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Publications:  Dr Matthew Caley

Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A et al.(2019). A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing. Int J Mol Sci vol. 20, (14)
10.3390/ijms20143428
Thomas BR, Caley MP, O'Toole EA (2019). Novel frameshift variant in EBP: late diagnosis of Conradi-Hunermann syndrome in a 41-year-old woman. BRITISH JOURNAL OF DERMATOLOGY. vol. 181, 79-80.
Langton AK, Ayer J, Griffiths TW, Rashdan E, Naidoo K, Caley MP, Birch-Machin MA, O'Toole E et al. (2019). Differential ageing responses to chronic ultraviolet irradiation: characterizing the molecular phenotype of atrophic and hypertrophic facial skin. BRITISH JOURNAL OF DERMATOLOGY. vol. 180, E198-E198.
Jones EM, Marsh ST, O'Shaughnessy RF, Aumailley M, Camera E, Picardo M, McGrath JA, O'Toole EA et al. (2019). Laminin 332: bottom-up control of the skin barrier?. BRITISH JOURNAL OF DERMATOLOGY. vol. 180, E185-E185.
Marsh S, Caley MP, Martins VLC, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. (2019). Type VII collagen and Nesprin 2: LINCing the basement membrane to altered cell cycle and increased DNA damage. BRITISH JOURNAL OF DERMATOLOGY. vol. 180, E188-E189.
Enjalbert F, Dewan P, Caley M, Morse M, Kelsell D, O'Toole E (2019). Understanding the role of ABCA12 in the pathogenesis of harlequin ichthyosis. BRITISH JOURNAL OF DERMATOLOGY. vol. 180, E185-E185.
Alexander SC, Marsh S, Caley M, O'Toole EA (2018). Understanding Angiogenesis in Squamous Cell Carcinoma with Loss of Type VII Collagen. JOURNAL OF PATHOLOGY. vol. 246, S44-S44.
Milligan D, Newman J, Caley M, Wainwright L, Jenkins G, Philpott M, Bishop C (2018). Development of a three-dimensional living skin equivalent to explore the influence of senescence on the skin ageing phenotype. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E420-E420.
Smith CJ, Caley M, Parkinson EK, O'Toole EA, Pratten J, Yang J, Braun KM (2018). Investigating the differences in the wound healing responses of skin and gingival keratinocytes. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E416-E416.
Enjalbert F, Dewan P, Caley M, Fell B, Morse M, Kelsell D, Enright A, O'Toole E (2018). Investigating the role of ABCA12 in the pathomechanisms of harlequin ichthyosis. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E406-E406.
Caley M, Martins V, Moore K, Lashari M, Marshall J, O'Toole E (2018). Loss of Lam alpha 3 drives M2 macrophage differentiation in squamous cell carcinoma. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E399-E400.
Huang M, Ruban E, Caley M, O'Toole E (2018). Phospholipase C-beta 4 regulation of chromatin via kindlin-2 in cutaneous squamous cell carcinoma. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E409-E409.
Jones E, Marsh S, O'Shaugnessy R, Aumailley M, O'Toole E, Caley M (2018). The role of laminin 332 in skin lipid biosynthesis. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E407-E408.
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, O'Toole EA, Caley MP (2018). A role for the basement membrane in skin lipid trafficking. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 138, S116-S116.
Marsh S, Caley MP, Martins V, Chen M, McGrath J, Barnes M, O'Toole EA (2018). Type VII collagen and Nesprin 2, LINCing the basement membrane to altered cell cycle and increased DNA damage. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 138, S138-S138.
Enjalbert F, Dewan P, Caley MP, Fell B, Morse M, Kelsell D, Enright A, O'Toole EA (2018). Understanding the role of ABCA12 in the pathogenesis of harlequin ichthyosis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 138, S112-S112.
Caley M, Wall IB, Peake M, Kipling D, Giles P, Thomas DW, Stephens P(2018). Development and Characterisation of a Human Chronic Skin Wound Cell Line-Towards an Alternative for Animal Experimentation. Int J Mol Sci vol. 19, (4)
10.3390/ijms19041001
Smith CJ, Caley M, Parkinson EK, O'Toole EA, Pratten J, Yang J (2018). INVESTIGATING THE DIFFERENCES IN THE WOUND HEALING RESPONSES OF SKIN AND GINGIVAL KERATINOCYTES. WOUND REPAIR AND REGENERATION. vol. 26, A30-A31.
Milligan D, Newman J, Caley M, Wainwright L, Jenkins G, Philpott M, Bishop C (2017). Development of a 3D living skin equivalent to explore the influence of senescence on the skin ageing phenotype. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 137, S310-S310.
