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Publications:  Dr Daniela Loessner

Wagner F, Holzapfel BM, Martine LC, McGovern J, Lahr CA, Boxberg M, Prodinger PM, Grässel S et al.(2019). A humanized bone microenvironment uncovers HIF2 alpha as a latent marker for osteosarcoma. Acta Biomaterialia vol. 89, 372-381.
10.1016/j.actbio.2019.02.051
Loessner D, Rockstroh A, Shokoohmand A, Holzapfel BM, Wagner F, Baldwin J, Boxberg M, Schmalfeldt B et al.(2019). A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns. Biomaterials vol. 190-191, 63-75.
10.1016/j.biomaterials.2018.10.014
https://qmro.qmul.ac.uk/xmlui/handle/123456789/53324
Peerani E, Candido JB, Loessner D(2019). Cell recovery of hydrogel-encapsulated cells for molecular analysis. vol. 2054, 3-21.
10.1007/978-1-4939-9769-5_1
McGovern JA, Shafiee A, Wagner F, Lahr CA, Landgraf M, Meinert C, Williams ED, Russell PJ et al.(2018). Humanization of the prostate microenvironment reduces homing of PC3 prostate cancer cells to human tissue-engineered bone. Cancers vol. 10, (11)
10.3390/cancers10110438
https://qmro.qmul.ac.uk/xmlui/handle/123456789/53304
Little JP, Pettet GJ, Hutmacher DW, Loessner D(2018). SpheroidSim—Preliminary evaluation of a new computational tool to predict the influence of cell cycle time and phase fraction on spheroid growth. Biotechnology Progress vol. 34, (6) 1335-1343.
10.1002/btpr.2692
https://qmro.qmul.ac.uk/xmlui/handle/123456789/53323
Wang P, Magdolen V, Seidl C, Dorn J, Drecoll E, Kotzsch M, Yang F, Schmitt M et al.(2018). Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer. British Journal of Cancer vol. 119, (7) 823-831.
10.1038/s41416-018-0260-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/57881
Loessner D, Goettig P, Preis S, Felber J, Bronger H, Clements JA, Dorn J, Magdolen V(2018). Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer. Expert Opin Ther Targets vol. 22, (9) 745-763.
10.1080/14728222.2018.1512587
Wagner F, Holzapfel BM, McGovern JA, Shafiee A, Baldwin JG, Martine LC, Lahr CA, Wunner FM et al.(2018). Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma. Biomaterials vol. 171, 230-246.
10.1016/j.biomaterials.2018.04.030
https://qmro.qmul.ac.uk/xmlui/handle/123456789/53347
Meinert C, Theodoropoulos C, Klein TJ, Hutmacher DW, Loessner D(2018). A Method for Prostate and Breast Cancer Cell Spheroid Cultures Using Gelatin Methacryloyl-Based Hydrogels. Methods Mol Biol vol. 1786, 175-194.
10.1007/978-1-4939-7845-8_10
https://qmro.qmul.ac.uk/xmlui/handle/123456789/53325
Quent VMC, Taubenberger AV, Reichert JC, Martine LC, Clements JA, Hutmacher DW, Loessner D(2018). A humanised tissue-engineered bone model allows species-specific breast cancer-related bone metastasis in vivo. Journal of Tissue Engineering and Regenerative Medicine vol. 12, (2) 494-504.
10.1002/term.2517
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25189
Momot KI, Bas O, Holzapfel NP, Loessner D(2017). Magnetic resonance microimaging of cancer cell spheroid constructs. Biomedical Spectroscopy and Imaging vol. 5, (1) 41-54.
10.3233/BSI-150130
Holzapfel NP, Shokoohmand A, Wagner F, Landgraf M, Champ S, Holzapfel BM, Clements JA, Hutmacher DW et al.(2017). Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load. Am J Cancer Res vol. 7, (6) 1322-1336.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25233
Muerza-Cascante ML, Shokoohmand A, Khosrotehrani K, Haylock D, Dalton PD, Hutmacher DW, Loessner D(2017). Endosteal-like extracellular matrix expression on melt electrospun written scaffolds. Acta Biomaterialia vol. 52, 145-158.
