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Publications:  Prof Trevor Graham

Werner B, Williams MJ, Barnes CP et al.(2018). Reply to 'Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution'. Nat Genet vol. 50, (12) 1624-1626.
10.1038/s41588-018-0235-4
Heide T, Zapata L, Williams MJ et al.(2018). Reply to 'Neutral tumor evolution?'. Nat Genet vol. 50, (12) 1633-1637.
10.1038/s41588-018-0256-z
Williams MJ, Werner B, Heide T et al.(2018). Reply to 'Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data'. Nat Genet vol. 50, (12) 1628-1630.
10.1038/s41588-018-0210-0
Al Bakir I, Curtius K, Graham TA(2018). From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and Biology. Frontiers in Immunology vol. 9, 2368-2368.
10.3389/fimmu.2018.02368
https://qmro.qmul.ac.uk/handle/123456789/49535
Cross W, Kovac M, Mustonen V et al.(2018). The evolutionary landscape of colorectal tumorigenesis. Nat Ecol Evol vol. 2, (10) 1661-1672.
10.1038/s41559-018-0642-z
https://qmro.qmul.ac.uk/handle/123456789/44792
Williams MJ, Werner B, Heide T et al.(2018). Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data. Nat Genet vol. 50, (9)
10.1038/s41588-018-0169-x
Caravagna G, Giarratano Y, Ramazzotti D et al.(2018). Detecting repeated cancer evolution from multi-region tumor sequencing data. Nat Methods vol. 15, (9) 707-714.
10.1038/s41592-018-0108-x
Baker A-M, Cross W, Curtius K et al.(2018). Evolutionary history of human colitis-associated colorectal cancer. Gut
10.1136/gutjnl-2018-316191
https://qmro.qmul.ac.uk/handle/123456789/43331
Araf S, Wang J, Ashton-Key M et al.(2018). Transmission of diffuse large B cell lymphoma by an allogeneic stem-cell transplant. Haematologica
10.3324/haematol.2018.196907
https://qmro.qmul.ac.uk/handle/123456789/43646
Temko D, Van Gool IC, Rayner E et al.(2018). Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response. J Pathol vol. 245, (3) 283-296.
10.1002/path.5081
Foxler DE, Bridge KS, Foster JG et al.(2018). A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. EMBO Mol Med
10.15252/emmm.201708304
https://qmro.qmul.ac.uk/handle/123456789/42128
Williams MJ, Werner B, Heide T et al.(2018). Quantification of subclonal selection in cancer from bulk sequencing data. Nat Genet vol. 50, (6) 895-903.
10.1038/s41588-018-0128-6
https://qmro.qmul.ac.uk/handle/123456789/49624
Temko D, Tomlinson IPM, Severini S et al.(2018). The effects of mutational processes and selection on driver mutations across cancer types. Nat Commun vol. 9, (1)
10.1038/s41467-018-04208-6
Araf S, Wang J, Korfi K et al.(2018). Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma. Leukemia vol. 32, (5) 1258-1263.
10.1038/s41375-018-0043-y
https://qmro.qmul.ac.uk/handle/123456789/36269
Heide T, Zapata L, Williams M et al.(2018). Reply: Neutral tumor evolution?.
10.1101/274142
Martinez P, Mallo D, Paulson TG et al.(2018). Evolution of Barrett's esophagus through space and time at single-crypt and whole-biopsy levels. Nat Commun vol. 9, (1)
10.1038/s41467-017-02621-x
Curtius K, Wright NA, Graham TA(2018). An evolutionary perspective on field cancerization. Nat Rev Cancer vol. 18, (1) 19-32.
10.1038/nrc.2017.102
Quante M, Graham TA, Jansen M(2018). Insights Into the Pathophysiology of Esophageal Adenocarcinoma. GASTROENTEROLOGY vol. 154, (2) 406-420.
10.1053/gastro.2017.09.046
Quante M, Graham TA, Jansen M(2018). Insights Into the Pathophysiology of Esophageal Adenocarcinoma. Gastroenterology vol. 154, (2) 406-420.
10.1053/j.gastro.2017.09.046
Williams MJ, Werner B, Barnes CP et al.(2018). Reply: Is the evolution of tumors Darwinian or non-Darwinian?. National Science Review vol. 5, (1) 17-19.