10.1016/j.jid.2017.07.359
Shams F, Krupiczojc MA, Alexander S, Rashidghamat E, McGrath J, Caley M, O'Toole EA, Harwood CA (2017). Investigation of the role of type VII collagen in the HIF1 alpha induced pro-angiogenic pathway. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 137, S289-S289.
10.1016/j.jid.2017.07.765
Marsh S, Caley M, Martins V, Barnes MR, Chen M, O'Toole EA (2017). Loss of keratinocyte type VII collagen induces increased DNA damage in vitro and in vivo. JOURNAL OF INVESTIGATIVE DERMATOLOGY. Conference: ESDR 2017 vol. 137, S225-S225.
10.1016/j.jid.2017.07.189
Caley M, Martins V, Moore K, Lashari M, Marshall J, O'Toole EA (2017). Tumour associated macrophage recruitment in SCC. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 137, S250-S250.
10.1016/j.jid.2017.07.531
Enjalbert F, Dewan P, Caley M, Fell B, Morse M, Kelsell DP, Enright A, O'Toole EA (2017). Understanding the role of ABCA12 in the Pathogenesis of Harlequin Ichthyosis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. Conference: ESDR 2017 vol. 137, S208-S208.
10.1016/j.jid.2017.07.398
O'Toole EA, Ruban EL, Balogun M, Martins VL, Caley MP, Falasca M (2016). Phospholipase C beta4 is a therapeutic target in cutaneous squamous cell carcinoma. BRITISH JOURNAL OF DERMATOLOGY. vol. 175, 56-57.
McGeoghan F, Menon M, Dewan P, Caley M, Donaldson M, O'Toole EA (2016). Identification of novel pathways linked to the pathogenesis of Recessive X-Linked Ichthyosis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 136, S183-S183.
10.1016/j.jid.2016.06.150
Caley M, Martins V, Moore K, Lashari M, Kahari V, Nissinen L, Donaldson M, Marshall J et al. (2016). Loss of Laminin alpha 3 drives SCC invasion via ROCK signalling. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 136, S241-S241.
10.1016/j.jid.2016.06.494
Krupiczojc MA, Caley M, Marsh S, Donaldson M, Martins V, O'Toole E (2016). Loss of collagen 7 drives HIF-1 alpha induced pro-angiogenic pathways. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 136, S258-S258.
10.1016/j.jid.2016.06.593
Enjalbert F, Dewan P, Caley M, Fell B, Donaldson M, Kelsell DP, O'Toole EA (2016). Understanding the role of ABCA12 in the pathogenesis of Harlequin Ichthyosis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 136, S183-S183.
10.1016/j.jid.2016.06.151
McGeoghan FT, O'Toole E, Caley M, Menon M, Dewan P, Donaldson M (2016). Modelling and understanding pathomechanisms of X-linked recessive ichthyosis in vitro. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 136, S66-S66.
10.1016/j.jid.2016.02.408
Caley M, Martins V, Moore K, Lashari M, Donaldson M, Marshall JF, O'Toole EA (2016). ROCK and Rac1 signalling in squamous cell carcinoma with loss of laminin 332. BRITISH JOURNAL OF DERMATOLOGY. vol. 174, E51-E51.
Caley MP, King H, Shah N, Wang K, Rodriguez-Teja M, Gronau JH, Waxman J, Sturge J(2016). Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces. Clin Exp Metastasis vol. 33, (2) 151-165.
10.1007/s10585-015-9765-7
Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ et al.(2016). Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell vol. 36, (2) 152-163.
10.1016/j.devcel.2015.12.027
Hill DS, Robinson NDP, Caley MP, Chen M, O'Toole EA, Armstrong JL, Przyborski S, Lovat PE(2015). A Novel Fully Humanized 3D Skin Equivalent to Model Early Melanoma Invasion. Mol Cancer Ther vol. 14, (11) 2665-2673.
10.1158/1535-7163.MCT-15-0394
Kopecki Z, Yang GN, Jackson JE, Melville EL, Calley MP, Murrell DF, Darby IA, O'Toole EA et al.(2015). Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression. Oncotarget vol. 6, (34) 36426-36440.
10.18632/oncotarget.5536
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M et al.(2015). Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC. J Natl Cancer Inst vol. 108, (1)
10.1093/jnci/djv293
Marsh S, Martins V, Caley M, Barnes M, Donaldson MJ, O'toole E (2015). Loss of keratinocyte type VII collagen induces pro-carcinogenic transcriptomic pathways. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 135, S44-S44.
