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Publications:  Dr Viji Draviam Sastry

Conti D, Gul P, Islam A, Martín-Durán JM, Pickersgill RW, Draviam VM(2019). Kinetochores attached to microtubule-ends are stabilised by astrin bound pp1 to ensure proper chromosome segregation. eLife vol. 8,
10.7554/eLife.49325
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62647
Hart M, Zulkipli I, Shrestha RL, Dang D, Conti D, Gul P, Kujawiak I, Draviam VM(2019). MARK2/Par1b kinase present at centrosomes and retraction fibres corrects spindle off-centring induced by actin disassembly. Open Biology vol. 9, (6)
10.1098/rsob.180263
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62648
Zulkipli I, Clark J, HART M, Shrestha R, GUL P, DANG D, Kasichiwin T, Kujawiak I et al.(2018). Spindle rotation in human cells is reliant on a MARK2-mediated equatorial spindle centering mechanism. Journal of Cell Biology
10.1083/jcb.201804166
https://qmro.qmul.ac.uk/xmlui/handle/123456789/41928
Zulkipli I, Shrestha RL, Clark J, Draviam VM (2017). Proper rotation of the mitotic spindle requires an equatorial spindle centering mechanism in human cells. MOLECULAR BIOLOGY OF THE CELL. Conference: ASCB vol. 28,
Shrestha RL, Conti D, Tamura N, Braun D, Ramalingam RA, Cieslinski K, Ries J, Draviam VM(2017). Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells. Nat Commun vol. 8, (1) 150-150.
10.1038/s41467-017-00209-z
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34884
Conti D, Cieslinski KA, Ries J, Draviam VM (2017). Outer kinetochore phosphatases-PP2A-B56 and PP1-differently contribute to the establishment of chromosome-microtubule attachments. MOLECULAR BIOLOGY OF THE CELL. vol. 28,
Hiroi N, Draviam VM, Funahashi A(2016). Editorial: Quantitative Biology: Dynamics of Living Systems. Front Physiol vol. 7, Article 196,
10.3389/fphys.2016.00196
Patel H, Stavrou I, Shrestha RL, Draviam V, Frame MC, Brunton VG(2016). Kindlin1 regulates microtubule function to ensure normal mitosis. Journal of Molecular Cell Biology vol. 8, (4) 338-348.
10.1093/jmcb/mjw009
Iorio F, Shrestha RL, Levin N, Boilot V, Garnett MJ, Saez-Rodriguez J, Draviam VM(2015). A semi-supervised approach for refining transcriptional signatures of drug response and repositioning predictions. PLoS ONE vol. 10, (10)
10.1371/journal.pone.0139446
Corrigan AM, Shrestha R, Draviam VM, Donald AM(2015). Modeling of Noisy Spindle Dynamics Reveals Separable Contributions to Achieving Correct Orientation. Biophysical Journal vol. 109, (7) 1398-1409.
10.1016/j.bpj.2015.08.014
Tamura N, Simon JE, Nayak A, Shenoy R, Hiroi N, Boilot V, Funahashi A, Draviam VM(2015). A proteomic study of mitotic phase-Specific interactors of EB1 reveals a role for SXIP-Mediated protein interactions in anaphase onset. Biology Open vol. 4, (2) 155-169.
10.1242/bio.201410413
Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q et al.(2015). PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Science vol. 347, (6218) 185-188.
10.1126/science.1261971
Nakai Y, Ozeki M, Hiraiwa T, Tanimoto R, Funahashi A, Hiroi N, Taniguchi A, Nonaka S et al.(2015). High-speed microscopy with an electrically tunable lens to image the dynamics of in vivo molecular complexes. Review of Scientific Instruments vol. 86, (1)
10.1063/1.4905330
Shrestha RL, Draviam VM (2014). Lateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAK. MOLECULAR BIOLOGY OF THE CELL. vol. 25,
Conti D, Draviam VM (2014). Role of phosphatases in chromosome segregation. MOLECULAR BIOLOGY OF THE CELL. vol. 25,
Shrestha RL, Tamura N, Fries A, Levin N, Clark J, Draviam VM(2014). TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes. Open Biology vol. 4, (JUNE)
10.1098/rsob.130108
Chin-Hui-Men S, Nandra K, Clark J, Draviam VM(2014). Need for multi-scale systems to identify spindle orientation regulators relevant to tissue disorganisation in solid cancers. Frontiers in Physiology vol. 5 JUL,
10.3389/fphys.2014.00278
Shrestha RL, Draviam VM(2013). Erratum: Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK (Current Biology (2013) 23 (1514-1526)). Current Biology vol. 23, (23) 2440-2441.
