol. 172, (2) 151-161.
10.1530/EJE-14-0541
Saari A, Virta LJ, Sankilampi U, Dunkel L, Saxen H(2015). Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life. Pediatrics vol. 135, (4) 617-626.
10.1542/peds.2014-3407
Boehm U, Bouloux PM, Dattani MT, De Roux N, Dodé C, Dunkel L, Dwyer AA, Giacobini P et al.(2015). Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism-pathogenesis, diagnosis and treatment. Nature Reviews Endocrinology vol. 11, (9) 547-564.
10.1038/nrendo.2015.112
Saari A, Harju S, Mäkitie O, Saha MT, Dunkel L, Sankilampi U(2015). Systematic growth monitoring for the early detection of celiac disease in children. JAMA Pediatrics vol. 169, (3)
10.1001/jamapediatrics.2015.25
Howard S, Dunkel L(2014). Delayed Puberty and Hypogonadism, Female. Reference Module in Biomedical Research,
Guasti L, Silvennoinen S, Bulstrode NW, Ferretti P, Sankilampi U, Dunkel L(2014). Elevated FGF21 leads to attenuated postnatal linear growth in preterm infants through GH resistance in chondrocytes. J Clin Endocrinol Metab vol. 99, (11) E2198-E2206.
10.1210/jc.2014-1566
Joustra SD, Joustra SD, Wehkalampi K, Oostdijk W, Biermasz NR, Howard S, Silander TL, Bernard DJ et al.(2014). IGSF1 variants in boys with familial delayed puberty. European Journal of Pediatrics
10.1007/s00431-014-2445-9
Frederiksen H, Kuiri-Hänninen T, Main KM, Dunkel L, Sankilampi U(2014). A longitudinal study of urinary phthalate excretion in 58 full-term and 67 preterm infants from birth through 14 months. Environ Health Perspect vol. 122, (9) 998-1005.
10.1289/ehp.1307569
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12338
Dunkel L, Quinton R(2014). Transition in endocrinology: induction of puberty. Eur J Endocrinol vol. 170, (6) R229-R239.
10.1530/EJE-13-0894
Palmert MR, Dunkel L, Witchel SF(2014). Puberty and its disorders in the male.
10.1016/B978-1-4557-4858-7.00026-3
Kuiri-Hänninen T, Sankilampi U, Dunkel L(2014). Activation of the hypothalamic-pituitary-gonadal axis in infancy: Minipuberty. Hormone Research in Paediatrics vol. 82, (2) 73-80.
10.1159/000362414
Kuiri-Hänninen T, Sankilampi U, Dunkel L(2014). Activation of the hypothalamic-pituitary-gonadal axis in infancy: minipuberty. Horm Res Paediatr vol. 82, (2) 73-80.
10.1159/000362414
Kuiri-Hänninen T, Haanpää M, Turpeinen U, Hämäläinen E, Seuri R, Tyrväinen E, Sankilampi U, Dunkel L(2013). Postnatal ovarian activation has effects in estrogen target tissues in infant girls. J Clin Endocrinol Metab vol. 98, (12) 4709-4716.
10.1210/jc.2013-1677
Sankilampi U, Saari A, Laine T, Miettinen PJ, Dunkel L(2013). Use of Electronic Health Records for Automated Screening of Growth Disorders in Primary Care. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION vol. 310, (10) 1071-1072.
10.1001/jama.2013.218793
Sankilampi U, Hannila M-L, Saari A, Gissler M, Dunkel L(2013). New population-based references for birth weight, length, and head circumference in singletons and twins from 23 to 43 gestation weeks. ANNALS OF MEDICINE vol. 45, (5-6) 446-454.
10.3109/07853890.2013.803739
Jahnukainen K, Tinkanen H, Wikstrom A, Dunkel L, Saarinen-Pihkala UM, Makinen S, Azarbaijani BA, Oskam IC et al.(2013). Bone marrow remission status predicts leukemia contamination in ovarian biopsies collected for fertility preservation. LEUKEMIA vol. 27, (5) 1183-1185.
10.1038/leu.2012.279
Saari A, Sankilampi U, Dunkel L(2013). Multiethnic WHO Growth Charts May Not Be Optimal in the Screening of Disorders Affecting Height: Turner Syndrome as a Model. JAMA PEDIATRICS vol. 167, (2) 194-195.
10.1001/jamapediatrics.2013.436
Karvonen M, Saari A, Hannila M-L, Lonnqvist T, Dunkel L, Sankilampi U(2013). Elevated Head Circumference-to-Height Ratio Is an Early and Frequent Feature in Children with Neurofibromatosis Type 1. HORMONE RESEARCH IN PAEDIATRICS vol. 79, (2) 97-102.
10.1159/000347119
Kuiri-Hänninen T, Haanpää M, Turpeinen U, Hämäläinen E, Dunkel L, Sankilampi U(2013). Transient postnatal secretion of androgen hormones is associated with acne and sebaceous gland hypertrophy in early infancy. J Clin Endocrinol Metab vol. 98, (1) 199-206.
10.1210/jc.2012-2680
Silventoinen K, Kaprio J, Dunkel L, Yokoyama Y(2012). Genetic and environmental influences on chest circumference during infancy: a longitudinal study of japanese twins. Paediatr Perinat Epidemiol vol. 26, (6) 553-560.
10.1111/ppe.12003
Saari A, Sankilampi U, Hannila M-L, Saha M-T, Mäkitie O, Dunkel L(2012). Screening of turner syndrome with novel auxological criteria facilitates early diagnosis. J Clin Endocrinol Metab vol. 97, (11) E2125-E2132.
10.1210/jc.2012-1739
Kilpelainen L, Ivaska KK, Kuiri-Hanninen T, Vaananen HK, Rehfeld JF, Goetze JP, Sankilampi U, Dunkel L(2012). Urinary osteocalcin and serum pro-C-type natriuretic peptide predict linear catch-up growth in infants. JOURNAL OF BONE AND MINERAL RESEARCH vol. 27, (7) 1528-1535.
10.1002/jbmr.1596
Karvonen M, Hannila M-L, Saari A, Dunkel L(2012). New Finnish reference for head circumference from birth to 7 years. ANNALS OF MEDICINE vol. 44, (4) 369-374.