10.1093/nsr/nwx131
Baker A-M, Huang W, Wang X-MM et al.(2017). Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution. Nat Commun vol. 8, (1) 1998-1998.
10.1038/s41467-017-02295-5
https://qmro.qmul.ac.uk/handle/123456789/31830
Curtius K, Wright NA, Graham TA(2017). Evolution of Premalignant Disease. Cold Spring Harb Perspect Med vol. 7, (12)
10.1101/cshperspect.a026542
https://qmro.qmul.ac.uk/handle/123456789/23546
Choi C-HR, Al Bakir I, Ding N-SJ et al.(2017). Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study. Gut
10.1136/gutjnl-2017-314190
https://qmro.qmul.ac.uk/handle/123456789/31463
Maley CC, Aktipis A, Graham TA et al.(2017). Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer vol. 17, (10) 605-619.
10.1038/nrc.2017.69
Williams MJ, Werner B, Barnes CP et al.(2017). Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures. Nat Genet vol. 49, (9) 1289-1291.
10.1038/ng.3877
Sun R, Hu Z, Sottoriva A et al.(2017). Between-region genetic divergence reflects the mode and tempo of tumor evolution. Nat Genet vol. 49, (7) 1015-1024.
10.1038/ng.3891
https://qmro.qmul.ac.uk/handle/123456789/25103
Caravagna G, Giarratano Y, Ramazzotti D et al.(2017). Detecting repeated cancer evolution in human tumours from multi-region sequencing data.
10.1101/156729
Martinez P, Kimberley C, BirkBak NJ et al.(2017). Quantification of within-sample genetic heterogeneity from SNP-array data. Sci Rep vol. 7, (1) 3248-3248.
10.1038/s41598-017-03496-0
https://qmro.qmul.ac.uk/handle/123456789/33691
Choi C-HR, Bakir IA, Hart AL et al.(2017). Clonal evolution of colorectal cancer in IBD. Nat Rev Gastroenterol Hepatol vol. 14, (4) 218-229.
10.1038/nrgastro.2017.1
https://qmro.qmul.ac.uk/handle/123456789/21199
Baker A-M, Davis CHRCH, Al-Bakir I et al. (2017). MULTI-REGION EXOME SEQUENCING REVEALS THE CLONAL EVOLUTION OF COLITIS-ASSOCIATED COLORECTAL CANCER. GASTROENTEROLOGY. vol. 152, S983-S984.
10.1016/S0016-5085(17)33330-9
https://qmro.qmul.ac.uk/handle/123456789/50083
Graham TA (2017). Grading Cancer Evolution for Prognostication. JOURNAL OF PATHOLOGY. vol. 241, S3-S3.
Temko D, Schuster-Boeckler B, Severini S et al. (2017). Mutation Signatures Linked to Polymerase Epsilon Defects and APOBEC Cytidine Deaminase Activity Occur Early in a Range of Cancer Types. JOURNAL OF PATHOLOGY. vol. 241, S10-S10.
https://qmro.qmul.ac.uk/handle/123456789/22743
Shah V, Nowinski S, Levi D et al.(2017). PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression. Breast Cancer Res vol. 19, (1)
10.1186/s13058-016-0789-y
https://qmro.qmul.ac.uk/handle/123456789/18926
Sottoriva A, Barnes CP, Graham TA(2017). Catch my drift? Making sense of genomic intra-tumour heterogeneity. Biochim Biophys Acta vol. 1867, (2) 95-100.
10.1016/j.bbcan.2016.12.003
https://qmro.qmul.ac.uk/handle/123456789/34991
GRAHAM TA, Sottoriva A(2016). Measuring cancer evolution from the genome. Journal of Pathology
10.1002/path.4821
https://qmro.qmul.ac.uk/handle/123456789/16184
Timmer MR, Martinez P, Lau CT et al.(2016). Derivation of genetic biomarkers for cancer risk stratification in Barrett's oesophagus: a prospective cohort study. Gut vol. 65, (10) 1602-1610.