10.1016/j.cub.2013.11.015
Shrestha RL, Draviam VM(2013). Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins cenp-e and MCAK. Current Biology vol. 23, (16) 1514-1526.
10.1016/j.cub.2013.06.040
Corrigan AM, Shrestha RL, Zulkipli I, Hiroi N, Liu Y, Tamura N, Yang B, Patel J et al.(2013). Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance. Cell Cycle vol. 12, (16) 2643-2655.
10.4161/cc.25671
Draviam VM, Funahashi A, Hiroi N, Kimura A, Kobayashi TJ(2013). Meeting report of the international workshop on quantitative biology 2012: Mesoscopic and microscopic worlds meet. Frontiers in Physiology vol. 3 JAN,
10.3389/fphys.2012.00479
Tamura N, Draviam VM(2012). Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles. Open Biology vol. 2, (NOV)
10.1098/rsob.120132
Tamura N, Shrestha RL, Draviam VM (2012). Microtubule-end bound complexes power chromosome movement during chromosome segregation. MOLECULAR BIOLOGY OF THE CELL. vol. 23,
Shrestha RL, Draviam VM (2012). TAO1 maintains genome integrity by mediating the timely maturation of chromosome attachments made to lateral walls of microtubules. MOLECULAR BIOLOGY OF THE CELL. vol. 23,
Shrestha RL, Tamura N, Zulkipli I, Draviam VM (2011). A mechanism linking microtubule destabilisation to maturation of chromosome-microtubule attachments. MOLECULAR BIOLOGY OF THE CELL. vol. 22,
Pagliuca C, Draviam VM, Marco E, Sorger PK, De Wulf P(2009). Roles for the conserved Spc105p/Kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint. PLoS ONE vol. 4, (10)
10.1371/journal.pone.0007640
McAinsh AD, Meraldi P, Draviam VM, Toso A, Sorger PK(2009). The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation (The EMBO Journal (2006) 25 (4033-4049) DOI:10.1038/sj.emboj.7601293). EMBO Journal vol. 28, (9)
10.1038/emboj.2009.94
Foijer F, Draviam VM, Sorger PK(2008). Studying chromosome instability in the mouse. Biochimica et Biophysica Acta - Reviews on Cancer vol. 1786, (1) 73-82.
10.1016/j.bbcan.2008.07.004
Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ et al.(2007). Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature vol. 447, (7141) 876-881.
Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK et al.(2007). A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nature Cell Biology vol. 9, (5) 556-564.
10.1038/ncb1569
Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ et al.(2007). Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature vol. 446, (7138) 876-881.
10.1038/nature05694
Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW(2007). Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans. Journal of Cell Science vol. 120, (7) 1278-1287.
10.1242/jcs.000604
McAinsh AD, Meraldi P, Draviam VM, Toso A, Sorger PK(2006). The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. EMBO Journal vol. 25, (17) 4033-4049.
10.1038/sj.emboj.7601293
Draviam VM, Shapiro I, Aldridge B, Sorger PK(2006). Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. EMBO Journal vol. 25, (12) 2814-2827.
10.1038/sj.emboj.7601168
Draviam VM, Stegmeier F, Nalepa G, Sowa M, Hannon G, Harper W, Elledge S, Sorger P (2006). Functional Genomic Screen Reveals the Role of a Novel Checkpoint Kinase, TAO1 in Mitosis and Cell Cycle Progression. MOLECULAR BIOLOGY OF THE CELL. vol. 17,
Meraldi P, Draviam VM, Sorger PK(2004). Timing and checkpoints in the regulation of mitotic progression. Developmental Cell vol. 7, (1) 45-60.
10.1016/j.devcel.2004.06.006
Draviam VM, Xie S, Sorger PK(2004). Chromosome segregation and genomic stability. Current Opinion in Genetics and Development vol. 14, (2) 120-125.
10.1016/j.gde.2004.02.007
Gergely F, Draviam VM, Raff JW(2003). The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes and Development vol. 17, (3) 336-341.
10.1101/gad.245603
Draviam VM, Orrechia S, Lowe M, Pardi R, Pines J(2001). The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus. Journal of Cell Biology vol. 152, (5) 945-958.
10.1083/jcb.152.5.945
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