10.3109/07853890.2011.558519
Hero M, Tommiska J, Vaaralahti K, Laitinen E-M, Sipila I, Puhakka L, Dunkel L, Raivio T(2012). Circulating antimullerian hormone levels in boys decline during early puberty and correlate with inhibin B. FERTILITY AND STERILITY vol. 97, (5) 1242-1247.
10.1016/j.fertnstert.2012.02.020
Kuiri-Hanninen T, Kallio S, Seuri R, Tyrvainen E, Liakka A, Tapanainen J, Sankilampi U, Dunkel L(2012). Postnatal Developmental Changes in the Pituitary-Ovarian Axis in Preterm and Term Infant Girls EDITORIAL COMMENT. OBSTETRICAL & GYNECOLOGICAL SURVEY vol. 67, (5) 284-285.
10.1097/OGX.0b013e318254713b
Lamminmaki A, Hines M, Kuiri-Hanninen T, Kilpelainen L, Dunkel L, Sankilampi U(2012). Testosterone measured in infancy predicts subsequent sex-typed behavior in boys and in girls. HORMONES AND BEHAVIOR vol. 61, (4) 611-616.
10.1016/j.yhbeh.2012.02.013
Turpeinen U, Hamalainen E, Haanpaa M, Dunkel L(2012). Determination of salivary testosterone and androstendione by liquid chromatography-tandem mass spectrometry. CLINICA CHIMICA ACTA vol. 413, (5-6) 594-599.
10.1016/j.cca.2011.11.029
Kallio S, Aittomaki K, Piltonen T, Veijola R, Liakka A, Vaskivuo TE, Dunkel L, Tapanainen JS(2012). Anti-Mullerian hormone as a predictor of follicular reserve in ovarian insufficiency: special emphasis on FSH-resistant ovaries. HUMAN REPRODUCTION vol. 27, (3) 854-860.
10.1093/humrep/der473
Palmert MR, Dunkel L(2012). Delayed Puberty. NEW ENGLAND JOURNAL OF MEDICINE vol. 366, (5) 443-453.
10.1056/NEJMcp1109290
Dunkel L, Hero M(2012). Aromatase inhibitors and growth disorders. Handbook of Growth and Growth Monitoring in Health and Disease,
Kuiri-Hänninen T, Kallio S, Seuri R, Tyrväinen E, Liakka A, Tapanainen J, Sankilampi U, Dunkel L(2011). Postnatal developmental changes in the pituitary-ovarian axis in preterm and term infant girls. J Clin Endocrinol Metab vol. 96, (11) 3432-3439.
10.1210/jc.2011-1502
Silventoinen K, Karvonen M, Sugimoto M, Kaprio J, Dunkel L, Yokoyama Y(2011). Genetics of Head Circumference in Infancy: A Longitudinal Study of Japanese Twins. AM J HUM BIOL vol. 23, (5) 630-634.
10.1002/ajhb.21190
Kallio S, Kuiri-Hanninen T, Tyrvainen E, Seuri R, Liakka A, Sankilampi U, Dunkel L, Tapanainen JS (2011). Evidence for fetal maturation and postnatal activation of ovarian follicle development in human. HUMAN REPRODUCTION. vol. 26, I4-I4.
10.1093/humrep/26.s1.3
Hero M, Dunkel L, Vaaralahti K, Raivio T(2011). Serum FGF21 in boys with idiopathic short stature: relationship to lipid profile, onset of puberty and growth. Clin Endocrinol (Oxf) vol. 75, (1) 141-142.
10.1111/j.1365-2265.2011.03999.x
Vaaralahti K, Wehkalampi K, Tommiska J, Laitinen EM, Dunkel L, Raivio T(2011). The role of gene defects underlying isolated hypogonadotropic hypogonadism in patients with constitutional delay of growth and puberty. FERTIL STERIL vol. 95, (8) 2756-2758.
10.1016/j.fertnstert.2010.12.059
Bang P, Bjerknes R, Dahlgren J, Dunkel L, Gustafsson J, Juul A, Kriström B, Tapanainen P et al.(2011). A comparison of different definitions of growth response in short prepubertal children treated with growth hormone. Hormone Research in Paediatrics vol. 75, (5) 335-345.
10.1159/000322878
Saari A, Sankilampi U, Hannila M-L, Kiviniemi V, Kesseli K, Dunkel L(2011). New Finnish growth references for children and adolescents aged 0 to 20 years: Length/height-for-age, weight-for-length/height, and body mass index-for-age. Ann Med vol. 43, (3) 235-248.
10.3109/07853890.2010.515603
Wikström AM, Dunkel L(2011). Klinefelter syndrome. Best Practice and Research: Clinical Endocrinology and Metabolism vol. 25, (2) 239-250.
10.1016/j.beem.2010.09.006
Wehkalampi K, Hovi P, Dunkel L, Strang-Karlsson S, Jarvenpaa AL, Eriksson JG, Andersson S, Kajantie E(2011). Advanced Pubertal Growth Spurt in Subjects Born Preterm: The Helsinki Study of Very Low Birth Weight Adults. J CLIN ENDOCR METAB vol. 96, (2) 525-533.
10.1210/jc.2010-1523
Wehkalampi K, Pääkilä K, Laine T, Dunkel L(2011). Adult Height in Girls with Delayed Pubertal Growth. Horm Res Paediatr. vol. 76, (2) 130-135.
10.1159/000328055
Dunkel L(2011). Chairman's Summary: Molecular Background of ISS. HORMONE RESEARCH IN PAEDIATRICS vol. 76, 9-9.
10.1159/000330137
Kuiri-Hänninen T, Seuri R, Tyrväinen E, Turpeinen U, Hämäläinen E, Stenman U-H, Dunkel L, Sankilampi U(2011). Increased activity of the hypothalamic-pituitary-testicular axis in infancy results in increased androgen action in premature boys. J Clin Endocrinol Metab vol. 96, (1) 98-105.
10.1210/jc.2010-1359
Wit JM, Dunkel L(2011). Overview: Developments in Idiopathic Short Stature. HORMONE RESEARCH IN PAEDIATRICS vol. 76, 1-2.