10.1016/j.actbio.2016.12.040
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22203
Tourell MC, Shokoohmand A, Landgraf M, Holzapfel NP, Poh PSP, Loessner D, Momot KI(2017). The distribution of the apparent diffusion coefficient as an indicator of the response to chemotherapeutics in ovarian tumour xenografts. Scientific Reports vol. 7,
10.1038/srep42905
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22264
Muerza-Cascante ML, Khosrotehrani K, Haylock D, Hutmacher DW, Loessner D(2017). 5.11 Engineering the haematopoietic stem cell niche in vitro. Comprehensive Biomaterials II,
Fuhrman-Luck RA, Stansfield SH, Stephens CR, Loessner D, Clements JA(2016). Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1. J Proteome Res vol. 15, (8) 2466-2478.
10.1021/acs.jproteome.5b01148
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22262
Fuhrman-Luck R, Hastie M, Ho B, Stoll T, Stephens C, Kryza T, Rockstroh A, Lehman M et al. (2016). Use multi-omics platforms for comprehensive assessment of the mechanism of action of kallikreinrelated peptidase 4 (KLK4) in the prostate tumour microenvironment. BJU INTERNATIONAL. Conference: Asia-Pacific Prostate Cancer Conference vol. 118, 28-28.
10.1111/bju.13567
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25206
Wagner F, Holzapfel BM, Thibaudeau L, Straub M, Ling M-T, Grifka J, Loessner D, Lévesque J-P et al.(2016). A Validated Preclinical Animal Model for Primary Bone Tumor Research. J Bone Joint Surg Am vol. 98, (11) 916-925.
10.2106/JBJS.15.00920
https://qmro.qmul.ac.uk/xmlui/handle/123456789/20319
Badenoch-Jones EK, Lynham AJ, Loessner D(2016). Consent for third molar tooth extractions in Australia and New Zealand: A review of current practice. Australian Dental Journal vol. 61, (2) 203-207.
10.1111/adj.12339
https://qmro.qmul.ac.uk/xmlui/handle/123456789/38604
Loessner D, Meinert C, Kaemmerer E, Martine LC, Yue K, Levett PA, Klein TJ, Melchels FPW et al.(2016). Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms. Nature Protocols vol. 11, (4) 727-746.
10.1038/nprot.2016.037
Kryza T, Silva ML, Loessner D, Heuzé-Vourc'h N, Clements JA(2016). The kallikrein-related peptidase family: Dysregulation and functions during cancer progression. Biochimie vol. 122, 283-299.
10.1016/j.biochi.2015.09.002
Holzapfel NP, Holzapfel BM, Theodoropoulos C, Kaemmerer E, Rausch T, Feldthusen J, Champ S, Clements JA et al.(2016). Lycopene's effects on cancer cell functions within monolayer and spheroid cultures. Nutrition and Cancer vol. 68, (2) 350-363.
10.1080/01635581.2016.1150498
Dorn J, Yassouridis A, Walch A, Diamandis EP, Schmitt M, Kiechle M, Wang P, Drecoll E et al.(2016). Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: Correlation with clinical outcome. American Journal of Cancer Research vol. 6, (1) 61-70.
Hutmacher DW, Holzapfel BM, De-Juan-Pardo EM, Pereira BA, Ellem SJ, Loessner D, Risbridger GP(2015). Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance. Current Opinion in Biotechnology vol. 35, 127-132.
10.1016/j.copbio.2015.06.001
Badenoch-Jones E, Lynham A(2015). Consent for third molar tooth extractions in Australia and New Zealand: a review of current practice. International Journal of Oral and Maxillofacial Surgery vol. 44, e32-e32.
10.1016/j.ijom.2015.08.454
Bock N, Loessner D, Clements JA, Hutmacher DW (2015). A Tissue Engineered Bone Construct as a 3D Metastasis Colonization Model. TISSUE ENGINEERING PART A. vol. 21, S277-S277.
Loessner D, Holzapfel BM, Clements JA, Hutmacher DW (2015). Design of Disease Models using Tissue Engineering Principles. TISSUE ENGINEERING PART A. vol. 21, S189-S189.
Bock N, Loessner D, Hutmacher D, Clements J (2015). A 3D in vitro model reflecting the androgen deprivation state in prostate cancer bone metastasis. BJU INTERNATIONAL. vol. 116, 38-38.
Fuhrman-Luck R, Kryza T, Hastie M, Stoll T, Kleifeld O, Ho B, Lehman M, Rockstroh A et al. (2015). Kallikrein-related peptidase 4 induces tumour microenvironment alterations that support tumour growth. BJU INTERNATIONAL. vol. 116, 38-38.