McGeoghan FT, Derwin P, Caley M, Donaldson MJ, O'toole E (2015). Modelling X-linked recessive ichthyosis in vitro. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 135, S62-S62.
Martins V, Caley M, Moore K, Szentpetery Z, Marsh S, Murrell DF, Kaehaeri V, McGrath J et al. (2015). Skin type VII collagen acts as a tumour suppressor by regulating TGF beta and angiogenesis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 135, S28-S28.
Caley M, Martins V, Marsh S, Moore K, Lashari M, Donaldson MJ, Marshall J, O'toole E (2015). Squamous Cell Carcinoma progression and Laminin 332. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 135, S23-S23.
Pinato DJ, Trousil S, Caley M, Mauri FA, Aboagye E, Sharma R (2015). Pharmacological inhibition of Axl tyrosine kinase as a novel therapeutic strategy in hepatocellular carcinoma. JOURNAL OF CLINICAL ONCOLOGY. vol. 33,
10.1200/jco.2015.33.15_suppl.e15152
McGeoghan F, Dewan P, Caley M, Donaldson M, O'Toole E (2015). Generation of an in vitro three-dimensional model of X-linked recessive ichthyosis. BRITISH JOURNAL OF DERMATOLOGY. vol. 172, E40-E40.
Caley MP, Martins VLC, O'Toole EA(2015). Metalloproteinases and Wound Healing. Adv Wound Care (New Rochelle) vol. 4, (4) 225-234.
10.1089/wound.2014.0581
Rodriguez-Teja M, Gronau JH, Breit C, Zhang YZ, Minamidate A, Caley MP, McCarthy A, Cox TR et al.(2015). AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival. J Pathol vol. 235, (4) 581-592.
10.1002/path.4485
Caley M, Martins V, Moore K, Marshall J, O'toole E (2014). Diverse roles for laminin 332 subunits in squamous cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 134, S19-S19.
Ruban EL, Balogun MA, Martins V, Caley M, Raimondi C, O'toole E, Falasca M (2014). Phospholipase C beta4 regulates invasion and proliferation in cutaneous SCC in vivo. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 134, S22-S22.
Marsh S, Martins V, Caley M, Barnes M, Donaldson M, O'toole E (2014). RNA-Seqing the skin basement membrane. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 134, S25-S25.
Cicho¿ MA, Szentpetery Z, Caley MP, Papadakis ES, Mackenzie IC, Brennan CH, O'Toole EA(2014). The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma. Oncogene vol. 33, (32) 4185-4192.
10.1038/onc.2013.388
Kopecki Z, Yang G, Jackson J, Melville E, Martin V, Caley M, Proby C, Pouniotis D et al. (2014). Cytoskeletal protein Flii is elevated in human cSCCs and overexpression of Flii in mice leads to higher incidence and severity of tumour formation. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 134, S28-S28.
Peake MA, Caley M, Giles PJ, Wall I, Enoch S, Davies LC, Kipling D, Thomas DW et al.(2014). Identification of a transcriptional signature for the wound healing continuum. Wound Repair Regen vol. 22, (3) 399-405.
10.1111/wrr.12170
Caley M, Martins V, Moore K, Marshall J, O'Toole E (2014). Diverse roles for laminin-332 subunits in squamous cell carcinoma. BRITISH JOURNAL OF DERMATOLOGY. vol. 170, E26-E26.
Marsh S, Martins V, Caley M, Barnes M, Donaldson M, O'Toole E (2014). Global transcriptomic changes in primary keratinocytes with loss of basement membrane genes. BRITISH JOURNAL OF DERMATOLOGY. vol. 170, E37-E38.
Caley MP, Martins V, Moore K, Marshall JF, O'Toole EA (2013). Diverse roles for laminin 332 subunits in squamous cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S64-S64.
Martins VL, Caley MP, Moore K, Szentpetery Z, Murrell DF, Kim MH, McGrath JA, Cerio R et al. (2013). Loss of type VII collagen in cutaneous SCC increases angiogenesis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S158-S158.
Ruban EL, Martins VL, Caley M, Raimondi C, Falasca M, O'Toole EA (2013). Phospholipase C-beta 4 regulates proliferation and invasion in cutaneous SCC. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S73-S73.
Marsh ST, Caley MP, Kwan A, O'Toole EA, Donaldson M (2013). Transcriptome profiling identifies novel functions of acitretin in human epidermis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S186-S186.
Pellegrino L, Stebbing J, Braga VM, Frampton AE, Jacob J, Buluwela L, Jiao LR, Periyasamy M et al.(2013). miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts. Nucleic Acids Res vol. 41, (10) 5400-5412.
