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Publications:  Dr Robert Lowe

WOJCIECHOWSKI M, LOWE R, Maleszka J, CONN D, Maleszka R, HURD PJ(2018). Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval development. Genome Research
DANSON AF, MARZI SJ, LOWE R, HOLLAND ML, RAKYAN V(2018). Early life diet conditions the molecular response to post-weaning protein restriction in the mouse. BMC Biology vol. 16, (51)
LOWE R, BARTON C, Jenkins C, Ernst C, Forman O, Fernandez-Twinn D, Bock C, ROSSITER S et al.(2018). Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation amongst mammalian species. Genome Biology vol. 19, Article 22,
Thurner M, van de Bunt M, Torres JM, Mahajan A, Nylander V, Bennett AJ, Gaulton KJ, Barrett A et al.(2018). Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci. Elife vol. 7,
Brugha R, Lowe R, Henderson AJ, Holloway JW, Rakyan V, Wozniak E, Mahmud N, Seymour K et al.(2017). DNA methylation profiles between airway epithelium and proxy tissues in children. Acta Paediatrica
Lowe R(2017). Heroes of peer review: Robert Lowe. Genome Biol vol. 18, (1) 72-72.
Finer S, Lowe R, Ogunkolade W, Bhowmik B, Hussain A, Khan AKA, Rakyan V, Hitman GA (2017). The influence of maternal and offspring environment on genome-wide methylation of the offspring in Bangladesh. Manchester Central, Manchester , from: 08/03/2017 to: 10/03/2017, vol. 34, pp. 20-21. Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob ,
Nijhuis A, Thompson H, Adam J, Parker A, Gammon L, Lewis A, Bundy JG, Tomoyoshi S et al.(2017). Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance. Human Molecular Genetics
Paul DS, Teschendorff AE, Dang MAN, Lowe R, Hawa MI, Ecker S, Beyan H, Cunningham S et al.(2016). Increased DNA methylation variability in type 1 diabetes across three immune effector cell types. Nat Commun vol. 7, 13555-13555.
Finer S, LOWE R, Ogunkolade BW, Pervin S, Mathews C, Smart M, Alam DS, Hitman GA(2016). Is famine exposure during developmental life in rural Bangladesh associated with a metabolic and epigenetic signature in young adulthood? A historical cohort study. BMJ Open
Breeze CE, Paul DS, van Dongen J, Butcher LM, Ambrose JC, Barrett JE, Lowe R, Rakyan VK et al.(2016). eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data. Cell Reports vol. 17, (8) 2137-2150.
Holland ML, Lowe R, Caton P, Gemma C, Carbajosa G, DANSON AF, Loche E, Carpenter AAM et al.(2016). Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice. Science
Leslie RD, Hawa MI, Paul D, Dang MAN, Tachendorff A, Lowe R, Vardhman RK, Beck S (2016). Increased DNA Methylation Variability in Type 1 Diabetes across Three Immune Effector Cell Types. DIABETES. vol. 65, A416-A416.
DOKAL I(2016). Germline heterozygous DDX41 vriants in a subset of familial myelodysplasia and acute myeloid leukaemia. Leukemia
Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK et al.(2015). The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans. Genome Biol vol. 16,
Armstrong JPK, Shakur R, Horne JP, Dickinson SC, Armstrong CT, Lau K, Kadiwala J, Lowe R et al.(2015). Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue. Nat Commun vol. 6,
Finer S, Mathews C, Lowe R, Smart M, Hillman S, Foo L, Sinha A, Williams D et al.(2015). Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring. Hum Mol Genet vol. 24, (11) 3021-3029.
Lowe R, Gemma C, Rakyan VK, Holland ML(2015). Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development. BMC Genomics vol. 16,
Hillman SL, Finer S, Smart MC, Mathews C, Lowe R, Rakyan VK, Hitman GA, Williams DJ(2015). Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates. Epigenetics vol. 10, (1) 50-61.
Lowe R, Slodkowicz G, Goldman N, Rakyan VK(2015). The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues. Epigenetics vol. 10, (4) 274-281.
Finer S, Iqbal S, Ogunkolade WB, Mathews C, Lowe R, Smart M, Rakyan VK, Alam DS et al.(2014). Variation in phenotype and DNA methylation is detectable in an observational cohort of young adult Bangladeshis exposed to famine during in utero and postnatal life. DIABETOLOGIA vol. 57, S105-S106.
Lowe R, Rakyan VK(2014). Correcting for cell-type composition bias in epigenome-wide association studies. Genome Medicine vol. 6, (3)
Lowe R, Rakyan VK(2013). Marmal-aid--a database for Infinium HumanMethylation450. BMC Bioinformatics vol. 14,
Ke X, Cortina-Borja M, Silva BC, Lowe R, Rakyan V, Balding D(2013). Integrated analysis of genome-wide genetic and epigenetic association data for identification of disease mechanisms. Epigenetics vol. 8, (11) 1236-1244.
Lowe R, Morris T(2013). Report on the 2nd Annual Infinium Humanmethylation450 Array Workshop: 15 April 2013 QMUL, London, UK. Epigenetics vol. 8, (10) 1123-1124.
Brugha R, Lowe R, Henderson J, Holloway J, Rakyan V, Shaheen S(2013). Comparison of DNA methylation profiles between airway epithelium and proxy tissues. EUROPEAN RESPIRATORY JOURNAL vol. 42,
Lowe R, Gemma C, Beyan H, Hawa MI, Bazeos A, Leslie RD, Montpetit A, Rakyan VK et al.(2013). Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies. Epigenetics : official journal of the DNA Methylation Society vol. 8, (4) 445-454.
Lowe R, Gemma C, Beyan H, Hawa MI, Bazeos A, Leslie RD, Montpetit A, Rakyan VK et al.(2013). Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies. Epigenetics vol. 8, (4) 445-454.
Fauzi FM, Koutsoukas A, Lowe R, Joshi K, Fan T-P, Glen RC, Bender A(2013). Chemogenomics Approaches to Rationalizing the Mode-of-Action of Traditional Chinese and Ayurvedic Medicines. JOURNAL OF CHEMICAL INFORMATION AND MODELING vol. 53, (3) 661-673.
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