Hutmacher DW, Little JP, Pettet GJ, Loessner D(2015). Biomaterial science meets computational biology. Journal of Materials Science: Materials in Medicine vol. 26, (5)
10.1007/s10856-015-5518-z
Loessner D, Rizzi SC, Stok KS, Magdolen V, Hutmacher DW, Clements JA (2015). An engineered tumour microenvironment provides new insights into cancer progression and drug responses. CLINICAL & EXPERIMENTAL METASTASIS. vol. 32, 220-220.
Fuhrman-Luck R, Stansfield S, Hastie M, Stoll T, Stephens C, Loessner D, Lehman M, Nelson C et al. (2015). The Kallikrein-related serine peptidase, KLK4, regulates the TGF beta 1 pathway in the tumour-stroma microenvironment in prostate cancer. CLINICAL & EXPERIMENTAL METASTASIS. vol. 32, 197-197.
Holzapfel BM, Hutmacher DW, Nowlan B, Barbier V, Thibaudeau L, Theodoropoulos C, Hooper JD, Loessner D et al.(2015). Tissue engineered humanized bone supports human hematopoiesis in vivo. Biomaterials vol. 61, 103-114.
10.1016/j.biomaterials.2015.04.057
Fuhrman-Luck RA, Loessner D, Clements JA(2014). Kallikrein-Related Peptidases in Prostate Cancer: From Molecular Function to Clinical Application. EJIFCC vol. 25, (3) 269-281.
Bonda UH, Bray LJ, Lister N, Ellem S, Risbridger G, Freudenberg U, Werner CC, Hutmacher DW et al. (2014). Mimicking the tumour microenvironment (TME): Angiogenesis in tumour progression. EUROPEAN JOURNAL OF CANCER. vol. 50, S62-S62.
10.1016/S0959-8049(14)50232-8
Clements J, Fuhrman-Luck R, Stansfield S, Hastie M, Stoll T, Stephens C, Loessner D, Lehman M et al. (2014). The kallikrein-related serine peptidase, KLK4, regulates the TGF beta 1 pathway in the tumour-stroma microenvironment in prostate cancer. EUROPEAN JOURNAL OF CANCER. vol. 50, S65-S66.
10.1016/S0959-8049(14)50246-8
Loessner D, Holzapfel BM, Baldwin J, Rockstroh A, Magdolen V, Hutmacher DW, Clements JA (2014). The tumour-stroma niche of ovarian cancer in 3D. EUROPEAN JOURNAL OF CANCER. vol. 50, S24-S24.
10.1016/S0959-8049(14)50090-1
Loessner D, Holzapfel BM, Baldwin J, Rockstroh A, Magdolen V, Clements JA, Hutmacher DW (2014). An engineered tumour-stroma niche provides new insights into disease progression. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. vol. 8, 314-315.
Holzapfel BM, Wagner F, Loessner D, Holzapfel NP, Thibaudeau L, Crawford R, Ling MT, Clements JA et al.(2014). Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone. Biomaterials vol. 35, (13) 4108-4115.
10.1016/j.biomaterials.2014.01.062
Loessner D, Holzapfel BM, Clements JA(2014). Engineered microenvironments provide new insights into ovarian and prostate cancer progression and drug responses. Advanced Drug Delivery Reviews vol. 79, 193-213.
10.1016/j.addr.2014.06.001
Kaemmerer E, Melchels FPW, Holzapfel BM, Meckel T, Hutmacher DW, Loessner D(2014). Gelatine methacrylamide-based hydrogels: An alternative three-dimensional cancer cell culture system. Acta Biomaterialia vol. 10, (6) 2551-2562.
10.1016/j.actbio.2014.02.035
Dong Y, Loessner D, Irving-Rodgers H, Obermair A, Nicklin JL, Clements JA(2014). Metastasis of ovarian cancer is mediated by kallikrein related peptidases. Clinical and Experimental Metastasis vol. 31, (1) 135-147.
10.1007/s10585-013-9615-4
Fuhrman-Luck RA, Silva ML, Dong Y, Irving-Rodgers H, Stoll T, Hastie ML, Loessner D, Gorman JJ et al.(2014). Proteomic and other analyses to determine the functional consequences of deregulated kallikrein-related peptidase (KLK) expression in prostate and ovarian cancer. Proteomics - Clinical Applications vol. 8, (5-6) 403-415.
