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Publications:  Dr Gabriella Ficz

Saunderson EA, Stepper P, Gomm JJ, Hoa L, Morgan A, Allen MD, Jones JL, Gribben JG et al.(2017). Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors. Nat Commun vol. 8, (1)
10.1038/s41467-017-01078-2
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29503
Hahn O, Grönke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, Andrews S, Zhang Q et al.(2017). Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism. Genome Biol vol. 18, (1)
10.1186/s13059-017-1187-1
Langie SAS, Cameron KM, Ficz G, Oxley D, Tomaszewski B, Gorniak JP, Maas LM, Godschalk RWL et al.(2017). The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice. Genes (Basel) vol. 8, (2)
10.3390/genes8020075
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34328
Hore TA, von Meyenn F, Ravichandran M, Bachman M, Ficz G, Oxley D, Santos F, Balasubramanian S et al.(2016). Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms. Proc Natl Acad Sci U S A vol. 113, (43) 12202-12207.
10.1073/pnas.1608679113
Giehr P, Kyriakopoulos C, Ficz G, Wolf V, Walter J(2016). The Influence of Hydroxylation on Maintaining CpG Methylation Patterns: A Hidden Markov Model Approach. PLoS Comput Biol vol. 12, (5)
10.1371/journal.pcbi.1004905
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19684
Relton CL, Gaunt T, McArdle W, Ho K, Duggirala A, Shihab H, Woodward G, Lyttleton O et al.(2015). Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES). Int J Epidemiol vol. 44, (4) 1181-1190.
10.1093/ije/dyv072
Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F et al.(2015). Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human. Cell vol. 162, (2) 452-453.
10.1016/j.cell.2015.06.052
Ficz G(2015). New insights into mechanisms that regulate DNA methylation patterning. J Exp Biol vol. 218, (Pt 1) 14-20.
10.1242/jeb.107961
Peat JR, Dean W, Clark SJ, Krueger F, Smallwood SA, Ficz G, Kim JK, Marioni JC et al.(2014). Genome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation. Cell Rep vol. 9, (6) 1990-2000.
10.1016/j.celrep.2014.11.034
Ficz G, Gribben JG(2014). Loss of 5-hydroxymethylcytosine in cancer: cause or consequence?. Genomics vol. 104, (5) 352-357.
10.1016/j.ygeno.2014.08.017
Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F et al.(2014). Resetting transcription factor control circuitry toward ground-state pluripotency in human. Cell vol. 158, (6) 1254-1269.
10.1016/j.cell.2014.08.029
Ficz G, Hore TA, Santos F, Lee HJ, Dean W, Arand J, Krueger F, Oxley D et al.(2013). FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency. Cell Stem Cell vol. 13, (3) 351-359.
10.1016/j.stem.2013.06.004
Ficz G, Reik W(2013). Reprogramming by cell fusion: boosted by Tets. Mol Cell vol. 49, (6) 1017-1018.
10.1016/j.molcel.2013.03.014
Iurlaro M, Ficz G, Oxley D, Raiber E-A, Bachman M, Booth MJ, Andrews S, Balasubramanian S et al.(2013). A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation. Genome Biol vol. 14, (10)
10.1186/gb-2013-14-10-r119
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19685
Heintzmann R, Ficz G(2013). Breaking the resolution limit in light microscopy. Methods Cell Biol vol. 114, 525-544.
10.1016/B978-0-12-407761-4.00022-1
Ficz G, Hore T, Santos F, Krueger F, Oxley D, Cook SJ, Xu G, Andrews S et al. (2012). 2i inhibition of Erk1/2 and Gsk3 beta drives genome-wide demethylation to the epigenetic ground state of pluripotency. GENETICS RESEARCH. vol. 94, 355-356.
Raiber E-A, Beraldi D, Ficz G, Burgess HE, Branco MR, Murat P, Oxley D, Booth MJ et al.(2012). Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase. Genome Biol vol. 13, (8)
10.1186/gb-2012-13-8-r69
https://qmro.qmul.ac.uk/xmlui/handle/123456789/17906
Booth MJ, Branco MR, Ficz G, Oxley D, Krueger F, Reik W, Balasubramanian S(2012). Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science vol. 336, (6083) 934-937.
10.1126/science.1220671
Branco MR, Ficz G, Reik W(2011). Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet vol. 13, (1) 7-13.
10.1038/nrg3080
Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F, Hore TA, Marques CJ, Andrews S et al.(2011). Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature vol. 473, (7347) 398-402.
10.1038/nature10008
Reik W, Popp C, Ficz G, Branco M, Branco M, Krueger C, Hemberger M, Dean W (2010). Epigenetic regulation of imprinting, reprogramming, and lineage commitment in mammals. NEW BIOTECHNOLOGY. vol. 27, S3-S3.
10.1016/j.nbt.2010.01.292
Farthing CR, Ficz G, Ng RK, Chan C-F, Andrews S, Dean W, Hemberger M, Reik W(2008). Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes. PLoS Genet vol. 4, (6)
10.1371/journal.pgen.1000116
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19683
Heintzmann R, Ficz G(2007). Breaking the resolution limit in light microscopy. Methods Cell Biol vol. 81, 561-580.
10.1016/S0091-679X(06)81026-5
Heintzmann R, Ficz G(2006). Breaking the resolution limit in light microscopy. Brief Funct Genomic Proteomic vol. 5, (4) 289-301.
10.1093/bfgp/ell036
Ficz G, Heintzmann R, Arndt-Jovin DJ(2005). Polycomb group protein complexes exchange rapidly in living Drosophila (vol 132, pg 3963, 2005). DEVELOPMENT vol. 132, (17) 4016-4016.
Ficz G, Heintzmann R, Arndt-Jovin DJ(2005). Polycomb group protein complexes exchange rapidly in living Drosophila. Development vol. 132, (17) 3963-3976.
10.1242/dev.01950
Ficz G, Heintzmann R, Rieger B, Arndt-Jovin DJ (2005). Epigenetic repression in living Drosophila. Stability and dissociation constants of Polycomb group Protein-chromatin complexes. FEBS JOURNAL. vol. 272, 473-473.
Ficz G, Heintzmann R, Rieger B, Arndt-Jovin DJ (2005). Diffusion and disassociation constants for Polycomb group protein-DNA complexes in living Drosophila. A study using fluorescence photobleaching techniques and multicomponent analysis. BIOPHYSICAL JOURNAL. vol. 88, 397A-398A.
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