10.1159/000330131
Dunkel L(2011). Treatment of idiopathic short stature: effects of gonadotropin-releasing hormone analogs, aromatase inhibitors and anabolic steroids. Horm Res Paediatr vol. 76 Suppl 3, 27-29.
10.1159/000330150
Hero M, Maury S, Luotoniemi E, Service E, Dunkel L(2010). Cognitive effects of aromatase inhibitor therapy in peripubertal boys. Eur J Endocrinol vol. 163, (1) 149-155.
10.1530/EJE-10-0040
Hero M, Toiviainen-Salo S, Wickman S, Mäkitie O, Dunkel L(2010). Vertebral morphology in aromatase inhibitor-treated males with idiopathic short stature or constitutional delay of puberty. J Bone Miner Res vol. 25, (7) 1536-1543.
10.1002/jbmr.56
Tommiska J, Wehkalampi K, Vaaralahti K, Laitinen E-M, Raivio T, Dunkel L(2010). LIN28B in constitutional delay of growth and puberty. J Clin Endocrinol Metab vol. 95, (6) 3063-3066.
10.1210/jc.2009-2344
Laitinen E-M, Tommiska J, Dunkel L, Sankilampi U, Vaaralahti K, Raivio T(2010). Idiopathic hypogonadotropic hypogonadism in a mother and her monozygotic twins born after a single embryo transfer. Fertil Steril vol. 93, (6) 2074.e13-2074.e16.
10.1016/j.fertnstert.2009.11.013
Dunkel L(2010). Off-label use of aromatase inhibitors to promote taller stature: is it safe. Horm Res Paediatr vol. 74, (6) 436-437.
10.1159/000317434
Hero M, Maury S, Luotoniemi E, Service E, Dunkel L(2009). Cognitive effects of aromatase inhibitor therapy in peripubertal boys. HORMONE RESEARCH vol. 72, 398-398.
Wehkalampi K, Lindfors K, Sinkkonen J, Dunkel L, Elovainio M(2009). Constitutional delay of growth and puberty predicts minor psychiatric morbidity in adolescence. HORMONE RESEARCH vol. 72, 394-394.
Hero M, Mäkitie O, Kröger H, Nousiainen E, Toiviainen-Salo S, Dunkel L(2009). Impact of aromatase inhibitor therapy on bone turnover, cortical bone growth and vertebral morphology in pre- and peripubertal boys with idiopathic short stature. Horm Res vol. 71, (5) 290-297.
10.1159/000208803
Kuiri-Hanninen T, Sankilampi U, Hamalainen E, Turpeinen U, Seuri R, Dunkel L(2009). Longitudinal assessment of urinary gonadotropin and testosterone levels and their relation to postnatal penile and testicular growth in full term and preterm boys. HORMONE RESEARCH vol. 72, 398-399.
Dunkel L(2009). Update on the role of aromatase inhibitors in growth disorders. Horm Res vol. 71 Suppl 1, 57-63.
10.1159/000178040
Bang P, Bjerknes R, Dahlgren J, Dunkel L, Gustafsson J, Juul A, Kristrom B, Tapanainen P et al.(2009). What is a poor growth response to rhGH therapy? A comparison of different definitions of growth response in 456 Nordic short statured children treated with rhGH. HORMONE RESEARCH vol. 72, 100-100.
Wehkalampi K, Silventoinen K, Kaprio J, Dick DM, Rose RJ, Pulkkinen L, Dunkel L(2008). Genetic and environmental influences on pubertal timing assessed by height growth. American Journal of Human Biology vol. 20, (4) 417-423.
10.1002/ajhb.20748
Silventoinen K, Haukka J, Dunkel L, Tynelius P, Rasmussen F(2008). Genetics of pubertal timing and its associations with relative weight in childhood and adult height: the Swedish Young Male Twins Study. Pediatrics vol. 121, (4) e885-e891.
10.1542/peds.2007-1615
Euling SY, Herman-Giddens ME, Lee PA, Selevan SG, Juul A, Sørensen TIA, Dunkel L, Himes JH et al.(2008). Examination of US puberty-timing data from 1940 to 1994 for secular trends: Panel findings. Pediatrics vol. 121, (SUPPL.3)
10.1542/peds.2007-1813D
Wehkalampi K, Widen E, Laine T, Palotie A, Dunkel L(2008). A locus on chromosome 2 regulates the timing of puberty. HORMONE RESEARCH vol. 70, 35-35.
Hero M, Dunkel L(2008). Aromatase inhibitors in bone and growth plate. HORMONE RESEARCH vol. 70, 13-14.
Wehkalampi K, Widén E, Laine T, Palotie A, DUNKEL L(2008). Association of the timing of puberty with a chromosome 2 locus. J Clin Endocrinol Metab vol. 93, (12) 4833-4839.
10.1210/jc.2008-0882
Dunkel L(2008). Klinefelter Syndrome (KS): Growth and Hormone Replacement. HORMONE RESEARCH vol. 70, 6-7.
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Wehkalampi K, Vangonen K, Laine T, Dunkel L(2007). Progressive reduction of relative height in childhood predicts adult stature below target height in boys with constitutional delay of growth and puberty. Hormone Research vol. 68, (2) 99-104.
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Hero M, Makitie H, Kroger H, Sanna T, Dunkel L (2007). The impact of aromatase inhibitor therapy on bone turnover, cortical bone growth and vertebral morphology in peripubertal boys with idiopathic short stature. BONE. vol. 40, S50-S50.
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Wikström AM, Hoei-Hansen CE, Dunkel L, Meyts ERD(2007). Immunoexpression of androgen receptor and nine markers of maturation in the testes of adolescent boys with Klinefelter syndrome: Evidence for degeneration of germ cells at the onset of meiosis. Journal of Clinical Endocrinology and Metabolism vol. 92, (2) 714-719.
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Raivio T, Wikström AM, Dunkel L(2007). Treatment of gonadotropin-deficient boys with recombinant human FSH: long-term observation and outcome. Eur J Endocrinol vol. 156, (1) 105-111.
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Dunkel L(2007). [Not Available]. Duodecim vol. 123, (2) 231-237.
