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Publications:  Dr Prabhakar Rajan

Thompson JE, Sridhar AN, Tan WS, Freeman A, Haider A, Allen C, Moore CM, Orczyk C et al.(2019). Pathological Findings and Magnetic Resonance Imaging Concordance at Salvage Radical Prostatectomy for Local Recurrence following Partial Ablation Using High Intensity Focused Ultrasound. J Urol vol. 201, (6) 1134-1143.
10.1097/JU.0000000000000135
De Laere B, Rajan P, Grönberg H, Dirix L, Lindberg J, CORE-ARV-CTC and ProBIO Investigators(2019). Androgen Receptor Burden and Poor Response to Abiraterone or Enzalutamide in TP53 Wild-Type Metastatic Castration-Resistant Prostate Cancer. JAMA Oncol
10.1001/jamaoncol.2019.0869
Heavey S, Costa H, Pye H, Burt EC, Jenkinson S, Lewis GR, Bosshard-Carter L, Watson F et al.(2019). PEOPLE: PatiEnt prOstate samPLes for rEsearch, a tissue collection pathway utilizing magnetic resonance imaging data to target tumor and benign tissue in fresh radical prostatectomy specimens. Prostate vol. 79, (7) 768-777.
10.1002/pros.23782
De Laere B, Oeyen S, Mayrhofer M, Whitington T, van Dam P-J, Van Oyen P, Ghysel C, Ampe J et al.(2019). TP53 Outperforms Other Androgen Receptor Biomarkers to Predict Abiraterone or Enzalutamide Outcome in Metastatic Castration-Resistant Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research vol. 25, (6) 1766-1773.
10.1158/1078-0432.CCR-18-1943
Mayrhofer M, De Laere B, Whitington T, Van Oyen P, Ghysel C, Ampe J, Ost P, Demey W et al.(2018). Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis. Genome Med vol. 10, (1)
10.1186/s13073-018-0595-5
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A et al.(2018). A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. EMBO Mol Med vol. 10, (8)
10.15252/emmm.201708304
Rajan P, Hagman A, Sooriakumaran P, Nyberg T, Wallerstedt A, Adding C, Akre O, Carlsson S et al.(2018). Oncologic Outcomes After Robot-assisted Radical Prostatectomy: A Large European Single-centre Cohort with Median 10-Year Follow-up. European Urology Focus vol. 4, (3) 351-359.
10.1016/j.euf.2016.10.007
Lamb BW, Rajan P(2018). The practicing urologists’ guide to clinical research. Journal of Clinical Urology
10.1177/2051415818761528
Munkley J, Maia TM, Ibarluzea N, Livermore KE, Vodak D, Ehrmann I, James K, Rajan P et al.(2018). Androgen-dependent alternative mRNA isoform expression in prostate cancer cells. F1000Research vol. 7,
10.12688/f1000research.15604.1
Rajan P, Sooriakumaran P, Nyberg T, Akre O, Carlsson S, Egevad L, Steineck G, Wiklund NP(2017). Effect of Comorbidity on Prostate Cancer-Specific Mortality: A Prospective Observational Study. J Clin Oncol vol. 35, (31) 3566-3574.
10.1200/JCO.2016.70.7794
Munkley J, Livermore K, Rajan P, Elliott DJ(2017). RNA splicing and splicing regulator changes in prostate cancer pathology. HUMAN GENETICS vol. 136, (9) 1143-1154.
10.1007/s00439-017-1792-9
Munkley J, McClurg UL, Livermore KE, Ehrmann I, Knight B, Mccullagh P, Mcgrath J, Crundwell M et al.(2017). The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration. Sci Rep vol. 7, (1) 5249-5249.
10.1038/s41598-017-05489-5
Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, McCullagh P, Mcgrath J et al.(2016). Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability. EBIOMEDICINE vol. 8, 103-116.
10.1016/j.ebiom.2016.04.018
Munkley J, Oltean S, Vodák D, Wilson BT, Livermore KE, Zhou Y, Star E, Floros VI et al.(2015). The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer. Oncotarget vol. 6, (33)
10.18632/oncotarget.6024
Munkley J, Livermore KE, McClurg UL, Kalna G, Knight B, McCullagh P, McGrath J, Crundwell M et al.(2015). The PI3K regulatory subunit gene <em>PIK3R1</em> is under direct control of androgens and repressed in prostate cancer cells. Oncoscience
10.18632/oncoscience.243
Stockley J, Markert E, Zhou Y, Robson CN, Elliott DJ, Lindberg J, Leung HY, Rajan P(2015). The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7. Scientific Reports vol. 5, (1) Article 13426,
10.1038/srep13426
Rajan P, Frew JA, Wilson JM, Azzabi AST, McMenemin RM, Stockley J, Soomro NA, Durkan G et al.(2015). Feasibility study of a randomized controlled trial comparing docetaxel chemotherapy and androgen deprivation therapy with sequential prostatic biopsies from patients with advanced non–castration-resistant prostate cancer. Urologic Oncology: Seminars and Original Investigations vol. 33, (8) 337.e1-337.e6.
10.1016/j.urolonc.2015.05.012
Munkley J, Lafferty NP, Kalna G, Robson CN, Leung HY, Rajan P, Elliott DJ(2015). Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells. BMC Cancer vol. 15, (1) Article 9,
10.1186/s12885-015-1012-8
Rajan P, Stockley J, Sudbery IM, Fleming JT, Hedley A, Kalna G, Sims D, Ponting CP et al.(2014). Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer. BMC Cancer vol. 14, (1) Article 977,
10.1186/1471-2407-14-977
Rajan P, Sudbery IM, Villasevil MEM, Mui E, Fleming J, Davis M, Ahmad I, Edwards J et al.(2014). Next-generation Sequencing of Advanced Prostate Cancer Treated with Androgen-deprivation Therapy. European Urology vol. 66, (1) 32-39.
10.1016/j.eururo.2013.08.011
Stockley J, Villasevil MEM, Nixon C, Ahmad I, Leung HY, Rajan P(2014). The RNA-binding protein hnRNPA2 regulates β-catenin protein expression and is overexpressed in prostate cancer. RNA Biology vol. 11, (6) 755-765.
10.4161/rna.28800
Lamb BW, Rajan P(2014). Clinical Research Toolkit for Urologists. Journal of Clinical Urology vol. 9, (3)
10.1177/2051415816632390
Munkley J, Rajan P, Lafferty NP, Dalgliesh C, Jackson RM, Robson CN, Leung HY, Elliott DJ(2013). A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation. Oncotarget vol. 5, (1)
10.18632/oncotarget.1405
Rajan P, Gaughan L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY, Elliott DJ(2008). The RNA-binding and adaptor protein Sam68 modulates signal-dependent splicing and transcriptional activity of the androgen receptor. The Journal of Pathology vol. 215, (1) 67-77.
10.1002/path.2324
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