10.1136/gutjnl-2015-309642
Martinez P, Timmer MR, Lau CT et al. (2016). Longitudinal Single Cell Clonal Analyis Reveals Evolutionary Stasis and Predetermined Malignant Potential in Non-Dysplastic Barrett's Esophagus. JOURNAL OF PATHOLOGY. vol. 240, 18-18.
https://qmro.qmul.ac.uk/handle/123456789/25724
Sottoriva A, Graham TA, Werner B et al. (2016). Neutral Evolution in Colorectal Cancer: How Can We Distinguish Functional from Non-functional Variation?. JOURNAL OF PATHOLOGY. vol. 240, 7-7.
https://qmro.qmul.ac.uk/handle/123456789/18164
Cross W, Graham TA, Wright NA(2016). New paradigms in clonal evolution: punctuated equilibrium in cancer. Journal of Pathology
10.1002/path.4757
https://qmro.qmul.ac.uk/handle/123456789/15453
Martinez P, Timmer MR, Lau CT et al.(2016). Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus. Nature Communications vol. 7, 12158-12158.
10.1038/ncomms12158
https://qmro.qmul.ac.uk/handle/123456789/15334
Williams MJ, Werner B, Graham TA et al.(2016). Functional versus non-functional intratumor heterogeneity in cancer. Molecular & Cellular Oncology vol. 3, (4) e1162897-e1162897.
10.1080/23723556.2016.1162897
https://qmro.qmul.ac.uk/handle/123456789/15910
Lavery DL, Martinez P, Gay LJ et al.(2016). Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus. Gut vol. 65, (6) 907-913.
10.1136/gutjnl-2015-310748
https://qmro.qmul.ac.uk/handle/123456789/15434
Findlay JM, Castro-Giner F, Makino S et al.(2016). Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy. Nature Communications vol. 7, 11111-11111.
10.1038/ncomms11111
https://qmro.qmul.ac.uk/handle/123456789/12752
Dhawan A, Graham TA, Fletcher AG(2016). A Computational Modeling Approach for Deriving Biomarkers to Predict Cancer Risk in Premalignant Disease. Cancer Prev Res (Phila) vol. 9, (4) 283-295.
10.1158/1940-6207.CAPR-15-0248
https://qmro.qmul.ac.uk/handle/123456789/14952
Williams MJ, Werner B, Barnes CP et al.(2016). Identification of neutral tumor evolution across cancer types. Nat Genet vol. 48, (3) 238-244.
10.1038/ng.3489
https://qmro.qmul.ac.uk/handle/123456789/13290
King LM, Marks JR, Hall AH et al. (2016). Genomic diversity of ductal carcinoma in situ (DCIS) as a driver of invasion and metastasis. CANCER RESEARCH. vol. 76,
10.1158/1538-7445.SABCS15-P6-05-03
Andor N, Graham TA, Jansen M et al.(2016). Pan-cancer analysis of the extent and consequences of intratumor heterogeneity. Nat Med vol. 22, (1) 105-113.
10.1038/nm.3984
Baker A-M, Graham TA(2016). Quantifying human intestinal stem cell and crypt dynamics: the implications for cancer screening and prevention. Expert Rev Gastroenterol Hepatol vol. 10, (3) 277-279.
10.1586/17474124.2016.1134314
Gay L, Baker A-M, Graham TA(2016). Tumour Cell Heterogeneity. F1000Res vol. 5,
10.12688/f1000research.7210.1
https://qmro.qmul.ac.uk/handle/123456789/15126
Sottoriva A, Kang H, Ma Z et al. (2015). A Big Bang model of human colorectal tumor growth. CANCER RESEARCH. vol. 75,
10.1158/1538-7445.COMPSYSBIO-B2-23
Andor N, Graham TA, Petritsch C et al. (2015). Pan-cancer analysis of the etiology and consequences of intra-tumor heterogeneity. CANCER RESEARCH. vol. 75,
10.1158/1538-7445.TRANSCAGEN-PR03
Andor N, Graham TA, Petritsch C et al. (2015). Pan-cancer analysis of the etiology and consequences of intratumor heterogeneity. CANCER RESEARCH. vol. 75,
10.1158/1538-7445.TRANSCAGEN-A1-54
Choi C-HR, Ignjatovic-Wilson A, Askari A et al.(2015). Low-grade dysplasia in ulcerative colitis: risk factors for developing high-grade dysplasia or colorectal cancer. Am J Gastroenterol vol. 110, (10) 1461-1471.