Dunkel L(2006). Management of children with idiopathic short stature. European Journal of Endocrinology, Supplement vol. 155, (1)
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Hero M, Ankarberg-Lindgren C, Taskinen M-R, Dunkel L(2006). Blockade of oestrogen biosynthesis in peripubertal boys: effects on lipid metabolism, insulin sensitivity, and body composition. Eur J Endocrinol vol. 155, (3) 453-460.
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Dunkel L(2006). Use of aromatase inhibitors to increase final height. Mol Cell Endocrinol vol. 254-255, 207-216.
10.1016/j.mce.2006.04.031
Vera Y, Erkkilä K, Wang C, Nunez C, Kyttänen S, Lue Y, Dunkel L, Swerdloff RS et al.(2006). Involvement of p38 mitogen-activated protein kinase and inducible nitric oxide synthase in apoptotic signaling of murine and human male germ cells after hormone deprivation. Molecular Endocrinology vol. 20, (7) 1597-1609.
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Wikström AM, Painter JN, Raivio T, Aittomäki K, Dunkel L(2006). Genetic features of the X chromosome affect pubertal development and testicular degeneration in adolescent boys with Klinefelter syndrome. Clin Endocrinol (Oxf) vol. 65, (1) 92-97.
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Vera Y, Erkkila K, Wang C, Nunez C, Kyttanen S, Lue Y, Dunkel L, Swerdloff RS et al.(2006). Involvement of p38 mitogen-activated protein kinase and inducible nitric oxide synthase in apoptotic signaling of murine and human. MOLECULAR ENDOCRINOLOGY vol. 20, (7) 1597-1609.
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Erkkila K, Kyttanen S, Wikstrom M, Taari K, Sinha Hikim AP, Swerdloff RS, Dunkel L(2006). Regulation of human male germ cell death by modulators of ATP production. American Journal of Physiology - Endocrinology and Metabolism vol. 290, (6)
10.1152/ajpendo.00142.2005
Wikström AM, Dunkel L, Wickman S, Norjavaara E, Ankarberg-Lindgren C, Raivio T(2006). Are adolescent boys with Klinefelter syndrome androgen deficient? A longitudinal study of Finnish 47,XXY boys. Pediatr Res vol. 59, (6) 854-859.
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Hero M, Wickman S, Dunkel L(2006). Treatment with the aromatase inhibitor letrozole during adolescence increases near-final height in boys with constitutional delay of puberty. Clinical Endocrinology vol. 64, (5) 510-513.
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Kajantie E, Dunkel L, Turpeinen U, Stenman UH, Andersson S(2006). Placental 11 beta-HSD2 activity, early postnatal clinical course, and adrenal function in extremely low birth weight infants. PEDIATRIC RESEARCH vol. 59, (4) 575-578.
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Kajantie E, Dunkel L, Turpeinen U, Stenman UH, Andersson S(2006). Placental 11β-HSD2 activity, early postnatal clinical course, and adrenal function in extremely low birth weight infants. Pediatric Research vol. 59, (4 PART 1) 575-578.
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Hero M, Lindgren CA, Taskinen MR, Dunkel L(2006). Blockade of oestrogen biosynthesis in peripubertal boys: effects on lipid metabolism, insulin sensitivity, and body composition. HORMONE RESEARCH vol. 65, 105-105.
Höglund P, Hihnala S, Kujala M, Tiitinen A, Dunkel L, Holmberg C(2006). Disruption of the SLC26A3-mediated anion transport is associated with male subfertility. Fertil Steril vol. 85, (1) 232-235.
10.1016/j.fertnstert.2005.06.043
Wehkalampi K, Dunkel L(2006). Familial aggregation of constitutional delay of growth and puberty (CDGP). HORMONE RESEARCH vol. 65, 106-106.
Wehkalampi K, Dunkel L(2006). Height outcome in boys with constitutional delay of growth and puberty (CDGP). HORMONE RESEARCH vol. 65, 107-107.
Erkkila K, Kyttanen S, Dunkel L, Lue YH, Wang C, Sinha-Hikim AP, Swerdloff RS (2006). N-acetyl-L-cysteine (NAC) restores GSH-GSSG ratio and prevents human male germ cell apoptosis. JOURNAL OF ANDROLOGY. 51-51.
Erkkila K, Kyttanen S, Dunkel L, Lue YH, Wang C, Hikim APS, Swerdloff RS (2006). N-acetyl-L-cysteine restores glutathione-to-glutathione disulfide ratio and prevents human male germ cell apoptosis. JOURNAL OF INVESTIGATIVE MEDICINE. vol. 54, S152-S152.
Aksglæde L, Wikström AM, Meyts ERD, Dunkel L, Skakkebæk NE, Juul A(2006). Natural history of seminiferous tubule degeneration in Klinefelter syndrome. Human Reproduction Update vol. 12, (1) 39-48.
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Wikstrom A, Bay K, Hero M, Andersson AM, Dunkel L(2006). Serum INSU levels during puberty in healthy boys and in boys with Klinefelter syndrome. HORMONE RESEARCH vol. 65, 32-33.
Wikström AM, Bay K, Hero M, Andersson AM, Dunkel L(2006). Serum insulin-like factor 3 levels during puberty in healthy boys and boys with Klinefelter syndrome. Journal of Clinical Endocrinology and Metabolism vol. 91, (11) 4705-4708.
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Hero M, Norjavaara E, Dunkel L(2005). Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases predicted adult height in boys with idiopathic short stature: a randomized controlled trial. J Clin Endocrinol Metab vol. 90, (12) 6396-6402.
10.1210/jc.2005-1392
Castanares M, Vera Y, Erkkilä K, Kyttänen S, Lue Y, Dunkel L, Wang C, Swerdloff RS et al.(2005). Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis. Biochemical and Biophysical Research Communications vol. 337, (2) 663-669.
10.1016/j.bbrc.2005.09.101
Hero M, Jänne OA, Näntö-Salonen K, Dunkel L, Raivio T(2005). Circulating antiandrogenic activity in children with congenital adrenal hyperplasia during peroral flutamide treatment. Journal of Clinical Endocrinology and Metabolism vol. 90, (9) 5140-5145.