10.1093/nar/gkt245
Martins VL, Caley M, O'Toole EA(2013). Matrix metalloproteinases and epidermal wound repair. Cell Tissue Res vol. 351, (2) 255-268.
10.1007/s00441-012-1410-z
Palmieri C, Caley MP, Purshouse K, Fonseca A-V, Rodriguez-Teja M, Kogianni G, Woodley L, Odendaal J et al.(2013). Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer. Br J Cancer vol. 108, (1) 163-169.
10.1038/bjc.2012.540
Stephens P, Caley M, Peake M(2013). Alternatives for animal wound model systems. Methods in Molecular Biology vol. 1037, 177-201.
10.1007/978-1-62703-505-7_10
Stephens P, Caley M, Peake M(2013). Alternatives for animal wound model systems. Methods Mol Biol vol. 1037, 177-201.
10.1007/978-1-62703-505-7_10
Ali I, Gautrot J, Caley M, Marshall JF, Wheeler A (2013). Formation and inhibition of invadopodia in oral squamous cell carcinoma. MOLECULAR BIOLOGY OF THE CELL. vol. 24,
Sturge J, Caley MP, Purshouse K, Fonseca A-V, Rodriguez-Teja M, Kogianni G, Waxman J, Palmieri C (2012). The Collagen Receptor Endo180: A Metastatic Plasma Marker In Breast Cancer Modulated By Bisphosphonate Treatment. CANCER RESEARCH. vol. 72,
10.1158/0008-5472.SABCS12-P2-02-03
Singh M, Caley M, Jones M, Breuer J, O'Toole E (2012). Keratin 15 and VZV replication in skin. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 132, S112-S112.
Martins V, Caley M, Moore K, Murrell DF, McGrath JA, Chen M, Marshall JF, O'Toole EA (2012). Loss of keratinocyte type VII collagen in SCC increases TGF-beta signalling and angiogenesis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 132, S45-S45.
Szentpetery Z, Cichon M, Caley M, O'Toole E (2012). The receptor tyrosine kinase Axl regulates intercellular adhesion, epithelial-mesenchymal transition and stemness in cutaneous squamous cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 132, S45-S45.
Ramasamy K, Khatun H, Macpherson L, Caley MP, Sturge J, Mufti GJ, Schey SA, Calle Y(2012). Fluorescence-based experimental model to evaluate the concomitant effect of drugs on the tumour microenvironment and cancer cells. Br J Haematol vol. 157, (5) 564-579.
10.1111/j.1365-2141.2012.09103.x
Martins V, Caley M, Moore K, Chen M, Marshall J, O'Toole E (2012). Loss of type VII collagen in squamous cell carcinoma increases angiogenesis in vitro and in vivo. BRITISH JOURNAL OF DERMATOLOGY. vol. 166, e25-e26.
Caley MP, Kogianni G, Adamarek A, Gronau JH, Rodriguez-Teja M, Fonseca A-V, Mauri F, Sandison A et al.(2012). TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis. J Pathol vol. 226, (5) 775-783.
10.1002/path.3958
Sturge J, Caley MP, Waxmanin J(2011). Authors' reply: Expanding horizons in metastatic prostate cancer treatment. NATURE REVIEWS CLINICAL ONCOLOGY vol. 8, (10)
10.1038/nrclinonc.2011.67-c2
Sturge J, Caley MP, Waxman J(2011). Bone metastasis in prostate cancer: emerging therapeutic strategies (vol 8, pg 357, 2011). NATURE REVIEWS CLINICAL ONCOLOGY vol. 8, (10) 568-568.
10.1038/nrclinonc.2011.127
Sturge J, Caley MP, Waxman J(2011). Bone metastasis in prostate cancer: emerging therapeutic strategies. Nat Rev Clin Oncol vol. 8, (6) 357-368.
10.1038/nrclinonc.2011.67
Bruche S, Caley MP, Pshezhetskiy D, Sturge J (2010). Sphingosine kinase-1 and the collagen-binding receptor Endo180 cooperate to mediate collagen remodelling by stromal fibroblasts. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 91, A9-A9.
Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V, Upadhyaya M(2008). Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals. Genes Chromosomes Cancer vol. 47, (3) 238-246.
10.1002/gcc.20525
Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V, Upadhyaya M(2008). Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type I individuals. GENES CHROMOSOMES & CANCER vol. 47, (3) 238-246.
10.1002/gcc.20525
Caley M, Wall I, Kipling D, Thomas DW, Stephens P(2007). Development and characterisation of a human cell-based chronic wound bioassay. WOUND REPAIR AND REGENERATION vol. 15, (6) A133-A133.
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