10.1038/ajg.2015.248
https://qmro.qmul.ac.uk/handle/123456789/12756
Jansen M, McDonald SA, Lavery D et al. (2015). Spatial Sampling in Barrett's Oesophagus Shows Clonal Evolution of Oesophageal Adenocarcinoma from Metaplastic Non-Goblet Columnar Epithelium. JOURNAL OF PATHOLOGY. vol. 237, S21-S21.
https://qmro.qmul.ac.uk/handle/123456789/13992
Andor N, Graham TA, Aktipis AC et al. (2015). Pan-cancer analysis of the causes and consequences of Intra-tumor heterogeneity. CANCER RESEARCH. vol. 75,
10.1158/1538-7445.AM2015-LB-163
Caulin AF, Graham TA, Wang L-S et al.(2015). Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis. Philos Trans R Soc Lond B Biol Sci vol. 370, (1673)
10.1098/rstb.2014.0222
https://qmro.qmul.ac.uk/handle/123456789/23664
Choi C-HR, Rutter MD, Askari A et al.(2015). Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: An Updated Overview. Am J Gastroenterol vol. 110, (7) 1022-1034.
10.1038/ajg.2015.65
https://qmro.qmul.ac.uk/handle/123456789/9771
Asfaha S, Hayakawa Y, Muley A et al.(2015). Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine. Cell Stem Cell vol. 16, (6) 627-638.
10.1016/j.stem.2015.04.013
Choi CHR, Wilson A, Rutter M et al. (2015). Low-Grade Dysplasia in Ulcerative Colitis: Shape and Size of the Lesion, and Previous Episode of Indefinite Dysplasia Are Important Predictors for Progression to High-grade Dysplasia or Cancer. GASTROINTESTINAL ENDOSCOPY. vol. 81, AB366-AB366.
10.1016/j.gie.2015.03.1501
Baker A-M, Graham TA, Elia G et al.(2015). Characterization of LGR5 stem cells in colorectal adenomas and carcinomas. Sci Rep vol. 5,
10.1038/srep08654
https://qmro.qmul.ac.uk/handle/123456789/24824
Sottoriva A, Kang H, Ma Z et al.(2015). A Big Bang model of human colorectal tumor growth. Nat Genet vol. 47, (3) 209-216.
10.1038/ng.3214
https://qmro.qmul.ac.uk/handle/123456789/23903
Sottoriva A, Graham T(2015). A pan-cancer signature of neutral tumor evolution.
10.1101/014894
Worthley DL, Churchill M, Compton JT et al.(2015). Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell vol. 160, (1-2) 269-284.
10.1016/j.cell.2014.11.042
McDonald SAC, Graham TA, Lavery DL et al.(2015). The Barrett's Gland in Phenotype Space. Cell Mol Gastroenterol Hepatol vol. 1, (1) 41-54.
10.1016/j.jcmgh.2014.10.001
https://qmro.qmul.ac.uk/handle/123456789/22406
Walther V, Graham TA(2014). Location, location, location! The reality of life for an intestinal stem cell in the crypt. J Pathol vol. 234, (1) 1-4.
10.1002/path.4370
Baker A-M, Cereser B, Melton S et al.(2014). Quantification of crypt and stem cell evolution in the normal and neoplastic human colon. Cell Rep vol. 8, (4) 940-947.
10.1016/j.celrep.2014.07.019
Baker A-M, Graham TA(2014). Revealing human intestinal stem cell and crypt dynamics. Mol Cell Oncol vol. 1, (3)
10.4161/23723548.2014.970069
Pipinikas CP, Kiropoulos TS, Teixeira VH et al.(2014). Cell migration leads to spatially distinct but clonally related airway cancer precursors. Thorax vol. 69, (6) 548-557.
10.1136/thoraxjnl-2013-204198
https://qmro.qmul.ac.uk/handle/123456789/12174
Jawad N, Graham TA, McDonald SAC et al.(2014). Re: Mitochondria and tumor progression in ulcerative colitis. J Natl Cancer Inst vol. 106, (2)
10.1093/jnci/djt436
(2014). Cell migration leads to spatially distinct but clonally related airway cancer precursors. Thorax vol. 69, (6) 548-557.
10.1136/thoraxjnl-2013-204198
Teixeira V, Nadarajan P, Graham TA et al. (2013). LINEAGE TRACING IN HUMANS REVEALS STOCHASTIC HOMEOSTASIS OF AIRWAY EPITHELIUM RESULTING FROM NEUTRAL COMPETITION OF BASAL CELL PROGENITORS. THORAX. vol. 68, A68-A68.