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Hero M, Jänne OA, Näntö-Salonen K, Dunkel L, Raivio T(2005). Circulating antiandrogenic activity in children with congenital adrenal hyperplasia during peroral flutamide treatment. J Clin Endocrinol Metab vol. 90, (9) 5141-5145.
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Hochberg Z, Khaesh-Goldberg I, Partsch CJ, Zadik Z, Bistritzer T, Cohen A, Doveh E, Sippell W et al.(2005). Differences in infantile growth patterns in Turner syndrome girls with and without spontaneous puberty. Hormone and Metabolic Research vol. 37, (4) 236-241.
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Suomalainen L, Pentikäinen V, Dunkel L(2005). Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. Am J Pathol vol. 166, (3) 773-781.
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Hero M, Wickman S, Hanhijärvi R, Siimes MA, Dunkel L(2005). Pubertal upregulation of erythropoiesis in boys is determined primarily by androgen. J Pediatr vol. 146, (2) 245-252.
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Erkkila K, Kyttanen S, Lapatto R, Dunkel L (2005). ATP production and pyridine nucleotides in human male germ cell death. JOURNAL OF ANDROLOGY. 75-75.
Vallette-Kasic S, Brue T, Pulichino AM, Gueydan M, Barlier A, David M, Nicolino M, Malpuech G et al.(2005). Congenital isolated adrenocorticotropin deficiency: An underestimated cause of neonatal death, explained by TPIT gene mutations. Journal of Clinical Endocrinology and Metabolism vol. 90, (3) 1323-1331.
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Otala M, Pentikäinen MO, Matikainen T, Suomalainen L, Hakala JK, Perez GI, Tenhunen M, Erkkilä K et al.(2005). Effects of acid sphingomyelinase deficiency on male germ cell development and programmed cell death. Biol Reprod vol. 72, (1) 86-96.
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Erkkila K, Dunkel L, Kyttanen S(2005). Regulation of human male germ cell death by modulators of ATP production. JOURNAL OF INVESTIGATIVE MEDICINE vol. 53, (1) S149-S149.
Suomalainen L, Dunkel L, Ketola I, Eriksson M, Erkkilä K, Oksjoki R, Taari K, Heikinheimo M et al.(2004). Activator protein-1 in human male germ cell apoptosis. Mol Hum Reprod vol. 10, (10) 743-753.
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Otala M, Mäkinen S, Tuuri T, Sjöberg J, Pentikäinen V, Matikainen T, Dunkel L(2004). Effects of testosterone, dihydrotestosterone, and 17β-estradiol on human ovarian tissue survival in culture. Fertility and Sterility vol. 82, (SUPPL. 3) 1077-1085.
10.1016/j.fertnstert.2004.06.032
Wikström AM, Raivio T, Hadziselimovic F, Wikström S, Tuuri T, Dunkel L(2004). Klinefelter syndrome in adolescence: onset of puberty is associated with accelerated germ cell depletion. J Clin Endocrinol Metab vol. 89, (5) 2263-2270.
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Otala M, Suomalainen L, Pentikäinen MO, Kovanen P, Tenhunen M, Erkkilä K, Toppari J, Dunkel L(2004). Protection from radiation-induced male germ cell loss by sphingosine-1-phosphate. Biol Reprod vol. 70, (3) 759-767.
10.1095/biolreprod.103.021840
Raivio T, Dunkel L, Wickman S, Jänne OA(2004). Serum androgen bioactivity in adolescence: a longitudinal study of boys with constitutional delay of puberty. J Clin Endocrinol Metab vol. 89, (3) 1188-1192.
10.1210/jc.2003-031655
Hovi L, Saarinen-Pihkala UM, Taskinen M, Wikström AM, Dunkel L(2004). Subnormal androgen levels in young female bone marrow transplant recipients with ovarian dysfunction, chronic GVHD and receiving glucocorticoid therapy. Bone Marrow Transplant vol. 33, (5) 503-508.
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Suomalainen L, Hakala JK, Pentikäinen V, Otala M, Erkkilä K, Pentikäinen MO, Dunkel L(2003). Sphingosine-1-phosphate in inhibition of male germ cell apoptosis in the human testis. J Clin Endocrinol Metab vol. 88, (11) 5572-5579.
10.1210/jc.2003-030776
Silventoinen K, Sammalisto S, Perola M, Boomsma DI, Cornes BK, Davis C, Dunkel L, De Lange M et al.(2003). Heritability of adult body height: a comparative study of twin cohorts in eight countries. Twin Res vol. 6, (5) 399-408.
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Dunkel L, Wickman S(2003). Novel treatment of short stature with aromatase inhibitors. J Steroid Biochem Mol Biol vol. 86, (3-5) 345-356.
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Erkkilä K, Suomalainen L, Wikström M, Parvinen M, Dunkel L(2003). Chemical anoxia delays germ cell apoptosis in the human testis. Biol Reprod vol. 69, (2) 617-626.
10.1095/biolreprod.102.013920
Wickman S, Kajantie E, Dunkel L(2003). Effects of suppression of estrogen action by the p450 aromatase inhibitor letrozole on bone mineral density and bone turnover in pubertal boys. J Clin Endocrinol Metab vol. 88, (8) 3785-3793.
10.1210/jc.2002-021643
Raivio T, Toppari J, Kaleva M, Virtanen H, Haavisto A-M, Dunkel L, Jänne OA(2003). Serum androgen bioactivity in cryptorchid and noncryptorchid boys during the postnatal reproductive hormone surge. J Clin Endocrinol Metab vol. 88, (6) 2597-2599.
10.1210/jc.2002-021676
Wikström AM, Hovi L, Dunkel L, Saarinen-Pihkala UM(2003). Restoration of ovarian function after chemotherapy for osteosarcoma. Arch Dis Child vol. 88, (5) 428-431.
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Pentikäinen V, Dunkel L, Erkkilä K(2003). Male germ cell apoptosis. Endocr Dev vol. 5, 56-80.
