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Publications:  Dr Dunja Aksentijevic

Faulkes CG, Eykyn TR, Aksentijevic D(2019). Cardiac metabolomic profile of the naked mole-rat-glycogen to the rescue. Biology Letters vol. 15, (11) 20190710-20190710.
10.1098/rsbl.2019.0710
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61866
Marelli-Berg FM, Aksentijevic D(2019). Immunometabolic cross-talk in the inflamed heart. Cell Stress vol. 3, (8) 240-266.
10.15698/cst2019.08.194
Aksentijevic D, O¿Brien BA, Eykyn TR, Shattock MJ(2018). Is there a causal link between intracellular na elevation and metabolic remodelling in cardiac hypertrophy?. Biochemical Society Transactions vol. 46, (4) 817-827.
10.1042/BST20170508
Faller KME, Atzler D, McAndrew DJ, Zervou S, Whittington HJ, Simon JN, Aksentijevic D, Hove MT et al.(2017). Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine. Cardiovasc Res
10.1093/cvr/cvx242
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32353
Cole MA, Abd Jamil AH, Heather LC, Murray AJ, Sutton ER, Slingo M, Sebag-Montefiore L, Tan SC et al.(2016). On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury. FASEB J vol. 30, (8) 2684-2697.
10.1096/fj.201500094R
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32355
Mansor LS, Mehta K, Aksentijevic D, Carr CA, Lund T, Cole MA, Page LL, Sousa Fialho MDL et al.(2016). Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation. Journal of Physiology vol. 594, (2) 307-320.
10.1113/JP271242
Aksentijevi¿ D, Lewis HR, Shattock MJ(2015). Is rate-pressure product of any use in the isolated rat heart? Assessing cardiac 'effort' and oxygen consumption in the Langendorff-perfused heart. Exp Physiol vol. 101, (2) 282-294.
10.1113/EP085380
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32356
Robb EL, Gawel JM, Aksentijevi¿ D, Cochemé HM, Stewart TS, Shchepinova MM, Qiang H, Prime TA et al.(2015). Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology and Medicine vol. 89, 883-894.
10.1016/j.freeradbiomed.2015.08.021
Eykyn TR, Aksentijevi¿ D, Aughton KL, Southworth R, Fuller W, Shattock MJ(2015). Multiple quantum filtered (23)Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]i. J Mol Cell Cardiol vol. 86, 95-101.
10.1016/j.yjmcc.2015.07.009
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32369
Chouchani EE, Pell V, Gaude E, Aksentijevic D, Sundier S, Duchen M, Shattock M, Frezza C et al. (2015). Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. EUROPEAN JOURNAL OF HEART FAILURE. vol. 17, 29-30.
Chouchani ET, Pell VR, Gaude E, Aksentijevi¿ D, Sundier SY, Robb EL, Logan A, Nadtochiy SM et al.(2014). Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature vol. 515, (7527) 431-435.
10.1038/nature13909
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32368
Aksentijevi¿ D, McAndrew DJ, Karlstädt A, Zervou S, Sebag-Montefiore L, Cross R, Douglas G, Regitz-Zagrosek V et al.(2014). Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity. Journal of Molecular and Cellular Cardiology vol. 75, 76-87.
10.1016/j.yjmcc.2014.07.008
Aksentijevi¿ D, Zervou S, Faller KME, McAndrew DJ, Schneider JE, Neubauer S, Lygate CA(2014). Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart. PLoS One vol. 9, (10) e109021-e109021.
10.1371/journal.pone.0109021
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32366
Chouchani E, Pell V, Gaude E, Aksentijevic D, Shattock M, Davidson S, Duchen M, Frezza C et al. (2014). Comparative metabolomics identifies conserved metabolic pathways that control mitochondrial ROS production during ischaemia reperfusion injury. CARDIOVASCULAR RESEARCH. vol. 103,
10.1093/cvr/cvu091.118
Pavlovic D, Aksentijevic D, Rumjon A, Newbury L, Fuller W, Seymour AM, Sharpe C, Shattock MJ (2014). The role of endogenous cardiotonic steroids in cardiorenal syndrome - Serum cardiotonic steroids contribute to raised intracellular Na and Ca concentrations in the heart. EUROPEAN JOURNAL OF HEART FAILURE. vol. 16, 211-211.