10.1136/thoraxjnl-2013-204457.139
Shaw JA, Graham TA, Stebbing J(2013). Genomic instability in pre-neoplastic colonic lesions. Oncogene vol. 32, (46) 5331-5332.
10.1038/onc.2013.21
Teixeira VH, Nadarajan P, Graham TA et al.(2013). Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors. Elife vol. 2,
10.7554/eLife.00966
(2013). Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation. American Journal of Gastroenterology vol. 108, (10) 1584-1592.
10.1038/ajg.2013.238
Zeki SS, Haidry R, Graham TA et al.(2013). Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation. Am J Gastroenterol vol. 108, (10) 1584-1592.
10.1038/ajg.2013.238
Khan S, McDonald SAC, Wright NA et al.(2013). Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells. JOURNAL OF PATHOLOGY vol. 231, (1) 98-104.
10.1002/path.4211
Humphries A, Cereser B, Gay LJ et al.(2013). Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution. Proc Natl Acad Sci U S A vol. 110, (27) E2490-E2499.
10.1073/pnas.1220353110
Khan S, McDonald S, Wright NA et al. (2013). CRYPT CELL DYSPLASIA WITH MATURATION IN BARRETT'S ESOPHAGUS SHOWS CLONAL IDENTITY BETWEEN THE CRYPT AND SURFACE CELLS. GUT. vol. 62, A198-A199.
10.1136/gutjnl-2013-304907.456
Cereser B, Baker A-MC, Tadrous PJ et al. (2013). TWO DIMENSIONAL MAPPING OF MUTANT CLONES IN HUMAN COLONIC CRYPTS REVEAL STEM CELL DYNAMICS AND MIGRATION PATTERNS. GUT. vol. 62, A194-A195.
10.1136/gutjnl-2013-304907.445
Willis L, Graham TA, Alarcon T et al.(2013). What Can Be Learnt about Disease Progression in Breast Cancer Dormancy from Relapse Data?. PLOS ONE vol. 8, (5) Article ARTN e62320,
10.1371/journal.pone.0062320
https://qmro.qmul.ac.uk/handle/123456789/4862
Wright NA, Khan S, McDonald SAC et al. (2013). Crypt Cell Dysplasia with Maturation in Barrett's Esophagus Shows Clonal Identity between the Crypt and Surface Cells. JOURNAL OF PATHOLOGY. vol. 229, S6-S6.
10.1002/path.4211
Al-Juffali N, Hamilton N, Nicholson AG et al.(2013). LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development. Journal of Pathology vol. 229, (4) 608-620.
10.1002/path.4148
Baker A-M, Graham TA, Wright NA(2013). Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: potential for biomarker development. J Pathol vol. 229, (4) 502-514.
10.1002/path.4157
Leedham SJ, Rodenas-Cuadrado P, Howarth K et al.(2013). A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts. Gut vol. 62, (1) 83-93.
10.1136/gutjnl-2011-301601
S Datta R, Gutteridge A, Swanton C et al.(2013). Modelling the evolution of genetic instability during tumour progression. Evol Appl vol. 6, (1) 20-33.
10.1111/eva.12024
Rodriguez-Justo M, Novelli M, Harrison R et al.(2012). Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor. Gut vol. 61, (10) 1380-1389.
10.1136/gutjnl-2011-301174
Gilbertson RJ, Graham TA(2012). Cancer: Resolving the stem-cell debate. Nature vol. 488, (7412) 462-463.
10.1038/nature11480
Gilbertson RJ, Graham TA(2012). Cancer: Resolving the stem-cell debate. Nature
10.1038/nature11480
Humphries A, Graham TA, Cereser B et al.(2012). HUMAN COLORECTAL ADENOMA GROWTH IS CHARACTERISED BY PERIODS OF QUIESCENCE AND RAPID CLONAL EXPANSION. GUT vol. 61, A7-A8.
10.1136/gutjnl-2012-302514a.16
Galandiuk S, Rodriguez-Justo M, Jeffery R et al.(2012). Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis. Gastroenterology vol. 142, (4) 855-864.e8.