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Hreinsson JG, Otala M, Fridström M, Borgström B, Rasmussen C, Lundqvist M, Tuuri T, Simberg N et al.(2002). Follicles are found in the ovaries of adolescent girls with Turner's syndrome. Journal of Clinical Endocrinology and Metabolism vol. 87, (8) 3618-3623.
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Jaatinen R, Bondestam J, Raivio T, Hildén K, Dunkel L, Groome N, Ritvos O(2002). Activation of the bone morphogenetic protein signaling pathway induces inhibin beta(B)-subunit mRNA and secreted inhibin B levels in cultured human granulosa-luteal cells. J Clin Endocrinol Metab vol. 87, (3) 1254-1261.
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Otala M, Erkkilä K, Tuuri T, Sjöberg J, Suomalainen L, Suikkari A-M, Pentikäinen V, Dunkel L(2002). Cell death and its suppression in human ovarian tissue culture. Mol Hum Reprod vol. 8, (3) 228-236.
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Raivio T, Dunkel L(2002). Inhibins in childhood and puberty. Best Pract Res Clin Endocrinol Metab vol. 16, (1) 43-52.
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Wickman S, Saukkonen T, Dunkel L(2002). The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor. Eur J Endocrinol vol. 146, (3) 339-346.
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Erkkilä K, Aito H, Aalto K, Pentikäinen V, Dunkel L(2002). Lactate inhibits germ cell apoptosis in the human testis. Mol Hum Reprod vol. 8, (2) 109-117.
10.1093/molehr/8.2.109
Dunkel L, Wickman S(2002). Novel treatment of delayed male puberty with aromatase inhibitors. Horm Res vol. 57 Suppl 2, 44-52.
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Pentikäinen V, Suomalainen L, Erkkilä K, Martelin E, Parvinen M, Pentikäinen MO, Dunkel L(2002). Nuclear factor-kappa B activation in human testicular apoptosis. Am J Pathol vol. 160, (1) 205-218.
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Malozowski S, Cianfarani S, Dunkel L(2001). Role of hormones in puberty [7] (multiple letters). Lancet vol. 358, (9291) 1459-1460.
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Wickman S, Dunkel L(2001). Inhibition of P450 aromatase enhances gonadotropin secretion in early and midpubertal boys: evidence for a pituitary site of action of endogenous E. J Clin Endocrinol Metab vol. 86, (10) 4887-4894.
10.1210/jcem.86.10.7927
Pentikäinen V, Erkkilä K, Suomalainen L, Otala M, Pentikäinen MO, Parvinen M, Dunkel L(2001). TNFα down-regulates the Fas ligand and inhibits germ cell apoptosis in the human testis. Journal of Clinical Endocrinology and Metabolism vol. 86, (9) 4480-4488.
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Pentikäinen V, Erkkilä K, Suomalainen L, Otala M, Pentikäinen MO, Parvinen M, Dunkel L(2001). TNFalpha down-regulates the Fas ligand and inhibits germ cell apoptosis in the human testis. J Clin Endocrinol Metab vol. 86, (9) 4480-4488.
10.1210/jcem.86.9.7861
Wickman S, Sipilä I, Ankarberg-Lindgren C, Norjavaara E, Dunkel L(2001). A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomised controlled trial. Lancet vol. 357, (9270) 1743-1748.
10.1016/S0140-6736(00)04895-9
Mäkitie OM, Tapanainen PJ, Dunkel L, Siimes MA(2001). Impaired spermatogenesis: an unrecognized feature of cartilage-hair hypoplasia. Ann Med vol. 33, (3) 201-205.
10.3109/07853890109002078
Raivio T, Palvimo JJ, Dunkel L, Wickman S, Jänne OA(2001). Novel assay for determination of androgen bioactivity in human serum. J Clin Endocrinol Metab vol. 86, (4) 1539-1544.
10.1210/jcem.86.4.7329
Dunkel L, Wickman S(2001). Treatment of delayed male puberty: efficacy of aromatase inhibition. J Pediatr Endocrinol Metab vol. 14 Suppl 6, 1541-1546.
Mäkitie O, Juvonen E, Dunkel L, Kaitila I, Siimes MA(2000). Anemia in children with cartilage-hair hypoplasia is related to body growth and to the insulin-like growth factor system. Journal of Clinical Endocrinology and Metabolism vol. 85, (2) 563-568.
10.1210/jc.85.2.563
Ketola I, Pentikäinen V, Vaskivuo T, Ilvesmäki V, Herva R, Dunkel L, Tapanainen JS, Toppari J et al.(2000). Expression of transcription factor GATA-4 during human testicular development and disease. J Clin Endocrinol Metab vol. 85, (10) 3925-3931.
10.1210/jcem.85.10.6900
Vaskivuo TE, Stenbäck F, Karhumaa P, Risteli J, Dunkel L, Tapanainen JS(2000). Apoptosis and apoptosis-related proteins in human endometrium. Molecular and Cellular Endocrinology vol. 165, (1-2) 75-83.
10.1016/S0303-7207(00)00261-6
Pentikäinen V, Erkkilä K, Suomalainen L, Parvinen M, Dunkel L(2000). Estradiol acts as a germ cell survival factor in the human testis in vitro. J Clin Endocrinol Metab vol. 85, (5) 2057-2067.
10.1210/jcem.85.5.6600
Raivio T, Saukkonen S, Jääskeläinen J, Komulainen J, Dunkel L(2000). Signaling between the pituitary gland and the testes: inverse relationship between serum FSH and inhibin B concentrations in boys in early puberty. Eur J Endocrinol vol. 142, (2) 150-156.
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Raivio T, Dunkel L(1999). Inverse relationship between serum inhibin B and FSH levels in prepubertal boys with cryptorchidism. Pediatr Res vol. 46, (5) 496-500.
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Erkkilä K, Pentikäinen V, Wikström M, Parvinen M, Dunkel L(1999). Partial oxygen pressure and mitochondrial permeability transition affect germ cell apoptosis in the human testis. J Clin Endocrinol Metab vol. 84, (11) 4253-4259.
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Pentikäinen V, Erkkilä K, Dunkel L(1999). Fas regulates germ cell apoptosis in the human testis in vitro. Am J Physiol vol. 276, (2) E310-E316.