Aksentijevic D, Medway DJ, Sebag-Montefiore L, Zervou S, Douglas G, Lopaschuk GD, Neubauer S, Lygate CA (2014). Metabolic Inflexibility of Malonyl CoA Decarboxylase (MCD) Knockout Mice Leads to Cardiac Remodelling and High Mortality During Peri-Weaning Period. BIOPHYSICAL JOURNAL. vol. 106, 187A-187A.
10.1016/j.bpj.2013.11.1054
Pavlovic D, Siddiqui S, Nagi G, Newbury L, Fuller W, Seymour A-ML, Sharpe C, Shattock MJ et al. (2014). Pathophysiologically-Relevant Levels of Endogenous Cardiotonic Steroids Inhibit the Cardiac Na/K ATPase and Activate ERK1/2 Hypertrophic Signaling In Vivo and In Vitro. BIOPHYSICAL JOURNAL. vol. 106, 304A-304A.
10.1016/j.bpj.2013.11.1765
Faller KME, Medway DJ, Aksentijevic D, Sebag-Montefiore L, Schneider JE, Lygate CA, Neubauer S(2013). Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart. PLoS One vol. 8, (6) e66461-e66461.
10.1371/journal.pone.0066461
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32365
Branovets J, Sepp M, Kotlyarova S, Jepihhina N, Sokolova N, Aksentijevic D, Lygate CA, Neubauer S et al.(2013). Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT<sup>-/-</sup> mouse hearts. American Journal of Physiology - Heart and Circulatory Physiology vol. 305, (4)
10.1152/ajpheart.00919.2012
Lygate CA, Aksentijevic D, Dawson D, Ten Hove M, Phillips D, De Bono JP, Medway DJ, Sebag-Montefiore L et al.(2013). Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice. Circulation Research vol. 112, (6) 945-955.
10.1161/CIRCRESAHA.112.300725
Kotlyarova S, Mandel M, Sokolova N, Aksentijevic D, Lygate CA, Neubauer S, Vendelin M, Birkedal R (2013). Cardiomyocytes from Creatine-Deficient Mice Lacking L-Arginine: Glycine Amidinotransferase (AGAT) Show No Changes in Mitochondrial Organization and Cellular Compartmentation. BIOPHYSICAL JOURNAL. vol. 104, 303A-303A.
10.1016/j.bpj.2012.11.1686
Branovets J, Sepp M, Kotlyarova S, Jepihhina N, Sokolova N, Aksentijevic D, Lygate CA, Neubauer S et al. (2013). Unchanged Mitochondrial Organization and Compartmentation in Creatine Deficient GAMT-/- Mouse Heart. BIOPHYSICAL JOURNAL. vol. 104, 314A-315A.
10.1016/j.bpj.2012.11.1744
Lygate CA, Bohl S, ten Hove M, Faller KME, Ostrowski PJ, Zervou S, Medway DJ, Aksentijevic D et al.(2012). Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction. Cardiovasc Res vol. 96, (3) 466-475.
10.1093/cvr/cvs272
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32364
Lygate CA, Medway DJ, Ostrowski PJ, Aksentijevic D, Sebag-Montefiore L, Hunyor I, Zervou S, Schneider JE et al.(2012). Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age. Basic Res Cardiol vol. 107, (5) 276-276.
10.1007/s00395-012-0276-2
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32363
Ashrafian H, Czibik G, Bellahcene M, Aksentijevi¿ D, Smith AC, Mitchell SJ, Dodd MS, Kirwan J et al.(2012). Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metabolism vol. 15, (3) 361-371.