10.1053/j.gastro.2011.12.004
Zeki S, Graham TA, McDonald SAC(2012). Utilizing DNA mutations to trace epithelial cell lineages in human tissues. Methods Mol Biol vol. 916, 289-301.
10.1007/978-1-61779-980-8_22
Zeki SS, McDonald SA, Graham TA(2011). Field cancerization in Barrett's esophagus. Discov Med vol. 12, (66) 371-379.
Gaisa NT, Graham TA, McDonald SA et al.(2011). Clonal architecture of human prostatic epithelium in benign and malignant conditions. J Pathol vol. 225, (2) 172-180.
10.1002/path.2959
Gaisa NT, Graham TA, McDonald SAC et al.(2011). The human urothelium consists of multiple clonal units, each maintained by a stem cell. J Pathol vol. 225, (2) 163-171.
10.1002/path.2945
Graham TA, McDonald SA, Wright NA(2011). Field cancerization in the GI tract. Future Oncol vol. 7, (8) 981-993.
10.2217/fon.11.70
Endesfelder D, McGranahan N, Birkbak NJ et al.(2011). A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables. Oncotarget vol. 2, (7) 529-537.
10.18632/oncotarget.298
Gutierrez-Gonzalez L, Graham TA, Rodriguez-Justo M et al.(2011). The clonal origins of dysplasia from intestinal metaplasia in the human stomach. Gastroenterology vol. 140, (4)
10.1053/j.gastro.2010.12.051
Graham TA, Humphries A, Sanders T et al.(2011). Use of methylation patterns to determine expansion of stem cell clones in human colon tissue. Gastroenterology vol. 140, (4)
10.1053/j.gastro.2010.12.036
Zeki SS, Graham TA, Wright NA(2011). Stem cells and their implications for colorectal cancer. Nat Rev Gastroenterol Hepatol vol. 8, (2) 90-100.
10.1038/nrgastro.2010.211
Nicholson AM, Graham TA, Simpson A et al.(2011). Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor. Gut
10.1136/gutjnl-2011-301174
Humphries A, Graham TA, McDonald SAC(2011). Stem cells and inflammation in the intestine. Recent Results Cancer Res vol. 185, 51-63.
10.1007/978-3-642-03503-6_3
Graham TA, Leedham SJ(2010). Field defects in DNA repair: is loss of MGMT an initial event in colorectal carcinogenesis?. Gut vol. 59, (11) 1452-1453.
10.1136/gut.2010.222398
Nicholson A, Graham T, Simpson A et al. (2010). Analysis of the Clonality of Barrett's Oesophagus Glands Reveals They are Clonal Units and Establishes a Common Stem Cell for Glandular and Squamous Epithelium. JOURNAL OF PATHOLOGY. vol. 222, S17-S18.
Graham T, Galandiuk S, McDonald S et al. (2010). Field Cancerization in Crohn's Disease. JOURNAL OF PATHOLOGY. vol. 222, S15-S16.
Graham T, Khan S, Oukrif D et al. (2010). Investigating Clonal Dynamics in Barrett's Associated tumorigenesis Using Spatial Maps of Genetic Heterogeneity. JOURNAL OF PATHOLOGY. vol. 222, S9-S9.
Nicholson A, Harrison L, Barr H et al. (2010). Pulse Chase Experiments Using IUdR Identifies Barrett's Label-Retaining Stem Cells. JOURNAL OF PATHOLOGY. vol. 222, S16-S16.
McDonald S, Jeffery R, Humphries A et al. (2010). Stem Cell Location Throughout the Human Gastrointestinal Tract as Defined by LGR5 mRNA In Situ Hybridisation. JOURNAL OF PATHOLOGY. vol. 222, S12-S12.
Gaisa N, Graham T, McDonald S et al. (2010). Stem Cell Niches in the Bladder? The Clonal Organization of Human Urothelium. JOURNAL OF PATHOLOGY. vol. 222, S47-S47.
Jankowski J, Graham T, Harrison R(2010). Authors' response. Gut vol. 59, (8)
10.1136/gut.2010.218776
Willis L, Alarcón T, Elia G et al.(2010). Breast cancer dormancy can be maintained by small numbers of micrometastases. Cancer Res vol. 70, (11) 4310-4317.
10.1158/0008-5472.CAN-09-3144
Graham TA, Jawad N, Wright NA(2010). Spindles losing their bearings: Does disruption of orientation in stem cells predict the onset of cancer?. BIOESSAYS vol. 32, (6) 468-472.