10.1152/ajpendo.1999.276.2.E310
Pentikäinen V, Erkkilä K, Dunkel L(1999). Fas regulates germ cell apoptosis in the human testis in vitro. American Journal of Physiology - Endocrinology and Metabolism vol. 276, (2 39-2)
10.1152/ajpendo.1999.276.2.e310
Raivio T, Perheentupa A, McNeilly AS, Groome NP, Anttila R, Siimes MA, Dunkel L(1998). Biphasic increase in serum inhibin B during puberty: a longitudinal study of healthy Finnish boys. Pediatr Res vol. 44, (4) 552-556.
10.1203/00006450-199810000-00014
Erkkilä K, Hirvonen V, Wuokko E, Parvinen M, Dunkel L(1998). N-acetyl-L-cysteine inhibits apoptosis in human male germ cells in vitro. J Clin Endocrinol Metab vol. 83, (7) 2523-2531.
10.1210/jcem.83.7.4949
Dunkel L, Taskinen S, Hovatta O, Tilly JL, Wikström S(1997). Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult. J Clin Invest vol. 100, (9) 2341-2346.
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Erkkilä K, Henriksén K, Hirvonen V, Rannikko S, Salo J, Parvinen M, Dunkel L(1997). Testosterone regulates apoptosis in adult human seminiferous tubules in vitro. J Clin Endocrinol Metab vol. 82, (7) 2314-2321.
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Dunkel L, Hirvonen V, Erkkilä K(1997). Clinical aspects of male germ cell apoptosis during testis development and spermatogenesis. Cell Death Differ vol. 4, (3) 171-179.
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Dunkel L, Raivio T, Laine J, Holmberg C(1997). Circulating luteinizing hormone receptor inhibitor(s) in boys with chronic renal failure. Kidney Int vol. 51, (3) 777-784.
10.1038/ki.1997.109
Albertsson-Wikland K, Rosberg S, Lannering B, Dunkel L, Selstam G, Norjavaara E(1997). Twenty-four-hour profiles of luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol levels: A semilongitudinal study throughout puberty in healthy boys. Journal of Clinical Endocrinology and Metabolism vol. 82, (2) 541-549.
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Laine J, Etelämäki P, Holmberg C, Dunkel L(1997). Apoptotic cell death in human chronic renal allograft rejection. Transplantation vol. 63, (1) 101-105.
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Raivio T, Toppari J, Perheentupa A, McNeily AS, Dunkel L(1997). Treatment of prepubertal gonadotrophin-deficient boys with recombinant human follicle-stimulating hormone [4]. Lancet vol. 350, (9073) 263-264.
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Dunkel L, Tapanainen P(1997). Whats new concerning endocrinology of puberty. Duodecim; lääketieteellinen aikakauskirja vol. 113, (7) 619-627.
Dunkel L, Tapanainen P(1997). [Whats new concerning endocrinology of puberty]. Duodecim vol. 113, (7) 619-627.
Demir A, Voutilainen R, Juul A, Dunkel L, Alfthan H, Skakkebaek NE, Stenman UH(1996). Increase in first morning voided urinary luteinizing hormone levels precedes the physical onset of puberty. Journal of Clinical Endocrinology and Metabolism vol. 81, (8) 2963-2967.
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Raivio T, Huhtaniemi I, Anttila R, Siimes MA, Hagenäs L, Nilsson C, Pettersson K, Dunkel L(1996). The role of luteinizing hormone-beta gene polymorphism in the onset and progression of puberty in healthy boys. J Clin Endocrinol Metab vol. 81, (9) 3278-3282.
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Heiskanen P, Billig H, Toppari J, Kaleva M, Arsalo A, Rapola J, Dunkel L(1996). Apoptotic cell death in the normal and cryptorchid human testis: the effect of human chorionic gonadotropin on testicular cell survival. Pediatr Res vol. 40, (2) 351-356.
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Huhtaniemi IT, Haavisto AM, Anttila R, Siimes MA, Dunkel L(1996). Sensitive immunoassay and in vitro bioassay demonstrate constant bioactive/immunoreactive ratio of luteinizing hormone in healthy boys during the pubertal maturation. Pediatric Research vol. 39, (1) 180-184.
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Demir A, Dunkel L, Stenman UH, Voutilainen R(1995). Age-related course of urinary gonadotropins in children. J Clin Endocrinol Metab vol. 80, (4) 1457-1460.
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Dunkel L, Siimes MA, Bremner WJ(1993). Reduced inhibin and elevated gonadotropin levels in early pubertal boys with testicular defects. Pediatr Res vol. 33, (5) 514-518.
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Dunkel L, Siimes MA, Bremner WJ(1993). Reduced inhibin and elevated gonadotropin levels in early pubertal boys with testicular defects. Pediatric Research vol. 33, (5) 514-518.
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Dunkel L, Alfthan H, Stenman UH, Selstam G, Rosberg S, Albertsson-Wikland K(1992). Developmental changes in 24-hour profiles of luteinizing hormone and follicle-stimulating hormone from prepuberty to midstages of puberty in boys. Journal of Clinical Endocrinology and Metabolism vol. 74, (4) 890-897.
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Siimes MA, Dunkel L, Rautonen J(1992). Risk factors for endocrine testicular dysfunction in adolescent and adult males who have survived malignancies in childhood. Cancer Journal vol. 5, (1) 28-31.
Lahdenne P, Dunkel L, Heikinheimo M, Koskimies AI, Siimes MA(1991). Hypergonadotropic hypogonadism and sperm abnormalities in men born with benign sacrococcygeal teratoma. J Androl vol. 12, (4) 226-230.
10.1002/j.1939-4640.1991.tb00256.x
Dunkel L, Huhtaniemi I(1990). Testicular responsiveness to hCG during infancy measured by salivary testosterone. Acta Endocrinol (Copenh) vol. 123, (6) 633-636.
10.1530/acta.0.1230633
Mäkipernaa A, Dunkel L, Siimes MA(1990). Growth after treatment of solid tumours in childhood. Acta Paediatr Scand vol. 79, (8-9) 817-822.