10.1002/prca.201300098
Shahinian H, Loessner D, Biniossek ML, Kizhakkedathu JN, Clements JA, Magdolen V, Schilling O(2014). Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells. Molecular Oncology vol. 8, (1) 68-82.
10.1016/j.molonc.2013.09.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54323
Loessner D, Rizzi SC, Stok KS, Fuehrmann T, Hollier B, Magdolen V, Hutmacher DW, Clements JA(2013). A bioengineered 3D ovarian cancer model for the assessment ofpeptidase-mediated enhancement of spheroid growth andintraperitoneal spread. Biomaterials vol. 34, (30) 7389-7400.
10.1016/j.biomaterials.2013.06.009
Loessner D, Rizzi SC, Stok KS, Magdolen V, Hutmacher DW, Clements JA (2013). A bioengineered ovarian cancer microenvironment to assess protease-associated functions. CLINICAL CANCER RESEARCH. vol. 19,
10.1158/1078-0432.OVCA13-A73
Fuhrman-Luck R, Kleifeld O, Ho B, Hastie M, Stoll T, Stephens C, Loessner D, Stansfield S et al. (2013). KALLIKREIN-RELATED PEPTIDASE 4 IS A KEY REGULATOR OF THE PROSTATE CANCER MICROENVIRONMENT. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. vol. 40, 14-14.
Loessner D, Kobel S, Clements JA, Lutolf MP, Hutmacher DW(2013). Hydrogel Microwell Arrays Allow the Assessment of Protease-Associated Enhancement of Cancer Cell Aggregation and Survival. Microarrays (Basel) vol. 2, (3) 208-227.
10.3390/microarrays2030208
Fuhrman-Luck R, Hastie M, Stansfield S, Stoll T, Rockstroh A, Lehman M, Nelson C, Loessner D et al. (2013). Kallikrein-related peptidase 4initiates tumour-stroma cross-talk in prostate cancer. BJU INTERNATIONAL. vol. 112, 44-45.
Loessner D, Paige Little J, Pettet GJ, Hutmacher DW(2013). A multiscale road map of cancer spheroids-incorporating experimental and mathematical modelling to understand cancer progression. Journal of Cell Science vol. 126, (13) 2761-2771.
10.1242/jcs.123836
LOESSNER D(2013). Integrin-functionalized artificial membranes as test platforms for monitoring small integrin ligand binding by surface plasmon-enhanced fluorescence spectroscopy. Handbook of Biofunctional Surfaces, CRC Press
Loessner D, Flegg JA, Byrne HM, Clements JA, Hutmacher DW(2013). Growth of confined cancer spheroids: A combined experimental and mathematical modelling approach. Integrative Biology (United Kingdom) vol. 5, (3) 597-605.
10.1039/c3ib20252f
Dong Y, Loessner D, Sieh S, Taubenberger A, Fuhrman-Luck RA, Magdolen V, Hutmacher DW, Clements JA(2012). Cellular model systems to study the tumor biological role of kallikrein-related peptidases in ovarian and prostate cancer. Novel cancer-related biomarkers,
Loessner D, Quent VMC, Kraemer J, Weber EC, Hutmacher DW, Magdolen V, Clements JA(2012). Combined expression of KLK4, KLK5, KLK6, and KLK7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance. Gynecologic Oncology vol. 127, (3) 569-578.
10.1016/j.ygyno.2012.09.001
Loessner D, Baldwin J, Rockstroh A, Irving-Rodgers H, Magdolen V, Hutmacher DW, Clements JA (2012). 3D bioengineered model of the tumor-stroma microenvironment of late stage ovarian cancer. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. vol. 6, 348-348.
Brown TD, Slotosch A, Thibaudeau L, Taubenberger A, Loessner D, Vaquette C, Dalton PD, Hutmacher DW(2012). Design and fabrication of tubular scaffolds via direct writing in a melt electrospinning mode. Biointerphases vol. 7, (1-4) 1-16.
10.1007/s13758-011-0013-7
Fuhrman-Luck R, Stansfield S, Stephens C, Loessner D, Clements J (2012). Kallikrein-related Peptidase 4 and Prostate Cancer - an Extended Role in Tumour Progression. EUROPEAN JOURNAL OF CANCER. vol. 48, S61-S61.