10.1002/bies.201000032
Nicholson AM, Graham TA, Simpson AI et al. (2010). ANALYSIS OF THE CLONALITY OF BARRETT'S OESOPHAGUS GLANDS REVEALS THEY ARE CLONAL AND ESTABLISHES A COMMON STEM CELL FOR GLANDULAR AND SQUAMOUS EPITHELIUM. GUT. vol. 59, A119-A119.
10.1136/gut.2009.209007c
Gutierrez-Gonzalez L, Graham TA, Rodriguez-Justo M et al. (2010). CLONAL ORIGINS OF DYSPLASIA FROM METAPLASIA IN THE HUMAN STOMACH. GUT. vol. 59, A17-A18.
10.1136/gut.2009.208959p
Thirlwell C, Will OCC, Domingo E et al.(2010). Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas. Gastroenterology vol. 138, (4) 1441-1454.e7.
10.1053/j.gastro.2010.01.033
Graham TA, McDonald SAC(2010). Genetic diversity during the development of Barrett's oesophagus-associated adenocarcinoma: how, when and why?. Biochem Soc Trans vol. 38, (2) 374-379.
10.1042/BST0380374
Graham TA, Khan S, Green A et al. (2010). INVESTIGATING CLONAL COMPETITION IN BARRETT'S ASSOCIATED TUMORIGENESIS USING SPATIAL MAPS OF GENETIC HETEROGENEITY. GUT. vol. 59, A111-A111.
10.1136/gut.2009.208983i
Lin W-R, Lim S-N, McDonald SAC et al.(2010). The histogenesis of regenerative nodules in human liver cirrhosis. Hepatology vol. 51, (3) 1017-1026.
10.1002/hep.23483
Obszynska JA, Atherfold PA, Nanji M et al.(2010). Long-term proton pump induced hypergastrinaemia does induce lineage-specific restitution but not clonal expansion in benign Barrett's oesophagus in vivo. Gut vol. 59, (2) 156-163.
10.1136/gut.2009.186775
McDonald SAC, Graham TA, Schier S et al.(2009). Stem cells and solid cancers. Virchows Arch vol. 455, (1) 1-13.
10.1007/s00428-009-0783-1
Lanza R, Hogan B, Gaerhart J et al.(2009). Stem Cells in the Gastrointestinal Tract. Essentials of stem cell biology, Edition. 2nd, Academic Pr
Graham TA, Humphries A, McDonald SA et al. (2009). Methylation and Clonality of Human Colonic Crypts. GASTROENTEROLOGY. vol. 136, A78-A78.
Graham TA, Humphries A, Leedham SJ et al. (2009). METHODS FOR TRACING CRYPT STEM CELLS ANCESTRY AND CLONAL ARCHITECTURE USING CPG ISLAND METHYLATION AND MITOCHONDRIAL DNA MUTATIONS. GUT. vol. 58, A2-A2.
Leedham SJ, Graham TA, Oukrif D et al.(2009). Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis-Associated Neoplasia. GASTROENTEROLOGY vol. 136, (2) 542-550.
10.1053/j.gastro.2008.10.086
Graham TA, Wright NA(2008). Investigating the fixation and spread of mutations in the gastrointestinal epithelium. FUTURE ONCOL vol. 4, (6) 825-839.
10.2217/14796694.4.6.825
Graham T, Halford S, Page KM et al.(2008). Most low-level microsatellite instability in colorectal cancers can be explained without an elevated slippage rate. J Pathol vol. 215, (2) 204-210.
10.1002/path.2351
Jones AM, Mitter R, Springall R et al.(2008). A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence. J Pathol vol. 214, (5) 533-544.
10.1002/path.2320
Leedham SJ, Graham T, Rodriguez-Justo M et al. (2008). Microdissecting the carcinogenesis pathways in sporadic and colitis-associated colon cancer. GUT. vol. 57, A26-A27.
Jones AM, Thirlwell C, Howarth KM et al.(2007). Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas. J Pathol vol. 213, (3) 249-256.
10.1002/path.2234
McDonald SAC, Graham T, Potten CS et al.(2006). Intestinal stem cells and the development of colorectal neoplasia. Tissue Stem Cells,
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