10.1111/j.1651-2227.1990.tb11560.x
Dunkel L, Alfthan H, Stenman UH, Tapanainen P, Perheentupa J(1990). Pulsatile secretion of LH and FSH in prepubertal and early pubertal boys revealed by ultrasensitive time-resolved immunofluorometric assays. Pediatr Res vol. 27, (3) 215-219.
10.1203/00006450-199003000-00003
Dunkel L, Alfthan H, Stenman UH, Perheentupa J(1990). Gonadal control of pulsatile secretion of luteinizing hormone and follicle-stimulating hormone in prepubertal boys evaluated by ultrasensitive time-resolved immunofluorometric assays. Journal of Clinical Endocrinology and Metabolism vol. 70, (1) 107-114.
10.1210/jcem-70-1-107
Haavisto AM, Dunkel L, Pettersson K, Huhtaniemi I(1990). Lhmeasurements by in vitro bioassay and a highly sensitive immunofluorometric assay improve the distinction between boys with constitutional delay of puberty and hypogonadotropic hypogonadism. Pediatric Research vol. 27, (3) 211-214.
10.1203/00006450-199003000-00002
Riikonen R, Simell O, Dunkel L, Santavuori P, Perheentupa J(1989). Hormonal background of the hypertension and fluid derangements associated with adrenocorticotrophic hormone treatment of infants. Eur J Pediatr vol. 148, (8) 737-741.
10.1007/BF00443098
Sorva R, Kuusi T, Dunkel L, Taskinen MR(1988). Effects of endogenous sex steroids on serum lipoproteins and postheparin plasma lipolytic enzymes. J Clin Endocrinol Metab vol. 66, (2) 408-413.
10.1210/jcem-66-2-408
Dunkel L, Hovi L, Siimes MA(1987). Impaired prolactin responsiveness to a dopamine antagonist in long-term survivors of acute lymphoblastic leukaemia. Acta Endocrinol (Copenh) vol. 116, (1) 85-89.
10.1530/acta.0.1160085
Anttila PH, Dunkel L, Simell O(1987). Abnormal LH and prolactin responses in acrodermatitis enteropathica during hypozincaemia. J Inherit Metab Dis vol. 10, (2)
10.1007/BF01800048
Perheentupa J, Riikonen R, Dunkel L, Simell O(1986). Adrenocortical hyporesponsiveness after treatment with ACTH of infantile spasms. Archives of Disease in Childhood vol. 61, (8) 750-753.
10.1136/adc.61.8.750
Dunkel L(1986). Metoclopramide test in the diagnosis of isolated hypogonadotrophic hypogonadism. Acta Endocrinologica vol. 111, (2) 241-245.
10.1530/acta.0.1110241
Huhtaniemi I, Dunkel L, Perheentupa J(1986). Transient increase in postnatal testicular activity is not revealed by longitudinal measurements of salivary testosterone. Pediatric Research vol. 20, (12) 1324-1327.
10.1203/00006450-198612000-00028
Dunkel L, Taino VM, Savilahti E, Eskola J(1985). Effect of endogenous androgens on lymphocyte subpopulations. Lancet vol. 2, (8452) 440-441.
10.1016/s0140-6736(85)92755-2
Dunkel L, Huhtaniemi I(1985). Abnormal prolactin secretion in prepubertal boys with hypogonadotrophic hypogonadism — possible involvement in regulation of testicular steroidogenesis. International Journal of Andrology vol. 8, (5) 385-392.
10.1111/j.1365-2605.1985.tb00851.x
Dunkel L(1985). Decrease in serum sex hormone binding globulin during human chorionic gonadotrophin stimulation in prepubertal boys. Acta Endocrinologica vol. 109, (3) 423-427.
10.1530/acta.0.1090423
Dunkel L, Perheentupa J, Virtanen M, Mäenpää J(1985). GnRH and HCG Tests Are Both Necessary in Differential Diagnosis of Male Delayed Puberty. American Journal of Diseases of Children vol. 139, (5) 494-498.
10.1001/archpedi.1985.02140070068036
Dunkel L, Perheentupa J, Virtanen M, Mäenpää J(1985). Gonadotropin-releasing hormone test and human chorionic gonadotropin test in the diagnosis of gonadotropin deficiency in prepubertal boys. The Journal of Pediatrics vol. 107, (3) 388-392.
10.1016/S0022-3476(85)80512-6
Dunkel L, Perheentupa J, Apter D(1985). Kinetics of the steroidogenic response to single versus repeated doses of human chorionic gonadotropin in boys in prepuberty and early puberty. Pediatric Research vol. 19, (1) 1-4.
10.1203/00006450-198501000-00001
Dunkel L, Sorva R, Voutilainen R(1985). Low levels of sex hormone-binding globulin in obese children. The Journal of Pediatrics vol. 107, (1) 95-97.
10.1016/S0022-3476(85)80623-5
DUNKEL L, PERHEENTUPA J, TAPANAINEN J, VIHKO R(1984). Hypergonadotropic Hypogonadism in Newborn Males with Primary Testicular Failure. Acta Pædiatrica vol. 73, (6) 740-744.
10.1111/j.1651-2227.1984.tb17768.x
Dunkel L, Perheentupa J, Tapanainen J, Leinonen P, Vihko R(1984). Responsiveness of the Pituitary–testicular axis to gonadotropin–releasing hormone and chorionic gonadotropin during the first week of life. Pediatric Research vol. 18, (11) 1085-1087.
10.1203/00006450-198411000-00005
LEINONEN P, DUNKEL L, PERHEENTUPA J, VIHKO R(1983). MALE PSEUDOHERMAPHRODITISM DUE TO DEFICIENCY OF TESTICULAR 17‐KETOSTEROID REDUCTASE. Acta Pædiatrica vol. 72, (2) 211-214.
10.1111/j.1651-2227.1983.tb09699.x
TAPANAINEN J, MARTIKAINEN H, DUNKEL L, PERHEENTUPA J, VIHKO R(1983). STEROIDOGENIC RESPONSE TO A SINGLE INJECTION OF hCG IN PRE‐ AND EARLY PUBERTAL CRYPTORCHID BOYS. Clinical Endocrinology vol. 18, (4) 355-362.
10.1111/j.1365-2265.1983.tb00579.x
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