10.1016/S0959-8049(12)70946-2
Loessner D, Baldwin J, Rockstroh A, Irving-Rodgers H, Magdolen V, Hutmacher DW, Clements JA (2012). Unravelling the Tumour-stroma Microenvironment of Late Stage Ovarian Cancer. EUROPEAN JOURNAL OF CANCER. vol. 48, S28-S28.
10.1016/S0959-8049(12)70817-1
Brown TD, Slotosch A, Thibaudeau L, Taubenberger A, Loessner D, Vaquette C, Dalton PD, Hutmacher DW(2012). Design and fabrication of tubular scaffolds via direct writing in a melt electrospinning mode. Biointerphases vol. 7, (1-4) 1-16.
10.1007/s13758-011-0013-7
Lawrence MG, Margaryan NV, Loessner D, Collins A, Kerr KM, Turner M, Seftor EA, Stephens CR et al.(2011). Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells. Prostate vol. 71, (11) 1198-1209.
10.1002/pros.21335
Loessner D, Stok KS, Lutolf MP, Hutmacher DW, Clements JA, Rizzi SC(2010). Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. Biomaterials vol. 31, (32) 8494-8506.
10.1016/j.biomaterials.2010.07.064
Quent VMC, Loessner D, Friis T, Reichert JC, Hutmacher DW(2010). Discrepancies between metabolic activity and DNA content as tool to assess cell proliferation in cancer research. Journal of Cellular and Molecular Medicine vol. 14, (4) 1003-1013.
10.1111/j.1582-4934.2010.01013.x
Dong Y, Tan OL, Loessner D, Stephens C, Walpole C, Boyle GM, Parsons PG, Clements JA(2010). Kallikrein-related peptidase 7 promotes multicellular aggregation via the α<inf>5</inf>β<inf>1</inf> Integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma. Cancer Research vol. 70, (7) 2624-2633.
10.1158/0008-5472.CAN-09-3415
Hutmacher DW, Loessner D, Rizzi S, Kaplan DL, Mooney DJ, Clements JA(2010). Can tissue engineering concepts advance tumor biology research?. Trends in Biotechnology vol. 28, (3) 125-133.
10.1016/j.tibtech.2009.12.001
Lössner D, Abou-Ajram C, Benge A, Aumercier M, Schmitt M, Reuning U(2009). Integrin αvβ3 upregulates integrin-linked kinase expression in human ovarian cancer cells via enhancement of ILK gene transcription. Journal of Cellular Physiology vol. 220, (2) 367-375.
10.1002/jcp.21774
Hutmacher DW, Horch RE, Loessner D, Rizzi S, Sieh S, Reichert JC, Clements JA, Beier JP et al.(2009). Translating tissue engineering technology platforms into cancer research. Journal of Cellular and Molecular Medicine vol. 13, (8 A) 1417-1427.
10.1111/j.1582-4934.2009.00853.x
Klein T, Schrobback K, Georgi N, Reichert J, Loessner D, Crawford R, Clements J, Hutmacher D (2008). Low-serum conditions for expansion culture of multiple cell types. TISSUE ENGINEERING PART A. vol. 14, 874-874.
Lössner D, Abou-Ajram C, Benge A, Reuning U(2008). Integrin αvβ3 mediates upregulation of epidermal growth-factor receptor expression and activity in human ovarian cancer cells. The International Journal of Biochemistry & Cell Biology vol. 40, (12) 2746-2761.
10.1016/j.biocel.2008.05.014
Lenski C, Kooy RF, Reyniers E, Loessner D, Wanders RJA, Winnepenninckx B, Hellebrand H, Engert S et al.(2007). The reduced expression of the HADH2 protein causes X-linked mental retardation, choreoathetosis, and abnormal behavior. American Journal of Human Genetics vol. 80, (2) 372-377.
10.1086/511527
Lössner D, Kessler H, Thumshirn G, Dahmen C, Wiltschi B, Tanaka M, Knoll W, Sinner E-K et al.(2006). Binding of Small Mono- and Oligomeric Integrin Ligands to Membrane-Embedded Integrins Monitored by Surface Plasmon-Enhanced Fluorescence Spectroscopy. Analytical Chemistry vol. 78, (13) 4524-4533.
10.1021/ac052078+
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