10.1016/j.cmet.2012.01.017
Lygate CA, Aksentijevic D, Dawson D, ten Hove M, Makinen K, Faller KM, Medway DJ, Sebag-Montefiore L et al. (2011). Adaptations to Maintain Energy Homeostasis Compensate for Creatine-Deficiency in GAMT Knockout Mice Following Myocardial Infarction, but May Contribute to Early Mitochondrial Pathology During Aging. CIRCULATION. vol. 124,
Lygate CA, Bohl S, ten Hove M, Medway DJ, Sebag-Montefiore L, Zervou S, Aksentijevic D, Faller KM et al. (2011). Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics. CIRCULATION. vol. 124,
Aksentijevi¿ D, Lygate CA, Makinen K, Zervou S, Sebag-Montefiore L, Medway D, Barnes H, Schneider JE et al.(2010). High-energy phosphotransfer in the failing mouse heart: Role of adenylate kinase and glycolytic enzymes. European Journal of Heart Failure vol. 12, (12) 1282-1289.
10.1093/eurjhf/hfq174
Pavlovic D, Aksentijevic D, Seymour A-ML, Fuller W, Shattock MJ (2010). A Soluble Inhibitor Depresses Na/K ATPase Activity in Cardiomyopathic Hearts from Uremic Rats. CIRCULATION. vol. 122,
Zervou S, Aksentijevic D, Lygate C, Neubauer S (2010). Creatine reduces mitochondrial permeability transition pore opening in response to oxidative stress in vitro. CARDIOVASCULAR RESEARCH. vol. 87, S126-S126.
Aksentijevic D, Lygate C, Makinen K, Sebag-Montefiore L, Medway D, Schneider J, Neubauer S (2010). High energy phosphotransfer in the failing mouse heart-role of adenylate kinase and glycolytic enzymes. CARDIOVASCULAR RESEARCH. vol. 87, S115-S115.
Smith K, Semple D, Aksentijevic D, Bhandari S, Seymour A-ML(2010). Functional and metabolic adaptation in uraemic cardiomyopathy. Front Biosci (Elite Ed) vol. 2, 1492-1501.
10.2741/e208
Aksentijevic D, Lygate C, Makinen K, Sebag-Montefiore L, Medway D, Neubauer S (2010). COMPENSATION FOR IMPAIRED MYOCARDIAL PHOSPHOTRANSFER IN GUANIDINOACETATE-N-METHYLTRANSFERASE KNOCKOUT MICE. HEART. vol. 96,
10.1136/hrt.2009.191049b
Smith K, Semple D, Aksentijevic D, Bhandari S, Seymour AML(2010). Functional and metabolic adaptation in uraemic cardiomyopathy. Frontiers in Bioscience - Elite vol. 2 E, (4) 1492-1501.
Aksentijevi¿ D, Bhandari S, Seymour AML(2009). Insulin resistance and altered glucose transporter 4 expression in experimental uremia. Kidney International vol. 75, (7) 711-718.
10.1038/ki.2008.691
Aksentijevic D, Bhandari S, Seymour A-ML (2008). Uraemic cardiomyopathy is characterized by altered metabolic substrate transport. CARDIOVASCULAR DRUGS AND THERAPY. vol. 22, 152-153.
Aksentijevic D, Lee KY, Smith K, Bhandari S, Seymour A-ML (2007). Altered expression of myocardial [Ca2+] handling proteins in experimental uraemia. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. vol. 42, S139-S140.
10.1016/j.yjmcc.2007.03.385
Aksentijevic D, Bhandari S, Seymour A-ML (2007). The effect of increased [Ca2+] on myocardial function and energy provision in experimental uraemia. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. vol. 42, S67-S67.
10.1016/j.yjmcc.2007.03.796
Aksentijevic D, Bhandari S, Seymour A-ML (2006). Alteration in GLUT 4 expression in experimental uraemia. CARDIOVASCULAR DRUGS AND THERAPY. vol. 20, 397-397.
Aksentijevic D, Bhandari S, Seymour A-ML (2006). The effect of increased calcium on myocardial function in experimental uraemia. CARDIOVASCULAR DRUGS AND THERAPY. vol. 20, 396-396.
Aksentijevic D, Bhandari S, Seymour A-ML (2006). The impact of increasing calcium on myocardial function in experimental uraemia. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. vol. 40, 932-932.
10.1016/j.yjmcc.2006.03.048
Aksentijevic D, Bbandari S, Seymour AML (2005). Cardiac remodelling in chronic uraemia. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. vol. 39, 191-192.
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